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Wai-Hong Tham

@thamlab.bsky.social
337 followers 346 following 45 posts

🇲🇾 scientist in 🇦🇺 | 🦟 🩸 #malaria |🦙 #nanobodies | Prof @WEHI_research @ourANU | on Wurundjeri, Ngunnawal & Ngambri lands | views my own 🏃🏻‍♀️ 🍜

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Reposted by Wai-Hong Tham
WEHI (The Walter and Eliza Hall Institute of Medical Research) @wehi-research.bsky.social · 29/07/2026
We’re excited to share researchers from WEHI and global biopharmaceutical company MSD have been named finalists in the 2026 Eureka Prizes for their teamwork that has led to a new class of antimalarial treatment candidates 👏👏 Read the story: www.wehi.edu.au/news/from-la...
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Joost Snijder @joostsnijder.bsky.social · 30/06/2026
Very happy with this ERC Proof of Concept grant 😁. We get to test our new DENV prefusion stabilized E-dimers as immunogens. www.uu.nl/en/news/thre...
uu.nl
Security verifications
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Melanie Bonhivers @mbonhivers.bsky.social · 12/06/2026
The CNRS has opened a Junior Professor Chair (CPJ) call in Parasitology, and the Microbiologie Fondamentale et Pathogénicité (MFP, Bordeaux) laboratory is among the potential host institutions. More information: www.insb.cnrs.fr/fr/cnrsinfo/... #Parasitology #Protozoology #ResearchJobs #CNRS
insb.cnrs.fr
Junior Professor Chairs (CPJ) 2026 – CNRS Biology
CNRS Biology is recruiting researchers through its Junior Professor Chair (CPJ) program, subject to final approval by the French Ministry of Higher Ed
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Wai-Hong Tham @thamlab.bsky.social · 25/05/2026
Nanobodies against malaria parasite adhesins that block receptor engagement and invasion Lovely work by @jaisondsa.bsky.social and Jill Chmielewski on PfRh5, PfRh4 & PvRBP2b nanobodies + stabilized PfRh4 🦙🩸⛰️ Have a read, share widely and please give us feedback! www.biorxiv.org/content/10.6...
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Madhu Pai, MD, PhD @madhupai.bsky.social · 22/05/2026
A year before he passed away, I interviewed Dr Paul Farmer @pih.org about his book on Ebola So relevant right now, especially the dangers of “control-over-care approach” - i.e. isolation & quarantine, but fails to ensure adequate clinical care to the sick www.forbes.com/sites/madhuk...
forbes.com
Ebola, Covid-19 And The Elusive Quest For Global Health Equity
Published during this pandemic, Paul Farmer’s new book, “Fevers, Feuds, And Diamonds,” is important, as it presents a critical dissection of the Ebola outbreak in West Africa, and the lessons we can l...
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British Society for Parasitology @bspparasitology.bsky.social · 12/05/2026
We’re excited to welcome Lina Pinto-García @linapintogarcia.bsky.social as our special guest speaker to discuss her recent book, Maraña: War and Disease in the Jungles of Colombia. Time: Thursday 28.05.2026 , 3 PM BST Location: Zoom (Link available after registration) forms.gle/cVADyb6F5Dmh...
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Jonathan Pruneda @jnpruneda.bsky.social · 28/04/2026
Registration has been reopened to fill the last few remaining spots! Last chance to join us in Leiden this June!
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Reuters Legal @legal.reuters.com · 27/04/2026
Eli Lilly said on Monday it would buy privately held blood cancer treatment developer Ajax Therapeutics for up to $2.3 billion in cash.
reut.rs
Eli Lilly to buy Ajax Therapeutics for up to $2.3 billion
Eli Lilly said on Monday ‌it would buy privately held blood cancer treatment developer Ajax Therapeutics for up to $2.3 ​billion in cash.
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Madhu Pai, MD, PhD @madhupai.bsky.social · 24/04/2026
“Women today make up nearly a third of the global research workforce. But workforce representation does not automatically translate into senior or leadership positions” theconversation.com/women-in-sci...
theconversation.com
Women in science – global study finds presence without power
Women make up one in three researchers worldwide, but they remain sidelined in scientific organisations.
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Michelle Wille @duckswabber.bsky.social · 23/04/2026
How does HPAI affect different animals? Here airway organoids from ten diverse wildlife + livestock. host-specific differences in infection rate + patho. Useful for receptor-binding, viral dynamics, early host adaptation in poorly characterized animals 👉 www.tandfonline.com/doi/full/10....
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Sylvie Callegari @sylviecallegari.bsky.social · 23/04/2026
Glycogen is ubiquitinated in vivo! And there is a clever method to detect it. It had been a privilege seeing this story come together by my colleagues in the @komanderlab.bsky.social. This will no doubt have important implications for metabolism.
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Marco Jochem @marcojochem.bsky.social · 23/04/2026
Interested in non-proteinaceous ubiquitination, induced proximity or glycogen? Then you should have a look at our newest article, “Ubiquitination of glycogen and metabolites in cells and tissues”, just published in Nature: www.nature.com/articles/s41...
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Kelvin Lau @klausenhauser on 🙅‍♂️🐘🪡 @klausenhauser.bsky.social · 22/04/2026
Calling all xray structure folks that have worked with denovo proteins. Do you suffer from high rfactors? Myself, someone else I know and now multiple structures all seem to suffer from this. Assuming we all tried our best in model building, what could be some causes?
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Biochemical Society @biochemsoc.bsky.social · 14/04/2026
A huge congratulations to César de la Fuente who receives the Biochemical Society Award for Significant Breakthrough or Achievement for his pioneering research into AI-driven antibiotic discovery! With AMR an increasing threat, Cesar's work paves the way for new treatments.
