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Ryuji Yanase

@ryanase.bsky.social
300 followers 439 following 12 posts

Senior Research Scientist at the National Institute of Infectious Diseases (NIID), Japan Institute for Health Security (JIHS) studying the cell & molecular biology of parasitic Excavata & amoebae

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Reposted by Ryuji Yanase
Andrew Kennard @askennard.bsky.social · 19/08/2026
The kinetochore is essential for cell division across species, but its components and organization evolve dramatically. How can that be? Our first foray into this fascinating question is up now on biorxiv: 🧪 1/12 www.biorxiv.org/content/10.6...
biorxiv.org
Kinetochore diversification in Naegleria reveals plasticity in the kinetochore-microtubule interface
The kinetochore--the molecular machine that couples chromosomes to spindle microtubules--performs an essential, tightly regulated function, yet varies dramatically across eukaryotes. Microtubules are ...
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Scott Coyle @cellraiser.bsky.social · 24/06/2026
@zjmaggiexu.bsky.social's story on suctorian trap structure adaptation is now online in @currentbiology.bsky.social , with new evolutionary analyses and modeling! This fall, Maggie will keep exploring predatory protists as a PD in @nbellono.bsky.social group; keep an eye out for her she's amazing!
sciencedirect.com
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Nature Communications @natcomms.nature.com · 15/05/2026
#Symbiosis Magnetoreception in a freshwater ciliate arises from endosymbiosis The endosymbiotic bacteria produce magnetite crystals, allowing the protist to move efficiently in stratified waters dlvr.it/TSYMwZ
Visualization of the four types of endosymbiotic bacteria within the protist.
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Ryuji Yanase @ryanase.bsky.social · 15/05/2026
Pleased to share that our paper on Plasmodium NEK4 is now published in @natcomms.nature.com. We show that NEK4 act as a key regulator coupling meiotic entry with cytoskeletal morphogenesis, coordinating microtubule formation and nuclear dynamics in malaria parasites. www.nature.com/articles/s41...
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Dr Joanne Power @hanniepower.bsky.social · 09/04/2026
Thank you so much to everyone who made it to #BSP2026 in beautiful, sunny Glasgow!!! (We asked the weather to behave while everyone was around)! The @bspparasitology.bsky.social 2027 meeting will be in Cardiff! I hope everyone enjoyed themselves! Like Glasgow, People Make #Parasitology! 🥳🧬🧫🔬
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Helen Price @helenpprice.bsky.social · 07/04/2026
Our Spring meeting starts today in Glasgow! All the best to all those presenting @bspparasitology.bsky.social
Logo for the 2026 BSP Spring meeting of buildings in Glasgow and parasites flying above them
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Bungo Akiyoshi @bungoakiyoshi.bsky.social · 01/04/2026
New preprint! We identified many components that localize to the structure involved in "eating" in a marine organism. #ProtistOnSky #diplonemid www.biorxiv.org/content/10.6...
biorxiv.org
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Ryuji Yanase @ryanase.bsky.social · 08/04/2026
I have officially started my new position as a Senior Research Scientist at the National Institute of Infectious Diseases (NIID) 🇯🇵. My new research group will focus on the cell/molecular biology of parasitic Excavata & amoebae (incl. Trypanosoma, Naegleria, Acanthamoeba, & more) (1/3)
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Thibaut Brunet @thibautbrunet.bsky.social · 28/02/2026
Final version @nature.com of our paper describing unconventional multicellular development in a choanoflagellate inhabiting an extreme environment. A ton of new data since the first @biorxivpreprint.bsky.social preprint (which we've kept updating). A brief 🧵 (carried over from the old place)
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Eelco Tromer @eelcotromer.bsky.social · 26/02/2026
Now in Nature Comms w/ @ritatewari.bsky.social, Pushkar Sharma & @ryanase.bsky.social (thanks!). Aurora kinases fascinate me: single ancestor - parallel duplications in eukaryotes - paralogs with distinct functions. ARK1 is the CPC Aurora in the malaria parasite. rdcu.be/e5NRT #plasmodium #mitosis
rdcu.be
Plasmodium ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex
Nature Communications - This study reveals that the malaria parasite Plasmodium uses a unique Aurora kinase complex to control cell division. This divergent machinery regulates spindle formation...
