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Andrew Roger

@andrewjroger.bsky.social
1.3K followers 1.6K following 321 posts

deep-time evolution, phylogenetics, anaerobic protists, the tree of Life. Science depends on vigorous respectful debate and evidence-based reasoning. I like cats. This is my personal page and what I post here has nothing to do with my employer.

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Reposted by Andrew Roger
Julie Boisard @protistsforthewin.bsky.social · 18/09/2026
Now published :) doi.org/10.1093/bib/... and available here github.com/theLabUpstai...
doi.org
CoMR: an integrative scoring pipeline for comprehensive mitochondrial proteome reconstruction across eukaryotes
Abstract. Mitochondrial proteome reconstruction from eukaryotic sequence data typically relies on prediction of mitochondrial targeting signals (MTSs). How
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Andrew Roger @andrewjroger.bsky.social · 21/09/2026
The brilliant Prof. Edward Susko gave a great online lecture on modeling heterogeneity in sequence evolution in the phylogenetic context as part of the @phyloseminar.bsky.social series: www.youtube.com/watch?v=-1aJ...
youtube.com
Phyloseminar #157: Ed Susko (Dalhousie University)
YouTube video by phyloseminar.org
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Andrew Roger @andrewjroger.bsky.social · 11/09/2026
If you are interested to see an update of how the predatory Nous group (Nous Cubane) "higher education consultants" have been scamming Canadian universities, read this: breachmedia.ca/a-notorious-...
breachmedia.ca
A notorious consulting firm is selling austerity. Canada’s universities are buying ⋆ The Breach
The Nous Group, an Australian consulting firm, has raked in millions for “fixing” universities in financial freefall. Their solution? Corporatization
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Reposted by Andrew Roger
Sishuo Wang @sishuowang.bsky.social · 09/09/2026
[new preprint] By sampling new basal non-symbiotic members and applying mixture subs models (incl GTRmpix) in dating, we show a contemporaneous emergence of Bradyrhizobium nodulation and legumes using an approach that co-dates both symbionts and legumes. www.biorxiv.org/content/10.6...
biorxiv.org
Molecular clock dating under mixture substitution models indicates contemporaneous emergence of Bradyrhizobium nodulation and legumes anchored by non‑symbiotic relatives
The transition from free‑living bacteria to mutualistic symbionts is a major evolutionary innovation, but its timing and stepwise nature remain unresolved because non‑symbiotic ancestors have rarely b...
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Reposted by Andrew Roger
Wayne Maddison @waynemaddison.bsky.social · 09/09/2026
The Tree of Life web project is back! A phylogenetic view of biodiversity way ahead of its time (ca. 1995!), conceived and led by David Maddison, collaborative & human-curated, widely used in teaching. Defunct technology had doomed it until Travis, Danny, and Andrew revived it. 🥳🎉 🧪 #evolbiol
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Andrew Roger @andrewjroger.bsky.social · 01/09/2026
Another groundbreaking paper from these wizards.
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Andrew Roger @andrewjroger.bsky.social · 21/08/2026
Beautiful work!!
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Andrew Roger @andrewjroger.bsky.social · 20/08/2026
Does anyone else have the problem that their cats don't like Rammstein?
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American Society for Cell Biology @ascbiology.bsky.social · 24/07/2026
From MBoC A new localization atlas maps more than 600 Giardia proteins, revealing the locations of hundreds of previously uncharacterized proteins and creating a valuable resource for functional discovery. www.molbiolcell.org/doi/10.1091/mbc…
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Molecular Biology and Evolution @molbioevol.bsky.social · 03/08/2026
Záhonová et al. tested whether hydrogenosomes and mitosomes in Metamonada originated from an independent endosymbiosis, finding instead that these organelles originated from an Alphaproteobacterium during a single common endosymbiosis. 🔗 doi.org/10.1093/molbev/msag175 #societyjournal #compbio
doi.org
Phylogenetic ancestry of Metamonada proteins points to a common origin of mitochondria in all eukaryotes
Abstract. Hypotheses concerning eukaryogenesis, the evolution of eukaryotic cells, differ in the relative timing of mitochondrial acquisition. Recently, a
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Reposted by Andrew Roger
Dr John Clarke @jclarkepaleo.bsky.social · 03/08/2026
Our new paper introduces a fast & Bayesian state-dependent OU model in RevBayes that implements joint inference, to test adaptive macroevolutionary hypotheses. Congrats @prilau.bsky.social! Be sure to give her a follow & give her original tweet some love! Many more exciting PCMs in her future!
