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Dave Baltrus 🦦

@surtlab.bsky.social
8K followers 3.2K following 2.3K posts

Professor at UArizona interested in genome rummaging, microbial evolution, and occasional tales about having backyard farm animals. “I’m something of a scientist myself” Baltrus(at)Arizona.edu

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Reposted by Dave Baltrus 🦦
Coach Finstock @coachfinstock.bsky.social · 1h
I'm being silly here but the point still stands that every single person using AI is apparently oblivious to the fact that somewhere, someone has their thumb on the scale to feed you shit.
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Benjamin @benjaminschneider.ch · 4h
Werner Herzog will be the last human being whose next word no language model can predict
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Dave Baltrus 🦦 @surtlab.bsky.social · 2h
They’re both bangers…but you gotta go with “I learned it by watching you”
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Dave Baltrus 🦦 @surtlab.bsky.social · 2h
Man, what a great political ad
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Faine Greenwood @faineg.com · 18h
GOAT OR BIRD????
This is even better than the
"what color is this dress" dress.
Goat?
or Bird?
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JD (by way of Blacksky) @jdot.blacksky.team · 16h
Boosting in light of the discourse surrounding Cornell University.
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Matt Olm @mattolm.bsky.social · 23h
This is an interesting paper! Starting with a really big screen to look for GPCR activation by microbes, and ending with a convincing story by which microbes make acetylcholine in the gut to promote IgA production, ultimately leading to better colonization. www.nature.com/articles/s41...
nature.com
Commensal-derived acetylcholine enhances mucosal immune education - Nature
A diet–microbiome–host axis strengthens mucosal immune defences and reinforces host–microbiota mutualism.
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mtsw @mtsw.bsky.social · 18h
I feel like if AI wants to be in the business of offering medical opinions, then AI companies need to be in the "getting sued for medical malpractice" business too
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Vivek Mutalik @vivekmutalik.bsky.social · 23h
In our brand new 🥳 review, @hemaa-selvakumar.bsky.social & team pull a scattered literature in phage biology into a coherent framework for scaling up to engineering complex communities. We poured our hearts into this to share challenges & future opportunities for the nextGen!
Next generation application space with systematic characterization of phage-host interaction landscapes.
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Dave Baltrus 🦦 @surtlab.bsky.social · 20h
Embarrassing ass President
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Dave Baltrus 🦦 @surtlab.bsky.social · 22h
The account doesn’t miss
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Reposted by Dave Baltrus 🦦
Will Ratcliff @wcratcliff.bsky.social · 28/09/2026
New paper out with @kaylastoy.bsky.social: academic.oup.com/evlett/advan...
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Dave Jorgenson @davejorgenson.bsky.social · 26/09/2026
🎃 Pumpkin Spice GLP-1 season 🍂
Smoothie King’s new pumpkin spice GLP-1 smoothie??
And
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Jesse Shapiro @bjesseshapiro.bsky.social · 29/09/2026
Our latest, spearheaded by the truly indefatigable @emderrick.bsky.social in which we search for selective sweeps in nature and genetic targets of selection within a species in the context of a diverse background community @isme-microbes.bsky.social doi.org/10.1093/isme... 🧵 1/n
doi.org
Validate User
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c0nc0rdance @c0nc0rdance.bsky.social · 27/09/2026
I'll save you the click-through: A lab at University of Copenhagen had been feeding draft manuscripts & data into "Claude Science" & then Anthropic announces a discovery that this lab made a year ago but hasn't published yet. It's plausible that Claude found the same signatures independently...
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Nicholas Grossman @nicholasgrossman.bsky.social · 27/09/2026
What's a good way to visualize how the AI boom/bubble is propping up the economy? Ah, thanks.
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Dave Baltrus 🦦 @surtlab.bsky.social · 27/09/2026
Ruh Roh
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Alex Gibney @alexgibneyfilm.bsky.social · 24/09/2026
The trailer for my new film, "Musk," has just been released.
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Neil Lewis, Jr. @neillewisjr.bsky.social · 26/09/2026
Random Saturday thought: in either middle or high school my school brought in entrepreneurs to talk to us about starting businesses. One of the things they emphasized was the importance of a good name/brand. Anyway, it's funny now that a multi-billion dollar company is called Hugging Face 🤗.
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BWJones @bwjones.bsky.social · 25/09/2026
Science peeps: Looks like SciENcv updated the digital certificate used to sign Biosketch and Current & Pending documents without notification. The old certificate expires Saturday, September 26, 2026. SciENcv docs before that date may fail validation in eRA Commons delaying or blocking submission.
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Nature Microbiology @natmicrobiol.nature.com · 25/09/2026
Out Now! Systematic mapping of bacteriophage gene essentiality with HIDEN-SEQ #MicroSky
go.nature.com
Systematic mapping of bacteriophage gene essentiality with HIDEN-SEQ
Nature Microbiology, Published online: 25 September 2026; doi:10.1038/s41564-026-02455-8HIDEN-SEQ (hidden Acr-enabled transposon-insertion sequencing) is a transposon-insertion sequencing method for phages that systematically links their genes to selectable phenotypes.
