AIFM1 is crucial for mitochondrial function. Here, Rothemann, Pavlenko et al. show that AK2A interacts with NADH-dependent AIFM1 dimers. They demonstrate that this interaction stabilizes AIFM1 dimers and enhances their activity. Given the proximity to ADP/ATP translocases and ATP synthase, the AIFM1-AK2A complex may contribute to metabolic adaptation.

The history of mitochondria begins with their recognition as distinct cellular organelles in 1888 by Walther Flemming and the introduction of the term mitochondrion from the Greek roots meaning ‘thre…

This article presents NAPstars, a family of genetically-encoded biosensors that enable real-time monitoring of NADP redox dynamics across species. The sensors reveal robust NADP redox regulation, cell...