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Andrew Roger @andrewjroger.bsky.social · 23/02/2026
Before he passed away in 2021, Tom Cavalier-Smith had drafted parts of his autobiography. It's now 'published' because Gáspár Jékely put a lot of effort in! Please enjoy and share: doi.org/10.5281/zeno...
doi.org
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Bungo Akiyoshi @bungoakiyoshi.bsky.social · 23/02/2026
What I have been arguing is that without knowing the root position, one cannot conclude that Euglenozoa (or any group) are monophyletic. You make an assumption that the root is not within Euglenozoa when you say Euglenozoa are monophyletic.
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Bungo Akiyoshi @bungoakiyoshi.bsky.social · 13/02/2026
I appreciate the comments by Max Raas, Eelco Tromer and others on my paper published last year "Hypothesis that ancestral eukaryotes sexually proliferated without kinetochores or mitosis". However, I do not think their critiques can reject my hypothesis. For details, please read the paper. 1/n
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kinetoplastids papers @kinetoplastpapers.bsky.social · 14/02/2026
Euglenozoa are paraphyletic if the eukaryotic root lies between glycomonads and the rest of eukaryotes. Response to 'The LECA had a conventional kinetochore and the kinetoplastid kinetochore is a derived feature' pubmed.ncbi.nlm.nih.gov/41685547/
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Kirsty Wan @micromotility.bsky.social · 20/02/2026
Great to see our paper on light-intensity dependent swimming patterns in #Chlamydomonas out now in Phys Rev Lett. as an Editors' suggestion! With a nice commentary by @philipcball.bsky.social. Chlamy actively modulate the beat planes of their #cilia! journals.aps.org/prl/abstract... #protistsonsky
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Gautam Dey @gautamdey.bsky.social · 04/02/2026
Thank you @mollyherring.bsky.social for the stunning showcase 😍 Like what you see? Come ExM with us! Let’s flood the internet with microbial marvels 🦠 #ProtistsOnSky #MicroEvoSky 🧪🔬🌍 @dudinlab.bsky.social @centriolelab.bsky.social @moorefound.bsky.social @embl.org @erc.europa.eu @embo.org
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Imperial Life Sciences @imperiallifesci.bsky.social · 04/02/2026
New PNAS study identifies ESBX, a protein controlling which surface coat gene is active in sleeping sickness parasites - key to immune evasion. @tiengwe-tryplab.bsky.social @zephyris-science.bsky.social @fariatrypslab.bsky.social www.imperial.ac.uk/news/article...
imperial.ac.uk
Scientists reveal how sleeping sickness parasites control their surface coat
Researchers have revealed how parasites hide thousands of antigens behind a single-colour coat and how disrupting this control could make the parasit...
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Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦ @dudinlab.bsky.social · 26/12/2025
Another #notTHECover unfortunately. But this gorgeous, Tron-like vibe, drawn by the amazing @munafomarzia.bsky.social for our recent #ExM work with @gautamdey.bsky.social & @centriolelab.bsky.social will still be printed out in the lab. Read here: www.cell.com/cell/fulltex...
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Bungo Akiyoshi @bungoakiyoshi.bsky.social · 22/12/2025
The discovery of the first kinetochore proteins (CENP-A, CENP-B, CENP-C) was reported by Bill Earnshaw and Naomi Rothfield in 1985 in Chromosoma. Forty years later, Chromosoma/Chromosome Research has published a special issue (most articles are open access) link.springer.com/collections/...
link.springer.com
40 years of CENP-A
In 1985, Earnshaw and Rothfield published in Chromosoma a landmark discovery of the centromere-specific protein CENP-A. Subsequent research has shown that ...
