iiinova — where your digital self keeps evolving

Reposted by Albert Heck

Cees Dekker @ceesdekker.bsky.social · 09/09/2026

Latest #CDlab paper on BioRxiv: www.biorxiv.org/content/10.6... 1st author Eva Bertosin developed huge DNA origami nanopores that can dilate and constrict in size. With diameters up to 87 nm, they can insert into lipid membranes, showing selective transport when filled with nuclear pore proteins.

biorxiv.org

https://www.biorxiv.org/content/10.64898/2026.09.03.749129v1

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Albert Heck @hecklab.bsky.social · 20/08/2026

Cool to see the natural advantages of dimeric IgA as present also in swum. Nice work

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Dr Ino Agrafioti @inoagrafioti.bsky.social · 01/07/2026

Congratulations to LS1 grantees @hecklab.bsky.social and Annarita Miccio at @institutimagine.bsky.social , for being awarded ERC POC grants! :)

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Nikolai Slavov @slavov-n.bsky.social · 24/06/2026

Since the 1960s, the genetic code has been used to predict protein sequences from DNA and mRNA sequences. Our @nature.com article demonstrates that these predictions miss thousands of protein sequences present in human tissues. www.nature.com/articles/s41... 1/

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Laura Pérez @lperezpaneda.bsky.social · 23/06/2026

Our article is out in Nature Communications! We identify ATP synthase as a new link between OXPHOS and the TCA cycle, and these interactions are remodelled upon mitochondrial dysfunction. Co-authored with Jelena Misic, @tkadava.bsky.social, @nils-goranlarsson.bsky.social, @hecklab.bsky.social

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Joe Loo @joelooucla.bsky.social · 06/06/2026

It was great to have you @asms.org #ASMS2026 in San Diego! Your Plenary Lecture was a great way to end our conference. I hope you didn't mind talking about Science Integrity continuously during the USS Midway tour afterwards with our members. Thanks for discussing this important topic in science.

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Reposted by Albert Heck

Elisabeth Bik @elisabethbik.bsky.social · 03/06/2026

Traveling today to San Diego, to give the closing plenary at the @asms.org #ASMS2026 #MassSpectrometry meeting. I am not aware of a lot of MS fraud, and would have a hard time finding it myself, but hopefully we can learn from each other. This might be my biggest audience ever (7K participants)!

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Ying Ge @yingge2121.bsky.social · 02/06/2026

#ASMS2026 Huge congratulations to Albert @hecklab.bsky.social for winning the ASMS John Fenn award for a Distinguished contribution in Mass spectrometry! well-deserved! A truly inspiring talk👍👏✨

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Albert Heck @hecklab.bsky.social · 07/05/2026

The next episode in our quest at @utrechtuniversity.bsky.social to answer "what do we know about your antibodies?" Structural promiscuity in the human circulatory IgA1 clonal repertoire | PNAS www.pnas.org/doi/10.1073/.... Funded by @erc.europa.eu. Congrats to Amber Rolland

pnas.org

Structural promiscuity in the human circulatory IgA1 clonal repertoire | PNAS

Immunoglobulin A (IgA) is the most abundant antibody in humans, with high concentrations in both mucosae/secretions and circulation. While mucosal ...

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Reposted by Albert Heck

ASMS @asms.org · 05/05/2026

Congratulations to Albert J.R. Heck, recipient of the 2026 #ASMS John B. Fenn Award for Distinguished Contribution! A leader in the field, his work continues to shape the future of #massspectrometry. We’re excited to celebrate his achievements at #ASMS2026 in San Diego.

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Albert Heck @hecklab.bsky.social · 02/05/2026

A nice Polish - Dutch collaboration with the @iimcb.bsky.social. Congratulations to Mayra Borrero, Vanessa Linke and @tkadava.bsky.social. A dynamic gateway: Uncovering the expanded human TOM complex interactome and its regulatory complexity | Science Advances www.science.org/doi/10.1126/...

science.org

A dynamic gateway: Uncovering the expanded human TOM complex interactome and its regulatory complexity

Human TOM complex was revealed as a dynamic hub, with FKBP8 as a human-specific interactor shaping biogenesis.

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Reposted by Albert Heck

Joost Snijder @joostsnijder.bsky.social · 23/03/2026

We did a plasma proteomics study on dengue disease severity in children with Tineke Cantaert and identified early markers of endothelial and inflammatory activation. Great work by @tshamorkina.bsky.social and Sofia! Thanks to all co-authors @hecklab.bsky.social. www.medrxiv.org/content/10.6...