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Maryn McKenna @marynmck.bsky.social · 25/09/2026
If you were transfixed by THE HOT ZONE when you were young, or then read SPILLOVER and trusted it, then as a career scary diseases reporter, I urge you to read this thread. Science moves on. People discover fresh stuff. The work careers were built on becomes outdated. Be open to the new. Please.
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Dave Baltrus 🦦 @surtlab.bsky.social · 25/09/2026
Do I use Claude to create pipelines for bioinformatics analyses, yes, yes I do…and it works pretty well so long as you keep vetting inputs and outputs manually But Claude is very very stupid when it comes to interpreting biological signals
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Dave Baltrus 🦦 @surtlab.bsky.social · 25/09/2026
“We thank the reviewer for their comments! We have rewritten this section to provide concrete evidence * of biological function” *evidence is that Claude says so
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Vivek Mutalik @vivekmutalik.bsky.social · 25/09/2026
Mapping structural constraints and adaptive potential in a capsule-degrading phage tailspike protein | Science Advances www.science.org/doi/10.1126/... #phagesky
science.org
Mapping structural constraints and adaptive potential in a capsule-degrading phage tailspike protein
Bacteriophage tailspike proteins (TSPs) degrade bacterial capsules to enable infection, yet the molecular determinants of their function and host range remain unclear. We applied deep mutational scann...
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Faine Greenwood @faineg.com · 25/09/2026
Imagine if instead of regulating drone risks the normal way (which we did), we instead paid weird bloggers lots of money to worry about superintelligent dogs sprouting thumbs and using drones to kill us. This is pretty much how the US is approaching AI risks and regulations. My latest:
little-flying-robots.ghost.io
Why We Can't Let Enormous Weirdos Regulate AI
Imagine if instead of regulating drones via the standard lengthy, boring, and bureaucratic process - which we did - we instead decided, in the name of fostering all-important American drone innovation...
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Heather Cherone @heathercherone.bsky.social · 24/09/2026
2023: White Sox lose 101 games 2024: White Sox lose 121 games 2025: White Sox lose 102 games 2026:
Pope Leo in a White Sox hat.
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Monteiro @monteiro.bsky.social · 24/09/2026
Me, when the printer dialogue box says “looking for printer.”
Leonardo DiCaprio pointing.
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Jennifer Biddle @jenbiddle.bsky.social · 24/09/2026
One of our students is facing a medical crisis so I set up a meal train. When I got into the system, it told me I still had access to when @patschloss.bsky.social set one up for @surtlab.bsky.social - and I am reminded that nice people exist!
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Maya Voichek @mayavoichek.bsky.social · 24/09/2026
Super excited to share my postdoctoral work at @imbavienna.bsky.social @viennabiocenter.bsky.social - We discovered that some retrotransposons, or "jumping genes" 🧬, are able to spread from cell to cell via a new viral infectivity route. A short thread: 🧵👇 (1/7)
AI-generated illustration of the soma-to-germline transmission of retrotransposons described in our work
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Dave Baltrus 🦦 @surtlab.bsky.social · 23/09/2026
Just texted my wife this picture with the caption “found my next tattoo” She has responded by questioning what I do at work
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Blue Heron Farm @blueheronfarm.bsky.social · 23/09/2026
No. That's too much orange.
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Dave Baltrus 🦦 @surtlab.bsky.social · 23/09/2026
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Colin Carlson @colincarlson.bsky.social · 23/09/2026
What's behind this tidal wave of epidemics? In the largest study ever conducted on emerging infectious diseases, we show that the popular explanation - "our relationship with nature is out of balance" - doesn't hold up. Out now in Nature, after half a decade of work: www.nature.com/articles/s41...
nature.com
The anthropogenic fingerprint on emerging infectious diseases - Nature
Emerging infectious disease outbreak risks are ubiquitous worldwide, and highest in landscapes where people, livestock and fragmented natural ecosystems coexist, but detection and data ...
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Terry McGlynn @hormiga.bsky.social · 23/09/2026
Been hearing this a lot lately and I think it needs to catch on: “Trust is infrastructure.”
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Drug Monkey @drugmonkey.bsky.social · 23/09/2026
Construction started on a new science building next to the one I work in. Big pit dug….then Trump threatened IDC cuts. It is now a big pit with sloping sides covered in soil retention planting.