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Florent Waltz @florentwaltz.bsky.social · 19/12/2025
Final version is out! Our large-scale cryo-ET dataset 🔬 of Chlamydomonas reinhardtii 🦠 is now published in @cp-molcell.bsky.social Huge collaborative effort! So glad to see the community already using it to develop new resources & tools. Check it out here: shorturl.at/z4i4c #CryoEM #CryoET
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Gautam Dey @gautamdey.bsky.social · 19/12/2025
Thanks @jcellsci.bsky.social for this opportunity to contribute to your centenary collection with our take on the state of the field - 10 years after its modern reincarnation 🧪🌍 W/ @alebenoit.bsky.social @eelcotromer.bsky.social @fritzlaylin.bsky.social journals.biologists.com/jcs/article/...
journals.biologists.com
Evolutionary cell biology comes of age
Summary: This Perspective discusses how the discipline of evolutionary cell biology, by integrating evolutionary theory, comparative physiology and modern molecular approaches, works to understand how...
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Scott Coyle @cellraiser.bsky.social · 17/12/2025
New in ACS SynBio: led by Dennis Bolshakov, we used the awesome power of yeast to define how expression levels, noise, and sequence program the dynamics of synthetic protein waves, allowing us to genetically encode new cellular timescales stable over generations! pubs.acs.org/doi/full/10....
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Luis Javier Galindo @luisjagago.bsky.social · 15/12/2025
Are you very busy but still want to learn what Aphelids are and why they are important to understand the evolution of Fungi? Then check out our “Quick guide” on Aphelids published in collaboration with @deemteam.bsky.social, Sergey and Guifré. #protistsonsky doi.org/10.1016/j.cu...
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kinetoplastids papers @kinetoplastpapers.bsky.social · 12/12/2025
Anatomy and mechanics of tsetse fly blood feeding www.biorxiv.org/content/10.64898/2025.12.08.692967v1
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PLOS Biology @plosbiology.org · 04/12/2025
#Diplonemids are among the most diverse & abundant #protists in the deep #ocean. This study localises >5,000 proteins of #Paradiplonema papillatum, revealing #organelle compartmentalisation, including a membrane coated with carbohydrate-degrading enzymes @plosbiology.org 🧪 plos.io/3XvmpIO
Endogenous tagging of novel proteins confirms supervised cluster predictions. Left: Tagged proteins highlighted (black) among relevant predicted clusters, resolved on neighbor-averaged imputed t-SNE. Right: Individual cell lines were generated via endogenous tagging and imaged through fluorescence microscopy for comparison with the compartment-relevant protein was predicted to. Merged microscopy images showing protein signal (green) merged with nuclear and mitochondrial DNA (blue). All imaged cells are oriented with their apical regions facing right and posterior facing left, cell membrane outlines are traced for all images except for L, showing only trace of the papilla, which lacks signal. Scale bar represents 5 μm.
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bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 04/12/2025
Differential contributions of β tubulin isotypes to acentrosomal oocyte meiosis in C. elegans www.biorxiv.org/content/10.64898/20…
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Jiménez-Ruiz Lab @jimenezruizlab.bsky.social · 28/11/2025
Our new paper is out in Nature Communications! 🎉 We explore how Toxoplasma gondii organizes parasite development, combining cell biology and expansion microscopy to reveal new structural insights. #Toxoplasma @meissnerlab.bsky.social @natcomms.nature.com www.nature.com/articles/s41...
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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 27/11/2025
New Online! Critical constituents and assembly principles of centriole biogenesis in human cells
bit.ly
Critical constituents and assembly principles of centriole biogenesis in human cells
Nature Reviews Molecular Cell Biology, Published online: 27 November 2025; doi:10.1038/s41580-025-00921-5The centriole is crucial for fundamental cellular processes in eukaryotes, including cell polarity, signalling and motility. This Review discusses recent insights into the molecular architecture of centrioles and the principles governing their assembly, with a focus on human cells.
