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Nature Communications - Here, Laidlaw, Garcia Sanchez and colleagues present a single-cell atlas for Trypanosoma cruzi, an important protozoan pathogen, providing insights into cell heterogeneity,...

An in vitro toolkit for studying VSG diversification defines key molecular requirements underlying the formation of mosaic VSGs, providing an experimental framework for the exploration of antigen diversification in Trypanosoma brucei and in other pathogenic microorganisms.

Nature Microbiology, Published online: 30 March 2026; doi:10.1038/s41564-026-02289-4To evade the immune system, Trypanosoma brucei relies on a specialized ‘expression site body’. Protein condensates within this nuclear compartment modulate expression of virulence genes via a targeted RNA decay mechanism.

YouTube video by MRC Laboratory of Molecular Biology

Researchers have revealed how parasites hide thousands of antigens behind a single-colour coat and how disrupting this control could make the parasit...

Nature Microbiology, Published online: 16 January 2026; doi:10.1038/s41564-025-02239-6A library of 400 phage protein-coding genes is used to find a trove of antiphage systems, revealing systems that target tail fibre and major capsid proteins.

The segregation of glycosylphosphatidylinositol-anchored proteins (GPI-APs) to distinct domains on the plasma membrane of eukaryotic cells is importan…