Sign in

Multi-Defence

@multidefence.bsky.social
560 followers 299 following 42 posts

Unravelling the genetic dance of MGEs and bacterial immunity 🧩|Embracing the diversity of research techniques| #BBSRC_sLOLA #Bioinfo #Evol #Biochem #Mathmodel sites.exeter.ac.uk/multidefence

PostsRepliesMedia
Multi-Defence @multidefence.bsky.social · 28/09/2026
New preprint out!
021
Reposted by Multi-Defence
Malcolm White @mfwhite2.bsky.social · 25/09/2026
New from the @multidefence.bsky.social consortium: a deep dive into MANTIS defence. Thanks to @ukri.org for funding. www.biorxiv.org/content/10.6...
biorxiv.org
Dual ATPase-activated DNA hemimethylation and cleavage by the MANTIS defence system
Bacterial defence systems are diverse and form major barriers to horizontal gene transfer and bacteriophage (phage) infection. Though restriction-modification systems were the first such defences disc...
02514
Reposted by Multi-Defence
Anna Olina @annaolina.bsky.social · 17/08/2026
@alekseiagapov.bsky.social and I are both presenting posters today at #ISME20 - come talk to us about phages and defences 🧬 PS2.14.246 and PS2.14.248 😉 @multidefence.bsky.social
194
Multi-Defence @multidefence.bsky.social · 11/07/2026
A few of us presented some of our ongoing research at #VOM2026 in Prague this week!
191
Multi-Defence @multidefence.bsky.social · 13/04/2026
Stimulating keynote from @jojofoth.bsky.social on advancing phage therapy for chronic respiratory infections in cystic fibrosis, addressing key translational challenges from clinical pathways and phage biobanking to delivery, diagnostics, and public engagement at #Microbio26.
194
Multi-Defence @multidefence.bsky.social · 13/04/2026
Great to see exciting work from @megllewellyn.bsky.social on how expression context shapes the protection provided by bacterial defence systems. Comparing chromosomal and plasmid-encoded systems highlights how regulatory architecture influences defence effectiveness.
294
Reposted by Multi-Defence
Evgenii Protasov @evgenii-protasov.bsky.social · 12/04/2026
DefensePredictor: A machine learning model to discover prokaryotic immune systems #microbiology #prokaryotes #CRISPR #MicroSky @science.org www.science.org/doi/10.1126/...
science.org
DefensePredictor: A machine learning model to discover prokaryotic immune systems
Antiphage defense systems protect bacteria from viral infection and have inspired important biotechnologies such as CRISPR-Cas9 while also revealing the evolutionary roots of eukaryotic innate immunit...
2229
Reposted by Multi-Defence
ShirlG @shirleyg72.bsky.social · 10/03/2026
@multidefence.bsky.social bowling is on. The quality is perhaps lacking
001
Multi-Defence @multidefence.bsky.social · 27/11/2025
181
Multi-Defence @multidefence.bsky.social · 27/11/2025
Highlights from our recent participation! Members of the Multi-Defence Consortium presented both talks and posters on phage defence systems — showcasing exciting progress across the field. Great discussions, great science, and we’re excited to share more soon! #MicroEvo25
1204
Reposted by Multi-Defence
Malcolm White @mfwhite2.bsky.social · 27/11/2025
@multidefence.bsky.social
011
Multi-Defence @multidefence.bsky.social · 14/11/2025
Antibiotics & phage infectivity www.findaphd.com/phds/project... (4/4)
findaphd.com
Understanding the effects of antibiotics on bacteriophage infectivity at University of Exeter on FindAPhD.com
PhD Project - Understanding the effects of antibiotics on bacteriophage infectivity at University of Exeter, listed on FindAPhD.com
000
Multi-Defence @multidefence.bsky.social · 14/11/2025
🦠 Defence systems & AMR www.swbio.ac.uk/files/2025/1... www.swbio.ac.uk/programme/ho... (3/4)
swbio.ac.uk
000
Multi-Defence @multidefence.bsky.social · 14/11/2025
🧬 MADS–CRISPR interaction www.findaphd.com/phds/project... (2/4)
findaphd.com
Funded PhD SWBio DTP- (CASE) Understanding the molecular mechanism of the MADS bacterial immune system and its synergy with CRISPR-Cas at University of Bristol on FindAPhD.com
PhD Project - Funded PhD SWBio DTP- (CASE) Understanding the molecular mechanism of the MADS bacterial immune system and its synergy with CRISPR-Cas at University of Bristol, ...
