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Pablo Alcón

@palconh.bsky.social
1.2K followers 1K following 48 posts

Scientist. Molecular and structural biology of DNA repair 🧬 Aarhus University 🇩🇰🇪🇺 From Extremadura, Spain 🌍 sites.google.com/view/alconlab/home

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Reposted by Pablo Alcón
Pablo Alcón @palconh.bsky.social · 16/09/2026
Deadline approaching! Please apply via this link. 👇 🧬🔬
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Pablo Alcón @palconh.bsky.social · 16/09/2026
Deadline approaching! Please apply via this link. 👇 🧬🔬
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Reposted by Pablo Alcón
Peter Andersen @germline.bsky.social · 08/09/2026
We are recruiting a PhD student 🥼🙋 Topic: how germ cells bend gene expression dogmas Fly genetics + proteomics + genomics. Fully funded. Aarhus University 🇩🇰 info on the project and how to apply👇 mbg.au.dk/en/peter-and... I'd really appreciate it if you'd help spread the word. Thanks
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Peter Andersen @germline.bsky.social · 02/09/2026
Finally - the 🧵! So, the piRNA pathway defends the animal germline from transposons. But most of what we know comes from narrow developmental windows like late oogenesis, where it's easiest to study. We asked if the pathway is the same across development. It is not! /+
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Pablo Alcón @palconh.bsky.social · 21/08/2026
The summer is (almost) over and, as promised, a postdoc position to join our lab is now officially open! Please apply on our website via the link below, or share with your fellow biochemists / structural biologists / DNA repair aficionados! (deadline 30 September) mbg.au.dk/en/news-and-...
mbg.au.dk
Position as postdoc in biochemistry and structural biology of DNA repair - Vacancy at Aarhus University
Vacancy at Department of Molecular Biology and Genetics - Protein Science, Aarhus University
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Francis O'Reilly @fjoreilly.bsky.social · 14/08/2026
PhIX-MS is out in Molecular Cell! Rapid in situ photo-crosslinking traps transient proteasome interactions before purification; crosslinking MS, cryo-EM and AlphaFold tell us where they bind. Paper: doi.org/10.1016/j.mo... Preview: doi.org/10.1016/j.mo...
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No Score Draws ✍🏻⚽ @noscoredraws.com · 14/07/2026
YOU BE THE JUDGE
A bad drawing of Lamine Yamal getting booted up the arse by Lucas Digne
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Korak Ray @korakray.bsky.social · 30/06/2026
🚨 Preprint alert 🚨 Excited to share our latest bioRxiv preprint introducing DeepDiffusion, a tool for analysing facilitated 1D diffusion! 🔗 Preprint: www.biorxiv.org/content/10.6... (1/3)
biorxiv.org
DeepDiffusion: a Physics-Informed Neural Network for Heterogeneous Facilitated 1D Diffusion
Single-molecule fluorescence microscopy combined with optical tweezers has enabled the direct observation of diffusing proteins on tethered DNA. These and complementary techniques reveal facilitated o...
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TK (Takashi DY) Kozai @bioniclab.bsky.social · 26/06/2026
🔬 Your tax dollars once paid a physicist whose own colleagues told him he was wasting the university's money. In 1951, Charles Townes sat on a D.C. park bench and worked out, on the back of an envelope, how to force molecules to release coherent radiation. 🧵 1/5
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Itai Yanai @itaiyanai.bsky.social · 24/06/2026
🔥 Published today, and just in time for summer conferences, here are your guidelines for presenting badly www.nature.com/articles/s41... rdcu.be/fqa92
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Svetlana Dodonova @dodonova-sveta.bsky.social · 19/06/2026
Excited to share our new preprint! 🧬❄️ by brilliant @mdreimann.bsky.social and great collaborators! Using cryo-ET&EM, we reveal archaeal chromatin in a near-native state: variable-beads-on-a-string fibers shaped by growth phase and histone composition #ArchaeaSky www.biorxiv.org/content/10.6...
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Pablo Alcón @palconh.bsky.social · 23/06/2026
Join us! Postdoc position (2-3 years) in our lab @molbiolau.bsky.social Looking for candidates with experience in cell culture, genome editing, biochemistry, and/or structural biology. Application opens in August via AU's system but informal enquiries by email are welcome from now. (1/2)
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Korak Ray @korakray.bsky.social · 18/06/2026
The first paper from my postdoc, looking at how tension activates DNA cleavage by the endonuclease ANKLE1, is out in @narjournal.bsky.social. ANKLE1 processes ultrafine bridges, persisting linkages between chromosomes that can lead to catastrophic DNA ruptures. (1/3) doi.org/10.1093/nar/...