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Reposted by Albert Heck

Joost Snijder @joostsnijder.bsky.social · 30/03/2026

Host cell remodeling via cyclin dependent kinases drives Ebola virus replication and transcription. www.biorxiv.org/content/10.6... Check out our latest preprint. Great work by @tshamorkina.bsky.social. Thanks to co-authors Danni Snikkers and @hecklab.bsky.social

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Albert Heck @hecklab.bsky.social · 21/03/2026

A nature-inspired ion trap for parallel manipulation of ions on a massive scale | Science Advances www.science.org/doi/10.1126/.... Very nice work by Brian Chait and Andrew Krutchinsky from @rockefeller.edu inspired by parallel sequencing in genomics and other technologies. Congratulations

science.org

A nature-inspired ion trap for parallel manipulation of ions on a massive scale

A nature-inspired ion trap enabling massively parallel mass spectrometry.

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Albert Heck @hecklab.bsky.social · 15/03/2026

Deep coverage and extended sequence reads obtained with a single archaeal protease expedite de novo protein sequencing by mass spectrometry: Cell Systems www.cell.com/cell-systems.... How great would it be to sequence proteins without a gene-template! We might be approaching this soon.

cell.com

Deep coverage and extended sequence reads obtained with a single archaeal protease expedite de novo protein sequencing by mass spectrometry

Highly efficient hyperthermal acidic proteases combined with hybrid-fragmentation schemes provide five times more unique peptide reads than trypsin or chymotrypsin, greatly boosting confidence in de n...

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Reposted by Albert Heck

Joost Snijder @joostsnijder.bsky.social · 11/03/2026

These HTA proteases from archaea work great for mass spec-based antibody sequencing. Paper out now in final form at Cell Systems. Congrats to @tshamorkina.bsky.social @tkadava.bsky.social @lperezpaneda.bsky.social and @hecklab.bsky.social www.sciencedirect.com/science/arti...

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Reposted by Albert Heck

Elisa Fadda @elisafadda.bsky.social · 06/03/2026

I wonder... 🤔🤔🧪 #chemsky a) what program did the authors use to make the original (left) figure in the paper? Wild guess, ChatGPT b) how such high school science level of disgrace pass peer review in @nature.com? Note this was Fig.4.a NOT in SI www.nature.com/articles/s41...

Original (left) and corrected (right) Fig. 4a in the paper https://www.nature.com/articles/s41586-026-10305-0 showing the chemical structures of amino acids (only the right one) the left figure is just an embarrassment

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Chris Ashwood @cashwood.proteaglyco.com · 17/01/2026

Got an Orbitrap-based mass spec that couldn’t do STORI/direct mass technology before (any aside from the UHMR and Tribrid Ascend)? This is a cool open-source implementation that even works on an Orbitrap Elite! #teammassspec

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Albert Heck @hecklab.bsky.social · 29/12/2025

A Universal Spectrum Annotator for Complex Peptidoforms in Mass Spectrometry-Based Proteomics | Analytical Chemistry pubs.acs.org/doi/10.1021/.... Making your data better viuable, no matter whether it is "boring" proteomics, or more exciting glycoproteomics, cross-linking mass spectrometry etc.

pubs.acs.org

A Universal Spectrum Annotator for Complex Peptidoforms in Mass Spectrometry-Based Proteomics

Accurate and comprehensive peptide spectrum annotation is a crucial step to interpreting mass spectrometry-based proteomics data. While peak assignment in peptide fragmentation spectra is central to a...

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Reposted by Albert Heck

Silvia Surinova @silviasurinova.bsky.social · 02/12/2025

Interested in ultra low input phosphoproteomics? Here we summarised the current considerations and opportunities when working with rare populations of cells. Congrats to @emgaiz.bsky.social! #TeamMassSpec

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Reposted by Albert Heck

Ying Ge @yingge2121.bsky.social · 10/11/2025

#HUPO2025 interested in #topdownproteomics please come to join us in the Friends of HUPO reception 18:45-19:45 pm Westin Frontenac Ballroom Foyer 😀❄️ @nlkproteomics.bsky.social @proteoforms.bsky.social @jyates.bsky.social @hecklab.bsky.social #teammassspec

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Albert Heck @hecklab.bsky.social · 05/11/2025

Every day’s commute on bike. Not every day is the same

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Albert Heck @hecklab.bsky.social · 31/10/2025

Since early 2024 we have been working with @brukercorporation.bsky.social on the first prototype timsOmni instrument, integrating an Omnitrap into a timsTOF. Here we report for the first time on the use of this instrument for protein-centric antibody sequencing. See www.biorxiv.org/content/10.1...

