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Michael Brockhurst

@brockhurstlab.bsky.social
3.6K followers 4.2K following 429 posts

Microbial evolution / University of Manchester

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Reposted by Michael Brockhurst
Willem van Schaik @wvschaik.bsky.social · 14/05/2026
Super-excited to be organising the first in-person meeting of the @target-amr.bsky.social network today and tomorrow. We will be launching an initiative for pump-priming and an amazing comic by Eddie Ross on AMR Genomics
A comic with a phylogenetic tree. The background is the opening slide of a conference
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Daniel Cazares @danielcazares.bsky.social · 11/05/2026
Happy to share that our latest research on the eco-evolutionary dynamics of MDR plasmids and PDPs is now out (open access vAuthor) in The ISME Journal doi.org/10.1093/isme... Here, we explored how plasmid-dependent phages (PDPs) act as a selective pressure against the spread of multidrug resistance
doi.org
Eco-evolutionary responses to plasmid-dependent phage constrain the spread of multidrug resistance plasmids
Abstract. Phage therapy offers a promising alternative to antibiotics for treating multidrug-resistant infections. Plasmid-dependent phages (PDPs) are part
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Michael Brockhurst @brockhurstlab.bsky.social · 08/05/2026
Less than 1 week to apply for this postdoc! If you want to find out more about the project have a look at our recent preprint: www.biorxiv.org/content/10.6... #mevosky
biorxiv.org
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Tera Levin @teralevin.bsky.social · 02/05/2026
Bacterial immune proteins have repeatedly evolved to become parts of eukaryotic immunity. But how? Our new preprint uncovers a recent horizontal transfer event & shows how eukaryotes co-opted a toxic bacterial immune protein 🦠🧪🧵 1/
Microscopy image showing yeast cells expressing a fluorescently tagged version of the amoeba TirC protein. TirC forms filaments that span the yeast cells.
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Michael Brockhurst @brockhurstlab.bsky.social · 01/05/2026
Why does antibiotic resistance evolution vary between patients? Come to @officialuom.bsky.social @mermanchester.bsky.social to help us find out! 2.5 year @wellcometrust.bsky.social postdoc position in experimental evolution Closing 15 May. Apply here: www.jobs.manchester.ac.uk/Job/JobDetai...
jobs.manchester.ac.uk
Research Associate in Microbial Evolution:Oxford Road
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Michael Brockhurst @brockhurstlab.bsky.social · 01/05/2026
Join us! @wellcometrust.bsky.social postdoc position using experimental evolution to understand real-world resistance dynamics. See preprint for the 🤯 strain collection we will be working with www.biorxiv.org/content/10.6... Closing 15 May. Apply: www.jobs.manchester.ac.uk/Job/JobDetai... #mevosky
biorxiv.org
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Megan Sorensen @messorensen.bsky.social · 30/04/2026
Interested in working on the evolution of photosynthetic endosymbioses? Come join us! I have 2 open positions in my new group @cemess.bsky.social in Vienna 3yr postdoc info: tinyurl.com/4emkjpn4 4yr PhD info: tinyurl.com/mtxmsjpy Apply by 1st June! Please share/repost #Protists #Symbiosis #PhD
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Michael Brockhurst @brockhurstlab.bsky.social · 28/04/2026
We have a PhD studentship available to develop genome safeguarding technologies for synthetic phage therapeutics www.findaphd.com/phds/project... It is part of an exciting new @officialuom.bsky.social PhD by Enterprise programme www.bmh.manchester.ac.uk/study/resear...
findaphd.com
(PhD by Enterprise) Genome safeguarding technologies for synthetic phage therapeutics against multidrug resistant bacterial infections at The University of Manchester on FindAPhD.com
PhD Project - (PhD by Enterprise) Genome safeguarding technologies for synthetic phage therapeutics against multidrug resistant bacterial infections at The University of Manchester, listed on FindAPhD...
