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Reid Alderson

@reidalderson.bsky.social
498 followers 410 following 10 posts

Group Leader at Helmholtz Munich 🇩🇪 Disordered proteins 🍝, protein dynamics 🏃‍♂️, and #NMR 🧲 Past: UW 🦡, Oxford 🇬🇧, NIH 🇺🇸, Toronto 🇨🇦

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Reposted by Reid Alderson
Andreas Kohler @akohler-mito.bsky.social · 23/09/2026
📢 We're recruiting! A 2-year postdoctoral fellowship is available in our lab at Umeå University! Please share with interested colleagues! 🔗 umustipendie.varbi.com/en/what:job/... 📅 Application deadline: 31 October 2026 #Postdoc #Mitochondria #Proteostasis #AcademicJobs #LifeScience
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Magnetic Resonance News @nmr900.bsky.social · 03/09/2026
Congratulations to Reid Alderson ! @reidalderson.bsky.social @helmholtzmunich.bsky.social awarded the 2026 ERC Starting Grant @erc.europa.eu Protein-DANCE - Protein Dynamic Atlas from NMR-based measurements of Conformational Exchange erc.europa.eu/news-events/... #NMRchat #NMR 🧲
erc.europa.eu
ERC Starting Grants: €705 million to back Europe's next generation of researchers
The European Research Council (ERC) has today announced the winners of its latest Starting Grant competition. The funding, worth €705 million in total, will go to 421 early-career researchers across E...
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Magnetic Resonance News @nmr900.bsky.social · 01/09/2026
Angela M. Gronenborn (University of Pittsburgh) to receive the 2027 Nakanishi Prize @acs.org to recognize her significant work that extends chemical and spectroscopic methods to the study of important biological phenomena cen.acs.org/acs-news/acs... #NMRchat 🧲
cen.acs.org
ACS names 2027 National Award winners
The winners are being acknowledged for their outstanding achievements in chemistry across various fields in the discipline
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Alexander Sever @aimsever.bsky.social · 04/08/2026
Really excited to have my work on the Caspase-11 non-canonical Inflammasome complex published today in @pnas.org! Check it out below 👇 www.pnas.org/doi/10.1073/...
pnas.org
The dynamic and heterogeneous structure of the non-canonical inflammasome | PNAS
Inflammasomes are high-molecular-weight complexes that play integral roles in the innate immune system, triggering an inflammatory cascade to prote...
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bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 06/07/2026
An Atlas of Short Linear Motif-Mediated Human Protein-Protein Interactions www.biorxiv.org/content/10.64898/20…
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Toth-Petroczy lab @tothpetroczylab.bsky.social · 02/07/2026
I am honored and excited about the opportunity to lead the Department of Systems Biology at the Center for Advanced Systems Understanding (CASUS) at HZDR @casusscience.bsky.social in Görlitz and join as a Professor at BIOTEC/CMCB @biotec-tud.bsky.social. www.casus.science/news-profess...
casus.science
News — Professorship and tenured position: Saxony retains top computational biologist – CASUS – Center for Advanced Systems Understanding
Ágnes Tóth-Petróczy to become third full professor working at CASUS and BIOTEC
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paulschanda.bsky.social @paulschanda.bsky.social · 29/06/2026
Happy to see our paper out today: Guiding AlphaFold3 with experimental data. We are totally excited about the possibility to leverage the power of AlphaFold3 AND of experiments! www.nature.com/articles/s41... It has been a fantastic collaboration with great colleagues in the Bronstein team at ISTA.
nature.com
Experiment-guided AlphaFold3 resolves measurement-consistent protein ensembles - Nature Biotechnology
A generative model using AlphaFold3 as prior infers protein conformational ensembles consistent with measured experimental data.