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Reposted by Albert Heck

Bavarian Center for Biomolecular Mass Spectrometry @baybioms.bsky.social · 15/10/2025

🧵(4/7) 🔬 We have put together a fascinating #Keynote #Speakers team: • Prof. Albert Heck - @hecklab.bsky.social • Dr. Hamish Stewart - @hamishs.bsky.social • Prof. Olga Vitek - @olgavitek.bsky.social l • Prof. Ron M.A. Heeren

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Reposted by Albert Heck

Ruth Huttenhain @rhuttenhain.bsky.social · 02/10/2025

My lab @stanfordmedicine.bsky.social is recruiting! We are looking for a postdoc at the interface of quantitative proteomics and G protein-coupled receptor (GPCR) biology: postdocs.stanford.edu/prospective/... #TeamMassSpec #Proteomics #GPCR #Postdoc

postdocs.stanford.edu

Open Postdoctoral position, faculty mentor Ruth Huttenhain | Office of Postdoctoral Affairs

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Albert Heck @hecklab.bsky.social · 02/10/2025

Having a great time at msandm2025.org with a great bunch of people interesting in visualizing biomolecules, together with my co-chairs @joostsnijder.bsky.social @vixklen.bsky.social & Kyle Fort. Learning so much from all posters & lectures. We thanks all participants for joining us in Utrecht.

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Reposted by Albert Heck

Joost Snijder @joostsnijder.bsky.social · 01/10/2025

We’re hosting the MS+M conference in Utrecht today, lots of great talks ahead at the intersection of mass spec and microscopy. Here’s @hecklab.bsky.social kicking things off.

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Albert Heck @hecklab.bsky.social · 19/09/2025

Breaking barriers in the sensitive and accurate mass determination of large DNA plasmids by mass photometry: Molecular Therapy Nucleic Acids www.cell.com/molecular-th.... Even visualizing > 10 million Da plasmids by the incredible Eduard Ebberink

cell.com

Breaking barriers in the sensitive and accurate mass determination of large DNA plasmids by mass photometry

Heck and colleagues developed a mass photometry-based method for accurate and fast mass determination of plasmid DNA. Conventional mass photometry methods are not applicable for large DNA particles; h...

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Albert Heck @hecklab.bsky.social · 18/09/2025

Preparations in full swing. Exciting program, looking forward to msandm2025.org and welcome our guests in Utrecht to discuss mass spectrometry, atomic force & electron microscopy and single molecule techniques

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Albert Heck @hecklab.bsky.social · 05/09/2025

Structural Insights Into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-Binding Protein Complexes With C4b and SAP - Molecular & Cellular Proteomics www.mcponline.org/article/S153.... See this work of @tkadava.bsky.social @utrechtuniversity.bsky.social artistically interpreted

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Albert Heck @hecklab.bsky.social · 04/09/2025

🕷️Spiders in your blood? Don’t worry, these are protein molecules of C4BP protein, part of your immune system. Just like real spiders, they grab prey with their “legs.” Watch them in action! Intrigued, check the paper of @tkadava.bsky.social doi.org/10.1016/j.mc... @bijvoet-centre.bsky.social

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Reposted by Albert Heck

Ying Ge @yingge2121.bsky.social · 29/08/2025

Our graduate student, Holden Rogers and Marie Curie postdoc fellow, Boris Krichel, did a fantastic job presenting their research projects at #TDP2025👍👏😀

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Ying Ge @yingge2121.bsky.social · 26/08/2025

#TDP2025 @proteoforms.bsky.social a great opening session with fantastic talks! @nlkproteomics.bsky.social @joelooucla.bsky.social @hecklab.bsky.social @metamorpheus.bsky.social 👍thanks Hartmut for organizing the conference! 👏

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Lorne Proteins @lorneproteins.bsky.social · 21/08/2025

🥁🥁🥁 The 51st Lorne Conference on Protein Structure and Function is officially live! After the resounding success of the 50th Lorne Conference in 2025 celebrating five decades of pioneering science and community, the legacy continues... 🏄🏖️🌞 February 8–12, 2026 Register here: www.lorneproteins.org

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Reposted by Albert Heck

IonOpticks @ionopticks.com · 18/08/2025

New plasma glycoproteomics method out of the @hecklab.bsky.social uses narrow-window DIA on Orbitrap Astral with Aurora Ultimate XT column. 50% more glycopeptide IDs vs. traditional approaches, with 181 glycoproteins detected across 7 orders of magnitude in just 10-40 minute runs. bit.ly/45bDXhv

bit.ly

Revolutionising plasma glycoproteomics with Orbitrap Astral and narrow-window DIA - IonOpticks

Jager et al.'s study into plasma glycoproteomics uses a 25 cm x 75 μm IonOpticks Aurora Ultimate 25x75 UHPLC column.

