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Modernising Medical Microbiology

@modmedmicro.bsky.social
163 followers 45 following 55 posts

Modernising Medical Microbiology is a research unit within @ox.ac.uk aiming to transform how we analyse and treat infections, to improve patient care.

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Reposted by Modernising Medical Microbiology
Sam Lipworth @samlipworth.bsky.social · 8h
Great new work from @dotnagy.bsky.social who has developed EpiSENTRY which performs sample size calculations for public health WGS surviellance studies. She applies to data from the NEKSUS study to estimate how much sequencing is enough for GNBSI surviellance in England. @modmedmicro.bsky.social
medrxiv.org
How much is enough? Optimising sampling frames for genomic surveillance of Escherichia coli and Klebsiella spp. bloodstream infections - a retrospective study
Background: Optimising sampling frames for genomic surveillance of E. coli and Klebsiella may support interventions to mitigate bloodstream infections (BSIs), but approaches to estimating sample size ...
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Bash the bug @bashthebug.net · 29/09/2026
Infusoria BioArt exhibition exploring microbiology opens at the John Radcliffe Hospital! 📅 26 September – 6 November 2026 📍 Artlink Corridor Gallery, John Radcliffe Hospital, Oxford #ArtAndScience #Microbiology #AntimicrobialResistance #InfectionPrevention #PublicEngagement
bashthebug.net
Infusoria BioArt exhibition exploring microbiology opens at the John Radcliffe Hospital
BioArt exhibition exploring microbiology opens at the John Radcliffe Hospital A new display of work by artist Anna Dumitriu is now on show at the John Radcliffe Hospital, bringing together art, microbiology and research into healthcare-associated infections. The exhibition draws on research from Modernising Medical Microbiology into hospital environments, bacteria and antimicrobial resistance. Through BioArt, Anna’s work explores the microbial world that usually remains unseen and encourages people to think differently about the relationship between microorganisms, healthcare and our surroundings.
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Bash the bug @bashthebug.net · 23/09/2026
Beyond the basin: my research internship at Oxford Hospital sinks are essential for handwashing, but beneath the basin lies a complex microbial environment that may present challenges for infection prevention... Read more on our blog! #AMR #InfectionPrevention
bashthebug.net
Beyond the basin: my research internship at Oxford
Hospital sinks are essential for handwashing, but beneath the basin lies a complex microbial environment that may present challenges for infection prevention. During my internship at the University of Oxford, I had the opportunity to contribute to research investigating the microorganisms found in hospital sinks and their potential relevance to patient safety. I worked under the supervision of Dr Aoife Kearney on the SELECTION project, building on Professor Nicole Stoesser and her colleagues’ research into hospital sink environments and healthcare-associated infections.
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Modernising Medical Microbiology @modmedmicro.bsky.social · 23/09/2026
DPhil opportunity at the University of Oxford 🦠 We’re looking for a motivated DPhil student to join us to develop innovative metagenomic approaches for surveillance of healthcare-associated pathogens and antimicrobial resistance (AMR). Find out more and apply here!
ndm.ox.ac.uk
DPhil project themes
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Philip Bejon @philipbejon.bsky.social · 11/09/2026
New publication from @modmedmicro.bsky.social on metagnomic RNA virus detection from upper respiratory samples - www.sciencedirect.com/science/arti... @nickdsandy.bsky.social @treestreet.bsky.social @dotnagy.bsky.social @samlipworth.bsky.social @oxfordbrc.bsky.social
sciencedirect.com
Clinical validation of an optimised metagenomic nanopore sequencing method for detecting viral respiratory pathogens
Clinical metagenomics (CMg) offers high-throughput respiratory pathogen detection with a wider range than targeted, probe-dependent diagnostics. Seque…
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Bash the bug @bashthebug.net · 03/09/2026
Microbiology is coming out of the lab! Infusoria, a new exhibition by MMM Artist-in-Residence Anna Dumitriu, runs in the JR Hospital from 26 Sept–6 Nov 2026. New works inspired by Oxford research explore hospital sinks, wastewater, water microbiomes and antimicrobial resistance.
