Track the Trump administration’s federal funding disruptions state by state — what was cut or frozen, who it hurts, and how states are fighting back in court.

Many animal species replace histones with protamines during spermatogenesis. Although essential for sperm function, protamines evolve rapidly for reasons that remain unknown. Using in vivo gene replac...

Natural transformation is a widespread mechanism driving genetic exchanges in bacteria. It proceeds from the capture of extracellular DNA released ...

PDB-101: Training, Outreach, and Education portal of RCSB PDB

From mapped.earth, a map of every lighthouse on the planet, along with other charted lights like lighted buoys and such. The screenshots above are static but the lights on the real map move: each lighthouse sweeps out it

An innovative safeguard could help to flag proteins devised by artificial-intelligence tools such as AlphaFold, but the digital marker can be erased.

Ageing reflects progressive decanalization of mammalian cell identity, driven by erosion of a regulatory grammar written during development.

AI predictions could help with pandemic preparedness, but they will need experimental confirmation.

Bidirectional cross-talk between neural circuits and tumors drives cancer progression and can be therapeutically targeted through drug repurposing.

Voyaging gut-derived immune cells ‘remember’ past stomach infections in mice.

Imaging spotlight: FOCUS-3D - News

Abstract. While mutations are the engine of evolution, how mutation rates themselves evolve remains poorly understood. Previous simulation and experimental

X-chromosome inactivation balances X-gene dosage between the sexes in eutherians and marsupials. The lncRNA Xist mediates X-inactivation in eutherians but is absent from marsupials. An evolutionarily ...

This study uses a precise and efficient clustered regularly interspaced short palindromic repeats (CRISPR) prime editing system to substitute lysine residues in histone H3, individually or in combinat...

Ribosomal RNA (rRNA) transcription rates vary during development, and their dysregulation is linked to diseases such as cancer and ribosomopathies. Owing to their high abundance and genomic redundancy...

RegVelo introduces an end-to-end generative framework that jointly infers gene regulatory networks and developmental dynamics. It serves as an actionable in silico “cell,” enabling researchers to simu...

Henipavirus nucleoprotein assemblies exist in different conformations, indicating temporary release of genome for RNA synthesis.

A nascent group of researchers sees planetary health as an urgent reason to bridge the molecular and planetary scales. This is shaping their strategies, methods, collaborations and outlook about their...

Attacks on science and immigrants are destroying America.

Author summary Coronaviruses are well known for their ability to jump between species, a process driven mainly by the spike protein on their surface. In this study, we examined spike proteins from coronaviruses found in marine mammals (whales and dolphins) to better understand how these viruses evolve and interact with their hosts. Using structural biology and mass spectrometry, we discovered several unusual features of the cetacean spike proteins. These spikes contain an extra domain within their receptor-binding region that resembles cupin proteins, assemble into trimers in a novel way that hides the receptor-binding domains, and show clusters of sugars (O-linked glycans) near the sites thought to interact with host receptors. These distinctive features suggest that cetacean coronaviruses may use a different entry mechanism, in which the extra domain acts as a switch to reveal the hidden receptor-binding regions. Such a mechanism could affect which species these viruses can infect, how easily they cross species barriers, and how they evade the immune system. Our findings emphasize the structural diversity and modularity of coronavirus spike proteins, highlight the unique adaptations of coronaviruses in marine mammals, and provide insight into their potential to give rise to new diseases in other species.

Hepatitis D-like satellite viruses, known as deltaviruses, have been recently discovered in a wide range of animals. These viruses are thought to expr…

Abstract. The origin of life is one of the great mysteries of science. Of the multiple unsolved problems, the origin of the translation system (the means b

Knudsen and colleagues use repli-ATAC-seq to compare replicated and unreplicated chromatin in two models of cell identity change. They find that lineage-specific elements are accessible earlier in rep...

Nature Structural & Molecular Biology - METALoci, a new three-dimensional genome computational tool, reveals a major rewiring of regulatory interactions during sex determination. By combining...

LARP6 is an EMT-associated RNA-binding protein with diverse RNA targets. Here, the authors show that the N-terminal disordered region of LARP6 promotes RNA-binding selectivity by modulating the adjace...

Large proportion worked at Columbia University, which had its grants cut and frozen by the administration of US President Donald Trump.

Moderna does not plan to ‌invest in new late-stage vaccine trials because of growing opposition to immunizations from U.S. officials, CEO Stephane Bancel said ‌in an interview with Bloomberg TV ​on Th...

Researchers identified anoctamin-2 (ANO2) as a frequent autoimmune target in multiple sclerosis, with T cell responses against ANO2 occurring in over half of patients. These ANO2-specific T cells shar...