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Noémie Lefrancq

@noemielefrancq.bsky.social
776 followers 263 following 20 posts

Phylogenetics 🧬 , infectious disease dynamics 🦠 & modelling 💻 #IDSky #IDModelling Postdoctoral fellow @ETH Zürich (in Basel) Previously @Cambridge_Uni and @institutpasteur

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Reposted by Noémie Lefrancq
Lewis C. E. Mason @lewiscemason.bsky.social · 12/07/2026
By Julia Marshall as first author and led by Professors Kate Baker and Henrik Salje as co-leading authors (@hsalje.bsky.social @ksbakes.bsky.social), please see our new article about the genomic epidemiology of the spread of sexually transmitted #Shigella: www.thelancet.com/journals/lan... 🛟🧪🧬🖥️🦠💉🧫😷
thelancet.com
The spread of sexually transmissible drug-resistant shigellosis in England: a genomic epidemiology study
Our study shows the distinct and intensifying sexual transmission of shigellosis, highlighting the urgent need to address sexually transmissible shigellosis as a distinct health threat. Traditional in...
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Megan O'Driscoll @meganodris.bsky.social · 18/12/2025
The final piece of my PhD work is now published in Science Translational Medicine! We present a new framework to jointly infer epidemiological and antigenic parameters from multi-pathogen population serological studies🦠 www.science.org/stoken/autho...
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Noémie Lefrancq @noemielefrancq.bsky.social · 03/07/2025
For the first time, we found phylogenetic evidence of importations and local transmission of Macrolide-resistant #pertussis strains in France. Needs further monitoring! Great work led by Valérie Bouchez, Carla Rodrigues and @sylvainbrisse.bsky.social! Paper: shorturl.at/2Npmm 🦠 🧪 🛟
clinicalmicrobiologyandinfection.com
Microbes know no borders: importation of macrolide-resistant Bordetella pertussis into France in 2024
Pertussis is a highly contagious respiratory disease, primarily caused by Bordetella pertussis that can be lethal in young infants. Acellular vaccines (aP) are used in France and other European countr...
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Reposted by Noémie Lefrancq
Cécile Tran Kiem @ceciletk.bsky.social · 05/03/2025
Pathogen genomes can provide insights into underlying disease transmission patterns but new methods are needed to analyze large genome datasets. Our work using identical pathogen sequences to characterize fine scale SARS-CoV-2 transmission was just published in @nature.com tinyurl.com/bdzk9xjj 🥳
tinyurl.com
Fine-scale patterns of SARS-CoV-2 spread from identical pathogen sequences - Nature
The analysis of pairs of identical SARS-CoV-2 genome sequences enables characterization of transmission patterns between geographies and age groups.
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Reposted by Noémie Lefrancq
Moritz Kraemer @mugkraemer.bsky.social · 20/02/2025
AI is poised to accelerate understanding in infectious diseases, but its value needs to be demonstrated through close collaboration between research, industry, society, and policy. Paper free to read: rdcu.be/eaxEw Summary here: www.ox.ac.uk/news/2025-02...
rdcu.be
Artificial intelligence for modelling infectious disease epidemics
Nature - This Perspective considers the application to infectious disease modelling of AI systems that combine machine learning, computational statistics, information retrieval and data science.
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Reposted by Noémie Lefrancq
Richard Neher @neher.io · 11/01/2025
Building on the UShER tree of millions of SARS-CoV-2 genomes maintained by Angie Hinrichs, Hugh Haddox and Georg Angehrn (and others in @matsen.bsky.social lab and @jbloomlab.bsky.social) have looked into how the neutral mutation rate varies along the genome: [1/N] www.biorxiv.org/content/10.1...
biorxiv.org
The mutation rate of SARS-CoV-2 is highly variable between sites and is influenced by sequence context, genomic region, and RNA structure
RNA viruses like SARS-CoV-2 have a high mutation rate, which contributes to their rapid evolution. The rate of mutations depends on the mutation type (e.g., A→C, A→G, etc.) and can vary between sites ...
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Reposted by Noémie Lefrancq
Noémie Lefrancq @noemielefrancq.bsky.social · 02/01/2025
Incredibly excited to share that our manuscript was just published in @nature.com ! What a way to start the new year! 🎉 buff.ly/4gyYCzx We present phylowave, a framework that enables to learn the fitness dynamics of pathogens from phylogenies. 🧵 A thread... 1/n #IDSky #IDModelling
buff.ly
Learning the fitness dynamics of pathogens from phylogenies - Nature
Phylowave, an innovative phylogenetic approach, can identify the main circulating pathogen lineages with increased fitness and the associated genetic changes, enabling the timely identification of…
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Reposted by Noémie Lefrancq