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Will Smith @willpjsmith.bsky.social · 20/03/2026
Here’s the latest preprint from my work on evolved resistance to Type VI Secretion system (T6SS) weaponry, funded by a @wellcometrust.bsky.social Sir Henry Wellcome Fellowship. So happy to see this out! www.biorxiv.org/content/10.6...
biorxiv.org
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Chris Hassall @katatrepsis.bsky.social · 09/03/2026
Very excited to announce that we are hiring for three faculty positions at @universityofleeds.bsky.social in @bioscienceleeds.bsky.social: A/Prof Plant Science, A/Prof Animal Biology and Lecturer in Ecology, Zoology, Biodiversity or Ecosystem Management. Please do get in touch to chat. Links below:
jobs.leeds.ac.uk
Job Opportunity at University of Leeds: Associate Professor of Plant Science
Associate Professor of Plant Science Salary: Grade 9 (£61,759 - £73,708 p.a, depending on experience)This role will be based on the university campus, with scope for elements of the job to be undertak...
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Aritz Roa-Eguiara @aritz-roa.bsky.social · 07/03/2026
🚨Preprint! Happy to share the research from my PhD “Genome delivery of a contractile tailed phage and its superinfection exclusion mechanism”. We use cryoEM to study the genome ejection of the phage T4, revealing how the tape measure protein regulates the process. www.biorxiv.org/content/10.6...
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Thibaut Brunet @thibautbrunet.bsky.social · 28/02/2026
Final version @nature.com of our paper describing unconventional multicellular development in a choanoflagellate inhabiting an extreme environment. A ton of new data since the first @biorxivpreprint.bsky.social preprint (which we've kept updating). A brief 🧵 (carried over from the old place)
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Mark A. Hanson @hansonmark.bsky.social · 06/03/2026
Pleased to finally share this fun collab that began at #Ento23 @cedricaumont.bsky.social presented & I had seen NCBI annotated some cockroach genomes as "contaminated." Turns out NCBI & I were wrong (much more fun). Horizontal transfer of an #AntimicrobialPeptide across insects bit.ly/DrsHGT 1/🧵
A phylogenetic tree of insects is shown annotating the presence or absence of a an antimicrobial peptide gene across winged insectsVarious phylogenetic secondary loss events are mapped to a tree of insects to explain the parsimony calculations necessary to explain the diversity of insect Drosomycin antimicrobial peptide genesAntimicrobial peptides (AMPs) are key defence molecules of the innate immune system of plants and animals. Understanding the evolutionary origins of AMPs can help to explain how immune systems acquire novelty and vary in their defensive capabilities. However, AMPs evolve rapidly, and so the origins of similar AMPs across organisms is often unclear. Furthermore, false negatives due to low search sensitivity are common and can hinder confident annotations about true absences. Due to these difficulties, understanding whether similar AMP genes found in diverse organisms represent ancestral molecules or evolutionary novelties has been challenging. In this report, we present evidence of
horizontal gene transfer (HGT) of the antifungal peptide gene Drosomycin across insects. We show that in Diptera, the presence of Drosomycin is restricted to the Melanogaster group and additionally the
distant relative Drosophila busckii. We go on to recover Drosomycin genes in cockroaches (Blattodea), mantises (Mantodea), one katydid (Orthoptera), various beetles (Coleoptera), and a recently acquired
pseudogenized Drosomycin locus in Liposcelis booklice (Psocodea), but no other insects. Explaining this diversity through shared ancestry requires at least 50 independent loss events, or just seven HGT
events. Previous studies have suggested that similar AMPs found across divergent species reflect conservation from a common ancestor, or due to their small size, that they arose via convergent evolution resulting from pathogen-imposed selection. Our findings suggest horizontal gene transfer can be responsible for the presence of some AMP genes found scattered across the tree of life. By presenting a mechanism through which immune systems can acquire novelty, our study also suggests a possible explanation for certain lineage-specific competencies for defence against infectious disease. While loss of AMP genes is common in certain lineages, here we suggest gain of AMPs can occur just as suddenly.