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Magnetic Resonance News @nmr900.bsky.social · 09/06/2026
@uofguelph.bsky.social Researchers at the University of Guelph & University of Toronto, led by Siavash Vahidi and Lewis E. Kay, together with Waters Corp, used NMR to identify a potential drug target in the tuberculosis stress-response system news.uoguelph.ca/2026/06/u-of... #NMRchat #NMR 🧲
news.uoguelph.ca
U of G Researchers Identify Potential Tuberculosis Target
New University of Guelph tuberculosis research, published in Nature Communications, sheds light on the role of the proteasome, the bacterial equivalent of a recycling centre, where damaged proteins ar...
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Reposted by Reid Alderson
Magnetic Resonance News @nmr900.bsky.social · 27/05/2026
PhD position in NMR-based structural biology in the Reid Alderson lab at Helmholtz Munich, the Bavarian NMR Center www.bnmrz.org the Technical University of Munich, solution-state NMR, protein biochemistry & AI-based computational modeling, contact @reidalderson.bsky.social #NMRjobs #NMRchat 🧲
bnmrz.org
BNMRZ - Bayerisches NMR-Zentrum
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Cell & Systems Biology (CSB) @uoftcellsysbiol.bsky.social · 20/05/2026
You can read more details about this research projecting chemical properties into high-dimensional space for functional prediction at @pnas.org www.pnas.org/doi/10.1073/...
pnas.org
A functional map of the human intrinsically disordered proteome | PNAS
Intrinsically disordered regions (IDRs) represent at least one-third of the human proteome and defy the established structure–function paradigm. Be...
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Cell & Systems Biology (CSB) @uoftcellsysbiol.bsky.social · 20/05/2026
It has been difficult to infer protein function from intrinsically disordered regions (IDRs), but new research from the Moses lab and Forman-Kay lab predicts the biological function of thousands of human IDRs for the first time! www.artsci.utoronto.ca/news/new-map...
artsci.utoronto.ca
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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 29/04/2026
"The ERC Scientific Council has listened to the concerns from members of the research community about the recent announcement on changes to the re-submission rules." erc.europa.eu/news-events/...
The clear request from the community has been for the ERC to reconsider how we manage the growing demand with an unchanged total budget. In the 2027 Work Programme, we have thus decided not to change the re-submission restrictions for Starting, Consolidator, Advanced and ERC Plus Grants from those employed over the past years (see footnote). However, we will use wider restrictions when it comes to applications for Synergy Grants (see footnote). Eligibility for the 2027 StG, CoG and AdG calls will follow the same rules as in the past: 
Applicants who received a C score at step 1 in the 2025 or 2026 StG/CoG/AdG call are not eligible.
Applicants who received a B score at step 1 in the 2026 StG/CoG/AdG call are not eligible. 

Eligibility for the 2027 ERC Plus call will be as follows: 
Applicants who received a C score at step 1 in the 2025 or 2026 StG/CoG/AdG call are not eligible. 
Applicants who received a B score at step 1 in the 2026 StG/CoG/AdG call are not eligible. 
Applicants who were not retained at step 1 in the 2026 ERC Plus call are not eligible. 

Eligibility for the 2027 SyG call will be as follows: 
Applicants who received a C score at step 1 in the 2025 or 2026 SyG/StG/CoG/AdG call are not eligible. 
Applicants who received a B score at step 1 in the 2026 SyG/StG/CoG/AdG call are not eligible.
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georghochberg.bsky.social @georghochberg.bsky.social · 04/04/2026
I will probably be hiring either a PhD or a Postdoc in the near future. If you are interested in deep biochemical history or molecular mechanisms of evolution please get in touch.
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Pedro Beltrao @pedrobeltrao.bsky.social · 31/03/2026
We have updated the yeast AlphaFold3 co-folding map. The 15GB docker also has an updated streamlit app that is more responsive and easier to search through if you want to just browse the results. There will be many false positives ! We added known interactions for those wanting to filter.
