This review synthesizes cross-species ubiquity, molecular mechanisms, and physiological/pathological roles of the 12-h ultradian rhythm, uncovering its core value independent of the circadian clock. ...

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Nuclear speckles have long been recognized as RNA-rich nuclear bodies, yet their role in genome organization and gene regulation remains incompletely understood. Using a rapid dTAG-mediated degradatio...

Targeting cellular structures called nuclear speckles could be a completely new approach for treating Alzheimer’s, Parkinson’s and prion diseases, according to new research led by the Univ...

Here the authors show that rehabilitating nuclear speckles, membraneless organelles involved in mRNA processing and gene regulation, can boost protein quality control and reduce toxic protein buildup,...

Traces of ocean-dwelling ancestors seem to live on in our biological rhythms.