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Sam Hobbs @hobbslabutah.bsky.social · 06/03/2026
CBASS is a cyclic nucleotide-based antiviral system in bacteria that is related to cGAS-STING signaling in animals. One of the big questions is how CBASS is activated during phage infection? We made some progress on this during my final year in the Kranzusch lab. www.biorxiv.org/content/10.6...
biorxiv.org
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Sorek Lab @soreklab.bsky.social · 05/03/2026
Out today: We discovered new viral proteins that target immune signaling molecules, solely based on their AlphaFold-predicted shapes www.science.org/doi/10.1126/... Congrats Nitzan Tal and coauthors! Thank you Kranzusch lab for the fun collaboration! Linking below previous thread on our findings
science.org
Structural modeling reveals phage proteins that manipulate bacterial immune signaling
Immune systems in animals, plants, and bacteria often rely on intracellular nucleotide signaling, which viruses can block by sequestering or degrading these signals. We identified structural and bioph...
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Géraldine Laloux @lalouxlab.bsky.social · 05/03/2026
#MicroSky Please RT @erc.europa.eu-funded postdoc position in my lab to identify the molecular basis of prey-predator interactions using our favorite micro-vampire Bdellovibrio exovorus as a model. Let's find what the bite is made of! 🧛 Flexible start date. Info: euraxess.ec.europa.eu/jobs/415877
euraxess.ec.europa.eu
Postdoctoral researcher in molecular and cellular bacteriology - ERC CoG VAMPIRE
The research group of Prof Géraldine Laloux at the de Duve Institute (UCLouvain) is looking for a highly motivated postdoc to elucidate the molecular factors underlying bacterial prey-predator interac...
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Peter Fineran @peterfineran.bsky.social · 04/03/2026
New post-doctoral research position in my phage-host interactions (Phi) laboratory in @otagomicroimmuno.bsky.social at @universityofotago.bsky.social New Zealand. The project is focused on defences against jumbo phages. Please share and if interested apply using the link in the comments.
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Vaughn Cooper @vscooper.micropopbio.org · 27/01/2026
Phage therapy offers a powerful tool against AMR infections—but only if we move from isolated cases to coordinated systems. The first initiative of the ASM Health Unit, led by Colleen Kraft and Dev Mittar, will tackle this. Delighted by this scientific leadership, join us! asm.org/about-asm/as...
asm.org
Phage Therapy Coordination Network | ASM.org
ASM Health is unlocking bacteriophage therapies for antimicrobial resistance (AMR) through coordinated access and regulatory approvals.
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Pedro Dorado-Morales @doradomoralesp.bsky.social · 26/02/2026
New preprint out on bioRxiv! www.biorxiv.org/content/10.6... Can conjugative plasmids be used to control plasmid and pathogen spread? Follow me down the rabbit hole that led to this story 🧵
biorxiv.org
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BejaLabTechnion @bejalab.bsky.social · 25/02/2026
Convergent MurJ flippase inhibition by phage lysis proteins www.nature.com/articles/s41...
nature.com
Convergent MurJ flippase inhibition by phage lysis proteins - Nature
A common mechanism of inhibition of the essential lipid II flippase MurJ by three distinct phage-encoded single-gene lysis proteins provides insights into potential new targets for antimicrobial devel...
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Jesse Shapiro @bjesseshapiro.bsky.social · 09/02/2026
Now out & nicely formatted in @isme-microbes.bsky.social A big analysis of ocean genomes & metagenomes co-led by former postdocs, now PIs, @gmdouglas.bsky.social & @cyanophage.bsky.social along with co-PIs @lbobay.bsky.social & Samuel Chaffron. A few highlights... 🧵 (1/n) doi.org/10.1093/isme...
