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xavier salvatella

@xsalvatella1.bsky.social
777 followers 524 following 43 posts

Scientist at ICREA and IRB Barcelona.

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xavier salvatella @xsalvatella1.bsky.social · 21/09/2026
PhD fellowship open in our lab at @irbbarcelona.org to work on intrinsically disordered proteins — activities, disease mutations, and druggability. Deadline: 28 Oct. 🔗 irbbarcelona.org/en/careers/young-scientists/irb-barcelona-international-phd-fellowships-extraordinary-call-2026
irbbarcelona.org
IRB Barcelona International PhD Fellowships - Extraordinary call 2026
The following will be offered in this call:Up to 8 FPI positions associated with the “Proyectos de Generación de Conocimiento 2025” Call (funded by the Agencia Estatal de Investigación AEI- MICINN).Ch...
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Marc A. Marti-Renom @mamartirenom.bsky.social · 08/08/2026
🚨the latest from the lab! 😃👇🏻 www.science.org/doi/10.1126/...
science.org
3D genome organization in tissue regeneration involves long-range chromatin loops
Chromosome conformation analysis in Drosophila wing discs reveals the requirement of specific meta-loops during regeneration.
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Ben Lehner @benlehner.bsky.social · 08/08/2026
Allostery is a widespread cause of loss-of-function variant pathogenicity by @xt117.bsky.social @sangerinstitute.bsky.social www.nature.com/articles/s41...
nature.com
Allostery is a widespread cause of loss-of-function variant pathogenicity - Nature Communications
Mutations at sites distant from a protein’s active site can disrupt function through allosteric mechanisms. Here, authors present evidence that allostery is a widespread and underappreciated cause of ...
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Natàlia de Martín Garrido @natalia-mg.bsky.social · 24/07/2026
I am so glad to share that our paper is finally out!!!
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Craig M. Crews @craigmcrews.bsky.social · 11/07/2026
Discovery of Potential First-in-Class Dual Ligand-Directed Degrader and Antagonist of the Androgen Receptor: BMS-986365 | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/...
pubs.acs.org
Discovery of Potential First-in-Class Dual Ligand-Directed Degrader and Antagonist of the Androgen Receptor: BMS-986365
Androgen receptor (AR) signaling is central to the progression of prostate cancer, including castration-resistant disease. Targeted protein degradation, particularly through heterobifunctional compoun...
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Sociedad Española de Bioquímica y Biología Molecular (SEBBM) @sebbm.bsky.social · 23/06/2026
Desorden intrínseco en proteínas, multivalencia y multimerización RevistaSEBBM 229junio2026 por @xsalvatella1.bsky.social  No todas las proteínas funcionan desde una estructura fija. @irbbarcelona.org  f.mtr.cool/mvwgjybijj
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Christine Mayr @christinemayr.bsky.social · 08/06/2026
Finally out in @Cellcellpress! Proteins with long IDRs are prone to misfolding during protein synthesis. This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones. www.cell.com/cell/fulltex...
cell.com
mRNA 3′ UTRs chaperone intrinsically disordered regions to control protein activity
Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis of fully active proteins.
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cryoEM papers @cryoempapers.bsky.social · 30/05/2026
Design and structure of protein cages based on helical fusion and machine learning www.biorxiv.org/content/10.64898/2026.05.27.727936v1 #cryoEM
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Magnetic Resonance News @nmr900.bsky.social · 08/05/2026
Memorial Minute for Martin Karplus - Harvard Gazette news.harvard.edu/gazette/stor... #NMRchat 🧲
news.harvard.edu
Memorial Minute for Martin Karplus — Harvard Gazette
At a meeting of the Faculty of Arts and Sciences on May 5, 2026, the following tribute to the life and service of the late Martin Karplus was spread upon the permanent records of the Faculty.
