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Alexandre Almeida

@alexmsalmeida.bsky.social
845 followers 1.1K following 57 posts

MRC Career Development Award fellow at the University of Cambridge | Group Leader of the Microbiome Function and Diversity lab (microfundiv-lab.github.io) | Bioinformatics, Machine Learning, Metagenomics, Functional modelling, Human microbiome

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Reposted by Alexandre Almeida
MicrobesNG @microbesng.bsky.social · 11/05/2026
🚨 Calling all microbial genomics & metagenomics researchers 🚨 Join us in Nottingham, 5 June for a day of talks, posters & FREE networking lunch 👀 🎤 Keynotes @halllab.bsky.social @alexmsalmeida.bsky.social 🤝 with @bugsinyourguts.bsky.social & Microbiome-Net 🔗 linktr.ee/microbesng#MicroSky #MNGPopUp
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Reposted by Alexandre Almeida
Nature Microbiology @natmicrobiol.nature.com · 22/02/2026
#NatMicroPicks A microbial signature of health! 🦠⚕️ A large meta-analysis highlights the importance of previously unknown and uncultured gut bacteria in maintaining human health #MicroSky www.cell.com/cell-host-mi...
cell.com
Meta-analysis of the uncultured gut microbiome across 11,115 global metagenomes reveals a candidate signature of health
Silva et al. perform a global analysis of over 11,000 gut microbiomes and reveal that uncultured bacteria are key markers of gut health. The uncultured genus CAG-170 is strongly linked to low gut dysb...
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Reposted by Alexandre Almeida
UK GIBA Network+ @ukgibanetwork.bsky.social · 04/03/2026
Do you want to learn essential GIBA concepts and techniques? We're hosting three mornings of expert-led sessions on gut, immune and brain research, from 23-26 March 📢🌟 🆓 Open to all across the GIBA Network 📅 Register by 13 March! 🔗 giba-uk.org/events/the-g...
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Reposted by Alexandre Almeida
UK GIBA Network+ @ukgibanetwork.bsky.social · 12/02/2026
🔬 New insights from gut-immune-brain research 🌟 A study with our network's @alexmsalmeida.bsky.social uncovers a "hidden” gut bacterial group found in higher levels in healthy people. Could this be key to microbiome health and future probiotic innovation? 🌍🦠 www.newscientist.com/article/2514...
newscientist.com
'Hidden' group of gut bacteria may be essential to good health
Scientists have pinpointed a group of bacteria that consistently appear in high numbers in healthy people, suggesting that these could one day be targeted through diet or probiotics
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Reposted by Alexandre Almeida
University of Cambridge Vet School @camvetschool.bsky.social · 11/02/2026
Congratulations to @alexmsalmeida.bsky.social and his research team at the @camvetschool.bsky.social on their latest paper exploring the ‘hidden’ microbes in our gut. Discover more about their fascinating findings on the University of Cambridge Research website 👇🏽 www.cam.ac.uk/research/new...
cam.ac.uk
‘Hidden’ bugs in our gut appear key to good health, finds global study
An understudied group of bacteria in our gut microbiome appears to play a central role in keeping us healthy, according to researchers at the University of
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Reposted by Alexandre Almeida
School of Biological Sciences @cambridgebiosci.bsky.social · 11/02/2026
Is there a missing link in our gut health? 🦠 New research from Alexandre Almeida’s lab has uncovered a ‘hidden group’ of bacteria - known as CAG-170 - that appears to be an indicator of human health. Read the full story: www.cam.ac.uk/research/new... @alexmsalmeida.bsky.social
cam.ac.uk
‘Hidden’ bugs in our gut appear key to good health, finds global study
An understudied group of bacteria in our gut microbiome appears to play a central role in keeping us healthy, according to researchers at the University of
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Reposted by Alexandre Almeida
Chris Simms @chrisnsimms.bsky.social · 09/02/2026
I still find it mad that even though pretty much everyone now knows what a gut microbiome is and might think we have a pretty good idea of what's going on in there, we still don't have much clue about the majority of species in our guts, saying they are part of the "hidden microbiome"
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Reposted by Alexandre Almeida
Chris Simms @chrisnsimms.bsky.social · 09/02/2026
The original research was published today in Cell Host & Microbe www.cell.com/cell-host-mi...
cell.com
Meta-analysis of the uncultured gut microbiome across 11,115 global metagenomes reveals a candidate signature of health
Silva et al. perform a global analysis of over 11,000 gut microbiomes and reveal that uncultured bacteria are key markers of gut health. The uncultured genus CAG-170 is strongly linked to low gut dysb...