doi.org
Co-occurrence is associated with horizontal gene transfer across marine bacteria independent of phylogeny
Abstract. Understanding the drivers and consequences of horizontal gene transfer (HGT) is a key goal of microbial evolution research. Although co-occurring
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Richard Lenski @relenski.bsky.social · 24/02/2026
Happy 38th birthday to the #LTEE! #BOTD in 1988. Keep on evolving! #science #evolution #microbiology
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Yonatan Grad @yhgrad.bsky.social · 30/01/2026
Now published: our work using phylodynamics from surveillance data to quantify and experimentally validate the fitness impact of antibiotic resistance determinants & how this changes with patterns of antibiotic use: www.nature.com/articles/s41...
nature.com
Quantifying the real-world impact of antibiotic use and genetic determinants of resistance on gonococcal dynamics
Nature Microbiology - Phylodynamic modelling shows how the changing antibiotic landscape and genetic determinants of resistance shape real-world gonococcal dynamics. Experiments validated that...
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Vaughn Cooper @vscooper.micropopbio.org · 25/02/2026
Thank you Mike! I encourage your colleagues to join the new initiative from ASM Health to develop and execute on synergies with phage therapy. Would be great to involve multiple societies and NGO's here as appropriate, as we share common goals. asm.org/about-asm/as...
asm.org
Phage Therapy Coordination Network | ASM.org
ASM Health is unlocking bacteriophage therapies for antimicrobial resistance (AMR) through coordinated access and regulatory approvals.
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David Sünderhauf @davvi36.bsky.social · 20/02/2026
Out now in @plosbiology.org : our big joint effort on the role of #CRISPR in plasmid competition. Read on for a really fun (I’m biased ok) analysis of how a defence system has new selective pressures when it’s mobile journals.plos.org/plosbiology/... 1/6
Two cartoon images of children with plasmids for faces about to fight. Commentators are saying "Plasmid-borne CRISPR-Cas systems provide significant defensive benefits" and "Yes, but toxin-antitoxin systems on competitor plasmids constrain the offensive CRISPR-Cas benefit"
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Guillermina Ramirez-SanJuan @guille-rochelle.bsky.social · 23/02/2026
Excited to share our new preprint exploring how Paramecium achieves diverse flow functions, i.e. feeding and swimming, simultaneously. This work was spearheaded by our ExM expert, PhD student Daphne Laan @daphnelaan.bsky.social : www.biorxiv.org/content/10.6...
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Laurent Duret @handle.invalid · 23/02/2026
Up to what degree of interspecific genetic distance is it possible to form viable and fertile hybrids? A strange species of paramecium breaks the record: www.biorxiv.org/content/10.6...
biorxiv.org
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Richard Lenski @relenski.bsky.social · 21/02/2026
Alita Burmeister (@aburmeister.bsky.social) is looking to hire a postdoc (or potentially a PhD student) for projects on phage resistance and evolution. The position description is posted to the Eco-Evo Jobs wiki and also available on her lab's website (arburmeister.weebly.com).
arburmeister.weebly.com
The Burmeister Lab: Studying Microbial Evolution and Extinction
​Our research integrates evolutionary biology and microbiology, using bacteria and phage as study systems to address fundamental questions in both fields. ​ ​We study microbial evolution, a...
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Siobhán O'Brien @siderophile.bsky.social · 18/02/2026
MENI is back! Join us in Dublin this August 2026 for our 3rd Meeting for Microbial Evolution in Ireland. We are delighted to have @rachelmwheatley.bsky.social @drrebeccajhall.bsky.social @jpjhall.bsky.social and @tweethinking.bsky.social join us as keynote speakers this year. miniurl.com/MENI
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Adam Mulkern @mulkern.bsky.social · 21/02/2026
Cancer therapies exploit DNA repair defects to kill tumours. We asked whether the same logic could constrain antibiotic resistance evolution... www.biorxiv.org/content/10.6...