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Raimon Sunyer @raimonsunyer.bsky.social · 08/05/2026
Interested in molecular motors? Don’t miss this wonderful symposium in Salamanca on "The Structure and Workings of Molecular Machines" with an outstanding lineup of speakers. 📍 Salamanca, Spain 📅 Monday, June 22, 2026 🎟️ Attendance is free, but registration is required 👇👇👇
Poster for “The Structure and Workings of Molecular Machines” international symposium, taking place Monday, June 22, 2026, at the Centro Internacional del Español, CIE-USAL, in Salamanca, Spain. The poster shows a colorful molecular-structure background and lists invited speakers Carlos Bustamante, Adam Frost, Taekjip Ha, Fernando Moreno, Eva Nogales, Félix Ritort, José M. Valpuesta, and Elizabeth Villa. It includes a QR code for the full program and registration and notes that attendance is free but registration is required.
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Magnetic Resonance News @nmr900.bsky.social · 08/05/2026
4th Workshop on Structural Biophysics, October 12-16, 2026, Bordeaux, France, registration closes May 19 www.cbmn.u-bordeaux.fr/ivth-worksho... #NMRchat 🧲
cbmn.u-bordeaux.fr
IVth Workshop on Structural Biophysics. - CBMN
5 jours de Workshop en Biophysique à Bordeaux ! Les techniques en biophysique permettent d’appréhender les mécanismes d’interactions entre entités biomoléculaires à une échelle allant de la taille de ...
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Junjie Guo @junjieguo.bsky.social · 08/05/2026
Check out the phenomenal PhD work by Katie Copley, a current postdoc in our lab @yaleneuro.bsky.social @yalerna.bsky.social. www.science.org/doi/10.1126/...
science.org
Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration
Aberrant aggregation of the prion-like RNA binding protein TDP-43 drives several fatal neurodegenerative proteinopathies, including amyotrophic lateral sclerosis (ALS). In this work, we define how sho...
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Department of Chemistry, Stanford University @stanfordchemistry.bsky.social · 01/05/2026
Join Stanford Chem for this year's McConnell Lecturer in Chem: Prof. Lewis E. Kay (Univ. of Toronto), a pioneer in biomolecular NMR. He’ll present “The Essentiality of Solution NMR Spectroscopy in the Post-Alpha Fold Era,” May 5, 3–4 PM, Sapp Center 114. chemistry.stanford.edu/events/mccon...
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IRB Barcelona @irbbarcelona.org · 23/04/2026
🧬 Mutations in the "translators" of the human cell alter the reading of the genetic code in #cancer and #aging. ✍️ Lluís Ribas (#IRBBarcelona) et al. 📰 @genomeresearch.bsky.social Read more ➡️ shorturl.at/5pk2P 📌 DOI: 10.1101/gr.281022.125 #IRBScience #AgeingResearch #AgingResearch 🧪
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Mohammed AlQuraishi @moalquraishi.bsky.social · 21/04/2026
Does AlphaFold’s latent space encode only the native state or something like a distribution over conformations? We begin to answer this question with ConforNets, a mechanism for producing diverse states, or very specific ones, via inference-time adaption of OF3p’s latent space👇
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BIST-Barcelona Institute of Science and Technology @bist.eu · 10/04/2026
El nou edifici que acolllirà grups de recerca de 5 centres #BISTCommunity i enfocat en medicina de precisió va prenent forma. 👉https://www.ara.cat/societat/horitzo-2028-gran-hub-biomedicina-sud-d-europa-pren-forma_1_5702563.html?giveAway=uCQdvPiwpW4GkqLE
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IRB Barcelona @irbbarcelona.org · 10/04/2026
🔬A new mechanism explains how protein production is regulated in #FattyLiver under metabolic stress. 📰 Science Advances ✍️ Raúl Méndez, Eulàlia Belloc, Vittorio Calderone, Mercedes Fernández, @idibaps.bsky.social @ptck72.bsky.social et al. ➡️ shorturl.at/UtRVB 📌 DOI: 10.1126/sciadv.aea4125
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Kazuhiro Maeshima @kazu-maeshima.bsky.social · 10/04/2026
Our linker histone H1 paper is featured on the cover of the April 10 issue of #ScienceAdvances. www.science.org/doi/10.1126/... A molecular dynamics simulation of nucleosomes and linker histone H1, with single-H1 trajectories (background). 🎉 Full cover caption: www.science.org/toc/sciadv/1...
