Cryo-electron tomography provides an unprecedented view of cellular architecture, yet extracting meaningful biological insights remains challenging. S…

Early enthusiasm for the “cellular revolution” in cryo-electron tomography (cryo-ET) was largely driven by the promise of resolving protein structures…

We are pleased to announce the 11th International Congress on Electron Tomography, taking place August 9 – 12, 2026, in Madison, WI. This landmark gathering will bring together leading researchers, mi...

Back to the density: using Surface Morphometrics to measure organelle membrane thickness in cryo-electron tomography - Tools

Nature - PIEZO2 is intrinsically more rigid than PIEZO1, and disparate mechanical stimuli paradoxically evoke opposite conformational and gating responses in each channel.

Cellular cryo-electron tomography (cryo-ET) holds the grand promise of integrating cellular architecture with molecular structure. Yet, for many cell biologists, this method can seem technically…

In situ cryo-EM coupled with 2D template matching (2DTM) holds the potential to visualize the cellular structureome in context, but further developments are required to make this a reality. We describ...