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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 17/03/2026
AlphaFold database has entered the era of complexes. Together with NVIDIA, DeepMind and EBI, we use ColabFold, OpenFold and MMseqs2-GPU to predict ~31 million complexes (homo & hetro-dimers) resulting in 1.8 million high-quality predictions 📄 research.nvidia.com/labs/dbr/ass... 🌐 alphafold.ebi.ac.uk
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Magnetic Resonance News @nmr900.bsky.social · 22/01/2026
EMBO Practical Course: Structural dynamics, interactions & function of biological macromolecules by NMR @embo.org 📅 July 24–31, 2026 📍 BNMRZ, Technical University of Munich (Garching) 📝 Registration open | Deadline: Apr 17, 2026 🔗 embo2026.bnmrz.org #NMR #StructuralBiology #EMBO #NMRchat 🧲
EMBO Practical Course: Structural dynamics, interactions & function of biological macromolecules by NMR
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Reposted by Reid Alderson
paulschanda.bsky.social @paulschanda.bsky.social · 14/01/2026
📢 New preprint alert! How do proteins enter mitochondria? We uncovered a surprising mechanism at the mitochondrial entry gate—using #NMR, in vivo single-particle tracking, yeast experiments, and MD simulations to crack the code. www.biorxiv.org/content/10.6... #StructuralBiology #Mitochondria 🧵 1/8
biorxiv.org
A dynamic displacement mechanism drives protein import into mitochondria
Most mitochondrial proteins are produced in the cytosol and imported through the translocase of the outer mitochondrial membrane (TOM) to reach their final destination. Although this protein entry gat...
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Magnetic Resonance News @nmr900.bsky.social · 23/12/2025
EMBO @embo.org Practical Course, Structural dynamics, interactions and function of biological macromolecules by NMR, July 24-31, 2026, Bayerisches NMR-Zentrum (BNMRZ) Technical University of Munich, Garching embo2026.bnmrz.org Application & registration will open in January #NMRchat 🧲
embo2026.bnmrz.org
EMBO 2026
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Magnetic Resonance News @nmr900.bsky.social · 29/05/2025
AIP Structural Dynamics, request for submissions, Special Issue, Tribute to a Lifelong Innovator: Prof John Markley @nmrfam.bsky.social and the Evolution of Biomolecular NMR. Submission Deadline: December 31, 2025 publishing.aip.org/publications... #NMRchat #NMR 🧲
publishing.aip.org
Tribute to a Lifelong Innovator: John Markley and the Evolution of Biomolecular NMR - AIP Publishing LLC
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Biophysical Society @biophysicalsoc.bsky.social · 15/12/2025
Join 2026 BPS Lecturer Lewis Kay on Tuesday, February 24, 2:00 PM - 3:00 PM at #bps2026 for an informal and inspiring discussion. Dr. Kay will share insights from his scientific career—from pioneering discoveries to lessons learned along the way—and reflect on how the field continues to evolve.
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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 09/12/2025
Our review on Integrative modelling of biomolecular dynamics 💃 is now live at COSB We discuss approaches to integrate computational methods with time-dependent & time-resolved experiments to study protein dynamics With @dariagusew.bsky.social & Carl G. Henning Hansen doi.org/10.1016/j.sb...
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Toth-Petroczy lab @tothpetroczylab.bsky.social · 01/12/2025
I am honored and proud to work with my amazing group @mpi-cbg.de and @csbdresden.bsky.social 🥰 🧬. Thanks to all my colleagues for the wonderful scientific environment. And thank you @kboes.bsky.social for preparing this superb video! 🤩
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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 27/11/2025
#AlphaFold is five years old — these charts show how it revolutionized science 40k citations Alphafold database has been used by more than 3.3 million people worldwide www.nature.com/articles/d41...
nature.com
AlphaFold is five years old — these charts show how it revolutionized science
Since it was unveiled in 2020, Google DeepMind's game-changing AI tool has helped researchers all over the world to predict the 3D structures of hundreds of millions of proteins.
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Borja Mateos @borjaml.bsky.social · 24/11/2025
Happy to contribute to this work!