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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 16/03/2026
We are hiring a postdoc in computational biophysics and machine learning studies of intrinsically disordered proteins We aim to study the function of IDPs by combining CG MD, ML and bioinformatics in collaboration with @tanjamittag.bsky.social & @rhp-lab.bsky.social tinyurl.com/REWIRE-PD
Postdoc position:Computational Biophysics of Disordered Proteins, Lindorff-Larsen group, University of Copenhagen, Denmark

https://tinyurl.com/REWIRE-PD
Deadline May 3rd, 2026
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IRB Barcelona @irbbarcelona.org · 06/04/2026
📢 We are #hiring! #GroupLeader positions open at #IRBBarcelona in #ChemicalBiology and #StructuralBiology. Application deadline: May 22, 2026 𝗚𝗿𝗼𝘂𝗽 𝗟𝗲𝗮𝗱𝗲𝗿 𝗶𝗻 𝗖𝗵𝗲𝗺𝗶𝗰𝗮𝗹 𝗕𝗶𝗼𝗹𝗼𝗴𝘆 ➡️ shorturl.at/1tE3n 𝗚𝗿𝗼𝘂𝗽 𝗟𝗲𝗮𝗱𝗲𝗿 𝗶𝗻 𝗦𝘁𝗿𝘂𝗰𝘁𝘂𝗿𝗮𝗹 𝗕𝗶𝗼𝗹𝗼𝗴𝘆 ➡️ shorturl.at/eKiJn #IRBJobs #Jobs #AcademicSky
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sbesp.bsky.social @sbesp.bsky.social · 26/03/2026
#paper #highlight February 2026 Oligomerization enables the selective targeting of an intrinsically disordered region by a small molecule By S. Bielskutė-García et al in #ScienceAdvances sbe.es/highlights-p... @xsalvatella1.bsky.social @irbbarcelona.org @icreacommunity.bsky.social
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IRB Barcelona @irbbarcelona.org · 23/03/2026
📢 Upcoming Seminar | Join us for a plenary seminar this Friday, with Dr. @adelaljord.bsky.social, from the @crg.eu. 🤝 Hosted by Dr. @xsalvatella1.bsky.social  Register here ➡️ shorturl.at/A9VMZ #IRBBarcelona #Seminar
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xavier salvatella @xsalvatella1.bsky.social · 16/03/2026
Happy to announce that my institution, @irbbarcelona.org, is opening two group leader positions, 1 in chemical biology and 1 in structural biology, to strengthen our expertise in molecular sciences: please spread the word !
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xavier salvatella @xsalvatella1.bsky.social · 16/03/2026
Our work on how oligomerization can enable selectively targeting intrinsic disorder with small molecules is now out in Science Advances: www.science.org/doi/10.1126/...). Congratulations Stase Bielskute and @borjaml.bsky.social and thanks to the collaborators and funders !
science.org
Oligomerization enables the selective targeting of an intrinsically disordered region by a small molecule
The druggability of intrinsically disordered regions.
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IDPSeminars @idpseminars.bsky.social · 04/03/2026
IDPSeminars is back TOMORROW! Come see @tanjamittag.bsky.social and @xsalvatella1.bsky.social ! Not to be missed!!
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The EMBO Journal @embojournal.org · 11/02/2026
Yeast ubiquilin Dsk2 scaffolds proteasome-containing condensates under stress via multivalent interactions – @castanedalab.bsky.social et al show how dynamic interactions among its STI1 domain & transient helices in its disordered region promote its phase-separation link.springer.com/article/10.1...
link.springer.com
STI1 domain engages transient helices to mediate Dsk2 phase separation and proteasome condensation - The EMBO Journal
Ubiquitin-binding shuttle proteins are important components of stress-induced biomolecular condensates in cells. Yeast Dsk2 scaffolds proteasome-containing condensates via multivalent interactions wit...
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Emmanuel Levy's lab @elevylab.bsky.social · 09/02/2026
In 2017 we showed that homomers evolve on the edge of supramolecular self-assembly. Here we show how to exploit this vulnerability so that ALL homomers can become bona fide drug-🎯. Delighted that Aim 3 of our @erc.europa.eu finally polymerized! Manuscript: 👉 rdcu.be/e27bT
The image illustrates a principle by which homomers can be polymerized by mutations or by multivalent small molecules.
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xavier salvatella @xsalvatella1.bsky.social · 07/02/2026
An excellent review on a fascinating topic !
