O-antigen loss in E. coli is not benign—wbbL mutations are associated with increased septic shock and higher mortality.

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

The authors developed a screen to find compounds that modulate intracellular Staphylococcus aureus metabolism and discovered KL1, which sensitizes persisters to antibiotics by reversing host-induced tolerance.

This Postdoctoral Research Associate will be involved with advanced independent biomedical research, including project development, experimental design and performance, data analysis, written progress...

Nature Communications - Choby et al. show that dynamic increases in the copy number of preexisting β-lactamase genes in heteroresistance enables resistance of continua of cellular...

Antibiotic treatment failure of Pseudomonas aeruginosa infection is a key driver of mortality in muco-obstructive airway diseases (MADs). The bacterial mechanisms that contribute to antibiotic toleran...

A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistanc...

Rifaximin use, particularly in patients with liver cirrhosis, may be compromising the clinical use of daptomycin.

Researchers found that infectious bacteria in diabetic mice rapidly evolved resistance to antibiotics.

Diabetic infections are a reservoir for the emergence and proliferation of antibiotic resistance in Staphylococcus aureus.

Inflammatory bowel disease (IBD)-associated fibrosis causes significant morbidity. Mechanisms are poorly understood but implicate the microbiota, espe…

The 16th confirmed case of VRSA in the United States offers new information regarding the risks posed by the drug-resistant infection.

At least 364 pertussis cases were reported, marking the worst Thanksgiving week on record.

Cell physiology requires innumerable metalloenzymes supported by the selective import of metal ions. Within the crowded cytosol, most enzymes acquire their cognate cofactors from a buffered labile poo...

In this Review, Giorgio and Helaine provide an overview of the physiology of antibiotic-recalcitrant Salmonella enterica during infection, discuss recent insights into the clinical implications of ant...

Hypervirulent Klebsiella pneumoniae is associated with severe community-acquired infections. Hypervi

Our public health system is imperfect, but it’s also a miracle that can be easily broken.

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Marsman et al. detect histone H1 in MRSA in human abscesses and demonstrate that it kills MRSA under physiological conditions. They identify through selective evolution and a genome-wide screen that h...