Sign in

Institut Imagine

@institutimagine.bsky.social
390 followers 26 following 165 posts

🔬 Premier centre européen dédié aux maladies génétiques. 📍 Campus Necker - Enfants Malades, Paris | #Recherche #Santé #Innovation 🌐 www.institutimagine.org

PostsRepliesMedia
Reposted by Institut Imagine
Manvendra Singh @manusingh.bsky.social · 28/09/2026
1/8 Proud and super thrilled to share our preprint, “A single-nucleus regulatory atlas links transposons to adult hippocampal neurogenesis.”, led by Umut, Fede, and Souad, the FIRST from our #RETROGEN lab @inem-necker.bsky.social . www.biorxiv.org/content/10.6... shrt thread on what we found 🧵
2139
Reposted by Institut Imagine
Alexandre Benmerah @alexbnmrh.bsky.social · 23/09/2026
Amandine Viau, Joran Martin and I had a very nice meeting @club-cfc.bsky.social in Aussoy where we could present our recent works @institutimagine.bsky.social in the @theracilproject.bsky.social ! Congrats to Joran who won the best talk price! #cilia #ciliopathies #nephronophthisis #kidney
042
Institut Imagine @institutimagine.bsky.social · 22/09/2026
🔴 Happening now at Institut Imagine: Prof. @danmucida.bsky.social (Rockefeller University, HHMI) on how immune cells and the gut lining talk to each other, and how the brain senses what's happening in the gut, from infection to inflammation. #Immunology #Neuroimmunology
142
Reposted by Institut Imagine
Cancer Grand Challenges @cancergrand.bsky.social · 21/09/2026
One bold idea can change everything. Paul Bastard is leading team ATLAS to explore whether autoantibodies also influence cancer risk. Read Paul’s full interview at bit.ly/4A4Og4B 📹 Includes footage from @institutimagine.bsky.social
044
Institut Imagine @institutimagine.bsky.social · 14/09/2026
🔴 Happening now at our Monday Seminar: Prof. Xavier Roca (NTU Singapore) on "Diagnostics of mutations affecting splicing in genetic disease." Exploring two decades of splicing biology, from mechanisms to variant interpretation & rare disease therapeutics. 🧬 #InstitutImagine #Genetics
032
Reposted by Institut Imagine
LabPrudent @prudentlab.bsky.social · 11/09/2026
Come and join us in building an exciting new mitochondrial cell biology lab in Paris! 🚀 📅 Start: Nov–Dec 2026 ⏳ Deadline: 2 Oct 2026 #Mitochondria #Postdoc #CellBiology #mtDNA #Microscopy #Paris
011
Reposted by Institut Imagine
LabPrudent @prudentlab.bsky.social · 11/09/2026
🔬 Laboratory Manager We’re looking for a scientist with a strong molecular/cell biology background to help run and develop the lab while contributing experimentally to our research. 👉 Apply: www.welcometothejungle.com/fr/companies...
welcometothejungle.com
Lab Manager - Institut Imagine - CDD / Temporaire à Paris
Institut Imagine recrute un(e) Lab Manager à Paris !
111
Reposted by Institut Imagine
LabPrudent @prudentlab.bsky.social · 11/09/2026
👉 Apply for the Postdoctoral positions: www.welcometothejungle.com/fr/companies...
welcometothejungle.com
Two (2) Postdoctoral Positions in Mitochondrial Cell Biology - Institut Imagine - CDD / Temporaire à Paris
Institut Imagine recrute un(e) Two (2) Postdoctoral Positions in Mitochondrial Cell Biology à Paris !
