Reposted by Pablo AlcónPablo Alcón @palconh.bsky.social · 16/09/2026Deadline approaching! Please apply via this link. 👇 🧬🔬 004
Pablo Alcón @palconh.bsky.social · 16/09/2026Deadline approaching! Please apply via this link. 👇 🧬🔬 004
Reposted by Pablo AlcónPeter Andersen @germline.bsky.social · 08/09/2026We are recruiting a PhD student 🥼🙋 Topic: how germ cells bend gene expression dogmas Fly genetics + proteomics + genomics. Fully funded. Aarhus University 🇩🇰 info on the project and how to apply👇 mbg.au.dk/en/peter-and... I'd really appreciate it if you'd help spread the word. Thanks 03246
Reposted by Pablo AlcónPeter Andersen @germline.bsky.social · 02/09/2026Finally - the 🧵! So, the piRNA pathway defends the animal germline from transposons. But most of what we know comes from narrow developmental windows like late oogenesis, where it's easiest to study. We asked if the pathway is the same across development. It is not! /+ 47737
Pablo Alcón @palconh.bsky.social · 21/08/2026The summer is (almost) over and, as promised, a postdoc position to join our lab is now officially open! Please apply on our website via the link below, or share with your fellow biochemists / structural biologists / DNA repair aficionados! (deadline 30 September) mbg.au.dk/en/news-and-...mbg.au.dkPosition as postdoc in biochemistry and structural biology of DNA repair - Vacancy at Aarhus UniversityVacancy at Department of Molecular Biology and Genetics - Protein Science, Aarhus University 036
Reposted by Pablo AlcónFrancis O'Reilly @fjoreilly.bsky.social · 14/08/2026PhIX-MS is out in Molecular Cell! Rapid in situ photo-crosslinking traps transient proteasome interactions before purification; crosslinking MS, cryo-EM and AlphaFold tell us where they bind. Paper: doi.org/10.1016/j.mo... Preview: doi.org/10.1016/j.mo... 15923
Reposted by Pablo AlcónKorak Ray @korakray.bsky.social · 30/06/2026🚨 Preprint alert 🚨 Excited to share our latest bioRxiv preprint introducing DeepDiffusion, a tool for analysing facilitated 1D diffusion! 🔗 Preprint: www.biorxiv.org/content/10.6... (1/3)biorxiv.orgDeepDiffusion: a Physics-Informed Neural Network for Heterogeneous Facilitated 1D DiffusionSingle-molecule fluorescence microscopy combined with optical tweezers has enabled the direct observation of diffusing proteins on tethered DNA. These and complementary techniques reveal facilitated o... 2154
Reposted by Pablo AlcónTK (Takashi DY) Kozai @bioniclab.bsky.social · 26/06/2026🔬 Your tax dollars once paid a physicist whose own colleagues told him he was wasting the university's money. In 1951, Charles Townes sat on a D.C. park bench and worked out, on the back of an envelope, how to force molecules to release coherent radiation. 🧵 1/5 28741
Reposted by Pablo AlcónItai Yanai @itaiyanai.bsky.social · 24/06/2026🔥 Published today, and just in time for summer conferences, here are your guidelines for presenting badly www.nature.com/articles/s41... rdcu.be/fqa92 13533199
Reposted by Pablo AlcónSvetlana Dodonova @dodonova-sveta.bsky.social · 19/06/2026Excited to share our new preprint! 🧬❄️ by brilliant @mdreimann.bsky.social and great collaborators! Using cryo-ET&EM, we reveal archaeal chromatin in a near-native state: variable-beads-on-a-string fibers shaped by growth phase and histone composition #ArchaeaSky www.biorxiv.org/content/10.6... 815363
Pablo Alcón @palconh.bsky.social · 23/06/2026Join us! Postdoc position (2-3 years) in our lab @molbiolau.bsky.social Looking for candidates with experience in cell culture, genome editing, biochemistry, and/or structural biology. Application opens in August via AU's system but informal enquiries by email are welcome from now. (1/2) 11112
