Inflammasomes are high-molecular-weight complexes that play integral roles in the innate immune system, triggering an inflammatory cascade to prote...

Companions Michael Andrew Fox, C.C. Burnaby, British Columbia and New York, New York, United States of America

Proceedings of the National Academy of Sciences, Volume 123, Issue 16, April 2026. SignificanceIn many cases accurate models of the low energy, most populated form of a protein’s three-dimensional structure can be rapidly determined using machine learning (ML) programs, such as AlphaFold. However, biomolecular function is often ...

In biological and biomedical research, the focus progressively moves towards difficult human proteins, which often can only be expressed in higher eukaryotic cells. Nuclear magnetic resonance (NMR) c...

Methyl groups are essential probes for characterising interactions and dynamics in large proteins. HN-based triple-resonance NMR experiments are often too insensitive for methyl assignments, making a ...