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Magnus Kjærgaard

@proteinmagnus.bsky.social
1.7K followers 944 following 144 posts

Protein biophysicist working on intrinsically disordered proteins in neuroscience and biotech. Assoc. prof at @MolBiolAU and @PromemoAU. (He/Him)

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Magnus Kjærgaard @proteinmagnus.bsky.social · 30/09/2026
How does the extreme thermostability of de novo designed proteins arise? We aimed to answer this question by combined chemical and thermal denaturation of de novo designed minibinders in a paper out now in Protein Science (@proteinsociety.bsky.social): dx.doi.org/10.1002/pro....
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Magnus Kjærgaard @proteinmagnus.bsky.social · 13/09/2026
How does linear motifs drive dephosphorylation - and does it matter where and how strong the motifs are? These are the question Evi answers in her brand new pre-print: www.biorxiv.org/content/10.6...
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Peter Andersen @germline.bsky.social · 02/09/2026
Finally - the 🧵! So, the piRNA pathway defends the animal germline from transposons. But most of what we know comes from narrow developmental windows like late oogenesis, where it's easiest to study. We asked if the pathway is the same across development. It is not! /+
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Magnus Kjærgaard @proteinmagnus.bsky.social · 26/08/2026
Great schedule for the new season of @idpseminars.bsky.social! Please help spread the word! 🙏
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Reese Richardson @reeserichardson.bsky.social · 25/08/2026
A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵
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Giulio Tesei @giuliotesei.bsky.social · 18/08/2026
Happy to share our new preprint on MEM-CALVADOS! Work led by @rsaltutti.bsky.social extending CALVADOS to flexible proteins at lipid membrane interfaces. 🗞️ doi.org/10.64898/202... 🖥️ github.com/gitesei/MEM-... @vetenskapsradet.bsky.social
Schematic showing the combination of CALVADOS with a coarse-grained lipid model, resulting in MEM-CALVADOS, illustrated using T-cell signaling proteins LAT (cyan), Grb2 (blue), and Sos1 PRR (orange).
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Magnus Kjærgaard @proteinmagnus.bsky.social · 03/08/2026
Why do intrinsically disordered proteins behave so weirdly during SDS-PAGE? This is the question we aim to answer in our recent paper: onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Sequence determinants of the hypomobility of intrinsically disordered proteins in <fc>SDS</fc>‐<fc>PAGE</fc>
Proteins with intrinsically disordered regions (IDRs) migrate at a higher apparent molecular weight in sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis, complicating their analysis and...
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bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 06/07/2026
An Atlas of Short Linear Motif-Mediated Human Protein-Protein Interactions www.biorxiv.org/content/10.64898/20…
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Stephen McLaughlin @lmbbiophysics.bsky.social · 29/06/2026
It will be our 10th Next Generation Biophysics Symposium @mrclmb.ac.uk on 16th September. Please join us in person or online and celebrate all things #biophysics www3.mrc-lmb.cam.ac.uk/sites/nextge...
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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 23/06/2026
Come join the new Novo Nordisk Foundation Center for Protein Design as a group leader Cool science in a great scientific environment in wonderful and very family friendly Copenhagen There are two positions that can either be at TT assistant or associate prof level employment.ku.dk/tenure-track...
employment.ku.dk
Tenure-track Assistant Professor or Associate Professor of De novo Protein Design
The Novo Nordisk Foundation Center for Protein Design at the University of Copenhagen seeks to appoint two new group leaders in de novo protein design from 1 February 2027 or as soon as possible thereafter. These positions will be at the Assistant or Associate Professor level and associated with the Department of Biology (Faculty of Science) or the Department of Drug Design and Pharmacology (Faculty of Health and Medical Sciences).