111
Reposted by Institut Imagine
LabPrudent @prudentlab.bsky.social · 11/09/2026
🧬 Two postdoc projects: 1️⃣ Inner mitochondrial membrane quality control & mtDNA dynamics 2️⃣ Golgi-derived vesicles, membrane contact sites & mitochondrial dynamics 📅 Start: Nov–Dec 2026 ⏳ Deadline: 2 Oct 2026
111
Reposted by Institut Imagine
LabPrudent @prudentlab.bsky.social · 11/09/2026
Our lab studies how mitochondrial membrane dynamics, mtDNA biology and inter-organelle contact sites regulate mitochondrial function and cellular homeostasis. We combine cell & molecular biology with cutting-edge live-cell and high-resolution microscopy. 🔬
121
Reposted by Institut Imagine
LabPrudent @prudentlab.bsky.social · 11/09/2026
🚀 We’re hiring! Join our newly established lab at the @institutimagine.bsky.social in Paris 🇫🇷 We’re recruiting: 🧬 2 Postdoctoral Researchers in Mitochondrial Cell Biology 🔬 1 Laboratory Manager Thread below 👇
243
Reposted by Institut Imagine
Frédéric Rieux-Laucat @frl-lab.bsky.social · 07/09/2026
Congratulations to Damien Glon and Quentin Riller on this fruitful collaboration between Yves Gaudin's team @cnrs-paris-saclay.bsky.social and our team @institutimagine.bsky.social . www.nature.com/articles/s41...
nature.com
NAP1 switches from an activator to a limiter of interferon induction by trapping TBK1 in condensates - Nature Communications
TBK1 kinase is a key regulator of type I interferon production and upon activation the TBK1adaptor proteins are known to form liquid condensates. Here the authors show NAP1 is a rheostat, switching fr...
132
Reposted by Institut Imagine
ISDN @isdnsociety.bsky.social · 25/08/2026
The #ISDN2027 symposium on molecular drivers of stability versus #plasticity of neural cell fate and their implication for #brain repair will be completed by @sarabiz86.bsky.social from @institutimagine.bsky.social and Samir Vaid from @tudresden.bsky.social.
121
Reposted by Institut Imagine
Casanova Lab @casanovalab.bsky.social · 24/08/2026
1/ We are excited to report in @PNASNews that autoantibodies neutralizing type I interferons underlie 35% of cases of Chikungunya virus (CHIKV) encephalitis or myelitis from a multiple cohort study. www.pnas.org/doi/10.1073/...
pnas.org
Autoantibodies neutralizing type I interferons underlie a third of cases of Chikungunya virus encephalitis or myelitis | PNAS
Chikungunya virus (CHIKV) infection is typically not life threatening but may, in rare cases, affect the central nervous system (CNS). In three coh...
153
Institut Imagine @institutimagine.bsky.social · 11/08/2026
🔬 Severe pediatric IBD with no genetic cause? Research by Institut Imagine & Uppsala University shows ~2% of cases have autoantibodies neutralizing IL-10, the gut's inflammation brake. Standard tests miss them, but finding them guides targeted care. 🔗 doi.org/10.1136/gutj... #IBD
054
Reposted by Institut Imagine
Philippe Bastin's Lab @bastinlab.bsky.social · 24/07/2026
There is more than cilia beating in the establishment of left-right symmetry! Proud to have contributed to this beautiful study by Amaia Ochandorena Saa @meilhacsigolene.bsky.social where Thierry Blisnick imaged mouse node by SEM doi/10.1126/sciadv.adx6486 @pasteur.fr @institutimagine.bsky.social
1124
Reposted by Institut Imagine
European Research Council (ERC) @erc.europa.eu · 06/08/2026
"The ERC funding that I was awarded was instrumental for my team to be selected by the scientific board of Institut Imagine." More about Edor Kabashi's research @institutimagine.bsky.social 👉 buff.ly/AXKfPvA More about EU support for researchers who would like to #ChooseEurope 👉 buff.ly/Y62mN2e
073
Reposted by Institut Imagine
Journal of Human Immunity @jhumimmunity.org · 05/08/2026
#FOXP3 deep intronic variant underlying #IPEX. New report from Pierre Gaufryau, Marie-Claude Stolzenberg, Jérémie Rosain @jrosain.bsky.social et al. @hopitalnecker.bsky.social @institutimagine.bsky.social: rupress.org/jhi/article/... #Atopy #Diagnostics #Autoimmunity #InbornErrorsOfImmunity
031
Institut Imagine @institutimagine.bsky.social · 04/08/2026
🩸 Violent immune reactions (HLH) often hide blood cancer. Biopsies are risky, but a new 2-step blood test (cytokine ratio & score) from Hermine's team at Institut Imagine quickly identifies underlying lymphomas—meaning fewer invasive procedures and faster treatment. 🔗 doi.org/10.1002/ajh....
