We’re excited to introduce scCHyMErA-Seq, a scalable #CRISPR-based #exon-deletion screening platform with #single-cell transcriptomic readouts, enabling high-throughput functional analysis of #alternative #splicing. In collaboration with the Gonatopoulos-Pournatzis lab. @natcomms.nature.com
rdcu.be
Single-cell exon deletion profiling reveals splicing events that shape gene expression and cell state dynamics
Nature Communications - Alternative splicing generates diverse protein isoforms, yet the functions of most exons remain unknown. Here, the authors introduce scCHyMErA-Seq, a scalable single-cell...
