Jul 27, 2026 | 2026 SITC Cell Avidity Travel Award | Click to read more...

During mitosis, chromosomes undergo a dramatic metamorphosis. Here, the authors show that Condensin I, but not Condensin II, is important for establishing chromosome stiffness and elasticity, as well ...

During mitosis, chromosomes undergo a dramatic metamorphosis. Here, the authors show that Condensin I, but not Condensin II, is important for establishing chromosome stiffness and elasticity, as well ...

Speaker: Alba Rodríguez Garcia, PhD, . In this webinar, we discuss Avidity and functional characterization of CD19/BCMA dual-targeting CAR-T cell designs in NHL. Category: Cell Therapy

Histidine scanning represents a broadly applicable technique for the identification of critical interaction sites within TCRs and other mechanosensory receptors to enhance receptor signaling strength ...

Li et al. developed a ferritin aggregation cell engager that helps CAR T cells better recognize and attack leukemia cells without re-engineering the CAR itself. This versatile platform overcomes antig...

Get 10% discount on Lumidyne advanced fluorophore dyes for optical tweezers (C-Trap) experiments. via the LUMICKS store. Photostable and self-healing.

Jul 01, 2026 | Alba Rodríguez Garcia, PhD presents Avidity and functional characterization of CD19/BCMA dual-targeting CAR-T cell designs in NHL

Abstract. DNA ends generated by double-strand breaks are vulnerable intermediates that must be rapidly recognized, protected, and resolved to preserve geno

Components of the glycocalyx have been shown to impair immune cell functions, including of CAR-T cells. Here the authors show that CAR-T cell mediated cytotoxicity in pancreatic cancer models can be e...

Cryo-EM structures of HSV-1 helicase-primase and replication fork complexes reveal mechanisms of drug inhibition, features that explain drug selectivity, and the molecular basis of replication fork co...

RNA aptamers play essential roles in gene regulation, sensing, and therapeutics, relying on ligand-induced kinetic changes for function. The theophylline aptamer has been engineered to regulate synthe...

Cas9 structures explain topology sensing and off-target activation.

Mar 26, 2026 | Xiaolan Zhao presents Molecular determinants of Smc5/6 association with DNA junctions

Anti-tumor functions of low-avidity T cells are often suboptimal. Here the authors show that genetic disruption of TIGIT in TCR-engineered T cells enhances their anti-tumor activity against pancreatic...

We are pleased to announce the SMBio26, the third UK-Ireland symposium focusing on single-molecule research! Featuring keynotes, talks, posters and discussions, this 2-day event aims to bring together...

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Histidine scanning represents a broadly applicable technique for the identification of critical interaction sites within TCRs and other mechanosensory receptors to enhance receptor signaling strength ...

Dynein–dynactin–cargo adaptor complexes typically function with two dynein motors. Rao et al. show that, under mechanical load, these complexes can recruit a third dynein via a second adaptor, increas...

Feb 23, 2026 | Steven Park Sangwoo, PhD presents Tuning CAR-T cells by targeting cancer-associated glycan in pancreatic cancer

Following the successes of the 2024 and 2025 events, the University of Sheffield and LUMICKS proudly present the third UK-Ireland symposium focusing on single-molecule research! Featuring keynotes, ta...

Get 10% discount on Lumidyne advanced fluorophore dyes for optical tweezers (C-Trap) experiments. via the LUMICKS store. Photostable and self-healing.

Your gateway to mastering single-molecule experiments​

Homologous recombination repairs DNA double strand breaks and protects stalled replication forks, but how the five RAD51 paralogs contribute to these processes remains unclear. Mutations in the RAD51 ...

Benton et al. identify binders against common mutant KRAS neoantigens and create peptide-centric CAR-T cells (NeoCARs). NeoCARs demonstrate a robust anti-tumor response against cancer cells expressing...