032
Reposted by Institut Imagine
Casanova Lab @casanovalab.bsky.social · 24/07/2026
1/ We are thrilled to share our first @cellcellpress.bsky.social paper with the ATLAS team studying the role of antibodies, emphasizing autoantibodies in cancer (authors.elsevier.com/a/1nUSAL7PXy...).
authors.elsevier.com
Please wait whilst we redirect you
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
173
Institut Imagine @institutimagine.bsky.social · 24/07/2026
🔬 How do ADPKD cysts form? A JCI study by @hkd-l.bsky.social at Institut Imagine & Frank Bienaimé's group @inem-necker.bsky.social shows: without polycystin-1, the tubule sleeve gets softer, not stiffer. This loosening lets the tube expand. A new therapeutic target! 👏 📄 jci.org/articles/vie...
074
Reposted by Institut Imagine
Cancer Grand Challenges @cancergrand.bsky.social · 23/07/2026
Why do some ‘super avoiders’ never develop cancer? Team ATLAS has launched its global effort to find out, supported by the Breast Cancer Research Foundation, the Susan Wojcicki Foundation, the Torrey Coast Foundation and @cancerresearchuk.org. ➡️ www.cancergrandchallenges.org/news/backing...
154
Reposted by Institut Imagine
LabPrudent @prudentlab.bsky.social · 20/07/2026
After 10 fantastic years at the @mrc-mbu.bsky.social, @cam.ac.uk, it is time for our lab to move to France!! I am delighted to announce that we will begin a new adventure at the @institutimagine.bsky.social in Paris in September 2026!!
1111
Institut Imagine @institutimagine.bsky.social · 20/07/2026
🧠 What if Alzheimer's isn't just about neurons? A new Nature Neuroscience study from Michela Deleidi's team at Imagine shows stressed mitochondria cause microglia (brain immune cells) to age prematurely, disrupting neural connections. 📄 lnkd.in/gCg5qdRb
072
Reposted by Institut Imagine
Journal of Experimental Medicine @jem.org · 16/07/2026
ADAR1 loss-of-function variants altering RNA editing define a new #interferon-dependent #psoriasis subtype. New study from Florence Assan, Hervé Bachelez @institutimagine.bsky.social and colleagues: rupress.org/jem/article/... #HumanDiseaseGenetics
041
Institut Imagine @institutimagine.bsky.social · 09/07/2026
Kicking off today's MAGIC meeting on "Development & Mechanics"! 🧬 First up: Audrey Desgrange (Institut Imagine) on the "Biomechanics of heart development." We're exploring how physical forces actively shape our most vital organ. ❤️🔬 🧵👇 #DevBio #Biomechanics #HeartResearch
194
Institut Imagine @institutimagine.bsky.social · 06/07/2026
📢 Happening Now: Weekly Monday Seminar! We are thrilled to welcome Prof. Aleixo Muise (University of Toronto & @sickkids.bsky.social sky.social) to Institut Imagine today. He is currently presenting: "Novel insights into Monogenic Intestinal Disease." #Genetics #Immunology #Research
0106
Institut Imagine @institutimagine.bsky.social · 02/07/2026
🏅 Notre directrice générale, la Pr Bana Jabri, figure dans le palmarès 2026 du TIME France Health, parmi « Les 20 personnalités françaises qui font la santé » !
031
Reposted by Institut Imagine
Dr Ino Agrafioti @inoagrafioti.bsky.social · 01/07/2026
Congratulations to LS1 grantees @hecklab.bsky.social and Annarita Miccio at @institutimagine.bsky.social , for being awarded ERC POC grants! :)
032
Institut Imagine @institutimagine.bsky.social · 22/06/2026
We're live from the Future of Genetic Medicine Symposium today at Institut Imagine! 🧬 We are incredibly delighted to partner with @genethonfr.bsky.social & the Broad Institute's Center of Genetic Surgery for this event.
