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Manvendra Singh

@manusingh.bsky.social
1.8K followers 268 following 160 posts

#NewPI #Recruiting CNRS-CPJ and Director of Research - RETROGEN lab, Retroelements and Genome Regulation Necker Institute and Institut Imagine, Paris. Alum: Feschotte lab (post-doc), Izsvak Lab (PhD) and Max-Planck Institute.

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Reposted by Manvendra Singh
Maya Voichek @mayavoichek.bsky.social · 24/09/2026
Super excited to share my postdoctoral work at @imbavienna.bsky.social @viennabiocenter.bsky.social - We discovered that some retrotransposons, or "jumping genes" 🧬, are able to spread from cell to cell via a new viral infectivity route. A short thread: 🧵👇 (1/7)
AI-generated illustration of the soma-to-germline transmission of retrotransposons described in our work
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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 05/09/2026
A single-nucleus regulatory atlas links transposable elements to adult hippocampal neurogenesis www.biorxiv.org/content/10.64898/20…
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Manvendra Singh @manusingh.bsky.social · 28/09/2026
1/8 Proud and super thrilled to share our preprint, “A single-nucleus regulatory atlas links transposons to adult hippocampal neurogenesis.”, led by Umut, Fede, and Souad, the FIRST from our #RETROGEN lab @inem-necker.bsky.social . www.biorxiv.org/content/10.6... shrt thread on what we found 🧵
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Manvendra Singh @manusingh.bsky.social · 21/09/2026
This time in Hamburg
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Manvendra Singh @manusingh.bsky.social · 26/08/2026
A Planet of Viruses. 🦠🌍 Scary but had a lot of fun talking about viruses today. They are everywhere, they have been with us forever, and they have even become part of our own genome. I have a feeling we’ll be talking a lot more about them in the years ahead. 😄 #Virology #HERVs #Genomics #Scienc
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Manvendra Singh @manusingh.bsky.social · 25/07/2026
What happened in India today teaches us a valuable lesson - To learn something new, one has to break their arrogance and pride, and Genz taught this #CJP
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European Research Council (ERC) @erc.europa.eu · 23/07/2026
🟠 Now open: ERC Starting Grant 2027 call for proposals! 🗓️ Deadline: 14 Oct 2026 📄 Call details: link.europa.eu/RwNMpX Planning to apply? Let our ERC Classes videos guide you through the application evaluation process. 👉 t.co/qGPy7Y8UhS #ERCStG #FrontierResearch @scienceinnovation.ec.europa.eu
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Rebecca Berrens @rberrens.bsky.social · 10/07/2026
Hi #TEsky, please remember that we have an amazing community in the TransposonsWorldWide slack channel (join.slack.com/t/transposon...), which I encourage you to join. Another great resource is tehub.org. Please share !
join.slack.com
Join TransposonsWorldwide on Slack
Slack is a new way to communicate with your team. It’s faster, better organized, and more secure than email.
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Manvendra Singh @manusingh.bsky.social · 10/07/2026
Proud moment for the RetroGen Lab! 🎉 Congratulations to Federica Mantovani on her selection for an oral presentation at the CNET meeting in Montpellier—a well-deserved recognition of her hard work and a fantastic opportunity to represent our lab. Bravo! 👏 #ProudPI
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Manvendra Singh @manusingh.bsky.social · 15/06/2026
Three Species in One House is Endless Entertainment One delegate refuses to acknowledge the other. The other delegate is desperately trying to make friends. And I’m the confused moderator wondering why nobody is speaking the same language.
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Manvendra Singh @manusingh.bsky.social · 05/06/2026
📍5 minutes before journal club. Today’s paper was… let’s say, not exactly light one of our PhD students sat down at the piano and played to calm everyone’s neurons before we wrestled with the paper. 🎹📖 Lucky to work with them. #AcademicLife #PhDLife #JournalClub #Science #ResearchLife #LabLife
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Manvendra Singh @manusingh.bsky.social · 16/04/2026
🔥Feeling so thrilled to see a story of our recent paper on Transposons and Preeclampsia on the front page of Femina Magazine. #TEsky www.femina.fr/article/gros...
femina.fr
Grossesse : une nouvelle piste pour détecter la pré-éclampsie plus tôt
Encore difficile à anticiper, la pré-éclampsie reste une complication redoutée de la grossesse. Mais une récente avancée scientifique, menée notamment par l’Institut Imagine, ouvre la voie à un dépist...