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Biophysical Society @biophysicalsoc.bsky.social · 29/01/2026
Join 2026 BPS Lecturer Lewis Kay on Tuesday, February 24, 2:00 PM - 3:00 PM at #bps2026 for an informal discussion. Dr. Kay will share insights from his scientific career—from pioneering discoveries to lessons learned along the way—and reflect on how the field continues to evolve
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IRB Barcelona @irbbarcelona.org · 29/01/2026
📢  #MAINFRAME Symposium comes to Barcelona! Experts in #AI, computational chemistry & small-molecule #DrugDiscovery meet to advance open, large-scale screening for 2,000+ human proteins. 📆 Mar 18–19 📍 Ateneu Barcelonès ℹ️ shorturl.at/1aKKS @ptck72.bsky.social
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Alejo Rodriguez-Fraticelli @alejofraticelli.bsky.social · 27/01/2026
🚨WE'RE RECRUITING AT @irbbarcelona.org !!!! --- ADVANCED GENOMICS FACILITY MANAGER --- An amazing opportunity to help us drive the fight against cancer and other aging-related diseases using Single-cell, Bulk and Spatial genomics!!!! APPLY NOW!!!! recruitment.irbbarcelona.org/jobs/7124180...
recruitment.irbbarcelona.org
Head, Advanced Genomics Technologies Core Facility (Ref. CF/26/01) - IRB Barcelona
IRB Barcelona invites applications for the position of Head, Advanced Genomics Technologies Core Facility. The successful candidate will report to the Director, Technology Strateg...
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Jerelle Joseph @jerelleaj.bsky.social · 14/01/2026
How does protein folding change inside biomolecular condensates? Our new preprint put forwards a framework for predicting this!! 🥳🥳🥳🥳 work by the talented @nathanieldhess.bsky.social
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IRB Barcelona @irbbarcelona.org · 16/01/2026
You can’t miss this video we shared today during the tribute to Dr. #JoanGuinovart. Today, the scientific community, institutional leaders, colleagues, friends, and family gathers to honour the life and legacy of the founder and first director of #IRBBarcelona. 🎥 youtu.be/_SJ5Rudj2ik
youtu.be
16 de enero de 2026
YouTube video by IRB Barcelona
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IRB Barcelona @irbbarcelona.org · 17/11/2025
📌 Don't miss our plenary #seminar this week, with Prof. Edward Lemke, from @unimainz.bsky.social.  Host: Dr. @xsalvatella1.bsky.social, #IRBBarcelona Register here ➡️ shorturl.at/I58yN 🧪
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The Francis Crick Institute @crick.ac.uk · 09/10/2025
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions. Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research. Apply now ➡️ www.crick.ac.uk/careers-stud...
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Giulio Tesei @giuliotesei.bsky.social · 02/10/2025
I'm hiring for a PhD position at Malmö University, Sweden! The project will focus on molecular modelling of proteins, lipids, and biomolecular condensates at cell membranes. More details and application form: tinyurl.com/4zm92365 Please feel free to share! @vetenskapsradet.bsky.social | @mau.se
Snapshot of a condensate near a lipid membrane with Swedish Research Council and Malmö University logos.
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xavier salvatella @xsalvatella1.bsky.social · 03/10/2025
Thank you Fundación @bbvaenespana.bsky.social for supporting our collaboration with Michael Krieg of @icfo.eu !
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The New Yorker @newyorker.com · 23/09/2025
Antoni Gaudí’s vision for the Sagrada Família, a church that’s been under construction for nearly 150 years, was never universally liked. George Orwell called the church “one of the most hideous buildings in the world.”
newyorker.com
Is the Sagrada Família a Masterpiece or Kitsch?
In the century since Antoni Gaudí died, his wild design has been obsessively realized, creating the world’s tallest church—and an endlessly debated icon.
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Nature @nature.com · 29/08/2025
RFK Jr has vowed to find out what’s responsible for the rise in autism diagnoses, but scientists say he is ignoring answers from decades of research go.nature.com/47R4brs
go.nature.com
Autism is on the rise: what’s really behind the increase?
Nature - RFK Jr has vowed to find out what’s responsible, but scientists say he is ignoring answers from decades of research.
