iiinova — where your digital self keeps evolving

Reposted by Nick Brown

Peiwei Chen @peiwei-chen.bsky.social · 17/07/2026

How do transposons jump when they’re released from host control? I babysat two chromosomes for 2 years, making sure they are ok without most piRNAs. Here’s what we found & excited to share my 1st postdoc paper: “piRNA loss unleashes episodic transposition bursts” www.biorxiv.org/content/10.6...

biorxiv.org

piRNA loss unleashes episodic transposition bursts

In Metazoa, transposon expression is suppressed by the piRNA pathway, and disruption of this pathway leads to rampant transposon expression. However, it remains unclear whether increased transposon ex...

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Reposted by Nick Brown

Rebecca Tarnopol @tarnopol.bsky.social · 05/03/2026

Now that the cat’s out of the bag: Excited to announce I will be starting a research group as a Sandler Fellow this August at UCSF! We will study the evolution of protein toxins at the host-pathogen interface across scales of biological organization. Learn more here: www.tarnopollab.org

tarnopollab.org

Tarnopol Lab

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Reposted by Nick Brown

Molecular Biology and Evolution @molbioevol.bsky.social · 02/03/2026

For a new MBE Review, Presgraves et al. argue that many features of genome evolution, content, and organization seemingly inexplicable by adaptation or nearly neutral processes are instead best accounted for by meiotic drive. 🔗 academic.oup.com/mbe/article/... #evobio #molbio

MBE | The evolutionary genomics of meiotic drive

Meiotic drivers gain transmission advantages by distorting equal, Mendelian segregation. This review discusses the evolutionary genomics of meiotic drive. The figure highlights the interactions of meiotic drive elements with other classes of selfish genetic elements including: direct interactions between drivers and transposable elements (TEs) (A) or satellites (C) that can facilitate the spread of drivers; other drive systems that cause the mutual destruction of all gametes (B; e.g. the presence of multiple toxin-antidote systems); indirect interactions where the host machinery responsible for silencing TEs are recruited to silence drivers (D); dosage-sensitive interactions involving sex-linked drivers that result in gene amplifications (E); and tradeoffs between suppressing drive and TEs (F).

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Reposted by Nick Brown

Mia Levine @levine-lab.bsky.social · 23/02/2026

So excited to share this manuscript led by the inimitable Cara Brand, who discovered that Topoisomerase II evolution causes hybrid female lethality in Drosophila. Congrats to Cara, @nickbr0wn.bsky.social, Anirban, and @buszczaklab.bsky.social! www.biorxiv.org/content/10.6...

biorxiv.org

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Reposted by Nick Brown

Dominik Handler @86dominik.bsky.social · 13/02/2026

How does the piRNA pathway solve the self vs. non-self problem? 🧬 Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)

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