Portrait of Professor César de la Fuente, recipient of the Biochemical Society Award for Significant Achievement in 2027.
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Biochemical Society @biochemsoc.bsky.social · 14/04/2026
Congratulations to Tom Deegan who receives the Colworth Medal in 2027! Pioneering work from the Deegan Lab has redefined our understanding of eukaryotic DNA replication and provided conceptual and technical frameworks that continue to drive new discoveries across molecular biology.
Dr Tom Deegan from University of Edinburgh awarded The Colworth Medal by The Biochemical Society 2027 Awards.
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Megan Sloan @sloanmegan.bsky.social · 07/04/2026
We open with @sheinerlab.bsky.social introducing a scientist who needs no introduction - Dominique Soldati-Favre. Dominique was awarded lifetime membership to the @bspparasitology.bsky.social for her immeasurable contributions to the field. #bsp #parasites #peoplemakeglasgow
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Jan-Hannes Schaefer @jhschaef.bsky.social · 07/04/2026
We identified the maltoside detergent DM as an effective and easy solution to address preferred orientation in cryo-EM. Helped me switch from graphene grids. Special congrats to Maria Rafiq! @landerlab.bsky.social @nanigrotjahn.bsky.social @wisemanlab.bsky.social #cryoEM doi.org/10.64898/202...
Blender Rendering of vitrified HA trimer with DM at the air-water interface
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Joost Snijder @joostsnijder.bsky.social · 30/03/2026
Host cell remodeling via cyclin dependent kinases drives Ebola virus replication and transcription. www.biorxiv.org/content/10.6... Check out our latest preprint. Great work by @tshamorkina.bsky.social. Thanks to co-authors Danni Snikkers and @hecklab.bsky.social
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Science Magazine @science.org · 19/03/2026
Wild rice is a perennial, creeping plant. The secret to its perennial growth habit lies in a developmental reversal directed by small RNAs. This image illustrates how combining perennial genes with prostrate growth genes allows cultivated rice to mimic wild rice. Learn more: scim.ag/40GOjDb
This image illustrates how combining perennial genes with prostrate growth genes allows cultivated rice to mimic wild rice.
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Emily Furlong @emfurlong.bsky.social · 17/03/2026
Very excited that the first publication from my lab is now online! Thanks to @actacrystd.iucr.org editors and reviewers for the smooth publication process. And congratulations to first author, Jiayi Pan, who completed this work in her Master’s year! @biologyanu.bsky.social
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Richard Sever @richardsever.bsky.social · 12/03/2026
"bioRxiv is exactly the type of living experiment we all should be striving for, to achieve our shared goals of optimizing how research evidence is shared and used.” via @chrisnsimms.bsky.social www.nature.com/articles/d41...
nature.com
How bioRxiv changed the way biologists share ideas – in numbers
Four million articles are now downloaded from bioRxiv every month, according to an analysis of the life-science preprint server’s first 13 years of existence.
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Daniel Hurdiss @danielhurdiss.bsky.social · 11/03/2026
Structures of Marburgvirus glycoprotein and its complex with NPC1 receptor doi.org/10.1038/s415...
doi.org
Structures of Marburgvirus glycoprotein and its complex with NPC1 receptor - Nature
Marburgvirus glycoprotein binds to the endosomal receptor NPC1 in a distinct orientation with higher affinity compared with Ebola virus glycoprotein, accompanied by fusion-relevant rearrangements...
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Joost Snijder @joostsnijder.bsky.social · 11/03/2026
These HTA proteases from archaea work great for mass spec-based antibody sequencing. Paper out now in final form at Cell Systems. Congrats to @tshamorkina.bsky.social @tkadava.bsky.social @lperezpaneda.bsky.social and @hecklab.bsky.social www.sciencedirect.com/science/arti...
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Wai-Hong Tham @thamlab.bsky.social · 10/03/2026
Congratulations to @jaisondsa.bsky.social who was awarded the JBC Herbert Tabor Early Career Investigator award from @asbmb.bsky.social 🎉 Awarded for Jaison’s PhD work on stabilized PvRBP2b variants using computational design for a better P. Vivax serological biomarker @wehi-research.bsky.social
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Prof Brendan Crabb AC @brendancrabb.bsky.social · 08/03/2026
Health and medical research is the only hope for so many health conditions, yet is chronically underfunded. Amazingly, a big part of the solution already exists. The money is literally in the bank, earmarked for health & medical research. It just has to be released. www.abc.net.au/news/2026-03...
abc.net.au
Up to $1.4 billion in medical research remains unused under government cap
Researchers say securing funding has become increasingly tough, with many left with no choice but to spend a disproportionate amount of time applying for grants.
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Lesley A Hall @erinacean.bsky.social · 08/03/2026
IWD: somehow her name is less familiar, and yet, she actually received the Nobel: Dorothy Crowfoot Hodgkin: en.wikipedia.org/wiki/Dorothy...
en.wikipedia.org
Dorothy Hodgkin - Wikipedia
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Women in Malaria @womeninmalaria.bsky.social · 08/03/2026
Happy International Women’s Day #IWD2026 🤩🎉 To celebrate the day we present the first WiM sketch of the year, featuring Dr Katharine Collins, the co-inventor of the R21 malaria vaccine 👩🏻‍🔬💉
The image shows a sketch of Dr Katharine Collins, the co-inventor of the R21 malaria vaccine. Dr Collins is wearing a lab coat on one side and holding a falcon tube and on the other side typing on a laptop. Surrounding Katharine are icons representing her contribution in the development of the R21 vaccine.International Women's Day 2026