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Sattler Lab @sattler-lab.bsky.social · 11/11/2025
Looking back on an inspiring and stimulating two days at the Ultra-Highfield NMR and 4D Structural Biology Symposium. Huge thanks to all speakers, participants, and organizers for making this such an insightful and engaging event! 🧲🧬
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Paolo De Los Rios @paolodelosrios.bsky.social · 07/11/2025
Fantastic opportunity! Great project with a great PI. A no-miss opportunity
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Technische Universität München @tum.de · 06/11/2025
Misfolded proteins can cause #Alzheimers, #Parkinsons and #Cancer. Johannes Buchner, part of the CHAPEROME team, receives an #ERC Synergy Grant to study how chaperone #proteins keep cells healthy: go.tum.de/904052 👏 #ERCSyG #biotechnology @erc.europa.eu 📷A. Heddergott
go.tum.de
Highly endowed ERC Synergy Grant for Prof. Johannes Buchner
Disease-causing proteins – ERC Synergy Grant for research at TUM on the role of chaperone “helper proteins.”
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PMC Protein Modules Community @pmc-modularity.bsky.social · 15/08/2025
We are back with an exciting seminar on September 8 at 3pm CEST! We’ll hear from Prof. Birthe Kragelund and Maximilian Vieler (@uu.se). Register to attend: tinyurl.com/PMCseminar2 Recordings of previous seminars: www.youtube.com/@PMCModularity
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Chris Waudby @chriswaudby.bsky.social · 28/08/2025
I’m carrying out a short survey of NMR TITAN users - if you’ve made use of this tool in your research, or have suggestions for its future development, I’d be grateful for your input: forms.gle/MMXYwSozszhi... #nmrchat
forms.gle
NMR TITAN user survey
This survey aims to assess the impact of NMR TITAN on biomolecular research and identify priorities for future development. The form should take approximately 5 minutes to complete. Your responses may...
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Biophysical Society @biophysicalsoc.bsky.social · 27/08/2025
Get important feedback from your community and move your work forward. Share your research at #bps2026! Submit an abstract today buff.ly/oOjstk6
biophysics.org
BPS2026 Annual Meeting | Biophysical Society
The BPS2026 Annual Meeting in San Francisco will showcase Biophysics by the Bay, highlighting the exciting advances in science and technology brought forth by big data and AI.  This year’s program…
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Helmholtz Munich @helmholtzmunich.bsky.social · 13/08/2025
#HelmholtzMunich’s BNMRZ has joined Germany’s Instruct-ERIC Centre 🔬 Instruct-ERIC provides open access to advanced structural biology technologies. #BNMRZ advances innovation in #NMR methods, drug discovery, and imaging - boosting the German Centre’s capabilities. 👉 Read more: t1p.de/pjtyv
Helmholtz Munich Joins Germany’s Instruct-ERIC Centre for Structural Biology
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Magnetic Resonance News @nmr900.bsky.social · 08/08/2025
Nature Communications (open) Seedless: on-the-fly pulse calculation for NMR experiments, Charles J. Buchanan, Gaurav Bhole, Gogulan Karunanithy, Virginia Casablancas-Antràs, Adeline W. J. Poh, Benjamin G. Davis, Jonathan A. Jones* & Andrew J. Baldwin* www.nature.com/articles/s41... #NMRchat #NMR 🧲
nature.com
Seedless: on-the-fly pulse calculation for NMR experiments - Nature Communications
The authors develop a computational tool to design NMR pulses, based on the GRadient Assisted Pulse Engineering approach, that can calculate optimal pulse shapes on the fly during the measurements, to...