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Janet Kumita @jrkumita.bsky.social · 23/06/2026
Come join us for the next monthly on-line seminar (3rd July 2026, 1 pm BST) aimed to connect the UK Biomolecular Condensate community (all are welcome to come and listen). Rebecca Beveridge and Janin Lautenschläger are presenting! @physicsoflifeuk.bsky.social
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Pablo Alcón @palconh.bsky.social · 23/06/2026
Join us! Postdoc position (2-3 years) in our lab @molbiolau.bsky.social Looking for candidates with experience in cell culture, genome editing, biochemistry, and/or structural biology. Application opens in August via AU's system but informal enquiries by email are welcome from now. (1/2)
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Osvaldo Burastero @osvalb.bsky.social · 10/06/2026
Do you want to study the stability of a designed protein that doesn't unfold below 90 ºC 🔥? Combine a denaturant and temperature and then analyse the results with our newest tool: CheMelt 🧪 Online: - spc.embl-hamburg.de/app/chemelt As Docker image (faster): - hub.docker.com/r/emblspc/ch...
Abstract illustration showing several thermal unfolding curves at different denaturant concentrations
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IDPSeminars @idpseminars.bsky.social · 02/06/2026
IDPSeminars is back for a final seminar of spring 2026! This week, we welcome Wenwei Zheng and Sigrid Milles! The seminar is at 10 AM PST / 1 pm EST / 7 PM European time on Thursday. Sign up via our website at idpseminars.com!
Wenwei Zheng (Arizona State University): "Structural Organization of Intrinsically Disordered Protein Ensembles"

Sigrid Milles (FMP Berlin): "How disorder regulates endocytosis: dynamics across molecular scales"
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Magnus Kjærgaard @proteinmagnus.bsky.social · 27/04/2026
How should we model and fit bivalent binding in biosensor assays? Current models don't work well, so we made a new one and used it to study the spatial tolerance of avidity in antibodies. www.cell.com/biophysj/abs...
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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 14/04/2026
Run an MD simulation of any protein in the AlphaFold Protein Structure Database using AF-CALVADOS Thanks to @sobuelow.bsky.social AF-CALVADOS is now on Colab colab.research.google.com/github/KULL-...
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Magnus Kjærgaard @proteinmagnus.bsky.social · 10/04/2026
Why are de novo designed proteins so extremely thermostable? We try to answer this question by dissecting the thermodynamics of unfolding of mini-binders emerging from our protein design pipeline – and establish a convenient GUI for data analysis in the process. doi.org/10.64898/202...
Graphical abstract for pre-print showing a) theoretical model for thermostability, b) a GUI based analysis platform, c) protein denaturation data of mini-binders assessed by nanoDSF and d) a correlation plot that shows the de novo designed mini-binders have a much lower deltaCp than expected for a protein of their size.
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Janet Kumita @jrkumita.bsky.social · 07/04/2026
Join us THIS Friday (10th April, 1 pm BST) for our UK Biomolecular Condensate seminar!! 👇👇
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Peter Andersen @germline.bsky.social · 01/04/2026
Germ cells have their own versions of core transcription factors and fertility depends on them. We're hiring a PhD student to figure out how! 📢 Fly genetics + proteomics + genomics. Fully funded. Aarhus University 🇩🇰 Deadline May 1 👇 Please share with anyone who might be interested!
phd.nat.au.dk
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IDPSeminars @idpseminars.bsky.social · 28/03/2026
IDPSeminars is BACK for a new season! Six new speakers in April, May, and June! First talk next week! Tell your friends!
Speaker information for IDPSeminars Season 21 
April 2nd:  Min Kyung Shinn (Kings, UK) and Hugo Sanabria, Clemson USA
May 7th:  Matt Parker (UTSW, USA) and Maria Hondele (Basel) 
June 4th: Wenwei Zheng (ASU USA) and Sigrid Milles (FMP, Berlin)
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Magnus Kjærgaard @proteinmagnus.bsky.social · 26/03/2026
Why do intrinsically disordered proteins appear larger than they are in SDS-PAGE? We investigate how sequence properties affect SDS-PAGE mobility using synthetic IDRs. Conclusion: We need to consider both SDS binding and the compaction of protein-SDS complexes. www.biorxiv.org/content/10.6...