Women in Malaria encourages everyone to take a moment today to celebrate and acknowledge International Women's Day (IWD). This day celebrates the achievements of women around the globe and aims to increase support for gender equality. Since its origin in 1911, IWD has helped bring awareness to gender biases in critical areas such as policy, education, pay, and representation, and has supported the development of gender-equality-focused legislation and practices worldwide. The conversations and actions inspired by this day have had (and can continue to have) a monumental impact. 

In honor of IWD, we would like to recognize Dr. Katharine Collins, who was nominated for the WiM Sketches. 

Dr. Collins is the co-inventor of the R21  malaria vaccine, which helps prevent malaria in children.  R21 is the second malaria vaccine recommended by the World Health Organisation. This work was the focus of her PhD at Oxford University under Professor Adrian Hill.  She later worked with James McCarthy at the Queensland Institute of Medical Research on transmission models of infection, and with Teun Bousema at Radboud University on controlled human malaria infection models. She has also served on the WHO malaria vaccine advisory committee and has actively been in involved with WiM for several years. 

Dr. Collins currently works inon Global Health R&D at Coefficient Giving (previously Open Philanthropy) where she helps support research with the greatest potential to improve global health and save lives. 

To learn more about IWD and how to get involved, please check out: https://www.unwomen.org/en/get-involved/international-womens-day  