Two panels showing ANKLE1 cleavage of DNA held between optically trapped beads. The left shows slow cleavage at low tension, and the right shows fast cleavage at high tension.
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IMP @impvienna.bsky.social · 17/06/2026
How do cells distinguish functional genetic messages from molecular noise? Researchers in Clemens Plaschka's lab at IMP, together with Julius Brennecke's lab at IMBA and collaborators at Aarhus University, reveal a new principle of gene regulation: www.nature.com/articles/s41586-026-…
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Pablo Alcón @palconh.bsky.social · 12/06/2026
Back in the lab with lots of energy and ideas after #Machinesongenes ⚙️🧬 @biochemsoc.bsky.social in beautiful Crete 🇬🇷 🐈 Besides the amazing science, it was wonderful to meet so many friends. A special highlight was this Passmore-lab mini-reunion:
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Stephen Curry @scurry.bsky.social · 12/06/2026
RIP David Hockney.
Pen and watercolour self-portrait of Hockney, in a jacket, checked shirt and dark tie staring straight at the viewer
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Jeremy Berg @jeremymberg.bsky.social · 07/06/2026
My quote of the day Rosalind Franklin
You look at science (or at least talk of it) as some sort of demoralising invention of man, something apart from real life, and which must be cautiously guarded and kept separate from everyday existence. But science and everyday life cannot and should not be separated.
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LUMES - USAL @lumes-usal.bsky.social · 19/05/2026
📢 ¡Anunciamos el Simposio "The Structure and Working of Molecular Machines" Más información en: biophysal.org/symposium/ #BioPhySal #SomosLUMES #USAL #MolecularMachines @usaloficial.bsky.social @ibfg.bsky.social @csiccyl.bsky.social @ciccancer.bsky.social @irnasa.bsky.social
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IRB Barcelona @irbbarcelona.org · 14/05/2026
🧬 Charlotte (Lotte) Auerbach, born on this day in 1899, was the 1st scientist to prove that chemicals could cause genetic mutations in living organisms. After fleeing Nazi Germany to Edinburgh, her work with fruit flies 🪰 & mustard gas ☢️ transformed modern genetics & cancer research. #WomenInSTEM
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Pablo Alcón @palconh.bsky.social · 12/05/2026
This should be a good one, don't miss it!
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Pablo Alcón @palconh.bsky.social · 08/05/2026
www.nature.com/immersive/d4...
nature.com
A life in pictures: Celebrating Attenborough at 100
As the British naturalist celebrates a milestone birthday, we take a look at how his work has shaped science.
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Raimon Sunyer @raimonsunyer.bsky.social · 08/05/2026
Interested in molecular motors? Don’t miss this wonderful symposium in Salamanca on "The Structure and Workings of Molecular Machines" with an outstanding lineup of speakers. 📍 Salamanca, Spain 📅 Monday, June 22, 2026 🎟️ Attendance is free, but registration is required 👇👇👇
Poster for “The Structure and Workings of Molecular Machines” international symposium, taking place Monday, June 22, 2026, at the Centro Internacional del Español, CIE-USAL, in Salamanca, Spain. The poster shows a colorful molecular-structure background and lists invited speakers Carlos Bustamante, Adam Frost, Taekjip Ha, Fernando Moreno, Eva Nogales, Félix Ritort, José M. Valpuesta, and Elizabeth Villa. It includes a QR code for the full program and registration and notes that attendance is free but registration is required.
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Pablo Alcón @palconh.bsky.social · 08/05/2026
www.theguardian.com/tv-and-radio...
theguardian.com
Happy centenary, David! Attenborough’s 100 most spectacular TV moments
He has been besieged by birds, had 120m crabs try to crawl up his trouser leg and stayed cool beside an erupting Icelandic volcano. As David Attenborough turns 100, we celebrate his most extraordinary...