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Magnus Kjærgaard @proteinmagnus.bsky.social · 26/03/2026
Definition of "staying abreast of the litterature": 4:52 am: BioRxiv: Your pre-print has been posted! 7:01 am: E-mail from @lindorfflarsen.bsky.social with comments on pre-print. 😀🙏
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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 09/03/2026
Community perspective: Toward a unified framework for determining conformational ensembles of disordered proteins 🍝 with framework for experimental data acquisition, computational ensemble generation & validation Led by @hamidrgh.bsky.social, Silvio Tosatto & Alex Monzon doi.org/10.1038/s415...
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IDPSeminars @idpseminars.bsky.social · 04/03/2026
IDPSeminars is back TOMORROW! Come see @tanjamittag.bsky.social and @xsalvatella1.bsky.social ! Not to be missed!!
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Magnus Kjærgaard @proteinmagnus.bsky.social · 26/02/2026
Interesting meeting for those interested in the interface between machine learning and non-globular proteins such a IDPs. ml4ngp.eu/conference-w...
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Magnus Kjærgaard @proteinmagnus.bsky.social · 20/02/2026
🚨New paper: We found - contrary to expectations - that oxygen is partially excluded from biomolecular condensates. We find a strong anti-correlation between oxygen and protein concentrations in the condensate showing that accessible volume dominates over polarity. www.nature.com/articles/s41...
nature.com
Oxygen depletion in biomolecular condensates is dominated by macromolecular density - Nature Communications
Biomolecules can control biochemical reactions via droplets of macromolecules known as condensates. Here, it is shown that oxygen is partially excluded from such condensates due to the high concentrat...
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Magnus Kjærgaard @proteinmagnus.bsky.social · 19/02/2026
Why does a synaptic protein need a 24kb 3'UTR? We asked ourselves that question when writing a review on the IDRs of the NMDA receptor. Alex answered this using a knock-out mouse ⬇️: Synaptic targeting of Grin2b mRNA is crucial for synaptic plasticity and learning. www.pnas.org/doi/10.1073/...
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Magnus Kjærgaard @proteinmagnus.bsky.social · 15/02/2026
🚨Postdoc opening: Integrative structural biology and interactions of disordered regions in plant transporters. Skills sought: Protein experience (ideally IDPs/MPs), NMR, SAXS, smFRET, biophysics and similar. Come find me at #BPS26 or reach out to learn more! mbg.au.dk/aktuelt/ledi...
mbg.au.dk
Postdoc: Integrative structural biology and biophysics of dynamic plant hormone transporters - Ledig stilling på Aarhus Universitet
Ledig stilling ved Institut for Molekylærbiologi og Genetik - Proteinvidenskab, Aarhus Universitet
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Magnus Kjærgaard @proteinmagnus.bsky.social · 02/02/2026
Does targeting enzymes and substrates in a condensate lead to rate enhancement? No. Here, we investigate how the condensate environment can inhibit an enzyme reaction. Spoiler: Mass-transport limitations. We find a strong correlation between diffusion and reaction rates. doi.org/10.64898/202...
Graphical abstract of pre-print
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Gilles Vanwalleghem @drgillesv.bsky.social · 15/01/2026
A new faculty position in our department in Molecular health as a broad topic, come join us! Send me a message if you have any question international.au.dk/about/profil...
international.au.dk
Faculty position in Molecular Health (Tenure-Track Assistant Professor / Associate Professor) at Aarhus University, Denmark - Vacancy at Aarhus University
Vacancy at Department of Molecular Biology and Genetics - Cellular Health, Intervention, and Nutrition, Aarhus University
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IDPSeminars @idpseminars.bsky.social · 06/01/2026
IDPSeminars is BACK THIS WEEK! Talks from Andrea Soranno and @bokaizhulab.bsky.social on Thursday! 1 pm EST / 7 PM European time! Sign up here: forms.gle/3yCHeYvuuqLh... And check out the full Spring 2026 schedule at idpseminars.com!