000
Multi-Defence @multidefence.bsky.social · 14/11/2025
🔬 Interested in bacterial immune systems & AMR, or how antibiotics affect phage infectivity? Three SWBio DTP PhD project opportunities linked to the MultiDefence consortium are now open (1/4) #PhD #DoctoralTraining #ResearchCarrers #LifeSciences #phagesky #AMR #microsky #PhDPositions
046
Reposted by Multi-Defence
Steven Shaw @steven-shaw.bsky.social · 08/11/2025
www.findaphd.com/phds/project... @nebiolabs.bsky.social @multidefence.bsky.social
findaphd.com
Funded PhD SWBio DTP- (CASE) Understanding the molecular mechanism of the MADS bacterial immune system and its synergy with CRISPR-Cas at University of Bristol on FindAPhD.com
PhD Project - Funded PhD SWBio DTP- (CASE) Understanding the molecular mechanism of the MADS bacterial immune system and its synergy with CRISPR-Cas at University of Bristol, ...
001
Multi-Defence @multidefence.bsky.social · 23/07/2025
More info & tickets see poster and link: sites.exeter.ac.uk/vanhoutelab/... (2/2)
sites.exeter.ac.uk
2025 Phage Therapy Workshop - Free Event
November 25th, 2025 at the Spine Building in Liverpool Rising levels of antimicrobial resistance threaten healthcare systems and economies worldwide. Phage therapy has proven to be an effective last-r...
010
Multi-Defence @multidefence.bsky.social · 23/07/2025
🦠🧬 Join us for a workshop on Phage Therapy in Liverpool (25 Nov 2025)! A 1-day free event bringing together clinicians, academics, regulators & industry to discuss the future of phage therapy; happening in tandem to a 2-day focus meeting on Microbial Evolutionary Dynamics (1/2)
111
Reposted by Multi-Defence
Anna Olina @annaolina.bsky.social · 24/06/2025
Happily representing @multidefence.bsky.social at the #EESMicrobiology in Heidelberg! Come to my poster if interested in prophage-mediated phage defence! Also don't miss @emgoodall.bsky.social's talk today, and @alekseiagapov.bsky.social and @davvi36.bsky.social posters!
1307
Reposted by Multi-Defence
Aleksei Agapov @alekseiagapov.bsky.social · 24/06/2025
Presenting a poster about Pseudomonas defence systems at #EESMicrobiology in Heidelberg. If you happen to like it, don't forget to check out our consortium @multidefence.bsky.social
1244
Multi-Defence @multidefence.bsky.social · 18/06/2025
Great to get together in Manchester last week for our consortium’s annual meeting – halfway through our 5-year collaboration! Inspiring discussions, exciting updates, and lots of ideas ahead. Excited for what’s next! 💡🔬🤝 #Science #Microbiology #TeamScience
1164
Reposted by Multi-Defence
Malcolm White @mfwhite2.bsky.social · 13/06/2025
Edze Westra kills viruses @multidefence.bsky.social
0172
Reposted by Multi-Defence
Kate Baker @ksbakes.bsky.social · 23/05/2025
As part of the @multidefence.bsky.social consortium, we worked with a globally curated dataset of >4,000 P. aeruginosa (from 10.1126/science.adi0908) to reveal differences in the number and composition of defence systems between isolates from (and not from) cystic fibrosis cases 2/n
171
Reposted by Multi-Defence
Malcolm White @mfwhite2.bsky.social · 12/06/2025
Great to be in Manchester for the annual @multidefence.bsky.social meeting, with Luna and Simon!