Reposted by Pablo AlcónKorak Ray @korakray.bsky.social · 18/06/2026The first paper from my postdoc, looking at how tension activates DNA cleavage by the endonuclease ANKLE1, is out in @narjournal.bsky.social. ANKLE1 processes ultrafine bridges, persisting linkages between chromosomes that can lead to catastrophic DNA ruptures. (1/3) doi.org/10.1093/nar/... 1197
Reposted by Pablo AlcónIMP @impvienna.bsky.social · 17/06/2026How do cells distinguish functional genetic messages from molecular noise? Researchers in Clemens Plaschka's lab at IMP, together with Julius Brennecke's lab at IMBA and collaborators at Aarhus University, reveal a new principle of gene regulation: www.nature.com/articles/s41586-026-… 13014
Pablo Alcón @palconh.bsky.social · 12/06/2026Back in the lab with lots of energy and ideas after #Machinesongenes ⚙️🧬 @biochemsoc.bsky.social in beautiful Crete 🇬🇷 🐈 Besides the amazing science, it was wonderful to meet so many friends. A special highlight was this Passmore-lab mini-reunion: 071
Reposted by Pablo AlcónJeremy Berg @jeremymberg.bsky.social · 07/06/2026My quote of the day Rosalind Franklin 312932
Reposted by Pablo AlcónLUMES - USAL @lumes-usal.bsky.social · 19/05/2026📢 ¡Anunciamos el Simposio "The Structure and Working of Molecular Machines" Más información en: biophysal.org/symposium/ #BioPhySal #SomosLUMES #USAL #MolecularMachines @usaloficial.bsky.social @ibfg.bsky.social @csiccyl.bsky.social @ciccancer.bsky.social @irnasa.bsky.social 177
Reposted by Pablo AlcónIRB Barcelona @irbbarcelona.org · 14/05/2026🧬 Charlotte (Lotte) Auerbach, born on this day in 1899, was the 1st scientist to prove that chemicals could cause genetic mutations in living organisms. After fleeing Nazi Germany to Edinburgh, her work with fruit flies 🪰 & mustard gas ☢️ transformed modern genetics & cancer research. #WomenInSTEM 02815
Pablo Alcón @palconh.bsky.social · 08/05/2026www.nature.com/immersive/d4...nature.comA life in pictures: Celebrating Attenborough at 100As the British naturalist celebrates a milestone birthday, we take a look at how his work has shaped science. 000
Reposted by Pablo AlcónRaimon Sunyer @raimonsunyer.bsky.social · 08/05/2026Interested in molecular motors? Don’t miss this wonderful symposium in Salamanca on "The Structure and Workings of Molecular Machines" with an outstanding lineup of speakers. 📍 Salamanca, Spain 📅 Monday, June 22, 2026 🎟️ Attendance is free, but registration is required 👇👇👇 098
Pablo Alcón @palconh.bsky.social · 08/05/2026www.theguardian.com/tv-and-radio...theguardian.comHappy centenary, David! Attenborough’s 100 most spectacular TV momentsHe has been besieged by birds, had 120m crabs try to crawl up his trouser leg and stayed cool beside an erupting Icelandic volcano. As David Attenborough turns 100, we celebrate his most extraordinary... 000
Reposted by Pablo AlcónJavier Martin @fjvrmrtn.bsky.social · 06/05/2026Paper alert 📣 Our group has just published a new review in Biochemical Society Transactions on emerging functions of STIM1, expanding its role beyond its classical function as an ER Ca2+ sensor. We discuss new insights into its involvement in key cellular processes portlandpress.com/biochemsoctr...portlandpress.comUnraveling new functions of the Ca2+ sensor STIM1 in cell signalingAbstract. Calcium (Ca2+) signaling is a fundamental regulator of virtually all aspects of eukaryotic cell physiology, including gene expression, secretion, metabolism, motility, and cell fate decision... 043
Reposted by Pablo AlcónAlexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 04/05/2026It's already back ???? #Maythe4thBeWithYou #MayThe4th #MayTheFourthBeWithYou Well, somebody has to do it @nucleosomepolice.bsky.social 🫣 poke @markhamillofficial.bsky.social Did you know that the nucleosome inspires the Millennium Falcon design and made the Kessel Run in less than 12 parsecs ? 35214
Reposted by Pablo Alcónallen institute @alleninstitute.org · 01/05/2026Happy Birthday to Santiago Ramón y Cajal - the "father of modern neuroscience." 110735
