iiinova — where your digital self keeps evolving

PyrexCorex @pyrexcorex.bsky.social · 20h

Thanks for reminding us that news didn’t always seek social media for street cred.

000

PyrexCorex @pyrexcorex.bsky.social · 20h

‘on the phone’. Do AI agents summon you while in progress?

200

PyrexCorex @pyrexcorex.bsky.social · 20h

Thanks again to all my friends who helped me move my BOOKS up all those stairs.

000

PyrexCorex @pyrexcorex.bsky.social · 20h

Your aspirational ‘anonymous source’ has more street cred.

000

PyrexCorex @pyrexcorex.bsky.social · 20h

🎯TY for that concise reminder.

000

Reposted by PyrexCorex

GlycoShape @glycoshape.org · 09/10/2026

Phenomenal #glycotime by Meg Lunn-Halbert, Joel Allen and colleagues demonstrates through de novo protein design how steric hindrance controls N-glycan maturation ⬇️ doi.org/10.64898/202... Protein design with RFdiffusionAA coupled with glycosylation with GlycoShape 🧪

screenshot of Fig. 2 in the paper, titled "Systematically altering steric restriction controls glycan processing" the following corresponds to the figure caption in the paper.
Panel a, AF3-predicted protein with GlycoShape-modeled Man9 glycan (green) for glycoproteins THRgly1-4. b-d, Deconvoluted intact
mass spectra for analyzing native glycosylation with 1–3 major peaks corresponding to glycosylation shifts labeled. Glycans
matching in theoretical molecular weight to the corresponding shift are schematically annotated as follows: mannose residues as
green circles, N-acetyl glucosamine residues as blue squares, galactose as yellow circles, sialic acid as pink diamonds, and glucose
as blue circles. Unglycosylated sizes are estimated based on predicted MW and labeled, when present. b: Native glycosylation. c:
Native protein digested with Endo H. d: Overlaid protein from kifunensine-treated cells (color, solid line) and digested with Endo H
(gray, dotted line). Estimated predominant glycans present are shown in MW (Da) differences from predicted unglycosylated size.
For peak table see Supplementary Data S3; amino acid sequences provided in Supplementary Data S1.

01211

Reposted by PyrexCorex

Will Ratcliff @wcratcliff.bsky.social · 07/10/2026

Out today in @nature.com: our review on how single cells evolve into multicellular organisms. With Ozan Bozdag, @kaitong25.bsky.social, Peter Yunker, and @matthewherron.bsky.social. rdcu.be/9ZuiKow9twKa For an overview, check out the video below.

11357157

Reposted by PyrexCorex

RCSB Protein Data Bank @rcsbpdb.bsky.social · 02/10/2026

Explore images that structural biologist Irina Bezsonova (UCONN Health) created for #inktober in PDB-101's #sciart gallery

pdb101.rcsb.org

PDB101: Irina Bezsonova Gallery

PDB-101: Training, Outreach, and Education portal of RCSB PDB

02610

Reposted by PyrexCorex

Scott McGrath @smcgrath.phd · 01/10/2026

🧪 Google DeepMind's SynthIDBio embeds a statistical watermark into both the amino-acid sequence and 3D structure of AI-designed proteins. While it preserves biological function, the tag can still be scrubbed by running sequences through another tool, leaving detection keys in dispute. 💻🧬

nature.com

Secret watermark labels proteins as ‘made by AI’

An innovative safeguard could help to flag proteins devised by artificial-intelligence tools such as AlphaFold, but the digital marker can be erased.

252

Reposted by PyrexCorex

Colin Carlson @colincarlson.bsky.social · 01/10/2026

Very cool new preprint I was very excited to be a VERY small part of, from @viralverity.bsky.social and @nathangrubaugh.bsky.social: "Phylodynamic analysis reveals asymmetric and accelerating global spread of dengue virus" www.biorxiv.org/content/10.6...

32610

PyrexCorex @pyrexcorex.bsky.social · 01/10/2026

What a convenient way to never accomplish anything.

000

Reposted by PyrexCorex

Svetlana Dodonova @dodonova-sveta.bsky.social · 30/09/2026

New preprint from Dodonova lab 🔔! Capturing multiple states by cryo-EM❄️, we show for the first time how archaeal RNA Polymerase engages a nucleosome and forms direct contacts with histones! 🧬 Great work by Gabriele & a fantastic collaboration with Dina Grohmann! 🧵 www.biorxiv.org/content/10.6...

110138

PyrexCorex @pyrexcorex.bsky.social · 30/09/2026

‘being right is going to be many layers of horrible’. ibid Sarah Kendzior

000

PyrexCorex @pyrexcorex.bsky.social · 30/09/2026

The ‘digits over data’ brigade strikes again.

001

Reposted by PyrexCorex

Rasmus Jensen @rasmusjensen.bsky.social · 25/09/2026

🎉 Out today in Cell: the paper I've been looking forward to sharing for a long time 🎉 We used cryo-ET to find a molecular machine nobody knew existed on the surface of a minimal bacterium, and worked out what it does. 🧵(1/7) #TeamTomo #cryoET

1023696

PyrexCorex @pyrexcorex.bsky.social · 27/09/2026

Are they changing the name to ‘Gros Cul National Park’ after him?