bashthebug.net
When microbiology becomes art: Infusoria
Infusoria 26 September – 6 November 2026Artlink Corridor Gallery, John Radcliffe Hospital, Oxford From hospital sinks to BioArt: our microbiology research inspires new exhibition Infusoria What does the microbial world of a hospital sink look like when viewed not only through the lens of microbiology, but through art? Research from Modernising Medical Microbiology (MMM) at the University of Oxford…
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Modernising Medical Microbiology @modmedmicro.bsky.social · 26/08/2026
A closer look at microplastics! Recently, we visited @ukceh.bsky.social to explore the analysis of #microplastics in sink trap aspirates collected from hospital environments. @afswinkels.bsky.social
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Cat Baker @catcsb10.bsky.social · 25/08/2026
Happy to share my first paper! We developed an optimised #ONT workflow for sequencing mycobacteria directly from positive MGIT cultures, achieving 98.3% agreement with Illumina for species identification, with reliable results often within 6 hours. #PathogenGenomics #TB @modmedmicro.bsky.social
journals.asm.org
Validation of an optimized Oxford Nanopore sequencing workflow versus Illumina for mycobacteria from primary MGIT culture | Microbiology Spectrum
Rapid genomic characterization of mycobacterial infections is important for timely patient management, infection control, and public health surveillance. However, many diagnostic laboratories rely on ...
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Bash the bug @bashthebug.net · 03/08/2026
Read our new blog post! Risk factors for antimicrobial resistance in cancer patients and survivors: an electronic health record study by Annie Hu
bashthebug.net
Risk factors for antimicrobial resistance in cancer patients and survivors: an electronic health record study
Bloodstream infections occur when bacteria (which are germs that can cause disease) enter the blood and grow there. These infections are usually treated with antibiotics. However, bacteria can become resistant, meaning the antibiotics no longer work, and this is called antimicrobial resistance (AMR). It is a major worldwide health problem and people with cancer are especially at risk because both cancer treatments and the cancer itself weaken their immune systems (bodies own protection system).
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Bash the bug @bashthebug.net · 01/06/2026
NIHR webinar on BashTheBug on YouTube BashTheBug was originally a large international citizen science project that invited anyone to help us classify how well different samples of M. tuberculosis grew in the presence of a range of antibiotics. It ran from 2017 to 2021 and in that time 46,427…
bashthebug.net
NIHR webinar on BashTheBug on YouTube
BashTheBug was originally a large international citizen science project that invited anyone to help us classify how well different samples of M. tuberculosis grew in the presence of a range of antibiotics. It ran from 2017 to 2021 and in that time 46,427 people took part and collectively they classified 4,746,420 images of M. tuberculosis growing on different concentrations of one of 13 antibiotics. 
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Bash the bug @bashthebug.net · 28/05/2026
Thanks to the team for all their hardwork preparing and delivering the activities, especially in this heatwave! 🌞🌞🌞
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Bash the bug @bashthebug.net · 28/05/2026
And our DNA detective programme was a smash🕵‍♀️ Follow the bioinformatic instructions to figure out which patient in a ward has which infection, and work out from the hints which drugs will help the patient get better!
