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Sam Lipworth

@samlipworth.bsky.social
121 followers 231 following 18 posts

Clinical Lecturer and ID/Micro registrar in Oxford

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Sam Lipworth @samlipworth.bsky.social · 30/09/2026
Great new work from @dotnagy.bsky.social who has developed EpiSENTRY which performs sample size calculations for public health WGS surviellance studies. She applies to data from the NEKSUS study to estimate how much sequencing is enough for GNBSI surviellance in England. @modmedmicro.bsky.social
medrxiv.org
How much is enough? Optimising sampling frames for genomic surveillance of Escherichia coli and Klebsiella spp. bloodstream infections - a retrospective study
Background: Optimising sampling frames for genomic surveillance of E. coli and Klebsiella may support interventions to mitigate bloodstream infections (BSIs), but approaches to estimating sample size ...
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Kate Baker @ksbakes.bsky.social · 25/09/2026
We have an open Assistant/Associate Professor position in Pathogen Biology at the Department of Genetics - come and join us! 🦠 🧫 🧬https://www.cam.ac.uk/jobs/assistantassociate-professor-in-pathogen-genetics-pc51175
cam.ac.uk
Assistant/Associate Professor in Pathogen Genetics
Applications are invited for an Assistant or Associate Professorship in Pathogen Genetics to be held in the Department of Genetics. We are searching for a talented individual with a track record of fu...
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Philip Bejon @philipbejon.bsky.social · 11/09/2026
New publication from @modmedmicro.bsky.social on metagnomic RNA virus detection from upper respiratory samples - www.sciencedirect.com/science/arti... @nickdsandy.bsky.social @treestreet.bsky.social @dotnagy.bsky.social @samlipworth.bsky.social @oxfordbrc.bsky.social
sciencedirect.com
Clinical validation of an optimised metagenomic nanopore sequencing method for detecting viral respiratory pathogens
Clinical metagenomics (CMg) offers high-throughput respiratory pathogen detection with a wider range than targeted, probe-dependent diagnostics. Seque…
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Jim Shaw @jimshaw.bsky.social · 27/03/2026
Myloasm, our long-read metagenome assembler, is now published! w/ @mgmarin.bsky.social and @lh3lh3.bsky.social Very rewarding after > a year of development and countless hours thinking about assembly. Thanks to beta testers, Li lab, and reviewers who gave very helpful feedback. rdcu.be/famFj
rdcu.be
High-resolution metagenome assembly for modern long reads with myloasm
Nature Biotechnology - A long-read metagenome assembly method recovers circular and complete genomes better than existing tools.
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Guillaume Méric @gmeric.bsky.social · 11/03/2026
🚨 New paper! Very excited to have been part of this collaborative work looking at the effect of antibiotics on the gut microbiota even years after prescription. Amazing effort led by Gabriel @tovefall.bsky.social and many others published today in Nature Medicine! 🔗 www.nature.com/articles/s41...
nature.com
Antibiotic use and gut microbiome composition links from individual-level prescription data of 14,979 individuals - Nature Medicine
Using individual-level data from the Swedish Prescribed Drug Register and fecal metagenomes of 14,979 individuals in Sweden, the authors examined the association between oral antibiotic use over 8 yea...
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Bede Constantinides @bede.im · 03/03/2026
Deacon can now run in the browser using WebAssembly. Sequence data never leaves your machine. It currently supports FASTA/Q filtering using indexes up to 1GB in size. Demo: bede.im/deacon
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Nick Sanderson @nickdsandy.bsky.social · 27/02/2026
New preprint from us @modmedmicro.bsky.social where we validate the diagnostic accuracy of a metagenomic nanopore sequencing method for respiratory RNA viruses. www.medrxiv.org/content/10.6...
medrxiv.org
Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study
Background Clinical metagenomics (CMg) offers high-throughput respiratory pathogen detection with a wider range than targeted, probe-dependent diagnostics. Sequencing cost and the challenges of high h...