Prof Sam Illingworth @samillingworth.com · 03/01/2025
🦠🔍 Tracking Pathogen Evolution in Real Time A new tool, 'phylowave', has been developed to help scientists track how viruses and bacteria evolve. It identifies new variants with increased fitness, offering insights into diseases like #COVID19 and flu. 🔗 www.nature.com/articles/s41... #SciComm 🧪
nature.com
Learning the fitness dynamics of pathogens from phylogenies - Nature
Phylowave, an innovative phylogenetic approach, can identify the main circulating pathogen lineages with increased fitness and the associated genetic changes, enabling the timely identification of eme...
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Noémie Lefrancq @noemielefrancq.bsky.social · 02/01/2025
Incredibly excited to share that our manuscript was just published in @nature.com ! What a way to start the new year! 🎉 buff.ly/4gyYCzx We present phylowave, a framework that enables to learn the fitness dynamics of pathogens from phylogenies. 🧵 A thread... 1/n #IDSky #IDModelling
buff.ly
Learning the fitness dynamics of pathogens from phylogenies - Nature
Phylowave, an innovative phylogenetic approach, can identify the main circulating pathogen lineages with increased fitness and the associated genetic changes, enabling the timely identification of…
321587
Reposted by Noémie Lefrancq
Zannah Salter @zannahdu.bsky.social · 02/12/2024
* rolls up newspaper * No Guardian! Bad Guardian! An infection is not a microbiome! www.theguardian.com/lifeandstyle...
theguardian.com
The brain microbiome: could understanding it help prevent dementia?
Long thought to be sterile, our brains are now believed to harbour all sorts of micro-organisms, from bacteria to fungi. How big a part do they play in Alzheimer’s and similar diseases?
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Reposted by Noémie Lefrancq
Conrad Hackett @conradhackett.bsky.social · 15/11/2024
Disease prevalence in US states before & after vaccine introduction Graphic from Edward Tufte More graphics.wsj.com/infectious-d... 🧪
Graphic shows dramatic reduction in polio, rubella, mumps, measles, and hepatitis A cases after the introduction of vaccines for each disease.
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Noémie Lefrancq @noemielefrancq.bsky.social · 25/11/2024
Super resource to explore publicly available genome sequencing data! Currently supports H5N1, West Nile, RSV-A, RSV-B and SARS-CoV-2 GenSpectrum.org #IDSky
genspectrum.org
GenSpectrum Dashboards
GenSpectrum is an interactive dashboard to query and analyze pathogen sequences, currently available for Influenza H5N1, RSV, SARS-CoV-2 and the West Nile virus.
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Noémie Lefrancq @noemielefrancq.bsky.social · 22/11/2024
Thrilled to have received this award, thank you @gensocuk.bsky.social! Many thanks to @hsalje.bsky.social @julianparkhill.bsky.social, Sylvain Brisse and the amazing research groups without whom the work wouldn't have been possible!
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Simon Cauchemez @scauchemez.bsky.social · 22/11/2024
Infectious Disease Modelling starter pack update! First pack is full so I created a second one. Pls keep on sending suggestions! (bio should contain experience relevant for this pack) IDModelling pack 1: go.bsky.app/86Ao1a5 IDModelling pack 2 : go.bsky.app/2oBB7KX
go.bsky.app
Infectious Disease Modelling #IDModelling
Join the conversation
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Oscar Cortes-Azuero @ocortesazuero.bsky.social · 15/11/2024
Hey bluesky! It's great to see so many new folks jumping on the #IDSky wagon. If you're at #TropMed24 drop by my poster tomorrow at 11am. We can talk all things chikungunya burden, sex and age-dependent disease risk, and potential vaccine impact!
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Reposted by Noémie Lefrancq
Simon Cauchemez @scauchemez.bsky.social · 10/11/2024
Infectious Disease Modelling starter pack! Suggestions are welcome! go.bsky.app/86Ao1a5
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Megan O'Driscoll @meganodris.bsky.social · 14/05/2024
New work led by Wei Wang characterises the dynamics of measles immunity in infant&child cohorts in China. @hsalje.bsky.social www.nature.com/articles/s41...
nature.com
Dynamics of measles immunity from birth and following vaccination - Nature Microbiology
Serological data modelling informs on immune interference from maternal antibodies on measles vaccine responses in infants and children.
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Reposted by Noémie Lefrancq
Henrik Salje @hsalje.bsky.social · 19/12/2023
We’re hiring!! postdoc and research assistant (with potential for PhD) positions on mathematical modeling of infectious diseases at Cambridge (UK). Mainly of arboviruses including with longitudinal cohorts, disease mapping and models applied to multiplex serology in Africa. jobs.cam.ac.uk/job/44461/
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