Seminar titles: Andrea Soranno (Single molecule spectroscopy of
disordered regions and nucleic acids) and Bokai Zhu (Nuclear speckle rejuvenation to ameliorate proteinopathy).
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idpgrc.bsky.social @idpgrc.bsky.social · 02/10/2025
🚨🚨The GRC on Intrinsically Disordered Proteins #IDPs is back!! 🍝🧵🏔️Join us for cutting-edge IDP science, great discussions, and mountain views 🌄🍝 📅 June 21-26, 2026 | Les Diablerets, Switzerland 👉 Details & registration: grc.org/intrinsicall...
grc.org
2026 Intrinsically Disordered Proteins Conference GRC
The 2026 Gordon Research Conference on Intrinsically Disordered Proteins will be held in Les Diablerets, Vaud (fr) Switzerland. Apply today to reserve your spot.
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Magnus Kjærgaard @proteinmagnus.bsky.social · 29/09/2025
Would you like to hear about our work developing a screening pipeline for de novo designed binders us the microfluidic sizing? Then tune in on Thursday for a virtual seminar. Sign-up below: fidabio.webinargeek.com/how-to-scree...
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Magnus Kjærgaard @proteinmagnus.bsky.social · 15/09/2025
Experimental verification is increasingly the bottleneck in protein design projects. In this paper, we develop a new mini-binder screening pipeline based on the microfluidic sizing technique called flow-induced dispersion analysis (FIDA). doi.org/10.1002/pro....
doi.org
Screening de novo designed protein binders in unpurified lysate using flow induced dispersion analysis
Computational protein design can create binders against targets of interest, but identifying binders with sufficient affinity still requires biochemical screening of many designs. In this work, we te....
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Magnus Kjærgaard @proteinmagnus.bsky.social · 19/06/2025
How do we screen do novo designed binders most efficiently? In this pre-print, we show that the microfluidic sizing technique FIDA allows us to pick successful binders in a single measurement using minimal sample: www.biorxiv.org/cgi/content/...
biorxiv.org
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IDPSeminars @idpseminars.bsky.social · 03/06/2025
IDPSeminars is back with another seminar this week from @sarahshammas.bsky.social and @sonia-longhi.bsky.social! Come hear about transcriptional regulation and viral pathogenesis! Thursday June 5th! PST 10 am EST 1 pm CET 7 pm! Info: idpseminars.com Signup form: forms.gle/3yCHeYvuuqLh...
Sarah Shammas (University of Oxford):Opportunities in DNA binding provided by protein disorder

Sonia Longhi (AFMB Marseille): Intrinsic disorder, phase transitions and fibril formation by the Henipavirus V and W proteins: a new hallmark of viral pathogenesis?
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Ian Dunt @iandunt.bsky.social · 30/05/2025
Reactionaries hate universities because they create open-minded liberated people open.substack.com/pub/iandunt/...
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DANDRITE @dandrite.bsky.social · 26/05/2025
Our annual report 2024 is out! Dive into our research highlights, talent development, collaborations, and new events and initiatives. dandrite.au.dk/annual-repor...
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Magnus Kjærgaard @proteinmagnus.bsky.social · 21/05/2025
🚨We have an opening for a postdoc to use protein design techniques to developing and characterizing binders against intrinsically disordered proteins involved in neuroscience. Experience in protein biochemistry and/or molecular neuroscience preferred. Share: 🙏 mbg.au.dk/aktuelt/ledi...
mbg.au.dk
Postdoc: De novo protein design for neuroscience - Ledig stilling på Aarhus Universitet
Ledig stilling ved Institut for Molekylærbiologi og Genetik - Neurobiologi, Aarhus Universitet
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Magnus Kjærgaard @proteinmagnus.bsky.social · 17/05/2025
The most wholesome Fox News show: 5 fox cubs playing in our garden.