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Alexandre Almeida @alexmsalmeida.bsky.social · 11/02/2026
Thanks to @chrisnsimms.bsky.social and the @newscientist.com for covering our new work on the uncultured microbiome in @cp-cellhostmicrobe.bsky.social. It was great chatting more about the implications of our findings!
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Reposted by Alexandre Almeida
Guillaume Méric @gmeric.bsky.social · 10/02/2026
Great work again from @alexmsalmeida.bsky.social et al highlights uncultured genus CAG-170 (Oscillospiraceae) to be central node in healthy co-abundance networks in >11k gut metagenomes, with predicted B12 biosynthesis/cross-feeding functions possibly involved. www.sciencedirect.com/science/arti...
sciencedirect.com
Meta-analysis of the uncultured gut microbiome across 11,115 global metagenomes reveals a candidate signature of health
The human gut microbiome is important for host health, yet over 60% of gut species remain uncultured and inaccessible to experimental manipulation. He…
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Alexandre Almeida @alexmsalmeida.bsky.social · 09/02/2026
Excited to share the newest paper from our team, where we uncovered a potential role of the uncultured gut #microbiome in health: www.cell.com/cell-host-mi.... Out now in @cp-cellhostmicrobe.bsky.social @cellpress.bsky.social. With Ana C. da Silva, Jacob Lapkin, Qi Yin and Efrat Muller.
cell.com
Meta-analysis of the uncultured gut microbiome across 11,115 global metagenomes reveals a candidate signature of health
Silva et al. perform a global analysis of over 11,000 gut microbiomes and reveal that uncultured bacteria are key markers of gut health. The uncultured genus CAG-170 is strongly linked to low gut dysb...
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Alexandre Almeida @alexmsalmeida.bsky.social · 12/01/2026
Our team wrote a review for Gut Microbes on the role of the gut #microbiome in modulating enteric infections. Great team effort by Qi Yin, @samriddhigupta.bsky.social and Efrat Muller: www.tandfonline.com/doi/full/10....
tandfonline.com
The human gut microbiome in enteric infections: from association to translation
Enteric infections remain a leading global cause of morbidity, mortality and economic loss, increasingly compounded by the rise of antimicrobial resistance. The gut microbiome — spanning bacteria, ...
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Alexandre Almeida @alexmsalmeida.bsky.social · 07/01/2026
Excited to be speaking at this ECR Symposium in Nottingham. Free to attend!
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Alexandre Almeida @alexmsalmeida.bsky.social · 15/10/2025
We have a fully-funded PhD studentship available to elucidate the host-adaptive traits of the human gut microbiome: bbsrcdtp.lifesci.cam.ac.uk/how-apply (targeted project: TRG-VET-AA26). Feel free to reach out with a CV and cover letter stating your interest in this project.
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Alexandre Almeida @alexmsalmeida.bsky.social · 14/10/2025
Applications to our free course on "Introduction to Experimental Design and Core Statistics" closes this Friday. Part of the @ukgibanetwork.bsky.social, this is a great opportunity to improve your statistical skills and get to meet other network members. Apply here: forms.office.com/e/sdys5HATUH
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Alexandre Almeida @alexmsalmeida.bsky.social · 01/10/2025
Applications to the first training event: "Introduction to Experimental Design and Core Statistics" of the UK GIBA Network+ (@ukgibanetwork.bsky.social) are now open! Taking place Dec 8-10 in Cambridge. Further info: www.giba-uk.org/training-opp... Apply here: forms.office.com/Pages/Respon...
giba-uk.org
Home | Giba Network UK | Gut Immune Brain Axis Network
Gut Immune Brain Axis Network (GIBA Network)
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Reposted by Alexandre Almeida
UK GIBA Network+ @ukgibanetwork.bsky.social · 01/10/2025
📊 Want to boost your research skills? Join our 3-day training on Experimental Design and Core Statistics in Cambridge (Dec 8–10). ✅ Free to attend 🙋‍♀️ Open to all career stages 🚆 Travel and accommodation costs reimbursed Apply by October 17th 👉 www.giba-uk.org/training-opp...