biorxiv.org
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Jonathan Eisen @phylogenomics.bsky.social · 20/02/2026
👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀
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Prof Jenny Rohn @jennyrohn.bsky.social · 20/02/2026
Super interesting - many roads lead to #AMR in different patients #IDSky
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Matthew J Shepherd @matthewjshepherd.bsky.social · 20/02/2026
🚨 New pre-print! 🚨 In the largest study of its kind to-date, we investigate the ecological and evolutionary mechanisms driving within-patient evolution of antimicrobial resistance (AMR). Read here: www.biorxiv.org/content/10.6... , and follow along with this thread, discussing our findings (1/21)
biorxiv.org
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Michael Brockhurst @brockhurstlab.bsky.social · 20/02/2026
How does treatment induced antibiotic resistance happen in real-world infections? We analysed 25k Pseudomonas isolates from 180 patients in a clinical trial to find out! TLDR: The ecological and evolutionary paths are surprisingly diverse & complex even in patients receiving identical treatment…
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Willem van Schaik @wvschaik.bsky.social · 20/02/2026
Fascinating and important study on Klebsiella plasmid diversity 'Plasmids from human, animal and marine [Klebsiella pneumoniae complex] isolates formed shared genetic clusters spanning ecological boundaries' www.microbiologyresearch.org/content/jour...
microbiologyresearch.org
A One Health study of Klebsiella pneumoniae species complex plasmids shows a highly diverse and ecologically adaptable plasmidome
Plasmids play a pivotal role in the horizontal gene transfer (HGT) of antimicrobial resistance (AMR) and virulence determinants among bacteria. Members of the Klebsiella pneumoniae species complex (Kp...
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Matthew J Shepherd @matthewjshepherd.bsky.social · 16/02/2026
Hoping to return to bluesky after a social media hiatus! Nice to start it off with some career updates - I've just started as a College for Life Sciences Fellow @wiko-berlin.bsky.social. Really excited to live+work in Berlin! Read about what i'll be up to here: www.wiko-berlin.de/en/fellows/a...
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The EMBO Journal @embojournal.org · 18/02/2026
Read how @embopress.org is expanding its focus on molecular ecology and evolution as central underpinnings of functions/interactions/diversification of biological systems – by @yehumoran.bsky.social, @berndpulverer.bsky.social, and our new team of Editorial Advisors link.springer.com/article/10.1...
link.springer.com
EMBO Press co-evolves with molecular ecology and evolutionary biology - The EMBO Journal
The EMBO Journal - Molecular ecology and evolution are central to understanding how biological systems function, interact, and diversify. A special issue of this journal reflects the growing...
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Christos C. Ioannou @ccioannou.bsky.social · 18/02/2026
📢📢📢Lectureships at Bristol!📢📢📢 We're hiring 3 x lecturers (=assistant professor) in Biological Sciences, across the discipline. Great department, great colleagues, great building, great city Details here: www.bristol.ac.uk/jobs/find/de...
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Will Matlock @wtmatlock.bsky.social · 20/02/2026
🚨 New preprint 🚨 How promiscuous really are conjugative plasmids, and what does that mean for plasmid co-occurrence? A pleasure to collaborate with @craigmaclean.bsky.social on the first paper of my fellowship! www.biorxiv.org/content/10.6...
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 20/02/2026
Conjugation structures plasmid populations through host-lineage restriction www.biorxiv.org/content/10.64898/20…
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Zamin Iqbal @zaminiqbal.bsky.social · 19/02/2026
Last year, we proposed a model of plasmid evolution via fusion and fragmentation (via mge mediated recombination) generating mosaics, by studying historical isolates. Excited to see a MASSIVE paper from @jrpenades.bsky.social , @epcrocha.bsky.social expanding on this www.biorxiv.org/content/10.6...