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Reif Lab @reiflab.bsky.social · 05/08/2025
Do you want to learn about all relevant aspects of biomolecular solid-state NMR, from theory to application? Join the 10th European Solid-State NMR Summer School❗️ 🗓️ October 20-24, 2025 | Garching, Germany 📌 Application Deadline: 01.09.2025 www.bio.nat.tum.de/ocb/upcoming... #NMRchat #BioNMR
bio.nat.tum.de
European Solid-State NMR School
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Magnetic Resonance News @nmr900.bsky.social · 04/08/2025
BNMRZ Symposium Ultra-Highfield NMR and 4D Structural Biology – From Mechanisms to Therapies, November 6–7, 2025, TUM Institute for Advanced Study, Garching @ias-tum.bsky.social registration opens soon www.bnmrz.org/4dstructbiol #BNMRZ #NMRchat #NMR 🧲
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Elias Adriaenssens @elias-adriaenssens.bsky.social · 25/07/2025
And it's out! I'm thrilled to share our new paper (Adriaenssens et al., Nat Cell Biol 2025). This paper describes a new mechanism for the initiation of autophagosome biogenesis. We found that this WIPI-ATG13-driven pathway is preferentially used by a group of transmembrane autophagy receptors.
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Magnetic Resonance News @nmr900.bsky.social · 03/07/2025
Featuring: The 2026 Biophysical Society Lecture, Lewis E. Kay, University of Toronto, The Essentiality of Solution NMR Spectroscopy in the Post-AlphaFold Era, Monday, February 23, 8:00 PM, Moscone Center www.biophysics.org/2026meeting/... #NMRchat 🧲
biophysics.org
2026 Biophysical Society Lecture | Biophysical Society
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Reif Lab @reiflab.bsky.social · 11/06/2025
We are happy to announce the “10th European solid-state NMR summer school” (October 19-24, 2025) that will take place at the Technical University Munich (@TUM.de) in Garching, Germany. #NMRchat #BioNMR For more detailed information, please follow the link: www.bio.nat.tum.de/ocb/upcoming...
bio.nat.tum.de
European Solid-State NMR School
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georghochberg.bsky.social @georghochberg.bsky.social · 11/06/2025
New paper from the lab from Sriram Garg in my group. We introduce a general substitution matrix for structural phylogenetics. I think this is a big deal, so read on below if you think deep history is important. academic.oup.com/mbe/advance-...
academic.oup.com
A general substitution matrix for structural phylogenetics.
Abstract. Sequence-based maximum likelihood (ML) phylogenetics is a widely used method for inferring evolutionary relationships, which has illuminated the
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Jack Bravo @jpkbravo.bsky.social · 10/06/2025
🚨 We're hiring! Join our excellent Electron Microscopy Facility at @istaresearch.bsky.social as an a Cryo-EM Specialist, providing support for groundbreaking research in a fantastic environment: ist.ac.at/en/job/?titl... #CryoEM #MicroscopyJobs #ScienceCareers
ist.ac.at
Job details
Job details
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Magnetic Resonance News @nmr900.bsky.social · 05/06/2025
Two postdoctoral positions in the group of Dr. Malene R. Jensen at the Institute for Structural Biology in Grenoble, France, protein kinase (MAPK) cell signaling pathways (incl NMR, X-ray crystallography and cryo-electron microscopy) www.jensen-nmr.fr #NMRjobs #NMRchat #NMR 🧲
jensen-nmr.fr
> Malene R. Jensen @ IBS Grenoble
Research team of CNRS research director Malene Ringkjøbing Jensen at the Institut de Biologie Structurale, Grenoble, France
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Roland Dunbrack 🏳️‍🌈 @rolanddunbrack.bsky.social · 03/06/2025
Nice summary of our ipSAE score for rescoring protein-protein and protein/nucleic-acid interactions in AF2, AF3, and Boltz-1. It works better than ipTM for full-length Uniprot sequences.