Pablo Alcón @palconh.bsky.social · 01/05/2026media.tenor.coma man in a suit and tie is talking to a man in a uniform .ALT: a man in a suit and tie is talking to a man in a uniform . 000
Reposted by Pablo AlcónMRC Laboratory of Molecular Biology @mrclmb.ac.uk · 29/04/2026Congratulations to @lapassmore.bsky.social, Joint Head of the LMB’s Structural Studies Division, who has been elected an international member of @nationalacademies.org Congratulations to #LMBalumni Andrea Brand who has also been elected. Read more: mrclmb.ac.uk/news-events/... #LMBNews 36910
Reposted by Pablo AlcónEnnio @amicoennio.bsky.social · 29/04/2026New preprint! We asked a simple question: How do very different activating adaptors all activate dynein? Turns out: same architecture, wildly different implementations 🧵👇 doi.org/10.64898/202...doi.org 13018
Reposted by Pablo AlcónFragileNucleosome @fnucleosome.bsky.social · 20/04/2026🕛🕔🕗 Heads up! Fragile Nucleosome Seminar is at a special time this week: 2pm US West / 5pm US East / 10pm UK / 6am Tokyo / 7am Melbourne We'll have outstanding talks on chromatin from Shabih Shakeel and @kazu-maeshima.bsky.social !!! register here: us06web.zoom.us/webinar/regi... 0148
Reposted by Pablo AlcónKazuhiro Maeshima @kazu-maeshima.bsky.social · 08/04/2026Our H1 paper is out #ScienceAdvances: www.science.org/doi/10.1126/... @masaashimazoe.bsky.social et al. reveal that linker histone H1 acts as a liquid-like glue to organize chromatin in live cells. 🎉 Fantastic collab with @rcollepardo.bsky.social @janhuemar.bsky.social and others—huge thanks! 🙌 1/ 26430
Reposted by Pablo AlcónTorben Heick Jensen @heick.bsky.social · 08/04/20262nd call for postdoc positions in the lab. Get in touch for more information or simply apply here: mbg.au.dk/en/news-and-...mbg.au.dkPostdoc positions in Nuclear RNA Biology - Vacancy at Aarhus UniversityVacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University 01313
Reposted by Pablo AlcónMerriam-Webster @merriam-webster.com · 08/04/2026Wake up, kids We got the dreamers disease. ‘Radical’ comes from a Latin word meaning "root." Because roots are the deepest part of a plant, ‘radical’ came to describe things understood as fundamental or essential. ‘Radical change’ was a change at the root of a system. 261646460
Reposted by Pablo AlcónPeter Andersen @germline.bsky.social · 01/04/2026Germ cells have their own versions of core transcription factors and fertility depends on them. We're hiring a PhD student to figure out how! 📢 Fly genetics + proteomics + genomics. Fully funded. Aarhus University 🇩🇰 Deadline May 1 👇 Please share with anyone who might be interested!phd.nat.au.dk 03442
Reposted by Pablo AlcónClinton Lau @ckylau.bsky.social · 30/03/2026Check out our first lab preprint: A real team effort to understand the Plasmodium GAPM proteins, which form part of a essential bridge between the parasite's cytoskeleton and motility apparatus. Below is a sneak peek of some beautiful microscopy - light and electron! www.biorxiv.org/content/10.6... 37427
Reposted by Pablo AlcónGuillermo Montoya @guillermo-montoya.bsky.social · 27/03/2026New preprint www.biorxiv.org/content/10.6... A stepwise mechanism for RAF1 activation involving novel assemblies exclusive of HSP90 RAF clients influencing MAPK signaling. Great collaboration between our group and the groups of @jespervolsen.bsky.social and M. Barbacid @cniostopcancer.bsky.social 0103
Reposted by Pablo AlcónHongmiao Hu @handle.invalid · 26/03/2026Excited to share my postdoc work on the cryo‑EM structure of the budding yeast telomerase holoenzyme! 🧫🧬 It’s been a real privilege to be part of the awesome Kelly Lab @kellythd-nguyen.bsky.social. Grateful as well to the incredible facilities @mrclmb.ac.uk.science.orgCryo–electron microscopy structure of the budding yeast telomerase holoenzymeTelomerase is a reverse transcriptase that synthesizes telomeric repeats at chromosome ends, safeguarding genome integrity. We present the cryo–electron microscopy structure of the budding yeast telom... 34610