0173
Reposted by Multi-Defence
Malcolm White @mfwhite2.bsky.social · 11/06/2025
Passing through the Borders on the train to Manchester for the annual @multidefence.bsky.social meeting
071
Reposted by Multi-Defence
Kate Baker @ksbakes.bsky.social · 23/05/2025
This work was led by the incredible @charlotteechong.bsky.social 💻 🧬 as part of the @multidefence.bsky.social sLoLa consortium funded by @ukri.org BBSRC and in collaboration with a wonderful set of new (and old!) colleagues 9/n
231
Reposted by Multi-Defence
Malcolm White @mfwhite2.bsky.social · 31/03/2025
www.findaphd.com/phds/project... A funded PhD studentship is available for a joint project between my lab and @andreashaag.bsky.social @uniofstandrews.bsky.social
findaphd.com
Harnessing Bacterial Viruses to Combat Antibiotic-Resistant Infections at University of St Andrews on FindAPhD.com
PhD Project - Harnessing Bacterial Viruses to Combat Antibiotic-Resistant Infections at University of St Andrews, listed on FindAPhD.com
0512
Multi-Defence @multidefence.bsky.social · 10/04/2025
🔬 Three fronts in bacterial defense! At EMBO symposium this week in Paris, our PIs showcased: • @mfwhite2.bsky.social: cyclic nucleotide defence signaling • Prof. Stineke Van Houte: prophage warfare in P. aeruginosa • Prof. Tim Blower: autoregulating toxins & phage defence
1237
Multi-Defence @multidefence.bsky.social · 09/04/2025
We had fantastic poster presentations at the EMBO symposium the Immune System of Bacteria in Paris this week
1141
Multi-Defence @multidefence.bsky.social · 03/04/2025
Coming back to Microbial Warfare session today we have @charlotteechong.bsky.social giving a talk about "Genomic analyses to infer defence system interactions among global Pseudomonas aeruginosa populations" at 12:15
1120
Multi-Defence @multidefence.bsky.social · 02/04/2025
@samriddhigupta.bsky.social gave her poster presentation today at #Microbio25 about discovering new counter-defence systems in prophage genomes
0124
Multi-Defence @multidefence.bsky.social · 02/04/2025
Second poster session starting soon #Microbio25
040
Reposted by Multi-Defence
Multi-Defence @multidefence.bsky.social · 02/04/2025
We also have a couple of poster presentations today 255 from @drramabht.bsky.social, 282 from @anna-k-richmond.bsky.social, 062 from Meg Llewellyn and 068 from Jasmine Thomas-Campbell. All cool stuff about defence systems!
0145
Reposted by Multi-Defence
Aleksei Agapov @alekseiagapov.bsky.social · 02/04/2025
Phage vs Phage from @annaolina.bsky.social at #Microbio25. Fantastic talk!
1177
Multi-Defence @multidefence.bsky.social · 02/04/2025
We also have a couple of poster presentations today 255 from @drramabht.bsky.social, 282 from @anna-k-richmond.bsky.social, 062 from Meg Llewellyn and 068 from Jasmine Thomas-Campbell. All cool stuff about defence systems!
0145
Multi-Defence @multidefence.bsky.social · 02/04/2025
Our upcoming talks today at #Microbio25 in the Microbial Warfare session: Prof Tim Blower's talk about “All the World’s a Phage” - Exploring phage-host interactions, at 14:45 and from @annaolina.bsky.social about Phage vs. Phage: When Pseudomonas’ own prophages step up the defenсe, at 15:45
181
Multi-Defence @multidefence.bsky.social · 01/04/2025
@brockhurstlab.bsky.social giving a talk about eco-evolutionary mechanisms of AMR in the AMR session at #Microbio25
0257
Multi-Defence @multidefence.bsky.social · 01/04/2025
Poster A092!
020
Multi-Defence @multidefence.bsky.social · 31/03/2025
Poster A097 tomorrow at #Microbio25!