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Sam Lipworth @samlipworth.bsky.social · 24/02/2026
🔔👇🔔
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Craig MacLean @craigmaclean.bsky.social · 20/02/2026
New pre-print with @wtmatlock.bsky.social!!! www.biorxiv.org/content/10.6... What shapes the distribution of plasmids across bacteria? Our paper shows that conjugative plasmids actually have a very narrow distribution compared to mobilizable plasmids. Conjugative systems restrict plasmid transfer!
biorxiv.org
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Sam Horsfield @samuelhorsfield.bsky.social · 07/02/2026
At long last, my final PhD chapter is out: we developed a novel evolutionary simulator of bacterial pangenomes, Pansim, fitting it to data from >600K genomes using a likelihood-free framework, PopPUNK-mod, to explore neutral and adaptive pangenome dynamics www.biorxiv.org/content/10.6...
biorxiv.org
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Nadia Nikulin, PhD @nadianikulin.bsky.social · 03/02/2026
First paper of my PhD @doerrlab.bsky.social is up! We characterized meropenem tolerance in Enterobacterales species, and then further dissected tolerance mechanisms in Klebsiella pneumoniae. journals.plos.org/plospathogen...
journals.plos.org
Prevalence and mechanisms of high-level carbapenem antibiotic tolerance in clinical isolates of Klebsiella pneumoniae
Author summary Bacteria can survive exposure to antibiotics by constantly repairing cellular damage induced by the drug. This “antibiotic tolerance” enables diverse bacteria to survive long enough to ...
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Theo @theukka.bsky.social · 29/01/2026
What if your dplyr pipelines ran on GPU? That's what I built with cuplyr! A CUDA-powered backend for #rstats data manipulation. Looking for testers and feedback! github.com/bbtheo/cuplyr
github.com
GitHub - bbtheo/cuplyr: GPU powered dataframes in R
GPU powered dataframes in R. Contribute to bbtheo/cuplyr development by creating an account on GitHub.
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John Lees @johnlees.bacpop.org · 30/01/2026
We are hiring for group leaders again — EBI is a great place to start your research group! embl.wd103.myworkdayjobs.com/EMBL/job/Hin...
embl.wd103.myworkdayjobs.com
Research Group Leader
Do you want to lead groundbreaking research in computational biology? Join us at EMBL-EBI! EMBL's European Bioinformatics Institute (EMBL-EBI) is seeking talented and highly-motivated scientists to jo...
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Professor Lesley Hoyles @bugsinyourguts.bsky.social · 06/01/2026
🧬 Free @microbesng.bsky.social PopUp ECR symposium 🧬 UK-based MRes or PhD student, research assistant or postdoc working on microbial genomics or metagenomics? Present your work and/or chair a session, plus excellent keynote speakers: @halllab.bsky.social and @alexmsalmeida.bsky.social. #MNGPopUp
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Sam Lipworth @samlipworth.bsky.social · 16/12/2025
"Me and the boys during advent"... www.instagram.com/reel/DSSWRyc...
instagram.com
Daily Choirs on Instagram: "“O Adonai” comes from Arvo Pärt’s ‘Seven Magnificat Antiphons’, a cycle where time seems to slow down and every sound feels intentional. Here, performed by the men of the ...
1,433 likes, 9 comments - dailychoirs on December 15, 2025: "“O Adonai” comes from Arvo Pärt’s ‘Seven Magnificat Antiphons’, a cycle where time seems to slow down and every sound feels intentional. H...
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NIHR Biomedical Research Centre: Oxford @oxfordbrc.bsky.social · 11/11/2025
Are you interested in infections, the micro-organisms that cause them and antimicrobial resistance? So are @bashthebug.net and they're looking for new members to join their patient & public group. More info: bashthebug.net/lay-represen... Deadline 27 Nov @ouhospitals.bsky.social @medsci.ox.ac.uk
x.com
Bash The Bug (@BashTheBug) / X
Bash The Bug (@BashTheBug) / X
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Sam Lipworth @samlipworth.bsky.social · 15/10/2025
🔔🔔Post-doc in microbial genomics with @modmedmicro.bsky.social🧬 - deadline tomorrow! Big genomic and clinical datasets to play with, friendly and very multidisciplinary team! my.corehr.com/pls/uoxrecru...
my.corehr.com
Job Details
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Viktoria Brunner @vbrunner.bsky.social · 13/10/2025
Our recent paper on rifampicin resistant subpopulations in M. tuberculosis (M. tb) has been published at JAC-antimicrobial resistance. I am really happy to see this work published just hours before submitting my DPhil thesis! 🔗👇 doi.org/10.1093/jaca...