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Joanna Masel @joannamasel.bsky.social · 27/07/2026
Our paper on how better amino acid substitution matrices trained on cleaned alignments improve gene tree inference, and on best practice for cleaning MSAs more broadly, is now out academic.oup.com/mbe/advance-.... New options in both IQTree and Muscle5. @phylowheeler.bsky.social
academic.oup.com
Improved gene tree inference from removing alignment errors both from focal genes and when training substitution models
Abstract. Multiple Sequence Alignment (MSA) is a key step in phylogenetic analysis and is prone to error. Unfortunately, algorithms that remove likely alig
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Andrew Roger @andrewjroger.bsky.social · 25/07/2026
A really nice essay. Worth reflecting on.
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Reposted by Andrew Roger
Bornberglab @bornberglab.bsky.social · 28/01/2026
New review out in Nat Rev Genet: Emergence & evolution of protein-coding de novo genes by Erich and Lars Eicholt @lacholt.bsky.social. How non-coding DNA becomes translated, persists or is lost in populations, and can yield structured/functional proteins—plus methods & open questions! rdcu.be/e09SM
rdcu.be
Emergence and evolution of protein-coding de novo genes
Nature Reviews Genetics - De novo gene evolution entails the birth of new genes from previously non-coding DNA. In this Review, Bornberg-Bauer and Eicholt overview how protein-coding de novo genes...
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Andrew Roger @andrewjroger.bsky.social · 19/06/2026
1/ Deep-time phylogenetics is hard: overly simplistic substitution models can mislead tree estimation at the billion year timescale. Our new preprint introduces GTRspmix, a protein modeling framework designed to more realistically model site-to-site heterogeneity in amino acid replacement. 🧵
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Rowan Green @rowancallumg.bsky.social · 16/06/2026
Where are mutations most likely to happen in the genome? @mattjago.bsky.social has answers! This paper is also a masterclass in simple visualizations of complicated ideas. I really enjoyed getting deep into these results as a middle author 🧬
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ISEP @isepprotists.bsky.social · 13/06/2026
New #ISEPpapers! Diversity and evolution of DNA polymerase θ in eukaryotes and the origin of mitochondrion-localized DNA polymerase PolIA in euglenozoa www.sciencedirect.com/science/arti... #Protists #Microbes #Evolution #Mitochondria
a schematic evolutionary tree of microbes illustrating a hypothesis discussed in the linked paper
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Pawel Burkhardt @pawelburkhardt.bsky.social · 16/06/2026
How ancient are the building blocks of animal sensory systems? Key components of animal sensory systems evolved before animals. We find that choanoflagellates possess diverse & spatially segregated TRP channels, pointing to ancient origins of sensory specialization. doi.org/10.64898/202...
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Claudio Slamovits 🇦🇷🇨🇦🏳️‍⚧️🏳️‍🌈 @cslamo.bsky.social · 23/12/2025
🎄 Just published 🎉! Our ongoing genome sequencing of the basal dinoflagellate Oxyrrhis marina uncovered a new lineage of endogenized Polinton-like viruses, OmPLV. Notably, OmPLV encodes ... [cont] #VirEvol #MicroSky #Mevosky #SymbioSky #ProtistsOnSky
doi.org
Endogenized polinton-like viruses in the dinoflagellate Oxyrrhis marina uncover novel PolB fusion
Marine viruses are ubiquitous entities that impact the biology of a large fraction of prokaryotic and eukaryotic diversity. Dinoflagellates are heterotrophic, mixotrophic and photosynthetic eukaryotes...
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Andrew Roger @andrewjroger.bsky.social · 04/06/2026
Very important work!