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Gautam Dey @gautamdey.bsky.social · 26/11/2025
Our attempt to give multinucleate cells the spotlight they deserve (seriously, they’re everywhere), led by the fearless @mrosjac.bsky.social and with @Markus Ganter doi.org/10.32942/X2M... We’d love your feedback while this goes through the peer review process! #MicroEvoSky #ProtistsonSky 🧪🌏
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Jana Helsen @helsenjana.bsky.social · 26/11/2025
How do new centromeres evolve while staying compatible with the division machinery? Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore. 👉 doi.org/10.1038/s41586-025-09779-1
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Scott Coyle @cellraiser.bsky.social · 18/11/2025
How do cells adapt morphology to function? In a 🔥 preprint by @zjmaggiexu.bsky.social , with @dudinlab.bsky.social and @amyweeks.bsky.social , we identify a self-organizing single-cell morphology circuit that optimizes the feeding trap structure of the suctorian P. collini. 🧵 tinyurl.com/4k8nv926
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Ryuji Yanase @ryanase.bsky.social · 24/11/2025
Our new preprint describes Plasmodium NEK4 as a key regulator coupling meiotic initiation and morphogenesis—a critical step for malaria transmission. This involves MTOC-driven nuclear movement strikingly analogous to "horsetail" movement in fission yeast. www.biorxiv.org/content/10.1...
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Healthcare-Global @healthcare-global.bsky.social · 18/10/2025
people.com/deadly-kissi...
people.com
Deadly ‘Kissing Bug’ Disease Chagas Has Spread in the U.S. — Here’s Which States Are Affected
The Centers for Disease Control and Prevention (CDC) reported that the triatomine insect — called the 'kissing bug' — has been found in 32 states in the U.S. and that there could be more than 300,000 ...
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PLOS Biology @plosbiology.org · 10/10/2025
The flagellar pocket collar (FPC) is a cytoskeletal structure essential for nutrient uptake & immune evasion in #Trypanosome. @mbonhivers.bsky.social &co use U-ExM to provide novel insights into FPC biogenesis, and reveal 2 unknown cytoskeletal structures @plosbiology.org 🧪 plos.io/4n3bWi6
A Trypanosoma brucei cell visualized by confocal microscopy after ultrastructure expansion. The cell was immunolabelled for the BILBO1 protein (yellow) and stained with fluorescent NHS-ester (grey). The flagellar pocket is highlighted in pink. Credit: Marie Zelená
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Ben Engel @cellarchlab.com · 25/09/2025
Time for a thread!🧵 How different is the molecular organization of thylakoids in “higher” plants🌱? To find out, we teamed up with @profmattjohnson.bsky.social to dive into spinach chloroplasts with #CryoET ❄️🔬. Curious? ..Read on! #TeamTomo #PlantScience 🧪 🧶🧬 🌾 elifesciences.org/articles/105... 1/🧵
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eLife @elife.bsky.social · 20/09/2025
🌱 Using ‘compelling’ methods, including #CryoET, researchers mapped spinach thylakoid membranes at single-molecule precision, revealing how photosynthetic complexes are organised and settling long-standing debates on chloroplast architecture. buff.ly/j3TSIkn
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Trends in Parasitology @cp-trendsparasitol.bsky.social · 04/09/2025
Our 2025 Sep issue bit.ly/2N9R8Es reviews species sanitation & structural resilience in malaria control, animal trypanosomosis control, parasite genome organization, Leishmania attachment in sandflies, nonchemotherapeutic nematode control, tick & host microbiotas, parasitic neural manipulation &more
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British Society for Parasitology @bspparasitology.bsky.social · 01/09/2025
A big welcome to everyone who has joined us for the @bspparasitology.bsky.social trypanosomiasis and leishmaniasis meeting this week in the beautiful city of Ceske Budějovice!