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Reposted by Alexandre Almeida
UK GIBA Network+ @ukgibanetwork.bsky.social · 22/09/2025
Our working groups support the development of effective collaborations across the UK to advance research. Introduced by Franziska Denk (@denklab.bsky.social) at our #GIBANetworklaunch. Want to know our first 5️⃣ topics? Find out here 👇 www.giba-uk.org/working-groups
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Reposted by Alexandre Almeida
UK GIBA Network+ @ukgibanetwork.bsky.social · 22/09/2025
✔️ Flexible funds ✔️ Fellowships ✔️ Mobility awards Our director Jonathan Swann shares some of the ways we will expand the mechanistic understanding of the gut-immune-brain axis. More details will appear on our Network website in the coming days 👇 www.giba-uk.org/funding-oppo... #GIBANetworklaunch
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Reposted by Alexandre Almeida
UK GIBA Network+ @ukgibanetwork.bsky.social · 22/09/2025
“One of the key pillars of our network is training,” says @alexmsalmeida.bsky.social. We are committed to equip our members with the skills, tools and methods essential for research. Our first course was announced at our #GIBANetworklaunch 🌟 Want to know more? 👇 🔗 giba-uk.org/training-opp...
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Alexandre Almeida @alexmsalmeida.bsky.social · 22/09/2025
Representing the bioinformatics crowd at the #GIBANetworklaunch
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Reposted by Alexandre Almeida
UK GIBA Network+ @ukgibanetwork.bsky.social · 22/09/2025
The past two decades have seen a global explosion of research into the gut-immune-brain axis. There is great energy in #Southampton today for our #GIBANetworklaunch. Together, we are building a vibrant and diverse research community to fully realise GIBA's potential. Learn more 👉 www.giba-uk.org
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Alexandre Almeida @alexmsalmeida.bsky.social · 10/09/2025
🚨 New pre-print from the lab! We performed a large-scale meta-analysis of the uncultured gut #microbiome in >10,000 metagenomes enabling us to identify a new candidate biomarker of health. www.biorxiv.org/content/10.1...
biorxiv.org
Meta-analysis of the uncultured gut microbiome across 11,115 global metagenomes reveals a new candidate biomarker of health
The human gut microbiome plays an important biological role in host health, yet over 60% of gut species remain uncultured and hence inaccessible to experimental manipulation. Here we analysed 11,115 h...
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Alexandre Almeida @alexmsalmeida.bsky.social · 14/07/2025
The GIBA network will be launching on September 22nd with an in-person event in Southampton. Do come along to hear and share your thoughts on our plans to drive innovation in the gut-immune-brain axis field in the UK. Sign-up here: www.eventbrite.com/e/uk-giba-ne...
eventbrite.com
UK GIBA Network+ launch event
Bringing together researchers and stakeholders to advance understanding of the gut-immune-brain axis.
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Reposted by Alexandre Almeida
School of Biological Sciences @cambridgebiosci.bsky.social · 28/04/2025
A new UK research network supported by UKRI will investigate how gut health impacts the brain, immune system, and mental wellbeing. Dr Alexandre Almeida (@alexmsalmeida.bsky.social) is part of the interdisciplinary team leading this new initiative. Read more: www.bio.cam.ac.uk/news/cambrid...
bio.cam.ac.uk
Cambridge partners on a new UK research network to unlock
A groundbreaking UK research network has been launched by UKRI to uncover how gut health influences the brain, immune system, and mental well-being – potentially leading to new treatments for
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Reposted by Alexandre Almeida
University of Cambridge Vet School @camvetschool.bsky.social · 28/04/2025
We're delighted that researchers from the @camvetschool.bsky.social are contributing to this important new network, advancing understanding of the gut-immune-brain connection.🧠👇🏽
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Alexandre Almeida @alexmsalmeida.bsky.social · 28/04/2025
Excited to be part of the leadership team of a new @ukri.org BBSRC Gut-Immunology-Brain Axis (GIBA) Network+ to drive further mechanistic understanding of the GIBA. See more: www.bio.cam.ac.uk/news/cambrid.... @camvetschool.bsky.social @cambridgebiosci.bsky.social
bio.cam.ac.uk
Cambridge partners on a new UK research network to unlock
A groundbreaking UK research network has been launched by UKRI to uncover how gut health influences the brain, immune system, and mental well-being – potentially leading to new treatments for
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Reposted by Alexandre Almeida
Svetlana Ugarcina Perovic @svetlanaup.bsky.social · 17/04/2025
argNorm is published now academic.oup.com/bioinformati...
academic.oup.com
argNorm: normalization of antibiotic resistance gene annotations to the Antibiotic Resistance Ontology (ARO)
AbstractSummary. Currently available and frequently used tools for annotating antimicrobial resistance genes (ARGs) in genomes and metagenomes provide resu
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Reposted by Alexandre Almeida
Jack A Gilbert @gilbertjacka.bsky.social · 11/04/2025
Me and a few of my mates got together and wrote a review on the current state of clinical translation of microbiome research. A great summary of the state of the art for microbiome research. www.nature.com/articles/s41...
nature.com
Clinical translation of microbiome research - Nature Medicine
This Review summarizes recent and compelling examples of microbiome-based interventions that are ripe for clinical adoption while also discussing the challenges and opportunities facing the field.