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Vaughn Cooper @vscooper.micropopbio.org · 16/02/2026
🧵 New preprint! Our 4-lab team evolved Streptococcus pneumoniae in antibiotic-treated mice of varying immune states and discovered something surprising: bacteria rarely evolved resistance. Instead, they found a different way to survive — by rewiring RNA turnover. 🔗 www.biorxiv.org/content/10.6...
biorxiv.org
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Pedro Dorado-Morales @doradomoralesp.bsky.social · 16/02/2026
A short research stay in 2019 (back in the pre-COVID era) at José R. Penadés lab turned into the third chapter of my PhD and today it finally sees the light.
nature.com
Targeted elimination of Staphylococcus aureus mastitis infections with synthetic phage-based CRISPR-Cas delivery systems - npj Biofilms and Microbiomes
npj Biofilms and Microbiomes - Targeted elimination of Staphylococcus aureus mastitis infections with synthetic phage-based CRISPR-Cas delivery systems
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Hassan Salem @hassansalem.bsky.social · 16/02/2026
How specific are heritable symbioses? And what can we learn from swapping obligate symbionts across host species? We address this in our latest, led by @inespons.bsky.social & in our collaboration w/ @microbiome.bsky.social 🦠🪲 Out today in @natcomms.nature.com! 1/n www.nature.com/articles/s41...
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Ed Feil @edfeil.bsky.social · 07/01/2026
It has been a long road, but our paper on Klebsiella plasmids is finally out in Lancet Microbe. Thanks to all co authors but especially Marjorie Gibbon and Natacha Couto www.sciencedirect.com/science/arti...
sciencedirect.com
Convergence and global molecular epidemiology of Klebsiella pneumoniae plasmids harbouring the iuc3 virulence locus: a population genomic analysis
Klebsiella pneumoniae is an important pathogen of humans and animals. In the past five years, increasing reports of convergent strains that carry both…
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Vivek Mutalik @vivekmutalik.bsky.social · 14/02/2026
#phagesky #phage www.nature.com/articles/s41...
nature.com
Realizing phage therapy in the UK - Nature Microbiology
On 25 November 2025, the international phage therapy research and biotechnology communities gathered in Liverpool, UK, to discuss progress in implementing clinical phage therapies and the latest techn...
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Michael Brockhurst @brockhurstlab.bsky.social · 14/02/2026
What’s holding back clinical use of phage therapy in the UK? Our workshop last year brought together international experts, biotech and regulators to find out Meeting Report out now in Nature Microbiology with our take on the challenges and opportunities facing the UK phage therapy sector
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Nature Microbiology @natmicrobiol.nature.com · 14/02/2026
Out Now! Realizing phage therapy in the UK #MicroSky
go.nature.com
Realizing phage therapy in the UK
Nature Microbiology, Published online: 13 February 2026; doi:10.1038/s41564-026-02280-zOn 25 November 2025, the international phage therapy research and biotechnology communities gathered in Liverpool, UK, to discuss progress in implementing clinical phage therapies and the latest technological breakthroughs in phage biology and engineering, while UK regulators and health agencies provided the latest guidance.
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Michael Brockhurst @brockhurstlab.bsky.social · 06/02/2026
New PDRA position with @knightjar.bsky.social @coytelab.bsky.social & me Community assembly processes in soil microbiomes with focus on bioinformatics and computational modelling of data from field and lab experiments www.jobs.manchester.ac.uk/Job/JobDetai...
jobs.manchester.ac.uk
'Research Associate in Microbiome Ecology:Manchester
We wish to appoint a PostDoctoral Research Associate to an exciting project exploring the assembly, stability and function of microbial decomposer communities.
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Michael Brockhurst @brockhurstlab.bsky.social · 06/02/2026
Exciting new PhD programme CODE-M Control and Design of Engineered Microbial Systems @officialuom.bsky.social Projects now advertised! Ours is on division of labour & horizontal gene transfer in microbial communities @biotechdixon.bsky.social @coytelab.bsky.social www.findaphd.com/phds/project...
findaphd.com
(CODE M) How do Division of Labour and Gene Mobility Impact Microbial Bioremediation? at The University of Manchester on FindAPhD.com
PhD Project - (CODE M) How do Division of Labour and Gene Mobility Impact Microbial Bioremediation? at The University of Manchester, listed on FindAPhD.com
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