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Dave Baltrus 🦦 @surtlab.bsky.social · 23/09/2026
Addendum: Building next to mine in heart of campus is number 1 building on campus needing extensive renovation. There exist architect paid for plans to refurb and renew However, no money for renovation, but also no money to demolish it…so they’re just going to board it up for foreseeable future
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Dave Baltrus 🦦 @surtlab.bsky.social · 23/09/2026
My Uni has had serious money issues for past 5+ years. the kind that mean my Dept has lost 14 faculty in that time and next replacement hire scheduled for 2030 (not joking) The University President just sent an email that he’s hiring a new “Special Advisor to the President” to help solve problem
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Richard Lenski @relenski.bsky.social · 22/09/2026
"Philosophy of Biology: The power of theory in the life sciences" elifesciences.org/articles/112... @zdblount.bsky.social shared this thought-provoking paper with the lab group.
elifesciences.org
Philosophy of Biology: The power of theory in the life sciences
Theory can help address cell and molecular biology’s major challenges, particularly those arising from large omics datasets.
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Taniel @taniel.bsky.social · 22/09/2026
A post that’s so eye-opening because this is exactly what liberals will say is GOP distraction tactics, almost as a parody— and here it really is what Gaetz is saying unironically as his GOP message.
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Dave Baltrus 🦦 @surtlab.bsky.social · 22/09/2026
Guess who is now the president of our local Little League? (It me, I’m the president, I get the parent emails now)
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Moi Expósito-Alonso (MOILAB) @mexpositoalonso.bsky.social · 21/09/2026
📣 We are looking for a PhD student in 2027! Interested in studying rapid evolutionary dynamics of species in changing climates? Apply to the MOI LAB by Nov 19! Flyer below & tinyurl.com/flyerphdmoilab @ucberkeleyofficial.bsky.social @innovativegenomics.bsky.social @hhmi-science.bsky.social
tinyurl.com
2027_PhD_RapidEvolutionGenomicsEcology-MoiLab_Berkeley-HHMI
PhD positions: Rapid evolutionary genomics in plants Moi Exposito-Alonso Lab — www.moilab.science Assistant Professor, Freeman Hrabowski Scholar HHMI · Department of Integrative Biology · Innovative G...
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Bryan Blessed @bryb.bsky.social · 21/09/2026
This picture of the Pope at his 40th birthday party is everything to me.x
The Pope at his crazy as fuck 40th birthday party wearing a tiny sea captain hat, holding a tiny ice cream surrounded by THREE sad looking balloons. He's wearing a blue jacket and jeans with a brown belt and he's got a navy polo shirt on.
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David Bikard @dbikard.bsky.social · 21/09/2026
New paper from the lab, out in Nature Microbiology. We ran CRISPRi screens to ask what genes E. coli needs in order to live in a gut and what this can tell us about the gut environment itself. doi.org/10.1038/s41564-026-02471-8
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Dave Baltrus 🦦 @surtlab.bsky.social · 21/09/2026
Like you just put on the glasses in the movie “They Live”
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Willem van Schaik @wvschaik.bsky.social · 20/09/2026
Brilliant paper by the labs of @epcrocha.bsky.social @jrpenades.bsky.social 'Mobile genetic elements drive a plasmid fusion and deletion lifecycle shaping evolution and antimicrobial resistance' www.nature.com/articles/s41...
nature.com
Mobile genetic elements drive a plasmid fusion and deletion lifecycle shaping evolution and antimicrobial resistance - Nature Communications
Plasmids drive bacterial adaptation, but how their diversity arises has remained unclear. Here, they show that in Staphylococcus aureus, mobile genetic elements repeatedly fuse and delete plasmids, re...
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Zamin Iqbal @zaminiqbal.bsky.social · 20/09/2026
Yes! Wonderful! also , can't resist, we proposed the same model (we called it fusion- fragmentation) in our paper on the Murray collection, where we look at how those plasmids end up in fusions, or fragmented. www.science.org/doi/10.1126/...
science.org
Pre- and postantibiotic epoch: The historical spread of antimicrobial resistance
Plasmids are now the primary vectors of antimicrobial resistance, but our understanding of how human industrialization of antibiotics influenced their evolution is limited by a paucity of data predati...
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Don Moynihan @donmoyn.bsky.social · 20/09/2026
Vought's goals are a) to reduce scientific funding generally, and b) especially to universities. Political appointees within agencies can already block spending. This would centralize this power in the White House. By requiring unanimity, it would ensure far less money will be spent on science.
The proposed board would include Bhattacharya and Vought and would be required to reach unanimous decisions on grant awards, the officials said.

The arrangement would give Vought, the director of the White House Office of Management and Budget, a direct role in determining how the nation’s largest biomedical research agency distributes its $48 billion in congressionally-appropriated money.
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Dave Baltrus 🦦 @surtlab.bsky.social · 20/09/2026
Ran is correct about this IMO…. There’s use and there’s abuse and there’s laziness with regard to AI and academia. And there’s no one size all answer that works for everything. I do disagree with the footnote but acknowledge old Twitter has been better for science discussions.
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Ran Blekhman @blekhman.bsky.social · 20/09/2026
The AI Discourse in Academia is Toxic. It Doesn’t have to be. My new post: blekhman.substack.com/p/the-ai-dis...
blekhman.substack.com
The AI Discourse in Academia is Toxic. It Doesn’t have to be.
You are allowed to have a nuanced opinion about AI
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