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Cedric Feschotte @cedricfeschotte.bsky.social · 07/05/2026
👋 Transposon lovers: registration is now open for the CSHL TE meeting! We have a 🔥 lineup of invited speakers and many slots for short talks selected upon abstract across all areas of TE biology. 🧬➰🧬 #TEsky Abstract deadline: July 10 meetings.cshl.edu/meetings.asp...
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Institut Imagine @institutimagine.bsky.social · 05/05/2026
🔬 What if we could spot preeclampsia before symptoms appear? Research by @manusingh.bsky.social in Genome Biology shows ancient viral remnants in our DNA act as "molecular switches" for placental development—leaving traces in maternal blood when they malfunction. 🎥 www.linkedin.com/feed/update/...
linkedin.com
#research #preeclampsia #genomics #medicalresearch #institutimagine | Institut Imagine
🔬 What if we could detect preeclampsia before the first symptoms even appear? That is the promise of new research led by Dr. Manvendra Singh, group leader at INEM - Institut Necker Enfants Malades, i...
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Manvendra Singh @manusingh.bsky.social · 16/04/2026
🔥Feeling so thrilled to see a story of our recent paper on Transposons and Preeclampsia on the front page of Femina Magazine. #TEsky www.femina.fr/article/gros...
femina.fr
Grossesse : une nouvelle piste pour détecter la pré-éclampsie plus tôt
Encore difficile à anticiper, la pré-éclampsie reste une complication redoutée de la grossesse. Mais une récente avancée scientifique, menée notamment par l’Institut Imagine, ouvre la voie à un dépist...
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Institut Imagine @institutimagine.bsky.social · 09/04/2026
🧬 We are LIVE at the weekly MAGIC seminar at Imagine! Kicking us off is @joshwaterfall.bsky.social (@institutcurie.bsky.social ) presenting "Improved Out of Distribution Embeddings with AutoEncoders." Fascinating insights into computational biology! 🧵
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Institut Imagine @institutimagine.bsky.social · 09/04/2026
🧫 Wrapping up today's fantastic MAGIC seminar is @manusingh.bsky.social (@inem-necker.bsky.social). His talk: "Single-Cell Mapping of the Reawakening of Ancient Foes in Ageing Disorders." A deep dive into the molecular & cellular mechanisms of Alzheimer. Thanks to all speakers & see you next week! 🧪
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Dr. Tyler A. Elliott @transposableman.bsky.social · 17/03/2026
#TEsky Another paper in our TE ecology exploration of the Octopus out in BioEssays. Types of niches for TEs and what that could mean for their expression in neural tissue doi.org/10.1002/bies...
doi.org
Transposon Ecology and the Octopus Genome
Transposable elements (TEs) are mobile strands of DNA prevalent in octopus genomes. TE activity in the octopus brain might reflect an organism-beneficial role in cognition; or could be a deleterious ...
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Alessandro Prigione @aleprigio.bsky.social · 11/03/2026
Our collaborative work is out now in CELL @cellpress.bsky.social We sugggest sildenafil as a repurposable drug for mitochondrial disease. A clinical trial is planned to start later this year. Thanks to collaborators, funders, and patient organizations! www.sciencedirect.com/science/arti...
sciencedirect.com
Pluripotent stem-cell-based screening uncovers sildenafil as a mitochondrial disease therapy
Mitochondrial disease encompasses inherited disorders affecting mitochondrial function. A severe and untreatable form of mitochondrial disease is Leig…
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Manvendra Singh @manusingh.bsky.social · 12/03/2026
Ancient viral DNA drives preeclampsia in pregnancy | Max Delbrück Center www.mdc-berlin.de/news/news/an...
mdc-berlin.de
Ancient viral DNA drives preeclampsia in pregnancy
Researchers have uncovered the molecular details of how ancient viral DNA controls a gene linked to preeclampsia. The study, published in “Genome Biology,” builds on previous research and may lead to a diagnostic test to identify preeclampsia risk much earlier.
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Manvendra Singh @manusingh.bsky.social · 08/03/2026
Happy Women’s Day 🎊🎊😊to all of us and especially three outstanding women leading science at the highest level around our Necker Campus. Fabiola, Bana, and Yasmine, the directors of Necker, IMAGINE and Pasteur Institutes, respectively. Proud to be part of this cluster.