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ISEP @isepprotists.bsky.social · 04/06/2026
New #ISEPpapers by @deemteam.bsky.social! Reversal to osmotrophy in eukaryotes www.nature.com/articles/s41... "Distant eukaryotic lineages convergently reverted from predation to osmotrophy through co-option of bacterial genes and their mobilization via eukaryote-to-eukaryote HGT" #Protists
a simplified evolutionary tree of eukaryotes
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Reposted by Andrew Roger
Heng Li @lh3lh3.bsky.social · 30/05/2026
Jeremy Wang developed rammap, a minimap2 rewrite in Rust. It achieves comparable or better performance than minimap2 and produces identical output to minimap2. During rewrite, Jeremy found two long-existing bugs in minimap2 which are fixed in v2.31. www.biorxiv.org/content/10.6...
biorxiv.org
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Andrew Roger @andrewjroger.bsky.social · 02/06/2026
I'm reposting this because I want to make a correction. In the thread below I mention using the -mset flag for testing site profile mixture models. But in fact you should use -madd flag. I'm sorry for this mistake.
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Molecular Biology and Evolution @molbioevol.bsky.social · 29/05/2026
Pisani, @elpiratavell.bsky.social et al. dissipate doubts about the utility of models accounting for compositional heterogeneity across sites and identify CAT-GTR as one of the most flexible models in the phylogenomic arsenal. 🔗 doi.org/10.1093/molbev/msag090 #evobio #molbio #phylogenomics
doi.org
Phylogenomic mixture models outperform homogeneous and partitioned models
Abstract. Significant advances have been made in resolving the tree of life, but many nodes remain debated. The last two decades saw the emergence of mixtu
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Andrew Roger @andrewjroger.bsky.social · 28/05/2026
1/ Our new paper in Systematic Biology "Modeling Site-and-Branch-Heterogeneity with GFmix" led by @cgpmcc.bsky.social describes improved ways to model compositional heterogeneity across both sites and branches—an important source of error in deep phylogenomics. doi.org/10.1093/sysb...
doi.org
Modeling Site-and-Branch-Heterogeneity with GFmix
Abstract. Phylogenetic trees are often inferred from protein sequences sampled from diverse taxa across the tree of life. The compositions of these amino a
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Andrew Roger @andrewjroger.bsky.social · 26/05/2026
Just saw a meme that said something like: "Yeah but would your thesis defend you?" which made me laugh...😂
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Reposted by Andrew Roger
Joanna Masel @joannamasel.bsky.social · 13/05/2026
We have a thread explaining it here: bsky.app/profile/joan...
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Andrew Roger @andrewjroger.bsky.social · 13/05/2026
A new method to filter alignment errors! CLOAK from @joannamasel.bsky.social 's group and collaborators: www.biorxiv.org/content/10.6...
biorxiv.org
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Andrew Roger @andrewjroger.bsky.social · 11/05/2026
Very interesting and useful thread.
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Andrew Roger @andrewjroger.bsky.social · 06/05/2026
IQ-TREE 3: Phylogenomic Inference Software using Complex Evolutionary Models academic.oup.com/mbe/article/...
academic.oup.com
IQ-TREE 3: Phylogenomic Inference Software using Complex Evolutionary Models
Abstract. IQ-TREE (https://iqtree.github.io/) is a widely used open-source software tool for efficiently inferring phylogenetic trees under maximum likelih
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Reposted by Andrew Roger
Jacquelyn Gill @jacquelyngill.bsky.social · 29/04/2026
I am begging people looking to make major donations to universities to either 1) care as much about academics as they do sports, or 2) make unrestricted gifts instead. Signed, A faculty member at a university with brand new athletic facilities and crumbling teaching and research infrastructure
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Andrew Roger @andrewjroger.bsky.social · 28/04/2026
Thank you Brian Golding!!
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Reposted by Andrew Roger
Elizabeth Jacobs, PhD @elizabethjacobs.bsky.social · 21/04/2026
RFK Jr. just said that immigration is to blame for the outbreaks of vaccine-preventable diseases in the U.S., not him.
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The Tennessee Holler @thetnholler.bsky.social · 21/04/2026
The media’s failure to cover Trump’s son-in-law Jared Kushner’s ongoing conflicts of interest as he gets billions from the Middle East while being Trump’s negotiator is insane. (Especially after what they did with Hunter Biden) popular.info/p/the-media-...
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Matthew Hahn @3rdreviewer.bsky.social · 20/04/2026
Wrote a fun little thing on gene tree discordance: authors.elsevier.com/a/1mzPI3QW8S...
authors.elsevier.com
Please wait whilst we redirect you
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
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Andrew Roger @andrewjroger.bsky.social · 20/04/2026
This will be really interesting!