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Toth-Petroczy lab @tothpetroczylab.bsky.social · 28/05/2025
Are you looking for homologous sequences but alignments do not seem to work? SHARK is available as a webserver: compare sequences or search against precomputed IDR datasets: bio-shark.org @narjournal.bsky.social @mpi-cbg.de @csbdresden.bsky.social @poldresden.bsky.social doi.org/10.1093/nar/...
doi.org
SHARK: web server for alignment-free homology assessment for intrinsically disordered and unalignable protein regions
Abstract. Whereas alignment has been fundamental to sequence-based assessments of protein homology, it is ineffective for intrinsically disordered regions
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Indra_Beķere @indrabekere.bsky.social · 23/05/2025
Our manuscript on dsRNA sensor OAS2 from the lab of @oliveiramann.bsky.social is now out in @cp-molcell.bsky.social ! Thanks again to the whole team for their effort putting this story together!
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Nature Chemical Biology @natchembio.nature.com · 25/04/2025
A Perspective by @stephanieaw.bsky.social and @fraserlab.com discusses ways macromolecules use conformational entropy to control binding, catalysis, and allostery www.nature.com/articles/s41...
nature.com
Advances in uncovering the mechanisms of macromolecular conformational entropy - Nature Chemical Biology
Protein conformational entropy plays a vital role in functions like binding and catalysis. This Perspective discusses three ways macromolecules use conformational entropy: prepaying entropic costs, re...
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Arne Elofsson @handle.invalid · 07/04/2025
www.nature.com/articles/d41...
nature.com
Where do proteins go in cells? Next-generation methods map the molecules’ hidden lives
Spatial proteomics is helping biologists to uncover how cells work by mapping where proteins operate.
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Toth-Petroczy lab @tothpetroczylab.bsky.social · 18/03/2025
Identifying functional motifs in disordered regions is challenging. We gave it a try. Check out SHARK-capture, an alignment-free method to detect SLiMs. Congrats Chi Fung Willis Chow @swlenz.bsky.social et al. @mpi-cbg.de @csbdresden.bsky.social @poldresden.bsky.social doi.org/10.1002/pro....
doi.org
SHARK‐capture identifies functional motifs in intrinsically disordered protein regions
Increasing insights into how sequence motifs in intrinsically disordered regions (IDRs) provide functions underscore the need for systematic motif detection. Contrary to structured regions where moti...
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Reid Alderson @reidalderson.bsky.social · 11/03/2025
An open #PhD position is available in my lab in Munich 🇩🇪 If you are interested in structural biology, #AlphaFold, or disordered proteins, see below for more details. jobs.helmholtz-muenchen.de/jobposting/b... #science #PhD #research
jobs.helmholtz-muenchen.de
PhD Position in Structural Biology (f/m/x)
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Nott Lab @nottlab.bsky.social · 24/02/2025
We're looking for a #postdoc to join our team at KCL Chemistry @kingsnmes.bsky.social. If you're interested in disordered proteins, please get in touch! 3 year post. Ad closes 12 March: www.kcl.ac.uk/jobs/105866-...
kcl.ac.uk
Postdoctoral Research Associate in Disordered Protein Interactions
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Roland Dunbrack 🏳️‍🌈 @rolanddunbrack.bsky.social · 16/02/2025
🧵 on our preprint: Zhang & Skolnick's TM score for comparing model of protein to experimental structures of same protein. The d_j are essentially the same as the aligned error in Alphafold. After any structure alignment, it's the displacement of model Calpha from experimental Calpha of residue j.
TM equation of Zhang and Skolnick
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John Rubinstein @johnrubinstein.bsky.social · 24/01/2025
Come be my boss! We're looking for a new Program Head for the Molecular Medicine Program at the Hospital for Sick Children. Toronto, Canada (the deadline has been extended from Jan 31) Please Re-post. jobs.sciencecareers.org/job/667223/p...
jobs.sciencecareers.org
Program Head - Molecular Medicine, The Hospital for Sick Children Research Institute - Toronto (City), Ontario (CA) job with The Hospital for Sick Children (SickKids) Research Institute | 667223
Provide leadership and mentorship to members of the Molecular Medicine Program and influence the scientific direction of the Research Institute
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