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Reposted by Alexandre Almeida
Guillaume Méric @gmeric.bsky.social · 09/04/2025
Everyone thinking of using MR for microbiome studies should read this! So many microbiome MR work is published w/o any validation😠 Here, Kaitlin Wade et al. explain (very well!) that a good MR result can be inconclusive after appropriate subsequent sensitivity checks 🔗 www.nature.com/articles/s41...
nature.com
Exploring the causal role of the human gut microbiome in endometrial cancer: a Mendelian randomization approach - Scientific Reports
Scientific Reports - Exploring the causal role of the human gut microbiome in endometrial cancer: a Mendelian randomization approach
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Reposted by Alexandre Almeida
Ryan Wick @rrwick.bsky.social · 27/03/2025
Do you (like me) create a bunch of conda environments, then later forget what they're for, when they were last updated, or which tools are in them? If so, you might this little project: github.com/rrwick/conda...
github.com
GitHub - rrwick/condaenvlist: a simple tool for listing conda environments with descriptions
a simple tool for listing conda environments with descriptions - rrwick/condaenvlist
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Reposted by Alexandre Almeida
Sebastian Eves-van den Akker @sebastianevda.bsky.social · 26/02/2025
New to bluesky - would appreciate a "retweet" please, so I can find everyone from twitter.
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Reposted by Alexandre Almeida
Gut Microbiota for Health @gmfhx.bsky.social · 23/01/2025
An in-depth analysis of 12,000 metagenomes looks at Enterobacteriaceae interactions in healthy humans These findings from @alexmsalmeida.bsky.social et al. highlight the critical role of the intestinal milieu in the colonization success of opportunistic pathogens
nature.com
Ecological dynamics of Enterobacteriaceae in the human gut microbiome across global populations - Nature Microbiology
Assessing more than 12,000 metagenomic samples from across the world using computational approaches, the authors determined interactions between species that co-colonize or co-exclude Enterobacteriaceae in terms of functional pathways and metabolites in healthy human gut microbiomes.
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Reposted by Alexandre Almeida
Ran Blekhman @blekhman.bsky.social · 24/01/2025
Use the Human Microbiome Compendium data! We made the data and code available, & created a website and R package to navigate the compendium. Links: - Website: microbiomap.org - Data: zenodo.org/records/1373... - R package: blekhmanlab.github.io/MicroBioMap/ - Code: github.com/blekhmanlab/...
microbiomap.org
Human Microbiome Compendium
An ongoing project to build a dataset of the human microbiome at an unprecedented scale.
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Reposted by Alexandre Almeida
Sorek Lab @soreklab.bsky.social · 23/01/2025
Our paper out @CellCellPress: Structure guided discovery of viral proteins that inhibit host immunity Congrats Erez Yirmiya, Azita Leavitt, Gil Amitai, our collaborators at the Kranzusch lab, and coauthors A 🧵 1/10 www.cell.com/cell/abstrac...
cell.com
Structure-guided discovery of viral proteins that inhibit host immunity
Large-scale, structure-guided computational pipeline sifts through millions of phage proteins to identify those that bind and antagonize host immune proteins. Detected proteins are shown to inhibit no...
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Reposted by Alexandre Almeida
Svetlana Ugarcina Perovic @svetlanaup.bsky.social · 17/01/2025
New #MicrobiomeDigest is OUT microbiomedigest.com/2025/01/16/j... • Enterobacteriaceae in the human gut / @alexmsalmeida.bsky.social • microGalaxy / @bebatut.bsky.social • bacterial vaginosis /‬ @mikeusyk.bsky.social • invitation for the next week @microbiomevif.bsky.social & more. Happy 2025!
microbiomedigest.com
January 17, 2025
Starting the new year with a new digest out, full of interesting findings.Check it out and see you at MVIF next week! Human gut microbiome Early life microbial succession in the gut follows common …
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Quadram Institute @quadraminstitute.bsky.social · 17/01/2025
🆕 Blog! Our experts Prof @mjpallen.bsky.social Dr Falk Hildebrand @bioinf.bsky.social and Dr Aimee Parker explain that there is no evidence for a brain microbiome 🧠 buff.ly/40gVxNH
quadram.ac.uk
Is there a “brain microbiome”? No - Quadram Institute
There is no scientific evidence of a brain microbiome, including no imaging, DNA-sequence-based or culture-based or immunological evidence.