doi.org
Subpopulations in clinical samples of M. tuberculosis can give rise to rifampicin resistance and shed light on how resistance is acquired
AbstractObjectives. WGS has become a key tool for diagnosing Mycobacterium tuberculosis infections, but discrepancies between genotypic and phenotypic drug
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Sam Lipworth @samlipworth.bsky.social · 08/10/2025
We have a fully funded PhD studentship available @modmedmicro.bsky.social in Oxford to work on a really cool project looking at population heterogeneity in bloodstream infections www.ndm.ox.ac.uk/study/dphil-... Please spread the word/get in touch if you'd like to chat.
ndm.ox.ac.uk
DPhil project themes
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The Lancet Microbe @lancetmicrobe.bsky.social · 08/10/2025
New research article Estimating the association of antimicrobial resistance genes with minimum inhibitory concentration in Escherichia coli: an observational study www.thelancet.com/journals/lan... #IDSky #ClinMicro #AMR #WGS #OpenAccess #OA
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Sam Lipworth @samlipworth.bsky.social · 08/10/2025
Pleased to see this out today in @lancetmicrobe.bsky.social www.sciencedirect.com/science/arti.... We estimate the independent effects of AMR genes on MIC at a drug-bug level and challenge the idea that resistance is a binary phenomenon.
sciencedirect.com
Estimating the association of antimicrobial resistance genes with minimum inhibitory concentration in Escherichia coli: an observational study
Surveillance and prediction of antibiotic resistance in Escherichia coli relies on curated databases of genes and mutations. We aimed to quantify the …
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Bash the bug @bashthebug.net · 30/09/2025
From Pipettes to Pipelines: Greening a Multidisciplinary Research Lab. @dotnagy.bsky.social writes about the experiences from the Modernising Medical Microbiology (MMM) research group on engaging wet lab, computer lab, and office teams on the #sustainability agenda. #GreenLab #SustainableScience
oxfordclimatesociety.com
From Pipettes to Pipelines — Oxford Climate Society
Dorottya Nagy writes about the experiences from the Modernising Medical Microbiology (MMM) Unit research group on engaging wet lab, computer lab, and office teams on the sustainability agenda.
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Will Matlock @wtmatlock.bsky.social · 30/09/2025
Now published in @natcomms.nature.com 🎉 www.nature.com/articles/s41... With Gillian Rodger, @nstoesser.bsky.social, @samlipworth.bsky.social, @stat-sarah.bsky.social, and many others!
nature.com
Escherichia coli phylogeny drives co-amoxiclav resistance through variable expression of TEM-1 beta-lactamase - Nature Communications
This study found E. coli phylogenetic background shapes TEM-1 beta-lactamase expression and co-amoxiclav resistance. Phylogeny alone shifted isolates from susceptible to resistant, stressing a need for lineage-sensitive genotype-phenotype prediction.
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Justine Rudkin @scousemicrobe.bsky.social · 30/09/2025
PhD opportunity to come and work in Glasgow, developing advanced tissue culture models to study Staphylococcus aureus colonisation and infection #microsky #PhD #DTPprogram Enquiries from potential applicants are welcome. www.gla.ac.uk/postgraduate... www.findaphd.com/phds/program...
gla.ac.uk
University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Biosciences - Our Projects - Understanding Pathogens, from Molecules to Phenotypes - Justine Rudkin
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John Lees @johnlees.bacpop.org · 29/09/2025
Now published, our tool to run (almost) all biological models interactively in your web browser Paper: academic.oup.com/bioinformati... Website: biomodels.bacpop.org Code: github.com/bacpop/SBMLt...
academic.oup.com
SBMLtoOdin and Menelmacar: interactive visualisation of systems biology models for expert and non-expert audiences
AbstractSummary. Computational models in biology can increase our understanding of biological systems, be used to answer research questions, and make predi
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Dorottya Nagy @dotnagy.bsky.social · 29/09/2025
To summarise our recent pre-print: Autocycler, the automated consensus assembler, when used with Nanopore long-read only Enterobacterales assemblies, produces more complete chromosomes and plasmids, with an accuracy comparable to hybrid assemblies.
Figure 2 from my recently pre-printed manuscript on the completeness and accuracy of Nanopore long-read only bacterial genome assembly for Enterobacterales. a) tile plot of chromosome circularisation, with assembler on the x-axis and sample on the y-axis, shows that the consensus long-read only assembler, Autocycler, circularised more chromosomes at 95% (87/92) than any other long-read or hybrid assembler. b) complex upset plot of plasmid reconstruction, showing that the best plasmid reconstruction was achieved by long-read assemblers incorporating the separate plasmid assembly tool, Plassembler, namely Autocycler and Hybracter, reconstructing >96% of plasmids.