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Bash the bug @bashthebug.net · 28/05/2026
The Mystery Outbreak poster was a hit! A cluedo-esque mystery where you had to follow the clues to find the source of illness in the hospital 🔍
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Bash the bug @bashthebug.net · 28/05/2026
Everybody loved the strawberry DNA extractions!🍓 Participants learnt how this technique can be used by scientists to diagnose infections in patients and the data used by doctors to see if the infection has any resistance and then choose which antibiotics to prescribe🧬 @oxfordbrc.bsky.social
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Bash the bug @bashthebug.net · 28/05/2026
We had an amazing time in Westgate, Oxford today! We had many attempts to 'bash the bug' and get the high score for the day on our dance mat 💃🕺 where overusing antibiotics causes resistance so you have to be careful what you're prescribing!💊 #AMR #ScienceOutreach #Microbiology #Oxford
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Bash the bug @bashthebug.net · 27/05/2026
Come see us at the @oxfordbrc.bsky.social showcase! We'll be in Westgate, Oxford 10-3.30. We'll be bringing the dance mat so come and try to beat the germs with antibiotics and claim the high score💃🕺 #AMR #PublicOutreach @ox.ac.uk
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 09/04/2026
Long-read sequencing of Mycobacterial tuberculosis is comparable to short-read sequencing for antimicrobial resistance prediction and epidemiological studies. www.biorxiv.org/content/10.64898/20…
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Modernising Medical Microbiology @modmedmicro.bsky.social · 24/03/2026
On #WorldTBDay, it’s important to reflect on the scale of the challenge we’re facing. In 2024 alone, tuberculosis (TB) caused 1.23 million deaths worldwide, remaining the leading cause of death from a single infectious agent, according to WHO @ndm.ox.ac.uk
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WHO @who.int · 24/03/2026
Rapid diagnosis of tuberculosis is available and recommended! Early diagnosis is a gamechanger. Ask your provider for access to WHO-recommended rapid tests for TB, including the latest near-point-of-care tests, to ensure a quick diagnosis and early treatment.
Rapid testing of tuberculosis is available & recommended. Early diagnosis is a gamechanger!
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Modernising Medical Microbiology @modmedmicro.bsky.social · 24/03/2026
Open datasets such as these are key for tackling AMR in diseases such as tuberculosis. #WorldTBDay
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Philip Fowler @philipwfowler.bsky.social · 24/03/2026
Since 2017 the CRyPTIC project collected and collated 53,897 clinical TB samples with genetics and drug susceptibility testing data. You can download the datasets via crypticproject.info and v4.0.0 will appear later this year. #WorldTBDay @modmedmicro.bsky.social
crypticproject.info
The CRyPTIC project
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Bash the bug @bashthebug.net · 17/03/2026
Bash the Bug at ATOM Festival: Dancing, Germs, and the Challenge of Antimicrobial Resistance! We had a fantastic time this weekend at ATOM Festival in Abingdon, bringing microbiology to life with our Bash the Bug public engagement activities.
bashthebug.net
Bash the Bug at ATOM Festival
Dancing, Germs, and the Challenge of Antimicrobial Resistance We had a fantastic time this weekend at ATOM Festival in Abingdon, bringing microbiology to life with our Bash the Bug public engagement activities. With plenty of sunshine and a steady stream of curious visitors, it was the perfect setting to spark conversations about one of the biggest challenges in global health: …
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Bash the bug @bashthebug.net · 16/03/2026
It was fantastic to see so many people getting involved, asking great questions, and learning about microbiology in the sunshine. Thanks to everyone who came to say hello, and to our brilliant team for all their enthusiasm! #BashTheBug #Microbiology #PublicOutreach #ATOMFestival
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Bash the bug @bashthebug.net · 16/03/2026
We had a brilliant time this weekend at ATOM Festival in Abingdon! ☀️🦠 We brought along our favourite interactive activities to help people learn about antimicrobial resistance #AMR, including our dance mat game where you fight germs with antibiotics, and we tested everyone’s handwashing skills!
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Philip Bejon @philipbejon.bsky.social · 27/02/2026
1/4 Thrilled to get this metagenomic diagnostic study over the line. We have an in house method that targets RNA viruses in respiratory samples, and evaluated this against 344 prospective samples tested by multiplex PCR. www.medrxiv.org/content/10.6...
medrxiv.org
Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study
Background Clinical metagenomics (CMg) offers high-throughput respiratory pathogen detection with a wider range than targeted, probe-dependent diagnostics. Sequencing cost and the challenges of high h...
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Nick Sanderson @nickdsandy.bsky.social · 27/02/2026
New preprint from us @modmedmicro.bsky.social where we validate the diagnostic accuracy of a metagenomic nanopore sequencing method for respiratory RNA viruses. www.medrxiv.org/content/10.6...
medrxiv.org
Clinical validation of a novel metagenomic nanopore sequencing method for detecting viral respiratory pathogens: diagnostic accuracy study
Background Clinical metagenomics (CMg) offers high-throughput respiratory pathogen detection with a wider range than targeted, probe-dependent diagnostics. Sequencing cost and the challenges of high h...