143
Institut Imagine @institutimagine.bsky.social · 18/06/2026
🔬 Kicking off our weekly MAGIC meeting! Our own Alice Lepelley is on stage sharing novel insights into type I IFN neuroinflammation driven by PTPN1 mutations in humans. 🧠🧬 #Neuroinflammation #Genetics #Interferon
142
Institut Imagine @institutimagine.bsky.social · 08/06/2026
🧬 Happening now: Prof. Yenan Bryceson (Karolinska Institutet) is presenting today's Monday Seminar at Imagine. He's discussing the "Regulation of flexibility in T cell signaling," exploring the biology of cytotoxic T cells to better understand primary immunodeficiencies & develop cancer therapies.
042
Reposted by Institut Imagine
Cancer Grand Challenges @cancergrand.bsky.social · 05/06/2026
Studying cancer avoidance isn’t straightforward. It means finding individuals who don’t develop cancer, and analysing them at scale. That level of research needs global collaboration, and Cancer Grand Challenges makes it possible. Read about this work ➡️ www.technologynetworks.com/cancer-resea...
232
Institut Imagine @institutimagine.bsky.social · 04/06/2026
Live from Institut Imagine for the MAGIC seminar! 🧬 Today, we're exploring major advances in therapeutic antibodies and immunology with 4 experts. Follow this thread for key takeaways from the presentations. ⬇️
133
Reposted by Institut Imagine
Journal of Human Immunity @jhumimmunity.org · 03/06/2026
STAT2 R148 variant: A 16th-century founder mutation and clinical response to high-dose JAK inhibitor therapy. New study from Nima Parvaneh (Tehran University of Medical Sciences), Jacinta Bustamante @institutimagine.bsky.social and colleagues: rupress.org/jhi/article/... #Autoinflammation #IEIs
063
Institut Imagine @institutimagine.bsky.social · 01/06/2026
Wrapping up Monday with some fantastic science! 👏 Earlier today, we had the pleasure of hosting Dr. Enzo Poirier (Institut Curie) for our #MondaySeminar. Huge thanks to him for sharing his work on engineering immunotherapies by harnessing the conservation of immunity. 🧬
042
Institut Imagine @institutimagine.bsky.social · 29/05/2026
🧠 What makes the human brain uniquely... human? That's the question at the heart of a study just published in @nature.com by Denis Jabaudon, Esther Klingler, and their teams. 📄 Javed, Gómez et al., Nature (2026) — DOI: lnkd.in/eF_mH72U
062
Institut Imagine @institutimagine.bsky.social · 28/05/2026
🔴 LIVE: Our weekly MAGIC seminar is starting! First up: Kesia Dethelot Delag on bridging the gap between clinical sites. She is discussing uncertainty quantification & federated learning strategies to improve patient stratification and rare disease diagnosis while keeping data secure. 🧬📊
133
Reposted by Institut Imagine
Cancer Grand Challenges @cancergrand.bsky.social · 27/05/2026
Why are some people immune to cancer? Learn more about team ATLAS, led by Paul Bastard, @institutimagine.bsky.social👉 www.youtube.com/watch?v=dFJA... ATLAS is funded by @cancerresearchuk.org and Torrey Coast Foundation through Cancer Grand Challenges.
032
Institut Imagine @institutimagine.bsky.social · 18/05/2026
Happening now at Institut Imagine! 🔬 Prof. Luis Barreiro (UChicago) is taking the stage for today's Monday Seminar to discuss why individuals and populations differ in their susceptibility to infections and immune-related diseases. 🦠🧬
142
Reposted by Institut Imagine
Journal of Human Immunity @jhumimmunity.org · 13/05/2026
Ribosomal RNA processing impairments in a B cell immunodeficient patient with WDR75 variants. New study from Nidia Moreno-Corona, Sven Kracker @institutimagine.bsky.social and colleagues: rupress.org/jhi/article/... #RareDisease #ClinicalPhenotypes #InbornErrorsOfImmunity
053
Reposted by Institut Imagine
Casanova Lab @casanovalab.bsky.social · 07/05/2026
1/ We are thrilled to share our collaborative study of B cells producing auto-Abs neutralizing type I IFNs in @cellpress.bsky.social (www.cell.com/cell/abstrac... ).
cell.com
Affinity-matured B cell responses neutralizing type-I interferons underlie severe viral infections
By integrating functional and structural approaches with AI-based analysis of autoantibodies against type-I IFNs, these neutralizing autoantibodies—linked to severe viral diseases in humans—are shown ...