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Zamin Iqbal @zaminiqbal.bsky.social · 25/09/2025
Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols. Thread 1/n
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Dorottya Nagy @dotnagy.bsky.social · 25/09/2025
Pleased to see this pre-printed, highlighting the completeness/accuracy of @nanoporetech.com long-read genome assembly for clinical Enterobacterales: www.biorxiv.org/content/10.1... Thanks to colleagues @modmedmicro.bsky.social, @ukhsa.bsky.social, @genewiz.bsky.social and @oxfordbrc.bsky.social!
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We Are RLadies+ @weare.rladies.org · 23/09/2025
Ever run `install.packages()` and wish it were faster, smarter, and more reliable? The {pak} package speeds things up with parallel downloads, dependency solving, and reproducible installs. 📦 pak.r-lib.org #RStats
you should be using pak
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Sam Lipworth @samlipworth.bsky.social · 23/09/2025
Come and work with Nicole Stoesser and I in Oxford with the fantastic team @modmedmicro.bsky.social - great opportunity for a postdoc in microbial genomics to do some creative research with great datasets as part of our HPRU. my.corehr.com/pls/uoxrecru...
my.corehr.com
Job Details
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bioRxiv Genomics @biorxiv-genomic.bsky.social · 15/09/2025
Identification of specific metabolic capacities associated with major extraintestinal pathogenic Escherichia coli lineages www.biorxiv.org/content/10.1101/202…
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Sam Lipworth @samlipworth.bsky.social · 18/09/2025
Great new work from #DotNagy @modmedmicro.bsky.social - she tool 96 clinical isolates from the NEKSUS study and sequenced with both Illumina and Nanopore - question was, can we do away with hybrid sequencing for the rest of the study? www.biorxiv.org/content/10.1...
biorxiv.org
Nanopore long-read only genome assembly of clinical Enterobacterales isolates is complete and accurate
Whole bacterial genome sequence reconstruction using Oxford Nanopore Technologies ('Nanopore') long-read only sequencing may offer a lower-cost, higher-throughput alternative for pathogen surveillance...
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Zamin Iqbal @zaminiqbal.bsky.social · 10/09/2025
Sometimes you meet absolutely incredible bioinfo-magicians. It was a huge privilege when @shenwei356.bsky.social joined our group for a year on an @embl.org sabbatical. While here, he developed a new way of aligning to millions of bacteria, called LexicMap 1/n www.nature.com/articles/s41...
nature.com
Efficient sequence alignment against millions of prokaryotic genomes with LexicMap - Nature Biotechnology
LexicMap uses a fixed set of probes to efficiently query gene sequences for fast and low-memory alignment.
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Alicia Calvo-Villamañán @aliciapcv.bsky.social · 13/08/2025
Very happy to be a (small) part of this story! The role of plasmid-encoded ISs in the acceleration of AMR evolution, through inactivation of different bacterial genes.
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nstoesser.bsky.social @nstoesser.bsky.social · 26/07/2025
New analysis from Kevin Chau @modmedmicro.bsky.social for the SinkBug Consortium (a collaboration with teams across 29 UK hospitals, NITCAR, UKHSA): Pathogen and AMR gene burden in 287 hospital sink-trap metagenomes and factors associated with high burdens.
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Kate Baker @ksbakes.bsky.social · 27/07/2025
There are half a million cases of invasive non-Typhoidal Salmonella (iNTS) every year and while you might know S. Typhimurim and Enteritidis, you may not have heard of S. Panama 💩 🩸 🧫 💊 Check out our latest in @lancetmicrobe.bsky.social doi.org/10.1016/j.la... and the 🧵 below to find out more 1/n
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Andrew Rambaut (🐏🎀) @arambaut.bsky.social · 02/07/2025
BEAST X v10.5.0 finally released – you can't just do beta releases forever. github.com/beast-dev/be... Details and instructions for installing on the BEAST website: beast.community
The BEAST X logo - an octopus wrapping its noodley appendages round the letter X.