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Reposted by Alexandre Almeida
Nature Portfolio @natureportfolio.nature.com · 15/01/2025
A paper in Nature Microbiology underscores the critical role of the intestinal environment in the colonization success of gut-associated opportunistic pathogens with implications for developing non-antibiotic therapeutic strategies. go.nature.com/4hgvQDA 🧪
This is figure 2, which shows the distribution and diversity of the most prevalent Enterobacteriaceae species.
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Reposted by Alexandre Almeida
Ana Santos Almeida @anasalmeida.bsky.social · 10/01/2025
🎉Huge congrats to @alexmsalmeida.bsky.social ‘s team on this fantastic publication! Honoured to have made a (tiny) contribution to our *first* work as collaborators. Here’s to many more 🥂🚀 @camvetschool.bsky.social @naturemicrobiol.bsky.social
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Nature Microbiology @natmicrobiol.nature.com · 10/01/2025
OUT NOW - Ecological dynamics of Enterobacteriaceae in the human gut microbiome across global populations www.nature.com/articles/s41...
nature.com
Ecological dynamics of Enterobacteriaceae in the human gut microbiome across global populations - Nature Microbiology
Assessing more than 12,000 metagenomic samples from across the world using computational approaches, the authors determined interactions between species that co-colonize or co-exclude Enterobacteriace...
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Reposted by Alexandre Almeida
Francisco Zorrilla @metagenomez.bsky.social · 10/01/2025
Interested in the ecological dynamics of Enterobacteriaceae across populations? Check out our new study 🧬
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DefinitelyNotAlice @alicele.bsky.social · 10/01/2025
Very interesting study! Must read for everybody working on enterobacterales!
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Kate Baker @ksbakes.bsky.social · 10/01/2025
Well done @alexmsalmeida.bsky.social and team on this next work on Enterobacteriaceae colonisation!
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Alexandre Almeida @alexmsalmeida.bsky.social · 10/01/2025
Delighted to share the first peer-reviewed paper from our team @camvetschool.bsky.social where we investigate the ecological dynamics of Enterobacteriaceae in the human gut #microbiome: www.nature.com/articles/s41... @naturemicrobiol.bsky.social
nature.com
Ecological dynamics of Enterobacteriaceae in the human gut microbiome across global populations - Nature Microbiology
Assessing more than 12,000 metagenomic samples from across the world using computational approaches, the authors determined interactions between species that co-colonize or co-exclude Enterobacteriace...
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Alexandre Almeida @alexmsalmeida.bsky.social · 18/12/2024
Great to get this out before the holidays: Integration of metagenome-assembled genomes with clinical isolates reveals genomic signatures of Klebsiella pneumoniae in carriage and disease (www.biorxiv.org/content/10.1...)
biorxiv.org
Integration of metagenome-assembled genomes with clinical isolates reveals genomic signatures of Klebsiella pneumoniae in carriage and disease
Klebsiella pneumoniae is an opportunistic pathogen causing diseases ranging from gastrointestinal disorders to severe liver abscesses. While clinical isolates of K. pneumoniae have been extensively st...
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Reposted by Alexandre Almeida
School of Biological Sciences @cambridgebiosci.bsky.social · 17/12/2024
We are thrilled to see 3 projects in the School receive funding from this call – congratulations to Alex Almeida (@alexmsalmeida.bsky.social), Charles Emogor, Máiréad Healy, and Zoe Kourtzi!
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Alexandre Almeida @alexmsalmeida.bsky.social · 10/12/2024
Really grateful to @acceleratescience.bsky.social for funding our project on combining AI and metagenomics to improve pathogen tracking. Look forward to getting started on this next year!
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John F. Cryan @jfcryan.bsky.social · 06/12/2024
International consensus statement on microbiome testing in clinical practice - just out in Lancet Gastro & Hepat www.sciencedirect.com/science/arti...
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Atin Sharma @atinsharma.bsky.social · 02/12/2024
I thought we learnt an important lesson during the pandemic - preprints should be taken with a grain of salt. I thought we did. www.theguardian.com/lifeandstyle...
theguardian.com
The brain microbiome: could understanding it help prevent dementia?
Long thought to be sterile, our brains are now believed to harbour all sorts of micro-organisms, from bacteria to fungi. How big a part do they play in Alzheimer’s and similar diseases?
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