Sign in

jaisondsa.bsky.social

@jaisondsa.bsky.social
2 followers 4 following 1 posts
PostsRepliesMedia
Reposted by @jaisondsa.bsky.social
Wai-Hong Tham @thamlab.bsky.social · 01/08/2025
Cryo-EM of fertilisation complex Pfs230-Pfs48/45 from malaria parasites! 💕💗 🦟 Transgenic parasites without Pfs230 D13D14 do not transmit 🦙 💉Nanobodies + mRNA induced antibodies reduce transmission New in @Science.org www.science.org/doi/10.1126/... #ScienceResearch #Malaria #WEHI
46217
Reposted by @jaisondsa.bsky.social
Wai-Hong Tham @thamlab.bsky.social · 27/04/2025
Pfs48/45 nanobodies block transmission 🦟 Pfs48/45 Nb-Fc reduce oocyst numbers 💎 Structure of transmission-blocking Nb with Pfs48/45 👐🏽 Bispecific Nb-Fc targeting both Pfs230 and Pfs48/45 🧑🏻‍🔬 PhD student Frankie Lyons 1st Author 🥳 Please repost and happy reading! www.biorxiv.org/content/10.1...
biorxiv.org
Pfs48/45 nanobodies block Plasmodium falciparum transmission
Malaria parasite fertilisation occurs within the Anopheles mosquito midgut. Interventions that inhibit parasite fertilisation prevent ongoing transmission and are important for malaria elimination eff...
1156
Reposted by @jaisondsa.bsky.social
Wai-Hong Tham @thamlab.bsky.social · 06/03/2025
Stabilized PvRBP2b variants - wonderful collab with Sarel Fleishman 🔥Increased yields and thermal stability ✌️Maintains human mAb recognition 🩸Sensitivity as a sero-diagnostic for P. vivax 💕 Editors Pick 👨🏻‍🔬First paper for PhD student Jaison Please read & repost! www.jbc.org/article/S002...
jbc.org
Stabilized designs of the malaria adhesin protein PvRBP2b for use as a potential diagnostic for Plasmodium vivax
Plasmodium vivax is emerging as the most prevalent species causing malaria outside Africa. Most P. vivax infections are relapses due to the reactivation of the dormant liver stage parasites (hypnozoit...
0187
jaisondsa.bsky.social @jaisondsa.bsky.social · 06/03/2025
Excited to share our latest work on stabilizing PvRBP2b, a key step toward P. vivax malaria diagnostics! Huge thanks and congratulations to my incredible co-authors and collaborators! Honoured that this is my first PhD publication with @thamlab.bsky.social www.jbc.org/article/S002...
jbc.org
Stabilized designs of the malaria adhesin protein PvRBP2b for use as a potential diagnostic for Plasmodium vivax
Plasmodium vivax is emerging as the most prevalent species causing malaria outside Africa. Most P. vivax infections are relapses due to the reactivation of the dormant liver stage parasites (hypnozoit...
000