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Zamin Iqbal @zaminiqbal.bsky.social · 19/05/2025
Delighted to see this paper from danderson123.bsky.social 's PhD out. We have been building tools for AMR gene detection for over a decade now, but multicopy genes remain challenging. Dan shows that with a gene-space de Bruijn graph and long reads, you can do well www.biorxiv.org/content/10.1...
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Vaughn Cooper @vscooper.micropopbio.org · 14/02/2025
Important paper by Lance Thurlow, @bconlon.bsky.social @sirmicrobe.bsky.social and others: Diabetes potentiates the emergence and expansion of antibiotic resistance. "hyperglycemia..facilitates.expansion and takeover of resistant mutants in diabetic infections." www.science.org/doi/10.1126/...
science.org
Diabetes potentiates the emergence and expansion of antibiotic resistance
Diabetic infections are a reservoir for the emergence and proliferation of antibiotic resistance in Staphylococcus aureus.
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a @asadz.bsky.social · 10/02/2025
Antimicrobial resistance data is now on the UKHSA data dashboard! 🧫 ukhsa-dashboard.data.gov.uk/antimicrobia...
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Onisillos @onisillos.bsky.social · 16/01/2025
New research article in The Lancet Microbe Prevalence, misclassification, and clinical consequences of the heteroresistant phenotype in Escherichia coli bloodstream infections in patients in Uppsala, Sweden: a retrospective cohort study www.thelancet.com/journals/lan... #IDSky #ClinMicro #AMR
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Sandra Reuter @sandrareuter.bsky.social · 14/01/2025
📣Our latest paper is out now in mSystems: Not quite as it may seem - investigating #plasmid diversity and evolution in #Klebsiella pneumoniae at a single institution over time. A short thread 🧵 @zaminiqbal.bsky.social
Composite of the paper header showing all authors and an equation showing phylogenetic trees plus plasmids give a complex plasmid picture.
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Jamie Hall @jpjhall.bsky.social · 10/01/2025
🚨PhD studentship opportunity! Bacteria protect themselves with a huge arsenal of defences, but does this affect how they gain new traits on plasmids? 🧫🦠💫 Apply for a funded 4y position with me @livuni-ives.bsky.social, @brockhurstlab.bsky.social @jojofoth.bsky.social & @multidefence.bsky.social ⬇️
findaphd.com
BBSRC NWD: Let the right one in: exploring the trade-offs between genome defence and openness in microbiomes at University of Liverpool on FindAPhD.com
PhD Project - BBSRC NWD: Let the right one in: exploring the trade-offs between genome defence and openness in microbiomes at University of Liverpool, listed on FindAPhD.com
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Alexandre Almeida @alexmsalmeida.bsky.social · 10/01/2025
Delighted to share the first peer-reviewed paper from our team @camvetschool.bsky.social where we investigate the ecological dynamics of Enterobacteriaceae in the human gut #microbiome: www.nature.com/articles/s41... @naturemicrobiol.bsky.social
nature.com
Ecological dynamics of Enterobacteriaceae in the human gut microbiome across global populations - Nature Microbiology
Assessing more than 12,000 metagenomic samples from across the world using computational approaches, the authors determined interactions between species that co-colonize or co-exclude Enterobacteriace...
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Marco Molari @mmolari.bsky.social · 06/01/2025
Thrilled to announce that our work (w. with fantastic @neher.io and Liam Shaw) has been published on Molecular Biology and Evolution! 🎉 academic.oup.com/mbe/advance-... Are you curious about how fast the genome of E.coli evolves structurally (gains, rearrangements...) ? 🧬 A summary thread [1/N]🧵
academic.oup.com
Quantifying the evolutionary dynamics of structure and content in closely-related E. coli genomes
Abstract. Bacterial genomes primarily diversify via gain, loss, and rearrangement of genetic material in their flexible accessory genome. Yet the dynamics
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Noémie Lefrancq @noemielefrancq.bsky.social · 02/01/2025
Incredibly excited to share that our manuscript was just published in @nature.com ! What a way to start the new year! 🎉 buff.ly/4gyYCzx We present phylowave, a framework that enables to learn the fitness dynamics of pathogens from phylogenies. 🧵 A thread... 1/n #IDSky #IDModelling
buff.ly
Learning the fitness dynamics of pathogens from phylogenies - Nature
Phylowave, an innovative phylogenetic approach, can identify the main circulating pathogen lineages with increased fitness and the associated genetic changes, enabling the timely identification of…
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