Reposted by Pablo AlcónKelly Nguyen @kellythd-nguyen.bsky.social · 26/03/2026Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍. www.science.org/doi/10.1126/... www.youtube.com/watch?v=gFE4...youtube.comCryo-EM structure of yeast telomeraseYouTube video by MRC Laboratory of Molecular Biology 920675
Reposted by Pablo AlcónQuentin Smith @qmsmith.bsky.social · 25/03/20261/11 In our story out today in @nature.com , we showcase the molecular mechanisms that enable Cas9 to bind and cleave negatively supercoiled ((-)SC) off-targets! 🧬🧵 🔗 www.nature.com/articles/s41... #CRISPR #Cas9 #DNATopology #AFM #CryoEM #SingleMolecule #Biophysicsnature.comStructural basis of supercoiling-induced CRISPR–Cas9 off-target activity - NatureCas9 structures explain topology sensing and off-target activation. 26020
Reposted by Pablo AlcónMRC Laboratory of Medical Sciences @mrc-lms.bsky.social · 25/03/2026New research in Nature shows that the physical twisting of DNA plays an important role in DNA editing mistakes made by CRISPR. Using nanometer-sized circles of DNA, scientists captured never-before-seen interactions between CRISPR & DNA, providing insights that could eradicate errors altogether.lms.mrc.ac.ukDNA shape explains crucial gene-therapy challengesCRISPR is a powerful DNA-editing tool that has underpinned huge advancements in human healthcare in the last decade. It is a precision tool, but is not perfect, and misplaced DNA edits can compromise ... 1123
Reposted by Pablo AlcónIMPRS for Living Matter @imprs-lm.bsky.social · 17/03/2026📣 Physicists and engineers: apply your experimental skills to biology! Join the group of Katerina Naydenova @imprs-lm.bsky.social for a #PhD to develop new technologies that enable answering fundamental biological questions. Apply NOW! 01112
Reposted by Pablo AlcónCarter Lab @carter-lab.bsky.social · 24/03/2026Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6... 620684
Reposted by Pablo AlcónBrian Cook @bcryo.bsky.social · 23/03/20261) The Herzik lab is excited to announce our newest preprint in collaboration with the Grotjahn lab! We have developed a surfactant cocktail that seeks to overcome one of the more nefarious problems in #cryoEM, Air-water interface (AWI)-induced damage and preferred orientation (PO). 49344
Reposted by Pablo AlcónStephen Montgomery @ebablab.bsky.social · 20/03/2026Dave Grohl in the Guardian casually casting shade on thousands of academics www.theguardian.com/music/2026/m... 2264
Pablo Alcón @palconh.bsky.social · 18/03/2026With the new year, we have welcomed several new members to our lab, so it is a perfect time to update our group picture. 🔬🧬 090
Reposted by Pablo AlcónJames Manton @jamesdmanton.bsky.social · 13/03/2026Myself and @immunoah.bsky.social are looking to hire a postdoctoral scientist to build a next-generation high-throughput high-resolution light sheet microscope for imaging entire cleared organs/tissues and to further develop live & fixed tissue clearing methods. www.nature.com/naturecareer... 01916
Reposted by Pablo AlcónAgnel Sfeir @agnelsfeir.bsky.social · 02/03/2026The Sfeir Lab at MSKCC is hiring a Research Assistant! We are looking for a motivated scientist with at least 2 years of research experience and a two-year commitment. Learn more about our work here www.sfeirlab.com, and message me your CV and cover letter if interestedsfeirlab.comSfeir LabThe official website of the Sfeir Lab at the Skirball Institute of Biomolecular Medicine of New York University Langone Medical Center. 178
Pablo Alcón @palconh.bsky.social · 28/02/2026elpais.com/opinion/2026...elpais.comRiki Blanco: ilusiónViñeta del 28 de febrero de 2026 000