-the WiM team
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Matt Higgins @parasitematt.bsky.social · 03/03/2026
Introducing our new blood-stage malaria vaccine immunogen based on the essential invasion protein PfCyRPA. By understanding where on PfCyRPA the best antibodies bind, we used structure guided design to generate PfCyRPA-EM, which contains only the epitopes of the best antibodies.
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Bloom lab @jbloomlab.bsky.social · 25/02/2026
In new study led by Brendan Larsen, we map functional constraint across the Nipah virus F protein to define constrained epitopes for antibody targeting and identify mutations that stabilize the prefusion conformation for vaccine immunogens. www.pnas.org/doi/10.1073/...
pnas.org
Functional and antigenic constraints on the Nipah virus fusion protein | PNAS
Nipah virus is a highly pathogenic virus in the family Paramyxoviridae that utilizes two distinct surface glycoproteins to infect cells. The recept...
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Diego del Alamo @delalamo.xyz · 25/02/2026
We're hiring - looking for folks with experience designing and training foundation models from scratch, particularly biomolecular language models, GNNs, or vision models. Lots of room for creativity in this role. Contact me if you have any interest
jobs.takeda.com
Research Senior Scientist AI/ML Foundational Models at Takeda Pharmaceutical
Learn more about applying for Research Senior Scientist AI/ML Foundational Models at Takeda Pharmaceutical
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Richard Sever @richardsever.bsky.social · 24/02/2026
Pretty reasonable summary of the state of COVID origin debate: what most experts think (zoonosis), where information is missing (some virology lab activities), what's clearly nonsense (cold chain), what's unsupported (deliberately made) www.nature.com/articles/d41...
nature.com
COVID’s origins: what we do and don’t know
Researchers summarize key insights from the world’s first comprehensive investigation into how a pandemic started.
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Tom McLean @tommclean.bsky.social · 25/02/2026
Come do a PhD with me and @trevor-lithgow.bsky.social at @monashuniversity.bsky.social ! We’re at the leading edge of pathogen biology using cutting edge Cryo-EM and AI-driven genetic screens to uncover the mysteries of outer membrane biology. Reach out to me for a chat! macsys.org/phd-scholars...
macsys.org
PhD Scholarship at Monash University - MACSYS
Do cutting-edge research at the intersection of cryo‑EM, genome-wide profiling, and AI-driven modelling. Work with world‑class cryo-EM/cryo-ET imaging and AI tools to discover how the dangerous bacter...
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Andrew Burgess @drandrewburgess.bsky.social · 25/02/2026
Do you or do you know someone impacted by bacterial #StrepA ? We are looking to hear from you! Use the QR code (or link) to register your interest in our Consumer Workshop to Help Shape the Future of a Breakthrough Vaccine to Eliminate Childhood Strep A Diseases. forms.office.com/r/7wjTxedG5G
QR code that links to a webform to express interest in participating in a Consumer Workshop
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Kristian G. Andersen @kgandersen.bsky.social · 24/02/2026
In 2025, GISAID cut off access to many critical SARS-CoV-2 resources, incl. our outbreak.info. A month ago, GISAID leveled accusations against us, Cov-Spectrum, Nextstrain, and members of COG-UK, which are false and misrepresent known facts. Our joint response: blog.outbreak.info/joint-respon...
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ARC Tracker @arc-tracker.bsky.social · 25/02/2026
The ARC have said (on LinkedIn) they will release outcomes for Discovery Projects Expressions of Interest (2027) tomorrow👇
Screenshot of LinkedIn post from ARC saying that DP27 EOI outcomes will be released on RMS on the 26th Feb 2026.
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WEHI (The Walter and Eliza Hall Institute of Medical Research) @wehi-research.bsky.social · 19/02/2026
We’re proud to welcome Prof Laura Mackay as our first Sir Gustav Nossal Professor of Immunology – advancing Sir Gus’ remarkable legacy, thanks to the generosity and vision of the Nossal family. More: www.wehi.edu.au/news/world-r...
The inaugural Sir Gustav Nossal Professor of Immunology, Professor Laura Mackay.
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ANU Research School of Biology @biologyanu.bsky.social · 18/02/2026
Join us on campus & online on Friday, 6 March 2026 at 1pm for a seminar by Kate O'Hara, PhD Candidate from the Moritz Group! Details: rb.gy/u9aqza
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Charles Bayly-Jones @charlesbj.bsky.social · 18/02/2026
I’ve officially started my lab at Monash University! 🎉 We’re diving into #cellgrowth and #lysosome biology, through the lens of molecular #structure and mechanism. I’m thrilled to say that PhD student scholarships are available—so please share widely and get in touch if you’re interested. 🤩
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sturalph.bsky.social @sturalph.bsky.social · 18/02/2026
Some lovely work on the Plasmodium fertilisation machinery at #lorneiandi presented by Melanie Dietrich from the Tham Lab @thamlab.bsky.social -