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Tereza Kadavá @tkadava.bsky.social · 04/08/2025

We show that C4BP has two distinct binding modes, either involving a single “spider leg” or the entire spider-like structure wrapping around the target. Thanks to everyone involved! @victoryin.bsky.social, @hecklab.bsky.social, Jürgen, Johannes, Maryam, and Leendert

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Vanessa Linke @massspecvanili.bsky.social · 31/07/2025

🤩 JOB ALERT 🤩 Come work with me and two cutting-edge LC-MS/MS systems at our brand new Mass Spectrometry Facility @iimcb.bsky.social in Warsaw! Apply here tinyurl.com/y47mzafa or send any questions my way. #TeamMassSpec please share widely!

tinyurl.com

Mass Spectrometry Technology Specialist, Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie, Warszawa

Job offer Mass Spectrometry Technology Specialist, Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie, Warszawa

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Ardem Patapoutian @ardemp.bskyverified.social · 31/07/2025

confession: I often get excited by n=1 results.

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maxquant.bsky.social @maxquant.bsky.social · 28/07/2025

Special thanks to our keynote speakers: Alexander Makarov, Albert Heck(@hecklab.bsky.social‬), Kelly Stecker, Noortje de Haan & Ron Heeren. And to the organising team: Corine Heuzer, Albert Heck, Pavel Sinitcyn(@sinitcyn.bsky.social) & the full MaxQuant team(@coxlab.bsky.social).

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Lorne Proteins @lorneproteins.bsky.social · 25/07/2025

📣 Save the date for the 51st Lorne Conference on Protein Structure and Function! ✨ Lorne, Victoria, Australia. We have a packed program and we'll be sharing all the details here - Like, Follow and Share - because friends don't let friends miss the epic Lorne Proteins 😊 www.lorneproteins.org

A cartoon image of a beach with a banner that reads "save the date!" 8th-12th February, 2026, Victoria, Australia. Lorne Proteins 2026.

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Sarafan ChEM-H @stanford-chemh.bsky.social · 15/07/2025

"You can literally lose who you are." Institute Scholar Monther Abu‑Remaileh @abu-remaileh.bsky.social and team are working to uncover the role of lysosomes, our cells’ recycling centers, in degenerative brain disorders in order to identify a cure:

news.stanford.edu

‘You can literally lose who you are’

Scientists in the lab of chemical engineer Monther Abu-Remaileh are uncovering the cellular functions that go awry in degenerative brain disorders and identifying therapies that could treat them.

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KNAW - Koninklijke Nederlandse Akademie van Wetenschappen @knaw-nl.bsky.social · 10/07/2025

Breng Nederland terug aan kop, investeer in wetenschap en innovatie. Want onze veiligheid, welvaart, gezondheid en democratische waarden zijn niet vanzelfsprekend. In aanloop naar de verkiezingen doet de KNAW die oproep aan de politieke partijen: www.knaw.nl/nieuws/breng...

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Thomas Arnesen @natmachinery.bsky.social · 01/07/2025

Acetylhistidine in our blood can prevent kidney disease and is produced by the HisAT (NAT16) enzyme displaying a rare double-GNAT structure. Great efforts by Matti Myllykoski and the rest of the team at @unibergen.bsky.social to get this published. #acetyltransferase www.nature.com/articles/s41...

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UW–Madison School of Pharmacy @uwmadpharmacy.bsky.social · 16/06/2025

Why is cocaine so addictive? A new study from Professor Lingjun Li (@liresearch.bsky.social) reveals that it’s not just about dopamine — neuropeptides across the brain play a key role. These insights could lead to better addiction treatments. Learn how: pharmacy.wisc.edu/2025/03/22/u...

pharmacy.wisc.edu

Unlocking Cocaine’s Grip on the Brain - School of Pharmacy

Professor Lingjun Li and lab members reveal the crucial role of neuropeptides in cocaine addiction, paving the way for novel therapies.

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