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Alex Holehouse @alexholehouse.bsky.social · 28/08/2025
Are you a computational biologist who loves the outdoors & is thinking about faculty positions? Then check this out: eeik.fa.us2.oraclecloud.com/hcmUI/Candid... Tenure track position at the University of Wyoming - amazing colleagues, beautiful landscape, and fantastic work-life balance.
eeik.fa.us2.oraclecloud.com
Asst Professor - Molecular Biology - Computational Biochemist
The Department of Molecular Biology (MOLB) and the School of Computing (SoC) at the University of Wyoming seeks candidates for a tenure-track position at the rank of Assistant Professor starting in th...
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Tanja Mittag @tanjamittag.bsky.social · 09/07/2025
New paper on transcription factor phase separation published from my colleague Aseem Ansari's and my lab: Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function authors.elsevier.com/sd/article/S...
authors.elsevier.com
ScienceDirect.com | Science, health and medical journals, full text articles and books.
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Centre de Regulació Genòmica (CRG) @crg.eu · 01/07/2025
Exciting news: our Board of Trustees has appointed @monicabettencourt.bsky.social as the CRG's new Director. Prof Bettencourt-Dias is expected to take up the post in 2026, replacing Dr. Luis Serrano, who will continue to maintain a research group at the institute. www.crg.eu/en/news/moni...
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RSC-ESR Group @esr-group.bsky.social · 01/07/2025
Congratulations to RSC-ESR group committee member Adam Brookfield and his colleague, Dr Muralidharan Shanmugam, for winning the RSC Technical Excellence Prize for their operations of the EPSRC NRF for EPR in Manchester, UK. www.manchester.ac.uk/about/news/f...
manchester.ac.uk
Four University colleagues win prestigious Royal Society of Chemistry prizes
Four University of Manchester colleagues have been honoured by the Royal Society of Chemistry for their outstanding contributions to the chemical sciences.Professor Igor Larrosa has been selected to r...
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IRB Barcelona @irbbarcelona.org · 30/06/2025
🏆 La investigación sobre la causa del #autismo, premio #VanguardiadelaCiencia 2025! ¡Enhorabuena a las premiadas: Dra. Carla Garcia Cabau y Dra. Anna Bartomeu, del #IRBBarcelona!👏👏👏 ➡️ shorturl.at/1hXF0 @lavanguardia.com @xsalvatella1.bsky.social  🧪
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Nature Biotechnology @natbiotech.nature.com · 25/06/2025
Today’s uniquely challenging biotech climate may result in a more resilient sector nature.com/articles/s41... rdcu.be/etg7h
nature.com
Biotech financing: divide and reset - Nature Biotechnology
Today’s uniquely challenging biotech climate may result in a more resilient sector.
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Derek Lowe @dereklowe.bsky.social · 17/06/2025
“What is common knowledge in your field, but shocks outsiders?” Most drugs have several activities in the human body, and discovery of these effects goes on for years after they are on the market.
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Philip Ball @philipcball.bsky.social · 15/06/2025
...the amino-acid sequence does not necessarily determine 3D shape, because many of our proteins have functionally crucial disordered regions that don't really have a shape. (Sometimes they fold on binding, perhaps in a ligand-specific way, sometimes they don't.)...
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Rachel W. Martin @rwmartin.bsky.social · 15/06/2025
Here's an anniversary worth celebrating!
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Stan Stanminson @lancetungsten.bsky.social · 03/06/2025
Patent departments have budget targets that lead to “pound foolish” decisions to abandon all the time.
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IDPSeminars @idpseminars.bsky.social · 03/06/2025
IDPSeminars is back with another seminar this week from @sarahshammas.bsky.social and @sonia-longhi.bsky.social! Come hear about transcriptional regulation and viral pathogenesis! Thursday June 5th! PST 10 am EST 1 pm CET 7 pm! Info: idpseminars.com Signup form: forms.gle/3yCHeYvuuqLh...
Sarah Shammas (University of Oxford):Opportunities in DNA binding provided by protein disorder

Sonia Longhi (AFMB Marseille): Intrinsic disorder, phase transitions and fibril formation by the Henipavirus V and W proteins: a new hallmark of viral pathogenesis?
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