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Victorian Infection and Immunity Network @theviin.bsky.social · 18/02/2026
Great to hear from Dr Melanie Dietrich from @thamlab.bsky.social @wehi-research.bsky.social. They found the native cryo-EM structure of Pfs230-Pfs48/45 complex, and identified domain 13 and 14 of Pfs230 as leading malaria transmission blocking vaccine candidates! 🦟 💉#lorneiandi
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Sjors Scheres @sjorsscheres.bsky.social · 16/02/2026
Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳 mrc.tal.net/vx/mobile-0/...
mrc.tal.net
Research Group Leader Tenure Track - Structural Studies - LMB 2775 - Medical Research Council
Location: Cambridge. Vacancy: Research Group Leader Tenure Track - Structural Studies - LMB 2775. Closing Date: 16/03/2026, 23:55
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Professor Euan Ritchie FAMS @euanritchie.bsky.social · 16/02/2026
Our son, Rohan, is smiling in this photo, but make no mistake, he worked so hard to reach his goal of 100km. @scidocmartin.bsky.social & I couldn't be prouder. www.theage.com.au/national/vic... There's still time to support his fundraiser for mental health 👉 www.mycause.com.au/page/385454/...
theage.com.au
‘He smashed it’: Teen marks 18th birthday with 100km run for charity
‘I will not be going out partying’: teen runs nine hours straight to raise funds for charity.
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Olivier Neyrolles @oneyrolles.bsky.social · 13/02/2026
🎉 𝐄𝐱𝐜𝐢𝐭𝐞𝐝 𝐭𝐨 𝐬𝐡𝐚𝐫𝐞 𝐨𝐮𝐫 𝐧𝐞𝐰 𝐩𝐮𝐛𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐢𝐧 𝐓𝐡𝐞 𝐄𝐌𝐁𝐎 𝐉𝐨𝐮𝐫𝐧𝐚𝐥! After 8 months of revision, our work is now online: shorturl.at/WHmFq We uncover a previously unrecognized way that 𝑀𝑦𝑐𝑜𝑏𝑎𝑐𝑡𝑒𝑟𝑖𝑢𝑚 𝑡𝑢𝑏𝑒𝑟𝑐𝑢𝑙𝑜𝑠𝑖𝑠 survives toxic metal stress during infection. ...
shorturl.at
Membrane-associated effluxosomes coordinate multi-metal resistance in Mycobacterium tuberculosis - The EMBO Journal
Bacterial pathogens must withstand metal-induced stress during infection, yet the mechanisms by which they sense and respond to toxic metal ions remain incompletely understood. Here, we uncover a prev...
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Tom Churcher @thomaschurcher.bsky.social · 12/02/2026
Generous international scolarships for our MSc in Epidemiology here in London. In memory of Bob May. My career is 100% resulting from something similar to this *cough* *cough* 25 *cough*.....years ago! www.imperial.ac.uk/study/fees-a...
imperial.ac.uk
Search our scholarships
Search scholarship opportunities.
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Sylvie Callegari @sylviecallegari.bsky.social · 11/02/2026
I'm hiring! If you are a structural biology postdoc with strong cryo-EM experience who is excited about mitochondrial membrane complexes, please apply! WEHI is a great place to work with access to state-of-the art cryo-EM facilities. Apply here 👇 wehi.wd3.myworkdayjobs.com/broadbean_ex...
wehi.wd3.myworkdayjobs.com
Research Officer
Job Title Research Officer Job Description An excellent opportunity is available for a Research Officer/Senior Research Officer to join the Callegari Lab in the Ubiquitin Signalling Division at Austra...
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Victorian Infection and Immunity Network @theviin.bsky.social · 09/02/2026
It's not too late to join us for Lorne I&I 2026! We have an incredible line-up of stellar Invited Speakers joining us from interstate and across the globe; check out our live Program for more details. Don't miss out, register now! www.lorneinfectionimmunity.org/registration #lorneiandi
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Lorraine Reese @lorraine-reese.bsky.social · 06/02/2026
Internationally renowned as one of the leaders in neurotransmitter transport research, don't miss Professor Renae Ryan (@renaeryan.bsky.social) present her #BiochemSoc International Award Lecture at Membrane #Proteins Conference 2026! 🧪
The Biochemical Society 2025 Awards. International Award, Professor Renae Ryan, University of Sydney. Includes photo of Prof Ryan and Biochemical Society awards logo.
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Nichollas Scott @nickescott.bsky.social · 05/02/2026
Really happy to see this work out! Super fun project with a great team. For me the highlight was that we finally were able to show the O-linked glycosylation systems of H. pylori/C. jejuni are general glycosylation systems which target non-flagellin proteins (suggest >10 years ago by click chem).
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Dave Baltrus 🦦 @surtlab.bsky.social · 05/02/2026
Been on multiple search committees For me (personally so YMMV)…I basically dismiss everything that’s labeled *submitted* unless there’s a preprint I can read
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Angie Rasmussen @angierasmussen.bsky.social · 06/02/2026
Have I ever mentioned how surreal it is to be an Editor-in-Chief of a journal called Vaccine right now? www.science.org/content/arti... It’s pretty wild, at least by typical academic journal editorial office standards.
science.org
Controversial Danish vaccine research group faces new allegations
Researchers say they couldn’t find complete data for 10 trials that together enrolled tens of thousands of children in Guinea-Bissau
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