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Javier Martin @fjvrmrtn.bsky.social · 06/05/2026
Paper alert 📣 Our group has just published a new review in Biochemical Society Transactions on emerging functions of STIM1, expanding its role beyond its classical function as an ER Ca2+ sensor. We discuss new insights into its involvement in key cellular processes portlandpress.com/biochemsoctr...
portlandpress.com
Unraveling new functions of the Ca2+ sensor STIM1 in cell signaling
Abstract. Calcium (Ca2+) signaling is a fundamental regulator of virtually all aspects of eukaryotic cell physiology, including gene expression, secretion, metabolism, motility, and cell fate decision...
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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 04/05/2026
It's already back ???? #Maythe4thBeWithYou #MayThe4th #MayTheFourthBeWithYou Well, somebody has to do it @nucleosomepolice.bsky.social 🫣 poke @markhamillofficial.bsky.social Did you know that the nucleosome inspires the Millennium Falcon design and made the Kessel Run in less than 12 parsecs ?
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allen institute @alleninstitute.org · 01/05/2026
Happy Birthday to Santiago Ramón y Cajal - the "father of modern neuroscience."
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Pablo Alcón @palconh.bsky.social · 01/05/2026
media.tenor.com
a man in a suit and tie is talking to a man in a uniform .
ALT: a man in a suit and tie is talking to a man in a uniform .
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 29/04/2026
Congratulations to @lapassmore.bsky.social, Joint Head of the LMB’s Structural Studies Division, who has been elected an international member of @nationalacademies.org Congratulations to #LMBalumni Andrea Brand who has also been elected. Read more: mrclmb.ac.uk/news-events/... #LMBNews
Lori passmore
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Ennio @amicoennio.bsky.social · 29/04/2026
New preprint! We asked a simple question: How do very different activating adaptors all activate dynein? Turns out: same architecture, wildly different implementations 🧵👇 doi.org/10.64898/202...
doi.org
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Pablo Alcón @palconh.bsky.social · 25/04/2026
Happy DNA day! 🧬
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FragileNucleosome @fnucleosome.bsky.social · 20/04/2026
🕛🕔🕗 Heads up! Fragile Nucleosome Seminar is at a special time this week: 2pm US West / 5pm US East / 10pm UK / 6am Tokyo / 7am Melbourne We'll have outstanding talks on chromatin from Shabih Shakeel and @kazu-maeshima.bsky.social !!! register here: us06web.zoom.us/webinar/regi...
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Kazuhiro Maeshima @kazu-maeshima.bsky.social · 08/04/2026
Our H1 paper is out #ScienceAdvances: www.science.org/doi/10.1126/... @masaashimazoe.bsky.social et al. reveal that linker histone H1 acts as a liquid-like glue to organize chromatin in live cells. 🎉 Fantastic collab with @rcollepardo.bsky.social @janhuemar.bsky.social and others—huge thanks! 🙌 1/
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Torben Heick Jensen @heick.bsky.social · 08/04/2026
2nd call for postdoc positions in the lab. Get in touch for more information or simply apply here: mbg.au.dk/en/news-and-...
mbg.au.dk
Postdoc positions in Nuclear RNA Biology - Vacancy at Aarhus University
Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University
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Merriam-Webster @merriam-webster.com · 08/04/2026
Wake up, kids We got the dreamers disease. ‘Radical’ comes from a Latin word meaning "root." Because roots are the deepest part of a plant, ‘radical’ came to describe things understood as fundamental or essential. ‘Radical change’ was a change at the root of a system.
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Peter Andersen @germline.bsky.social · 01/04/2026
Germ cells have their own versions of core transcription factors and fertility depends on them. We're hiring a PhD student to figure out how! 📢 Fly genetics + proteomics + genomics. Fully funded. Aarhus University 🇩🇰 Deadline May 1 👇 Please share with anyone who might be interested!
phd.nat.au.dk
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Clinton Lau @ckylau.bsky.social · 30/03/2026
Check out our first lab preprint: A real team effort to understand the Plasmodium GAPM proteins, which form part of a essential bridge between the parasite's cytoskeleton and motility apparatus. Below is a sneak peek of some beautiful microscopy - light and electron! www.biorxiv.org/content/10.6...