000

PyrexCorex @pyrexcorex.bsky.social · 26/09/2026

Maybe, say, pulling out of the Iran war? That itself would be a monkey’s wrench.

000

Reposted by PyrexCorex

Nature @nature.com · 24/09/2026

AlphaFold is being upgraded to better represent some of the least known and deadliest species: viruses go.nature.com/4cZivjx

go.nature.com

AlphaFold 'goes viral': database adds protein complexes of common viruses

AI predictions could help with pandemic preparedness, but they will need experimental confirmation.

04113

Reposted by PyrexCorex

Arnaud Vanden Broeck @avbroeck.bsky.social · 23/09/2026

Very happy to share the first paper from our lab, out now in Nature Communications!🎉🥳 Structural basis of step II Spliced Leader RNA trans-splicing in trypanosomatid parasites 🧬🔬 🔗 www.nature.com/articles/s41... @natcomms.nature.com @universitedeliege.bsky.social @rockefeller.edu #cryoEM #cryo-EM

33410

Reposted by PyrexCorex

Science Magazine @science.org · 24/09/2026

A recent Science Translational Medicine Review synthesizes the translational pipeline of research decoding how tumors interact with both the central and peripheral nervous systems to fuel their growth. Learn more on #WorldCancerResearchDay: scim.ag/3V3HaNK

scim.ag

Cancer neuroscience: Mechanisms to medicine

Bidirectional cross-talk between neural circuits and tumors drives cancer progression and can be therapeutically targeted through drug repurposing.

0205

PyrexCorex @pyrexcorex.bsky.social · 24/09/2026

These freaks are bastions of superficial intelligence.

000

Reposted by PyrexCorex

Martin Pacesa @martinpacesa.bsky.social · 21/09/2026

ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use. We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition. github.com/PacesaLab/Bi...

4294142

Reposted by PyrexCorex

Daniel Hurdiss @danielhurdiss.bsky.social · 21/09/2026

Excited to share that our norovirus NS3 study is now online in Nature Communications! 🎉 These enzymes, found across an entire order of RNA viruses, have long been molecular motors in search of a function. We think we’ve uncovered their role. (🧵) www.nature.com/articles/s41... #virology #cryoEM

59728

PyrexCorex @pyrexcorex.bsky.social · 19/09/2026

Yeah, “bitch, please” comes to mind.

000

PyrexCorex @pyrexcorex.bsky.social · 19/09/2026

Also, why does Don Jr. always look like he’s modeling a training bra?

000

Reposted by PyrexCorex

Chise @sailorrooscout.bsky.social · 18/09/2026

Oh to be a little Tardigrade walking around a microscopic volvox algae colony. 🫧🐻🧪

8141141020

PyrexCorex @pyrexcorex.bsky.social · 18/09/2026

No sh*t. I’ve worked in biological containment facilities & you’ve never heard of them because containment *worked*.

060

PyrexCorex @pyrexcorex.bsky.social · 18/09/2026

DJT needs us to believe he’s pertinent so that *he* can believe it. He’ll never stop trashing the country to prove it.

000

PyrexCorex @pyrexcorex.bsky.social · 18/09/2026

This president needs a reflecting pool as shallow as he is.

000

Reposted by PyrexCorex

Nature @nature.com · 15/09/2026

Immune cells that fight stomach bugs can migrate from the gut to the brain, where they establish a lasting ‘memory’ of previous infection. go.nature.com/4yZK30T

go.nature.com

‘Stomach bugs’ send protective immune cells rushing from gut to brain

Voyaging gut-derived immune cells ‘remember’ past stomach infections in mice.

05117

Reposted by PyrexCorex

Kazuhiro Maeshima @kazu-maeshima.bsky.social · 15/09/2026

How are mitotic chromosomes built? Our Review @cp-trendsgenetics.bsky.social revisits the classical chromosome scaffold model and connects it to condensins, topoIIα, and physical forces. We propose interphase chromatin domains as “building blocks”🧩of chromosomes: authors.elsevier.com/a/1nmwrcQbJI...

12820

PyrexCorex @pyrexcorex.bsky.social · 15/09/2026

🎯 Worse yet, on reality.

000

PyrexCorex @pyrexcorex.bsky.social · 15/09/2026

If Thomas & Alito had been twins, one would have reabsorbed the other.

010

Reposted by PyrexCorex

FocalPlane @focalplane.bsky.social · 10/09/2026

🔬🔦Our latest Imaging spotlight highlights FOCUS-3D, a tool for segmenting cells from 3D fluorescence images from Qinghua Zhang, @mads100tist.bsky.social, @gqyu.bsky.social & team. They tell us what’s different about FOCUS-3D and what makes it so useful and usable for biologists.

focalplane.biologists.com

Imaging spotlight: FOCUS-3D - FocalPlane

Imaging spotlight: FOCUS-3D - News

02911

Reposted by PyrexCorex

EMBL Events @events.embl.org · 10/09/2026

🧬 Ready to dive into the world of RBPs? The #EMBLRBP Conference is back in 2027! Submit your abstract by 6 December 2026 to present your work to our global community of researchers: s.embl.org/rbp27-01-bl Date: 15 – 18 March 2027 EMBL Heidelberg and Virtual Organised with the support of KAUST.

054