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Peter Andersen @germline.bsky.social · 16/05/2025
📣 🥳 🧑‍💻 Our department is hiring: Tenure-Track Assistant Professor / Associate Professor in Bioinformatics at Aarhus University, Denmark Deadline June 1st Thanks for sharing! mbg.au.dk/en/news-and-...
mbg.au.dk
Tenure-Track Assistant Professor / Associate Professor in Bioinformatics at Aarhus University, Denmark - Vacancy at Aarhus University
Vacancy at Department of Molecular Biology and Genetics - BiRC - Bioinformatics Research Center, Aarhus University
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Magnus Kjærgaard @proteinmagnus.bsky.social · 15/05/2025
Baby fox in the garden!
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Magnus Kjærgaard @proteinmagnus.bsky.social · 13/05/2025
Trigger warning: FOMO How often do you go to a conference where you are excited about EVERY SINGLE TALK! Well, I guess it helps if you get to make the program. 😀 "Biomolecular condensates: From fundamental principles to applications in health and biotech" kicking off at 9 AM!
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Magnus Kjærgaard @proteinmagnus.bsky.social · 12/05/2025
Probably the best conference venue in Denmark? Tomorrow, we kick-off our condensate meeting in the Carlsberg Academy ⬇️. Thank you to the Novo Nordisk Foundation for the grant to host our dream meeting, and to the Carlsberg Foundation for hosting us at this beautiful site.
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Magnus Kjærgaard @proteinmagnus.bsky.social · 08/04/2025
We have a new review/perspective on the potential of biomolecular condensates in microbial cell factories. The emphasis is on the trade-offs that have to be navigated when designing such synthetic organelles.
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Magnus Kjærgaard @proteinmagnus.bsky.social · 29/03/2025
Since the Trump team are making videos about US-Greenland history, maybe the next one could be about that time when USAF crashed a B-52 spilling four nuclear bombs - one of which his probably never been recovered: en.m.wikipedia.org/wiki/1968_Th...
en.m.wikipedia.org
1968 Thule Air Base B-52 crash - Wikipedia
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Lars Løkke Rasmussen @lars-loekke.bsky.social · 28/03/2025
Dear American friends. We agree that status quo in the Artcic is not an option. So let’s talk about how we can fix it - together. Lars Løkke Rasmussen Danish Foreign Minister
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Magnus Kjærgaard @proteinmagnus.bsky.social · 19/03/2025
Surprised - in a good way - to find myself as a recipient of a big teaching national prize within Natural Science together with good colleagues @ditlevbrodersen.bsky.social and Gregers Rom Andersen. nat.au.dk/en/about-the...
nat.au.dk
Three Educators from MBG Receive the Novo Nordisk Foundation Prize for Natural Science Teachers at Universities
Magnus Kjærgaard, Gregers Rom Andersen, and Ditlev Egeskov Brodersen teach biochemistry and structural biology to students at the Department of Molecular Biology and Genetics. Now, they are receiving ...
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IDPSeminars @idpseminars.bsky.social · 05/03/2025
IDPSeminars is back this week (Tomorrow, March 6th)! Come hear about nucleolar organization and IDRs in host-pathogen interactions! PST 10 am EST 1 pm CET 7 pm! Info: idpseminars.com Signup form: forms.gle/3yCHeYvuuqLh...
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Michael Bang Petersen @m-b-petersen.bsky.social · 01/03/2025
Authoritarianism runs strong in this family. It is an utter disgrace. The world order has changed. The US is no longer the leader of the free world. The key question going forward: Who is? Which side of history do our politicians choose - and who will lead?
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