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Christopher Frank

@chrisfrank662.bsky.social

240 followers 90 following 23 posts

De novo Protein Designer DNA Origami wizzard I like lifting rocks PhD student @TU_Muenchen

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Reposted by Christopher Frank

owl @owlposting1.bsky.social · 25/04/2025

tomorrow!

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Christopher Frank @chrisfrank662.bsky.social · 20/02/2025

Cant wait for the first tests 🚀

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Christopher Frank @chrisfrank662.bsky.social · 07/02/2025

This is awesome! Great work! 🔥

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Christopher Frank @chrisfrank662.bsky.social · 16/01/2025

This www.biorxiv.org/content/10.1... Is so, so, so damn important work! 🔥 The designability filter bias, especially with AF2 single seq, is quite high. Designing idealized proteins is very usefull in some cases, but brings strong limitations. Time that we start "designing the un-Designable" 😆

biorxiv.org

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Christopher Frank @chrisfrank662.bsky.social · 22/11/2024

Crosspost from X: After showing that AF2 can be used to design very large proteins by performing #RSO, I am happy to share another fun project we did: the #af2cycler @sokrypton.org @hendrikdietz.bsky.social www.biorxiv.org/content/10.1...

biorxiv.org

Alphafold2 refinement improves designability of large de novo proteins

Recent advances in computational protein design have enabled the creation of novel proteins for a variety of purposes. The capability for producing custom-shape high-quality backbones for very large p...

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Reposted by Christopher Frank

Gabriele Corso @gcorso.bsky.social · 17/11/2024

Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!

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