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nstoesser.bsky.social @nstoesser.bsky.social · 24/02/2026
Are you a post-doctoral microbiologist interested in characterising bacterial resistance evolution and want to apply your knowledge and expertise to developing new therapeutics for Klebsiella (and other Enterobacterales) infections? Then we need you! Apply now bit.ly/3MX39Ce close date March 13th 👀
my.corehr.com
Job Details
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nstoesser.bsky.social @nstoesser.bsky.social · 25/02/2026
Hoping to innovate community population-level AMR surveillance with the ALARUM team bmjopen.bmj.com/content/16/2.... Can we use metagenomics of pooled colonisation samples to predict clinical AMR burden & inform antimicrobial guidelines?
bmjopen.bmj.com
ALARUM: Active One Health surveillance in LMICs to monitor and predict Antimicrobial Resistance Using Metagenomics – a cross-sectional study protocol
Background In rural sub-Saharan Africa (sSA), the burden of antimicrobial resistance (AMR) remains high. As AMR continues to rise, there is a strong need for practical, implementable surveillance to m...
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Modernising Medical Microbiology @modmedmicro.bsky.social · 11/02/2026
International Day of Women and Girls in Science 👩‍🔬 Proud to work alongside the scientists in our #microbiology lab whose work in antimicrobial resistance, public health and diagnostics has real-world impact! #WomenInScience #AMR #PublicHealth @medsci.ox.ac.uk @ox.ac.uk @oxfordbrc.bsky.social
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Modernising Medical Microbiology @modmedmicro.bsky.social · 09/02/2026
MMM has an exciting UNIQ+ project running this summer -apply now! Bacteria, microplastics & resistance — what’s the connection? #Microplastics are everywhere, even in hospitals. But what happens when bacteria stick to them? Come and find out! @afswinkels.bsky.social @nstoesser.bsky.social
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Cat Baker @catcsb10.bsky.social · 08/02/2026
Happy our preprint is out🦠: "Evaluation of an Oxford Nanopore sequencing workflow for mycobacteria from primary MGIT culture" We developed and tested a workflow for long-read sequencing of #mycobacteria, including optimising DNA extraction and assessing how #ONT performs compared with #Illumina.
biorxiv.org
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nstoesser.bsky.social @nstoesser.bsky.social · 30/01/2026
Our project "Sardinia’s Invisible Marine Microbiome" is one of six 2026 #PartArt4OW participatory art initiatives! Excited to do this with the brilliant @annadumitriu.bsky.social (image credit), Sardinian scientists, citizens of Alghero, and colleagues in @modmedmicro.bsky.social @bashthebug.net
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nstoesser.bsky.social @nstoesser.bsky.social · 26/01/2026
Delighted to be involved in the Gram-Negative Antibiotic Discovery Innovator (Gr-ADI) consortium novonordiskfonden.dk/en/news/new-... as part of a project led by Annette von Delft gcgh.grandchallenges.org/grant/discov... @modmedmicro.bsky.social @samlipworth.bsky.social @philipwfowler.bsky.social
gcgh.grandchallenges.org
Discovery of Novel Klebsiella Hits Through In-Depth Genomic Profiling, Fragment-Based Drug Design and Accumulation Assays
Annette von Delft and collaborators Nicole Stoesser, Lizbe Koekemoer, Ed Griffen, Paul Brennan, Frank von Delft, Phil Fowler, and Thomas Lanyon-Hoggat of the University of Oxford in the United Kingdom...
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nstoesser.bsky.social @nstoesser.bsky.social · 13/01/2026
Univ of Oxford UNIQ+ scheme applications open: 7-week research internship this Summer www.ox.ac.uk/admissions/g.... Lots of projects - one in our lab on microplastics & AMR & hospital environments at @modmedmicro.bsky.social led by Aram Swinkels www.ox.ac.uk/admissions/g... (Clin Med 04). Join us!
ox.ac.uk
What is UNIQplus? | University of Oxford
The UNIQplus programmeThe UNIQplus programme is aimed at supporting talented undergraduates from under-represented groups, who would find continuing into postgraduate study a challenge for reasons
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Bash the bug @bashthebug.net · 18/12/2025
Read the full paper here: tinyurl.com/2a5z6tt8
tinyurl.com
Nanopore adaptive sampling for bacterial identification from periprosthetic joint replacement tissue
Metagenomic approaches to the diagnosis of prosthetic joint infections promise more accurate and more rapid diagnosis. However, the high host DNA to bacterial DNA ratio is a challenge. Nanopore adapti...
