An der Frankfurter Goethe-Universität entsteht eine Datenbank für Forschungsdaten zur Entwicklung von Medikamenten. Sie sollen so vor Verlust und Einflussnahme von außen geschützt werden. Entwicklunge...

Abstract. The binding of fluorescent dyes to nucleic acids and their fluorogenic properties are indispensable tools for nucleic acid detection, quantificat

The Albert-Overhauser Award honours outstanding achievements in magnetic resonance and shares information about GDCh Division awardees.

The telomeric lncRNA TERRA forms RNA G-quadruplex structures that regulate telomere integrity. An indoloquinoxaline ligand (IQ4) selectively binds and stabilizes the TERRA rG4, disrupts the TERRA–TRF...

Targeting structured RNA elements with small molecules has emerged as a promising yet technically challenging strategy for antiviral drug discovery. Here, we present a comprehensive and experimentall....

In this Voices article, participants from the recent wwPDB Workshop on Fragment Screening at the EMBL-EBI and their colleagues discuss recent advances, current challenges, and future opportunities in ...

A collaborative team of scientists, including researchersGoethe University Frankfurt, has conducted research revealing how Streptococcus pneumoniae...

The respiratory pathogen Streptococcus pneumoniae uses the substrate binding protein SatA of the ABC transporter SatBC–MsmK to specifically bind the α-anomer of N-acetylneuraminic acid, the immediate ...

Artificial intelligence and machine learning have recently accelerated fragment-based drug discovery (FBDD) processes through structure-based optimization and generative compound design. Here, the aut...

An adaptable approach, many light-switchable RNA binders. We report a versatile strategy for rapidly synthesizing photoswitchable RNA binders. The ligands can target SMN2 pre-mRNA, restoring the leve...

Internationally networked research database will collect structural data on biomolecules obtained worldwide through nuclear magnetic resonance (NMR) studies

A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms

Instruct-ERIC is a pan-European research infrastructure in structural biology, making high-end technologies and methods available to all European researchers.

Traditionally, Nuclear Magnetic Resonance (NMR) infrastructures have relied on in-person access, requiring researchers to travel to centralized facili…

Abstract. We report that the kinase inhibitor Palbociclib is a very low nanomolar ligand for the HIV-1 TAR, a paradigmatic ‘difficult-to-drug’ RNA. Binding

Abstract. Several SARS-CoV-2 variants have evolved with clinical relevance due to their structural and functional impact on viral proteins and genomic RNA

Extended variants of the G-quadruplex thrombin binding aptamer exhibit differential anticoagulation activities. We show that 3’ terminal extensions increase nuclease resistance, while variations in t....

This study explores the origins of life by linking prebiotic chemistry, the emergence of information-carrying molecules such as RNA and proteins, and philosophical questions about consciousness. The ....

Isotopic enrichment of pharmacologically relevant protein targets is crucial for structural studies by nuclear magnetic resonance (NMR) and plays a key role in advancing structure-guided drug discover...

YouTube video by Schreibzentrum Frankfurt am Main

This study systematically evaluates methods for improving the identification and quantification of small proteins using bottom-up mass spectrometry, thereb

Understanding the molecular recognition underlying RNA–ligand complex formation is of key importance to explain the RNA regulatory function of riboswitches and to support the development of low-molecu...

Abstract. RNA aptamers obtained from in vitro selection experiments provide unique insights into the structural properties and ligand recognition capabilit

A combined virtual and nuclear magnetic resonance (NMR)-based screening approach identifies small molecules that bind conserved SARS-CoV-2 RNA structures. Diverse compound libraries are screened usin...

Abstract. Deoxyguanosine quadruplexes (G4s) form stable non-B-DNA structures that can affect transcription, replication, and genome stability. Depending on

Structure-guided design of a sulfamoyl-modified analog of GS-441524 yielded a selective, high-affinity inhibitor of the SARS-CoV-2 macrodomain Nsp3b. The compound occupies the phosphate-binding pocke...

Instruct-ERIC is a pan-European research infrastructure in structural biology, making high-end technologies and methods available to all European researchers.

Ephrin growth factors are attached to the membrane by either GPI-anchor or transmembrane domains and are known to signal bi-directionally: cells, expr…

Abstract. La-related proteins (LARPs) are RNA-binding proteins that are involved in a variety of disease-related processes. Most LARPs recognize short sing

G protein–coupled receptors (GPCRs) comprise a large class of membrane proteins that mediate cellular responses to a wide range of external signals...