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Reposted by Andrew Roger
Mohammed AlQuraishi @moalquraishi.bsky.social · 13/03/2026
New OpenFold3 preview out! (OF3p2) It closes the gap to AlphaFold3 for most modalities. Most critically, we're releasing everything, including training sets & configs, making OF3p2 the only current AF3-based model that is functionally trainable & reproducible from scratch🧵1/9
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Miguel Méndez Sandín @sandinmm.eurosky.social · 15/12/2025
New preprint out! Using ~75k environmental OTUs + 77 fossil calibrations, we reconstructed a Proterozoic timeline of eukaryote evolution. Our results show crown eukaryotes were already diversifying >1.6 Ga, long before the first undisputed fossils (~1.05 Ga). 🔗 DOI: www.biorxiv.org/content/10.6...
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ISEP @isepprotists.bsky.social · 15/04/2026
New #ISEPpapers! The genome sequence of the gastric gland parasite, #Cryptosporidium proliferans: Monika Wiśniewska et al. www.sciencedirect.com/science/arti... #Protists #Parasites #Microbes #Genomics
illustration of various aspect of biology of the microbe discussed in the article
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ISEP @isepprotists.bsky.social · 14/04/2026
New #ISEPpapers #preprint by @deemteam.bsky.social: Re-evaluating the eukaryotic Tree of Life with independent phylogenomic data www.biorxiv.org/content/10.6... #Protists #Microbes #Evolution #Eukaryotes #TreeOfLife #Phylogeny #Phylogenomics #Bioinformatics #Algae
a simplified evolutionary tree of eukaryotes with pictures of various microbes
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Courtney Stairs @cstairs.bsky.social · 11/04/2026
We stumbled upon an unusual gene called 'rqua' in the genome of some freshwater sponges. In microbes, this gene confers the ability to make a ubiquinone analog - rhodoquinone - which can help the respiratory chain run without oxygen.
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🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 11/04/2026
From Pisani et al: CAT-GTR is one of the most flexible models in the phylogenomic arsenal. Phylogenomic mixture models outperform homogeneous and partitioned models academic.oup.com/mbe/advance-...
academic.oup.com
Phylogenomic mixture models outperform homogeneous and partitioned models
Abstract. Significant advances have been made in resolving the tree of life, but many nodes remain debated. The last two decades saw the emergence of mixtu
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Andrew Roger @andrewjroger.bsky.social · 06/04/2026
Very useful article.
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Molecular Biology and Evolution @molbioevol.bsky.social · 02/04/2026
MBE is excited to launch our newest Call for Papers on the Major Transitions of Life, covering all aspects of phylogenomic research. 🔗 academic.oup.com/mbe/pages/call-for-papers-on-the-major-transitions-of-life Guest Editors: Davide Pisani Anja Spang #evobio #molbio #phylogenetics
MBE Call for Papers on the Major Transitions of Life
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Andrew Roger @andrewjroger.bsky.social · 01/04/2026
This looks interesting!
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KOJAMF🤘🖤🤘 @kojamf.bsky.social · 25/03/2026
Elizabeth Banks
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Sishuo Wang @sishuowang.bsky.social · 20/03/2026
fantastic! even more fantastically, can consider these subs models in #molecularclock dating. see a blog article "Late better than never: time to consider complex subs models in inferring div time" sishuowang2022.wordpress.com/2026/03/17/l...
sishuowang2022.wordpress.com
Late better than never: time to consider complex subs models in inferring div time
The present blog article gives some details behind a methodology paper on using mixture substitution model for molecular dating (Wang & Meade 2026), which btw is the first paper i published aft…
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Sishuo Wang @sishuowang.bsky.social · 13/03/2026
The first release of #iqtree 3 since last may is available github.com/iqtree/iqtree3 @bqminh.bsky.social
github.com
GitHub - iqtree/iqtree3: IQ-TREE version 3: software for phylogenetics
IQ-TREE version 3: software for phylogenetics. Contribute to iqtree/iqtree3 development by creating an account on GitHub.
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Andrew Roger @andrewjroger.bsky.social · 18/03/2026
Very important work!
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Andrew Roger @andrewjroger.bsky.social · 18/03/2026
So you are using IQ-TREE to estimate a tree for "deep time" phylogenetics using amino acid alignments. There is a lot of confusion about how to test model fit. Here are some suggestions.
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