2115
Institut Imagine @institutimagine.bsky.social · 07/05/2026
C’est avec une profonde tristesse que l’Institut Imagine annonce le décès du Professeur Claude Griscelli, son président fondateur, pédiatre, immunologiste et pionnier de la recherche sur les maladies génétiques. www.linkedin.com/feed/update/...
linkedin.com
#institutimagine #claudegriscelli #maladiesgénétiques #recherchemédicale #pédiatrie | Institut Imagine
C’est avec une profonde tristesse que l’Institut Imagine annonce le décès du Professeur Claude Griscelli, son président fondateur, pédiatre, immunologiste et pionnier de la recherche sur les maladies ...
031
Reposted by Institut Imagine
Journal of Human Immunity @jhumimmunity.org · 06/05/2026
Nidia Moreno-Corona, Sven Kracker et al. describe WDR75 variants in a patient with B cell immunodeficiency and #autism. Their findings suggest that altered #ribosome biogenesis may contribute to this rare presentation. rupress.org/jhi/article/... #RareDisease @institutimagine.bsky.social
033
Institut Imagine @institutimagine.bsky.social · 05/05/2026
🔬 What if we could spot preeclampsia before symptoms appear? Research by @manusingh.bsky.social in Genome Biology shows ancient viral remnants in our DNA act as "molecular switches" for placental development—leaving traces in maternal blood when they malfunction. 🎥 www.linkedin.com/feed/update/...
linkedin.com
#research #preeclampsia #genomics #medicalresearch #institutimagine | Institut Imagine
🔬 What if we could detect preeclampsia before the first symptoms even appear? That is the promise of new research led by Dr. Manvendra Singh, group leader at INEM - Institut Necker Enfants Malades, i...
063
Institut Imagine @institutimagine.bsky.social · 04/05/2026
Pourquoi certains ne développent jamais de cancer ? Sur @rfi.fr, le Dr Bastard présente ATLAS, un projet financé à hauteur de 25 M$ par @cancergrand.bsky.social pour identifier nos anticorps protecteurs. 🎧 : www.rfi.fr/fr/vid%C3%A9...
032
Reposted by Institut Imagine
Alexandre Benmerah @alexbnmrh.bsky.social · 23/04/2026
Si vous êtes sur Paris, passez voir le stand de l’institut @institutimagine.bsky.social place de la Concorde dans le cadre de l’exposition «vivre ensemble» de la fondation GoodPlanet! J’y suis et demain après-midi pour vous expliquer nos projets au @hkd-l.bsky.social #cilia #ciliopathies
172
Institut Imagine @institutimagine.bsky.social · 20/04/2026
We are thrilled to host Dr. Isidro Cortés-Ciriano (@ebi.embl.org/ @sangerinstitute.bsky.social) for our weekly Monday Seminar. He's sharing important insights on multimodal cfDNA profiling and novel single-molecule sequencing approaches for minimally invasive liquid biopsies in paediatric tumours. 🧬
052
Institut Imagine @institutimagine.bsky.social · 13/04/2026
Happening now at @institutimagine! 🔬 Prof. Elisa Oricchio (Swiss Institute for Experimental Cancer Research) is taking the stage for our Monday Seminar. She's diving into how integrating linear & 3D genomic analyses helps us understand tumor evolution & design new therapies. 🧬 #Cancer #Genomics
092
Institut Imagine @institutimagine.bsky.social · 09/04/2026
🧬 We are LIVE at the weekly MAGIC seminar at Imagine! Kicking us off is @joshwaterfall.bsky.social (@institutcurie.bsky.social ) presenting "Improved Out of Distribution Embeddings with AutoEncoders." Fascinating insights into computational biology! 🧵
163