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Manvendra Singh @manusingh.bsky.social · 05/03/2026
Happy Holi everyone 🌈 A festival where poetry meets science as every color carries meaning, every wavelength shapes how we see the world. Train your eyes with colors and your heart with kindness. May peace, harmony, and love spread across every spectrum of humanity.
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Manvendra Singh @manusingh.bsky.social · 03/03/2026
In a mouse model of Primrose syndrome, rhEPO reverses. This is preclinical & could be the first tangible therapeutic path. Huge thanks to Justus, @cakirumut.bsky.social , Klaus and Hannelore and to an amazing team. DOI: 10.1172/jci.insight.200021 #RareDisease #Neurobiology #TranslationalResearch
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Manvendra Singh @manusingh.bsky.social · 02/03/2026
Stranded due to airspace closures. Major grant + revision deadlines piling up. War reaches far beyond borders — even those who think they’re uninvolved feel it. And yet this inconvenience is nothing compared to what others are enduring. Please choose peace. Humanity first.
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JCI insight @insight.jci.org · 23/02/2026
Suggesting a potential therapy for these autism-related symptoms and intellectual disability… This issue’s Cover features work by Hannelore Ehrenreich & team on the improvement of Primose syndrome traits in mice following erythropoietin treatment: doi.org/10.1172/jci....
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Manvendra Singh @manusingh.bsky.social · 26/02/2026
So thrilled to have our research as a cover feature at @insight.jci.org, showing recombinant human Erythropoetin can compensate for the loss of function caused by the genetic mutation. I hope this research will age well. Thanks Hannelore, Klaus, @cakirumut.bsky.social , Justus and ex-colleagues
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Eric Topol @erictopol.bsky.social · 20/02/2026
The $100 whole human genome sequence finally reached! www.sandiegouniontribune.com/2026/02/19/s...
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Max Haase @maxhaase.bsky.social · 18/02/2026
Our paper is now out in Nature: “Ancient co-option of LTR retrotransposons as yeast centromeres” www.nature.com/articles/s41... A short thread on how retrotransposons helped give rise to yeast point centromeres. 1/14
nature.com
Ancient co-option of LTR retrotransposons as yeast centromeres - Nature
Evolutionarily related ‘proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with re...
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Manvendra Singh @manusingh.bsky.social · 06/02/2026
Many Congratulations @retrogenomics.bsky.social , very well deserved and well earned. 🙏🏽
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Manvendra Singh @manusingh.bsky.social · 30/01/2026
Such a great award and the reward too. Very well deserved @m-vincendeau.bsky.social , Many congratulations and hopefully many more to come ☺️ Keep cementing the #TEsky up above and high.
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Manvendra Singh @manusingh.bsky.social · 29/01/2026
Incredible article and resource too. Congratulations @kaessmannlab.bsky.social
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Manvendra Singh @manusingh.bsky.social · 27/01/2026
Gave a talk at @institutcurie.bsky.social on Friday and honestly… it felt unreal. Speaking in the same place where Marie Curie carried out her radiation experiments reminds how long science lasts beyond us. Thnks Elena Zueva, @mburbage.bsky.social , Sebastian Amigorena, Josh Waterfall and Lorena 🙏🏽
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Institut Pasteur | 130 years of biomedical research @pasteur.fr · 16/01/2026
🧠🧬 Psoriasis: Unraveling the Causes of Chronic Itching @belkaidlab.bsky.social and Institut Pasteur researchers show that an excessive immune response to skin microbes activates the IL‑17A pathway in nerves, leading to chronic itch and nerve regrowth. 👉 www.pasteur.fr/en/home/rese...
pasteur.fr
Psoriasis: Unraveling the Causes of Chronic Itching
In psoriasis and other inflammatory skin diseases, chronic itching or pruritus is a particularly distressing symptom for patients which remains difficult to treat today. Scientists at the Institut Pas...
