See how a synthetic gene regulating SynGR system desilenced the frataxin gene in Friedreich’s ataxia by shuttling BRD4 through HP1 condensates

Chen, Guo, Farag, Qian et al. present that biomolecular condensates formed by proteins lacking catalytic activity can mediate diverse hydrolysis reactions, highlighting the importance of condensate el...

See how an inactive tumor suppressor SPOP ‘double-donut’ state is converted to an active filament state with Cullin-3 to ubiquitinate key proteins like BRD4

Speckle-type POZ protein (SPOP), a substrate receptor for the Cullin-3-RING (CRL3) ubiquitin ligase, is mutated in different cancers. Both activating …

ALT: Classic Glazed Donut

Companions Michael Andrew Fox, C.C. Burnaby, British Columbia and New York, New York, United States of America

Nature Structural & Molecular Biology, Published online: 16 June 2026; doi:10.1038/s41594-026-01814-7Atomistic structural ensembles of protein folding intermediates on the ribosome are resolved by comprehensive 19F nuclear magnetic resonance analyses integrated with molecular dynamics simulations, providing insights into cotranslational folding pathways.

Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis of fully active proteins.

Learn about brain tumor organoids developed by St. Jude scientists that preserve tumor diversity, enabling faster research and better access to research models

The druggability of intrinsically disordered regions.

Langstein-Skora, Schmid, Huth et al. propose that intrinsically disordered region functionality can be driven by the interplay between linear binding motifs and contextual chemical characteristics suc...

Attendees will have the opportunity to present as well as learn from one another. They will give 20-minute talks on their own research questions, as well as in-depth 45-minute whiteboard tutorials on

Pre-mRNA processing components in nuclear speckles encompass one or more folded RNA recognition motifs (RRMs) and disordered regions with specific seq…