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Guillermo Montoya @guillermo-montoya.bsky.social · 27/03/2026
New preprint www.biorxiv.org/content/10.6... A stepwise mechanism for RAF1 activation involving novel assemblies exclusive of HSP90 RAF clients influencing MAPK signaling. Great collaboration between our group and the groups of @jespervolsen.bsky.social and M. Barbacid @cniostopcancer.bsky.social
cryoEM maps of the different assemblies
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Hongmiao Hu @handle.invalid · 26/03/2026
Excited to share my postdoc work on the cryo‑EM structure of the budding yeast telomerase holoenzyme! 🧫🧬 It’s been a real privilege to be part of the awesome Kelly Lab @kellythd-nguyen.bsky.social. Grateful as well to the incredible facilities @mrclmb.ac.uk.
science.org
Cryo–electron microscopy structure of the budding yeast telomerase holoenzyme
Telomerase is a reverse transcriptase that synthesizes telomeric repeats at chromosome ends, safeguarding genome integrity. We present the cryo–electron microscopy structure of the budding yeast telom...
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Kelly Nguyen @kellythd-nguyen.bsky.social · 26/03/2026
Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍. www.science.org/doi/10.1126/... www.youtube.com/watch?v=gFE4...
youtube.com
Cryo-EM structure of yeast telomerase
YouTube video by MRC Laboratory of Molecular Biology
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Quentin Smith @qmsmith.bsky.social · 25/03/2026
1/11 In our story out today in @nature.com , we showcase the molecular mechanisms that enable Cas9 to bind and cleave negatively supercoiled ((-)SC) off-targets! 🧬🧵 🔗 www.nature.com/articles/s41... #CRISPR #Cas9 #DNATopology #AFM #CryoEM #SingleMolecule #Biophysics
nature.com
Structural basis of supercoiling-induced CRISPR–Cas9 off-target activity - Nature
Cas9 structures explain topology sensing and off-target activation.
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MRC Laboratory of Medical Sciences @mrc-lms.bsky.social · 25/03/2026
New research in Nature shows that the physical twisting of DNA plays an important role in DNA editing mistakes made by CRISPR. Using nanometer-sized circles of DNA, scientists captured never-before-seen interactions between CRISPR & DNA, providing insights that could eradicate errors altogether.
lms.mrc.ac.uk
DNA shape explains crucial gene-therapy challenges
CRISPR is a powerful DNA-editing tool that has underpinned huge advancements in human healthcare in the last decade. It is a precision tool, but is not perfect, and misplaced DNA edits can compromise ...
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IMPRS for Living Matter @imprs-lm.bsky.social · 17/03/2026
📣 Physicists and engineers: apply your experimental skills to biology! Join the group of Katerina Naydenova @imprs-lm.bsky.social for a #PhD to develop new technologies that enable answering fundamental biological questions. Apply NOW!
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Carter Lab @carter-lab.bsky.social · 24/03/2026
Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6...
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Brian Cook @bcryo.bsky.social · 23/03/2026
1) The Herzik lab is excited to announce our newest preprint in collaboration with the Grotjahn lab! We have developed a surfactant cocktail that seeks to overcome one of the more nefarious problems in #cryoEM, Air-water interface (AWI)-induced damage and preferred orientation (PO).
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Stephen Montgomery @ebablab.bsky.social · 20/03/2026
Dave Grohl in the Guardian casually casting shade on thousands of academics www.theguardian.com/music/2026/m...
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Pablo Alcón @palconh.bsky.social · 18/03/2026
With the new year, we have welcomed several new members to our lab, so it is a perfect time to update our group picture. 🔬🧬
Group picture of the lab members
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James Manton @jamesdmanton.bsky.social · 13/03/2026
Myself and @immunoah.bsky.social are looking to hire a postdoctoral scientist to build a next-generation high-throughput high-resolution light sheet microscope for imaging entire cleared organs/tissues and to further develop live & fixed tissue clearing methods. www.nature.com/naturecareer...
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Agnel Sfeir @agnelsfeir.bsky.social · 02/03/2026
The Sfeir Lab at MSKCC is hiring a Research Assistant! We are looking for a motivated scientist with at least 2 years of research experience and a two-year commitment. Learn more about our work here www.sfeirlab.com, and message me your CV and cover letter if interested
sfeirlab.com
Sfeir Lab
The official website of the Sfeir Lab at the Skirball Institute of Biomolecular Medicine of New York University Langone Medical Center.
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Pablo Alcón @palconh.bsky.social · 28/02/2026
elpais.com/opinion/2026...
elpais.com
Riki Blanco: ilusión
Viñeta del 28 de febrero de 2026
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