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Institut Imagine @institutimagine.bsky.social · 15/01/2026
🦠 Closing our session is @manusingh.bsky.social discussing the "Long Shadow of Viral Infections". He's showing how HIV & EBV can reactivate persistent, ancient Endogenous Retroviral proteins. A powerful reminder that our genome's history still dictates our health today!🧬
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Manvendra Singh @manusingh.bsky.social · 07/01/2026
#TESKY 🎉 Phenomenal work! After the humans, the variety of mouse immune cell systems also co-opts transposon-derived enhancers/promoters. Big Kudos to Jason, Andrew Grimson, and @cedricfeschotte.bsky.social
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Institut Imagine @institutimagine.bsky.social · 06/01/2026
Does a neuron’s "address" define its function? 🧠 Featured in @lefigaro.fr, new nature neuroscience research from Denis Jabaudon & colleagues shows that misplaced neurons can work perfectly & process senses. Brain structure ≠ function! For more information: www.linkedin.com/posts/instit...
linkedin.com
#neuroscience #brainresearch #institutimagine #natureneuroscience #neurodevelopment #genetics | Institut Imagine
Does a neuron’s "address" define its function? 🧠 We are thrilled to share a new study published in Nature Neuroscience—also featured in Le Figaro—that challenges long-standing assumptions about how t...
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Manvendra Singh @manusingh.bsky.social · 05/01/2026
🔥🎉 🧠 SuperThrilled to share our paper (preprint) - Human erythropoietin (rhEPO) reshapes the adult hippocampal chromatin landscape, around transposons to promote neurogenesis. 🧵1/8 Massive kudos to #UmutCakir who drove multi-omics through dark roads of the genome. www.biorxiv.org/content/10.1...
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Manvendra Singh @manusingh.bsky.social · 02/01/2026
Happy new year and 3 more days to apply for Computational biology post doc position in my lab #Paris #transpoosns @inem-necker.bsky.social @institutimagine.bsky.social
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Manvendra Singh @manusingh.bsky.social · 20/12/2025
This is the view where we shall have our regular lab meetings. Maybe this persuades you to join our team. #hiring #postdoc #computationalBiology #multiomics #deeplearning
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Manvendra Singh @manusingh.bsky.social · 10/12/2025
#hiring #postdoc #bioinformatics We’re opening a Computational/Bioinformatics postdoc position in my new lab at INEM in Paris, connected with Imagine and Institut Pasteur. The big theme: 👉 How do endogenous retroviruses and other mobile DNA rewire human immune regulation and genome control? 👇⬇️🧵
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Guillaume Bourque @guilbourque.bsky.social · 04/12/2025
Congrats Manvendra, well deserved!
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Marianne Burbage @mburbage.bsky.social · 04/12/2025
Great news for the scientific community in France (especially TE aficionados :))!!
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Manvendra Singh @manusingh.bsky.social · 04/12/2025
It’s debatable, there exists arguments from both sides. I bet the quality of science will be diminished. When experts review the paper or grants, they get an idea of which citations hold how much water. AI doesn’t unless we first train it. So, I think it’s too soon to implement for grant review
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Manvendra Singh @manusingh.bsky.social · 04/12/2025
#NewPI #Neuroscience #Immunology #Transposons #SciComm #HERVs Stay tuned, a few postdoctoral, both molecular and computational biology positions are gonna be advertised soon.
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Stephen Turner @stephenturner.us · 03/12/2025
Benchmarking cell type and gene set annotation by large language models with AnnDictionary www.nature.com/articles/s41... 🧬🖥️🧪 github.com/ggit12/anndi...
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Manvendra Singh @manusingh.bsky.social · 03/12/2025
🎉 Thrilled to Announce a New Chapter! 🧵 I’m honoured to share that I’ve been appointed as CNRS Chaire de Professeur Junior (CPJ) at Université Paris Cité from 1st Jan. My independent lab is hosted at the Necker Institute (INEM), with co-affiliations at the Imagine Institute and Pasteur Institute. ⬇️
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Doudna Lab @doudna-lab.bsky.social · 02/10/2025
"Jane Goodall showed us what a life in science could look like: rigorous discovery paired with fierce advocacy for what you study. She gave the world six decades of groundbreaking research on chimpanzees and their habitats, then turned that knowledge into a global movement for conservation." (1/2)
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Arnau Sebé-Pedrós @arnausebe.bsky.social · 24/09/2025
Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life. www.nature.com/articles/s41...
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Carmelo Ferrai @carmeloferrai.bsky.social · 23/09/2025
Paper accepted!!!! Congratultions to @lizebonaaugust.bsky.social Blanca del Rosal and Leslie Yeo it was a pleasure to work together on this amazing project! 🎊🎊🎊🎊
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Cedric Feschotte @cedricfeschotte.bsky.social · 13/08/2025
One of my all-time faves
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