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Bash the bug @bashthebug.net · 18/12/2025
🔬 New blog post! Infections after joint replacement are serious, and identifying the bacteria quickly is crucial for patient care. We explain our research into metagenomic sequencing—reading all DNA in a sample to identify bacteria without needing lab growth. 👉 tinyurl.com/mrh8ukha #AMR #Genomics
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Modernising Medical Microbiology @modmedmicro.bsky.social · 17/12/2025
Our paper is out in Microbial Genomics! 🧬 We evaluate gnomonicus, an open-source AMR prediction tool, using 2,663 Mycobacterium tuberculosis genomes—showing how WGS can deliver faster, scalable TB resistance predictions. Read the full paper here🔗 bit.ly/4iZepd1 #TB #AMR #Genomics
bit.ly
Characterizing the performance of an antibiotic resistance prediction tool, gnomonicus, using a diverse test set of 2,663 Mycobacterium tuberculosis samples
Tuberculosis remains a global health problem. Making it easier and quicker to identify which antibiotics an infection is likely to be susceptible to will be a key part of the solution. Whilst whole-ge...
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Modernising Medical Microbiology @modmedmicro.bsky.social · 09/12/2025
📢Job Alert! Translational Research Collaboration Manager in Infectious Disease and Antimicrobial resistance. 🦠💊 Know anyone who would be good? Pass it on! www.imperial.ac.uk/jobs/search-...
imperial.ac.uk
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
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Bash the bug @bashthebug.net · 20/11/2025
Our team wore blue for World Antimicrobial Awareness Week 2025💙 Research into how resistance emerges, spreads and can be prevented is vital. Our group works to understand these processes and develop better tools to detect, monitor and combat antimicrobial resistance. #WAAW @oxfordbrc.bsky.social
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NIHR Biomedical Research Centre: Oxford @oxfordbrc.bsky.social · 20/11/2025
This World Antimicrobial Resistance Awareness Week #WAAW, we’re championing our microbiology and infection researchers whose work is benefiting patients and informing health care policy. Read: oxfordbrc.nihr.ac.uk/research-the... @ox.ac.uk @ouhospitals.bsky.social @modmedmicro.bsky.social
oxfordbrc.nihr.ac.uk
Modernising Medical Microbiology and Big Infection Diagnostics | NIHR Oxford Biomedical Research Centre
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Bash the bug @bashthebug.net · 19/11/2025
Why is antimicrobial awareness important? Antimicrobial resistant infections are rising. In the next 25 years an estimated 39.1 million people globally will die from infections with antimicrobial resistance. So what can you do to help? Something as simple as finishing your course of antibiotics!
An infographic stating that between now and 2050, 39.1 million people globally will die from infections attributed to antimicrobial resistance. This number is equivalent to over half the current UK population.An infographic stating that taking your full course of antibiotics can help reduce antimicrobial resistance and save lives.