083
Reposted by Multi-Defence
Tiffany Taylor @taylorlabgroup.bsky.social · 03/02/2025
Welcome to Maryam Ravari & @gretelwaugh.bsky.social to the @multidefence.bsky.social team! They will be supporting @yueyicai.bsky.social in establishing experimental pipelines to explore the regulation of multi-layered bacterial defence systems - what a team! tiffanybtaylor.wordpress.com/people/
0123
Reposted by Multi-Defence
Jamie Hall @jpjhall.bsky.social · 10/01/2025
🚨PhD studentship opportunity! Bacteria protect themselves with a huge arsenal of defences, but does this affect how they gain new traits on plasmids? 🧫🦠💫 Apply for a funded 4y position with me @livuni-ives.bsky.social, @brockhurstlab.bsky.social @jojofoth.bsky.social & @multidefence.bsky.social ⬇️
findaphd.com
BBSRC NWD: Let the right one in: exploring the trade-offs between genome defence and openness in microbiomes at University of Liverpool on FindAPhD.com
PhD Project - BBSRC NWD: Let the right one in: exploring the trade-offs between genome defence and openness in microbiomes at University of Liverpool, listed on FindAPhD.com
23235
Reposted by Multi-Defence
Tiffany Taylor @taylorlabgroup.bsky.social · 07/01/2025
Happy New Year! We're off to a great start in our lab as we welcome Yueyi Cai to the group. Yueyi joins as a postdoc who will be working on understanding how layered bacterial defence systems are regulated. She will join the brilliant @multidefence.bsky.social team. Welcome!
2223
Multi-Defence @multidefence.bsky.social · 23/10/2024
New member in the team 😀 Welcoming Meg Llewellyn who has joined as an MbyRes student with Prof Edze Westra and Dr Aleksei Agapov.
031
Multi-Defence @multidefence.bsky.social · 18/10/2024
A very warm welcome to Jasmine Thomas-Campbell - PhD student with @taylorlabgroup.bsky.social and Prof. Edze Westra; and to @taoranfu.bsky.social - PDRA with @brockhurstlab.bsky.social who have recently joined our Multidefence team 🥳 Looking forward to working together!!
064
Multi-Defence @multidefence.bsky.social · 30/09/2024
End of Day 1 of the Hooke meeting. Had an exciting line up of talks. Our talented ECRs @annakrichmond.bsky.social Anna Olina, Aleksei, Steven, Paritosh and Maureen showcased their amazing research. Looking forward to Day 2.
142
Multi-Defence @multidefence.bsky.social · 29/09/2024
The team is en route to London to be part of the Royal Society Hooke meeting!!! royalsociety.org/science-even...
royalsociety.org
The ecology and evolution of microbial immune systems | Royal Society
Discussion meeting organised by Professor Edze Westra, Professor Stineke van Houte, Professor Uri Gophna and Professor Rotem Sorek
031
Multi-Defence @multidefence.bsky.social · 16/09/2024
Shout to all the incredible postdocs on the #MultiDefence project! Your contributions drive research forward, and we're so grateful for all that you do 🎉 #NPAW Charlotte Chong, Rosanna Wright, Aleksei Agapov, Anna Olina, Steven Shaw, Sam Went, Maureen Micaletto @drramabht.bsky.social
010
Multi-Defence @multidefence.bsky.social · 23/07/2024
We have another position advertised 😃 with @taylorlabgroup.bsky.social in Bath to understand the regulation of multi layered defence systems!! You can apply at www.bath.ac.uk/jobs/Vacancy... Applications close on 9th September.
066
Multi-Defence @multidefence.bsky.social · 23/07/2024
Interested in defence systems and HGT?? Join our dynamic consortium for exciting research!!! We have a postdoctoral position in Liverpool with @jpjhall.bsky.social Details below👇
044
Reposted by Multi-Defence
Tatiana Dimitriu @tatianadimitriu.bsky.social · 18/06/2024
New preprint on the interactions between conjugative plasmids and defence systems (restriction-modification systems), with Mark Szczelkun and Edze Westra #MicroSky www.biorxiv.org/content/10.1...
biorxiv.org
Various plasmid strategies limit the effect of bacterial Restriction-Modification systems against conjugation.
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
22410