Nature Structural & Molecular Biology, Published online: 06 March 2026; doi:10.1038/s41594-026-01750-6METALoci, a computational framework to study the 3D genome, reveals a prominent rewiring of regulatory interactions during sex determination. This geostatistics-inspired method also uncovered a previously unknown non-coding regulatory region at the Fgf9 locus and identifies Meis genes as crucial regulators of sex differentiation.

Nature Structural & Molecular Biology - METALoci, a new three-dimensional genome computational tool, reveals a major rewiring of regulatory interactions during sex determination. By combining...

Spermatogenesis is the biological process by which male sperm cells (spermatozoa) are produced in the testes. Beyond facilitating the transmission of genetic information, spermatogenesis also provides...

Despite the growing abundance of sequenced animal genomes, we only have detailed knowledge of regulatory organization for a handful of lineages, particularly flies and vertebrates. These two groups of...

Nature Communications - The pluripotency program is maintained by transcription factors from the Sox and POU families. Here they identify SOX and POU factors from unicellular relatives of animals...