iiinova — where your digital self keeps evolving

Calvin Tiengwe @tiengwe-tryplab.bsky.social · 28/01/2026

New preprint from @tiengwe-tryplab.bsky.social _How do trypanosomes diversify their surface antigens? We found ESAG3 - a new glucosyltransferase - novel primary and quaternary structure that's essential for generating diversity in antibody epitopes. www.biorxiv.org/content/10.6...

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Reposted by Calvin Tiengwe

bioRxivpreprint @biorxivpreprint.bsky.social · 28/01/2026

An octadecameric O-glucosyltransferase generates diversity in antibody epitopes on variant surface antigens in African trypanosomes www.biorxiv.org/content/10.64898/20…

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Reposted by Calvin Tiengwe

kinetoplastids papers @kinetoplastpapers.bsky.social · 28/01/2026

An octadecameric O-glucosyltransferase generates diversity in antibody epitopes on variant surface antigens in African trypanosomes www.biorxiv.org/content/10.64898/2026.01.27.701950v1

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Reposted by Calvin Tiengwe

AlphaFold Unofficial @alphafold.bsky.social · 20/02/2025

"Enter BioEmu-1—a deep learning model that can generate thousands of protein structures per hour on a single graphics processing unit. Today, we are making BioEmu-1 open-source" #science #ai #microsoft www.microsoft.com/en-us/resear...

microsoft.com

AI is accelerating protein discovery

Meet BioEmu-1 from Microsoft Research. This deep learning model can generate thousands of protein structures per hour, unlocking new possibilities for protein scientists and drug discovery and researc...

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Reposted by Calvin Tiengwe

Catherine Sheard @sheardcat.bsky.social · 29/01/2025

If you're a non-UK scientist who wants to come to the UK for a postdoc, this year's Newton Fellowships are now open. You'll need a lab to host you (which could be me, but truly, could be any PI, so get in touch with someone you'd like to work with!) royalsociety.org/grants/newto...

royalsociety.org

Newton International Fellowships | Royal Society

This fellowship is for non-UK scientists who are at an early stage of their research career and wish to conduct research in the UK.

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Reposted by Calvin Tiengwe

Faria Tryps Lab @fariatrypslab.bsky.social · 16/01/2025

Are you interested in #trypanosomes #biomolecularcondensates and/or #geneexpression? We are looking for a highly motivated postdoc to work with with us in the beautiful city of York! Please share! jobs.york.ac.uk/vacancy/post...

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Calvin Tiengwe @tiengwe-tryplab.bsky.social · 23/11/2024

Excited to share our gene tagging toolkit! It's a protein tagging system that maintains regulatory elements. Originally built for Kinetoplastids but adaptable to any system - no parasite-specific sequences in vectors. Prefect for studying post-transcriptional control! www.biorxiv.org/content/10.1...

biorxiv.org

A high-throughput protein tagging toolkit that retains endogenous UTRs for studying gene regulation in Kinetoplastids

Kinetoplastid parasites cause diseases that threaten human and animal health. To survive transitions between vertebrate hosts and insect vectors, these parasites rely on precise regulation of gene exp...

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