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georghochberg.bsky.social

@georghochberg.bsky.social
267 followers 83 following 49 posts

Evolutionary biochemist and protein complex enthusiast at the University of Marburg.

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georghochberg.bsky.social @georghochberg.bsky.social · 04/04/2026
I will probably be hiring either a PhD or a Postdoc in the near future. If you are interested in deep biochemical history or molecular mechanisms of evolution please get in touch.
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georghochberg.bsky.social @georghochberg.bsky.social · 24/09/2025
A new preprint from the lab. I won't do a tweetorial until this is peer reviewed, but I think it's a banger, led by @JedNzy. It's about Rubisco and what chaperones are really for. He's on the market, get him while you can. www.biorxiv.org/content/10.1...
biorxiv.org
Origin of chaperone dependence and assembly complexity in Rubisco biogenesis
Molecular chaperones assist with the folding and assembly of protein clients. Consequently, they are essential to diverse cellular functions. In most aerobic photosynthetic organisms such as B-cyanoba...
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georghochberg.bsky.social @georghochberg.bsky.social · 01/07/2025
The Beeby lab's magnum opus on the Campylobacter flagellum is out. This is a uniquely powerful flagellum and how it evolved out of simpler precursors will keep us busy for a while still. Check it out! www.nature.com/articles/s41...
nature.com
In situ structure of a bacterial flagellar motor at subnanometre resolution reveals adaptations for increased torque - Nature Microbiology
In situ cryoEM and modelling of the Campylobacter jejuni flagellar motor characterize the periplasmic scaffold and the structural basis for increased torque generation.
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georghochberg.bsky.social @georghochberg.bsky.social · 26/06/2025
Franziska did a spectacularly successful PhD in my group and to a large extend set up the lab when we first started. I'm extremely happy for her (though not the least bit surprised) that she won these very important awards for her PhD. Watch this one, great things are certain to come.
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georghochberg.bsky.social @georghochberg.bsky.social · 11/06/2025
New paper from the lab from Sriram Garg in my group. We introduce a general substitution matrix for structural phylogenetics. I think this is a big deal, so read on below if you think deep history is important. academic.oup.com/mbe/advance-...
academic.oup.com
A general substitution matrix for structural phylogenetics.
Abstract. Sequence-based maximum likelihood (ML) phylogenetics is a widely used method for inferring evolutionary relationships, which has illuminated the
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georghochberg.bsky.social @georghochberg.bsky.social · 23/05/2025
An enormous amount of work went into this from so many people: our leadership at the MPI and the university, the scientific team, the administrative support and of course all the scientists that did the science that laid the foundation for all this. What a rush to be part of this!
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georghochberg.bsky.social @georghochberg.bsky.social · 12/05/2025
Dennis from the group contributed to this paper, showing that an assembly chaperone of PSII has identifiable precursors in non-photosynthetic organisms.
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georghochberg.bsky.social @georghochberg.bsky.social · 16/04/2025
This is a wild paper. The anaerobic biochemistry is definitely worth your while (and beyond me to explain), but let me try to explain why this is also an evolutionary bombshell. This is about how nitrogen fixation evolved as we know it.
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georghochberg.bsky.social @georghochberg.bsky.social · 20/01/2025
Now also on here to very occasionally post protein evolution stuff.
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