Abstract. Mitochondrial DNA (mtDNA) copy number regulation remains incompletely understood, despite its importance in cellular function. In Saccharomyces c

Nature Structural & Molecular Biology - Mitochondrial translational activators (TAs) facilitate transcript-specific translation. Using selective ribosome profiling and cryo-electron microscopy,...

Quantitative imaging of the mitochondrial central dogma identifies translation hubs that are suppressed during stress.

Mitochondrial DNA (mtDNA) copy number regulation remains incompletely understood, despite its importance in cellular function. In Saccharomyces cerevisiae, Mrx6 belongs to the Pet20-domain-containing ...

Mitochondrial DNA (mtDNA) copy number regulation remains incompletely understood, despite its importance in cellular function. In Saccharomyces cerevisiae, Mrx6 belongs to the Pet20-domain-containing ...

Edington et al. determine that Mdm33 and CCDC51 are functionally conserved mitochondrial inner membrane proteins that are required for normal mitochondrial

Hahn et al. report the presence of 6mA, a DNA modification, on the mitochondrial (mt)DNA of various animal and plant species. Modulating the activity of 6mA enzymatic modifiers implicates 6mA in regulating mtDNA replication and expression and the transmission of mtDNA mutations across generations, ultimately affecting mitochondrial health and organismal lifespan.

Rickgauer et al. dissect molecular motion of human ribosomes in situ using high-resolution template matching. Detecting individual ribosome subunits provides maps of native conformations, revealing ne...

Abstract. Mitochondrial DNA (mtDNA) is indispensable for mitochondrial function and is maintained by DNA repair, turnover, mitochondrial dynamics and mitop

The MBD2c splicing variant of MBD2 that is essential for nuclear transcription translocates to the mitochondria to regulate mitochondrial DNA transcription and respiration and is linked to drug resist...

Understanding the origin of eukaryotic cells is one of the most difficult problems in all of biology. This Consensus View lays out guidelines to identify the gene repertoire of the Last Eukaryotic Com...

Somatic mitochondrial DNA (mtDNA) mutations are heavily implicated as important drivers of ageing and age-related diseases. Their pathological effect can be partially counteracted by increasing the ab...

Upon various stresses, mtDNA leaks from mitochondria into the cytoplasm, leading to cellular dysfunction and inflammation, thereby exacerbating disease progression. The autophagy–lysosome pathway has ...

Mitochondria exist as dynamic tubular networks and the morphology of these networks impacts organelle function and cell health. Mitochondrial morphology is maintained in part by the opposing activitie...

Membrane contact sites (MCS) establish organelle interactomes in cells to enable communication and e