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Modernising Medical Microbiology @modmedmicro.bsky.social · 18/11/2025
For #WorldAntimicrobialAwarenessWeek, we introduce our recent paper on antibiotic-resistant subpopulations in TB. TB may be one of humanity’s oldest diseases, yet it still kills over 1M people yearly. As resistance spreads, knowing each patient’s resistance profile before treatment is vital. 🧬💊
academic.oup.com
Subpopulations in clinical samples of M. tuberculosis can give rise to rifampicin resistance and shed light on how resistance is acquired
AbstractObjectives. WGS has become a key tool for diagnosing Mycobacterium tuberculosis infections, but discrepancies between genotypic and phenotypic drug
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Bash the bug @bashthebug.net · 18/11/2025
Antimicrobial resistance occurs when bacteria, viruses, fungi & parasites change over time - leading to medicines being less effective against them. Here you see bacteria growing and antibiotics (the small discs) which kill the bacteria...unless they are resistant! #WAAW #AMR @oxfordbrc.bsky.social
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NIHR Biomedical Research Centre: Oxford @oxfordbrc.bsky.social · 11/11/2025
Are you interested in infections, the micro-organisms that cause them and antimicrobial resistance? So are @bashthebug.net and they're looking for new members to join their patient & public group. More info: bashthebug.net/lay-represen... Deadline 27 Nov @ouhospitals.bsky.social @medsci.ox.ac.uk
x.com
Bash The Bug (@BashTheBug) / X
Bash The Bug (@BashTheBug) / X
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fowlerlab.org @fowlerlab.org · 17/10/2025
New paper by @vbrunner.bsky.social looking at detecting rifampicin resistant subpopulations in M. tuberculosis infections using genetics and putting a lower limit on the proportion that arose due to secondary infections. bit.ly/47rwf42 @modmedmicro.bsky.social @oxfordbrc.bsky.social
bit.ly
New paper: What can subpopulations tell us about rifampicin resistance?
Last Thursday this work which we'd previously preprinted looking at looking at rifampicin-resistant subpopulations in clinical M. tuberculosis samples was published in JAC-Antimicrobial Resistance. If...
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Sam Lipworth @samlipworth.bsky.social · 15/10/2025
🔔🔔Post-doc in microbial genomics with @modmedmicro.bsky.social🧬 - deadline tomorrow! Big genomic and clinical datasets to play with, friendly and very multidisciplinary team! my.corehr.com/pls/uoxrecru...
my.corehr.com
Job Details
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Viktoria Brunner @vbrunner.bsky.social · 13/10/2025
Our recent paper on rifampicin resistant subpopulations in M. tuberculosis (M. tb) has been published at JAC-antimicrobial resistance. I am really happy to see this work published just hours before submitting my DPhil thesis! 🔗👇 doi.org/10.1093/jaca...
doi.org
Subpopulations in clinical samples of M. tuberculosis can give rise to rifampicin resistance and shed light on how resistance is acquired
AbstractObjectives. WGS has become a key tool for diagnosing Mycobacterium tuberculosis infections, but discrepancies between genotypic and phenotypic drug
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Sam Lipworth @samlipworth.bsky.social · 08/10/2025
We have a fully funded PhD studentship available @modmedmicro.bsky.social in Oxford to work on a really cool project looking at population heterogeneity in bloodstream infections www.ndm.ox.ac.uk/study/dphil-... Please spread the word/get in touch if you'd like to chat.
ndm.ox.ac.uk
DPhil project themes
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Will Matlock @wtmatlock.bsky.social · 30/09/2025
Now published in @natcomms.nature.com 🎉 www.nature.com/articles/s41... With Gillian Rodger, @nstoesser.bsky.social, @samlipworth.bsky.social, @stat-sarah.bsky.social, and many others!
nature.com
Escherichia coli phylogeny drives co-amoxiclav resistance through variable expression of TEM-1 beta-lactamase - Nature Communications
This study found E. coli phylogenetic background shapes TEM-1 beta-lactamase expression and co-amoxiclav resistance. Phylogeny alone shifted isolates from susceptible to resistant, stressing a need for lineage-sensitive genotype-phenotype prediction.
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Dorottya Nagy @dotnagy.bsky.social · 30/09/2025
🧪 ♻️ Want to make lab and computational research more sustainable? Check out our Oxford Climate Society blog post: oxfordclimatesociety.com/blog/from-pi... Shout out to Green Team colleagues @modmedmicro.bsky.social for helping! #LEAFAward #GreenDiSC #GreenImpact #SustainableScience
Photo of the Modernising Medical Microbiology Green Team wearing protective clothing, helmets, and safety goggles at the Ardley Energy Recovery Centre during their field trip to see first hand how Oxfordshire waste is burned, instead of ending up in landfill, to generate electricity.
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