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Korak Ray @korakray.bsky.social · 23/09/2026

🚨Preprint news!!🚨 Using specifically purified mitotic chromosomes, we show that chromosome mechanics vary based on identity and cell type. Chromosomes from differentiated cells are more compact and stiffer, likely due to increased non-covalent crosslinks within them www.biorxiv.org/content/10.6...

biorxiv.org

Individual mouse mitotic chromosomes exhibit cell type-specific differences in biomechanical properties

Cyclic episodes of chromosome compaction and de-condensation are features of eukaryotic cell division that aid mitotic segregation and help prevent aneuploidy. While biophysical data on mitotic chromo...

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bioRxiv Biophysics @biorxiv-biophys.bsky.social · 28/08/2026

Extending conventional TIRF microscopy to image single molecules in micromolar analyte backgrounds www.biorxiv.org/content/10.64898/20…

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Benjamin Ambrose @single-mole.bsky.social · 01/07/2026

KymoSketch started out as a GUI for our kymotracker script, but after I added DeepDiffusion to it I got suggestions to add more features and it’s since become a more fleshed out analysis platform (1/6)

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Korak Ray @korakray.bsky.social · 18/06/2026

The first paper from my postdoc, looking at how tension activates DNA cleavage by the endonuclease ANKLE1, is out in @narjournal.bsky.social. ANKLE1 processes ultrafine bridges, persisting linkages between chromosomes that can lead to catastrophic DNA ruptures. (1/3) doi.org/10.1093/nar/...

Two panels showing ANKLE1 cleavage of DNA held between optically trapped beads. The left shows slow cleavage at low tension, and the right shows fast cleavage at high tension.

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Alexis Barr @alexisbarr.bsky.social · 21/05/2026

We're looking for a new Roving Research @mrc-lms.bsky.social A unique post for those who love research, learning new techniques & working across different teams. Must be a great communicator & well organised! Apply by 21 June: fa-evzn-saasfaukgovprod1.fa.ocs.oraclecloud.com/hcmUI/Candid...

fa-evzn-saasfaukgovprod1.fa.ocs.oraclecloud.com

Investigator Scientist Roving Researcher

Investigator Scientist (Roving Researcher) (LMS 2369) Salary £42,159 – 44,801 plus London Allowance (£5,560) per annum | 2 years fixed term | Full time | Closing Date: 21 June

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Quentin Smith @qmsmith.bsky.social · 25/03/2026

1/11 In our story out today in @nature.com , we showcase the molecular mechanisms that enable Cas9 to bind and cleave negatively supercoiled ((-)SC) off-targets! 🧬🧵 🔗 www.nature.com/articles/s41... #CRISPR #Cas9 #DNATopology #AFM #CryoEM #SingleMolecule #Biophysics

nature.com

Structural basis of supercoiling-induced CRISPR–Cas9 off-target activity - Nature

Cas9 structures explain topology sensing and off-target activation.

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Quentin Smith @qmsmith.bsky.social · 22/01/2026

🔬 Calling all early-career researchers (ECRs) for the GRS Single Molecule Approaches to Biology! 🌎 Location: Les Diablerets, Switzerland 📆 Save the date: June 27-28, 2026 🔗 More information: www.grc.org/single-molec... #biology #biophysics #single-molecule #microscopy #ECR

Visual advertisement providing details for the 2026 Single Molecule Approaches to Biology GRS in Les Diablerets, Switzerland in June 27-28, 2026. Two-day event for early-career single-molecule biophysicists, with a keynote session, 12 selected talks, 2 poster sessions, and mentorship component. For more information contact Alba or Quentin or see the official GRS website.

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Ruben Gonzalez @rubenlgonzalez.bsky.social · 05/01/2026

Slightly overdue article highlight! In PNAS, we use smFRET to reveal how polypeptide release factor 2 (RF2) undergoes a cascade of structural changes to catalyze polypeptide release during translation termination and ArfA-mediated ribosome rescue. 🧵⬇️ doi.org/10.1073/pnas...

Energy-landscape model of RF2 activation. Comparison of termination complexes (TC), wild-type ArfA-bound nonstop elongation complexes (nsECs), and loss-of-function ArfA mutant-bound nsECs reveals that wild-type ArfA promotes RF2 docking to nsECs by reshaping the conformational cascade.

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Korak Ray @korakray.bsky.social · 31/07/2025

A bit of good news! Part of my PhD work in collaboration with @ssjang.bsky.social and David Lynall is out in @narjournal.bsky.social! We uncover a surprising mechanism by which an ultrastable RNA stem-loop tunes its flexibility, enabling it to both fold rapidly and resist unfolding.

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Anita Meier @anitafmeier.bsky.social · 18/02/2025

Are you at #bps2025 and want to hear about: HSV-1 DNA replication, DNA looping, #smFRET, TIRF, optical tweezers or cryoEM? Come and talk to me at my poster B175 on Wed, 10.30am!

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MRC Laboratory of Medical Sciences @mrc-lms.bsky.social · 10/01/2025

Exciting new research from the Cellular Stress and Single Molecule Imaging groups has created a new technique for transfecting cells that could pave the way for new gene therapies! We'll be recapping some of the highlights from the article in this thread. 🧵1/6

sciencedirect.com

Precise intracellular uptake and endosomal release of diverse functional mRNA payloads via glutathione-responsive nanogels

We present a novel, highly customizable glutathione-responsive nanogel (NG) platform for efficient mRNA delivery with precise mRNA payload release con…

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Korak Ray @korakray.bsky.social · 10/02/2024

tMAVEN, our open-source comprehensive platform for single-molecule data analysis, is finally here! Check out our article describing the platform and how we use it to investigate the use of kinetic models to extract mechanistic info from data, out in Biophys J. www.sciencedirect.com/science/arti...

sciencedirect.com

Increasing the accuracy of single-molecule data analysis using tMAVEN

Time-dependent single-molecule experiments contain rich kinetic information about the functional dynamics of biomolecules. A key step in extracting th…

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Mikko Jimenez @mikkojimenez.bsky.social · 23/10/2023

Spooky season reminder that, at its core, The Monster Mash is a cautionary tale about working in the lab late one night and, ultimately, the dangers of poor work/life balance under late capitalism.

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Korak Ray @korakray.bsky.social · 20/10/2023

🚨 Preprint news!! 🚨 The collaboration with @ckinzthompson on a novel definition of resolution and how it can be used to calculate the local atomic resolution and map-to-model correspondence in cryoEM structures is finally on bioRxiv!!!! www.biorxiv.org/content/10.1... 🧵(1/6)

biorxiv.org

Scale-dependent hierarchical resolution: applications to atomic resolution and model validation in c...

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

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C&EN (Chemical & Engineering News) @cenmag.bsky.social · 04/10/2023

BREAKING NEWS: Three scientists have won the 2023 #NobelPrize in Chemistry for their research on the discovery and synthesis of quantum dots. Moungi G. Bawendi, Louis E. Brus and Alexei I. Ekimov share prize for research that added color to nanotechnology: cen.acs.org/people/nobel...

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