Inflammasomes are high-molecular-weight complexes that play integral roles in the innate immune system, triggering an inflammatory cascade to prote...

Companions Michael Andrew Fox, C.C. Burnaby, British Columbia and New York, New York, United States of America

NMR relaxation studies of the precursor form of the pro-inflammatory cytokine interleukin-18, pro-IL-18, show that it adopts two sparsely populated (<0.5%) and transiently formed (ms lifetimes) excite...

Nature Reviews Molecular Cell Biology, Published online: 20 November 2025; doi:10.1038/s41580-025-00897-2Biomolecular condensates are non-membrane-encapsulated compartments that control various biological processes. Recent studies have revealed that condensates change in response to stimuli and over time. This Review discusses the heterogeneity and composition changes of nuclear and cytoplasmic condensates, their regulation and how the changes affect cellular biochemical reactions.

Nature Reviews Molecular Cell Biology, Published online: 20 November 2025; doi:10.1038/s41580-025-00897-2Biomolecular condensates are non-membrane-encapsulated compartments that control various biological processes. Recent studies have revealed that condensates change in response to stimuli and over time. This Review discusses the heterogeneity and composition changes of nuclear and cytoplasmic condensates, their regulation and how the changes affect cellular biochemical reactions.

The tools of structural biology have undergone remarkable advances in the past decade. These include new computational and experimental approaches tha…

Hao&ndash;Fountain syndrome is a rare neurodevelopmental disorder caused by mutations in the deubiquitinating enzyme Ubiquitin-Specific Protease 7 (USP7)...

Heteronuclear NMR methodologies developed over the past 40 years have enabled atomic level insights into the solution-state structure and dynamics of …

A wealth of insights into the mechanisms of GPCRs have been gained from biophysical studies of thermostabilized β1 adrenergic receptors (β1AR) from tu…

The BPS2026 Annual Meeting in San Francisco will showcase Biophysics by the Bay, highlighting the exciting advances in science and technology brought forth by big data and AI.  This year’s program…

The authors develop a computational tool to design NMR pulses, based on the GRadient Assisted Pulse Engineering approach, that can calculate optimal pulse shapes on the fly during the measurements, to...

Using RFdiffusion, a general method for targeting intrinsically disordered proteins and regions for protein design has been developed.

The National Institutes of Health can’t award grants to outside researchers under a new White House restriction.

USP7 is a key ubiquitin-specific protease involved in human development. Its activity is regulated by an intramolecular interaction between the cataly…

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USP7 is an important enzyme whose activity is tightly controlled in cells. Using advanced NMR techniques, researchers gained a rare glimpse into how the enzyme’s movements regulate its function. They ...

Correlating aromatic carbons attached to fluorine with meta-position hydrogens in fluorine-labelled phenylalanines can yield two-dimensional correlations with narrow linewidths in large proteins. Adap...

Academic science in the US is being gutted by Trump

Electrostatics play a dominant role in guiding many biological processes. This is especially the case in the context of chromatin, where charge interactions modulate diverse activities such as DNA rep...

The Chemistry Department at Lund University, Faculty of Engineering invites applications for a position as Assistant Professor in Biophysical Chemistry with a focus on NMR Spectroscopy. Description of

Intrinsically disordered proteins and protein regions are central to many biological processes but difficult to characterize at atomic resolution. Nuclear magnetic resonance is particularly well-suite...

Cre, a conservative site-specific tyrosine recombinase, is a powerful gene editing tool in the laboratory. Expanded applications in human health are hindered by a lack of understanding of the mechanis...

Provide leadership and mentorship to members of the Molecular Medicine Program and influence the scientific direction of the Research Institute

The Alexander Hollaender Award in Biophysics is presented every three years and carries with it a $20,000 prize. The Award recognizes outstanding contributions made to the field of biophysics. Henriet...

The tools of structural biology have undergone remarkable advances in the past decade. These include new computational and experimental approaches tha…

We invite you to the joint workshop From fast-field cycling to ultrafast high-resolution relaxometry, a joint meeting of the FC-RELAX doctoral network and the HIRES-MULTIDYN project from March 13 to M...