Title slide being projected on a screen for the BSP trypanosomiasis and leishmaniasis seminarView of Ceske Budějovice from above. Beautiful city with coloured houses on a clear sunny day
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Tanmay Bharat @tbharat-lab.bsky.social · 31/08/2025
Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social www.biorxiv.org/cgi/content/... @mrclmb.bsky.social @wellcometrust.bsky.social
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Eelco Tromer @eelcotromer.bsky.social · 31/08/2025
New work on ARK1 (AURKB?) in Plasmodium (malaria parasite) with @ritatewari.bsky.social and Pushkar Sharma. CPC in Plasmodium is (ofcourse..) different compared to conventional models: two INCENPs, no borealin/survivin - mainly at spindle microtubules/MTOCs. Special thanks to @ryanase.bsky.social!
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Ryuji Yanase @ryanase.bsky.social · 28/08/2025
Pleased to share our new preprint: "Plasmodium ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex". Many thanks to our collaborators. @ritatewari.bsky.social @eelcotromer.bsky.social @davidguttery.bsky.social www.biorxiv.org/content/10.1...
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Kristina Prokina @kristina-prokina.bsky.social · 26/08/2025
New paper is out! We have studied the cute tiny Discocelia plataet sp. n. to obtain the first molecular data of the order Discocelida and clarify its cell structure. All this for a better understanding of the evolution of Cercozoa. onlinelibrary.wiley.com/doi/epdf/10....
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Faria Tryps Lab @fariatrypslab.bsky.social · 11/08/2025
How do parasites strategically organise their genomes to influence gene expression? If you’re curious, check our latest review in @cp-trendsparasitol.bsky.social ! @biologyatyork.bsky.social @ybri-uoy.bsky.social @pasteur.fr www.sciencedirect.com/science/arti...
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Bungo Akiyoshi @bungoakiyoshi.bsky.social · 06/08/2025
My attempt to become a professor was unsuccessful again but the diplonema tagging paper is now published in Open Biology. royalsocietypublishing.org/doi/10.1098/...
royalsocietypublishing.org
Discovery of unique mitotic mechanisms in Paradiplonema papillatum | Open Biology
Diplonemids are highly diverse and abundant marine plankton with significant ecological importance. However, little is known about their biology, even in the model diplonemid Paradiplonema papillatum ...
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Kirsty Wan @micromotility.bsky.social · 06/08/2025
We have a postdoc opening for a protistologist with biophysics inclinations to join our @hfspo.bsky.social project! (focus will be on characterising the morphology, ultrastructure and behaviour of excavates) #protistsonsky Apply by Sept 17th (RTs appreciated!) jobs.exeter.ac.uk/hrpr_webrecr...
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bishara marzook @ghostpathogen.bsky.social · 24/07/2025
Our paper has finally graduated from pre-print to peer-reviewed, pretty much unscathed, and is out now! www.cell.com/cell/fulltex...
cell.com
The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment
An arrayed microscopy-based CRISPR screen revealed host genes affecting multiple infection phenotypes of the intracellular parasite Cryptosporidium. Hits in the host cholesterol biosynthesis pathway a...
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Vasily Zlatogursky @zlatogursky.bsky.social · 24/07/2025
Promethea = PROvora + MEteora + HEmimastigophora. The new supergroup, unifying previously “orphan” lineages with gene-rich mitogenomes. Position of #telonemids is still uncertain. #protistsonsky tinyurl.com/yk9xkt49
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Trends in Parasitology @cp-trendsparasitol.bsky.social · 23/07/2025
Drs Petr Volf, Katerina Pruzinova @ryanase.bsky.social‬ & Jack Sunter review #midgut & #stomodeal #valve #attachment of #Leishmania in #sandflies. #Kinetoplastid #Haptomonad #Promastigote #SecretoryGel @sciencecharles.bsky.social‬ @charlesuni.cuni.cz‬ authors.elsevier.com/a/1lTsW5Eb1x...
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