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Ye Lab

@liye-tsri.bsky.social
156 followers 140 following 19 posts

Ye lab at Scripps Research and HHMI. Neuroscience, Metabolism, and Chemical Biology. Opinions are my own and do not reflect those of my employer.

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Ye Lab @liye-tsri.bsky.social · 02/07/2026
Our new preprint is out!! The human brain runs on ~20 watts. Computers and modern AI systems require vastly higher energy. This gap raises a fundamental question: how does the brain compute so efficiently? In our new study, we take a critical step toward measuring and understanding this directly 1/3
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Ye Lab @liye-tsri.bsky.social · 10/06/2026
We are looking for a Research Technician! see job posting here: hhmi.wd1.myworkdayjobs.com/en-US/Extern...
hhmi.wd1.myworkdayjobs.com
Research Technician - Ye Lab
Primary Work Address: 10550 North Torrey Pines Road, La Jolla, CA, 92037 Current HHMI Employees, click here to apply via your Workday account. The Howard Hughes Medical Institute (HHMI) advances the d...
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Ishmail Abdus-Saboor @ishmailsaboor.bsky.social · 09/06/2026
Congratulations to the 2026 McKnight Scholars! Great to see many friends amongst this cohort! www.mcknight.org/news-ideas/2...
mcknight.org
2026 McKnight Scholar Awards
The Board of Directors of The McKnight Endowment Fund for Neuroscience is pleased to announce it has selected ten neuroscientists to receive the 2026 McKnight Scholar Award.
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HHMI @hhmi-science.bsky.social · 28/04/2026
What's better than one #HHMIInvestigator being elected to the @nasonline.org? Ten! Meet the newest members, recognized by their peers for distinguished, ongoing contributions to original research: bit.ly/4cCxRuv.
10 HHMI Investigators elected to the National Academy of Sciences:

- Jesse Bloom, Fred Hutchinson Cancer Center
- Clifford P. Brangwynne, Princeton University
- Ralph J. DeBerardinis, UT Southwestern Medical Center
- Chuan He, The University of Chicago
- Stephen Liberles, Harvard Medical School
- Vanessa Ruta, The Rockefeller University
- Pardis C. Sabeti, Harvard University
- Russell E. Vance, University of California, Berkeley
- Johannes Walter, Harvard Medical School
- Yi Zhang, Boston Children’s Hospital
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Ye Lab @liye-tsri.bsky.social · 05/04/2026
I’m so proud of myself!
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Ye Lab @liye-tsri.bsky.social · 03/04/2026
Excited to share our latest work with @antihebbiann.bsky.social, revealing a top-down mechanism regulating the fragmentation of feeding, led by Tianbo Qi. www.biorxiv.org/content/10.6...
biorxiv.org
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Ann Kennedy @antihebbiann.bsky.social · 23/03/2026
I had a great time talking to Meenakshi about my trajectory through neuroscience! Tune in for electric fish, imaging the hypothalamus, and trying to find a path in theory that stays relevant to the brain. Also, my early phd experiences of trying to do science when real life rears its head.
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Giordano Lippi @lippilab.bsky.social · 24/02/2026
Chuffed to see our paper with @geneyeo.bsky.social finally published in @nature.com. www.nature.com/articles/s41... Very grateful to Fede, Susie, and Dave from my lab, and Sammi, Eric, and Pratibha from Gene's lab. What did we find? ⬇️ ⬇️ ⬇️
nature.com
Single-cell and isoform-specific translational profiling of the mouse brain - Nature
Post-transcriptional regulation of mRNA translation was explored using Ribo-STAMP and single-cell RNA sequencing to reveal cell-type-specific and isoform-specific translation patterns across hipp...
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LifeCanvas Technologies @lifecanvastech.bsky.social · 10/02/2026
What if we could see 3D #biodistribution of cancer drugs at the cellular level... throughout an entire model animal? 🧐 A new paper from Li Ye's lab @scripps.edu, Zhengyuan Pang & Verina Leung et al. introduce a technique for doing just that. (1/3) 🧵
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Ye Lab @liye-tsri.bsky.social · 22/12/2025
Thrilled to share our latest work--combining CATCH with whole-body HYBRiD imaging, leveraging click chemistry to visualize and identify drug-targeted cells across organ systems. Led by a brilliant team: former PhD student Ben Pang and former undergrad Verina Leung.
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Simons Foundation @simonsfoundation.org · 21/12/2025
Fellows-to-Faculty awardee Chen Ran maps the senses of internal organs. Receiving this award — which is currently open for apps — has been crucial in enabling his work: www.simonsfoundation.org/autism-and… #science
quote from Chen Ran: “I feel very lucky to have the support of the Simons Foundation and to have access to this outstanding community.”
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Ardem Patapoutian @ardemp.bskyverified.social · 07/11/2025
RIP Jim Watson. You inspired many of us to pursue a life in research. I wish you had made it easier for us to celebrate your legacy.
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Ye Lab @liye-tsri.bsky.social · 09/11/2025
Nothing beats the ceremony of dragging a grant from my pending folder to dead grant folder hahaha (sometimes it did give a big relief though)
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Ye Lab @liye-tsri.bsky.social · 03/11/2025
Deeply honored to receive this year's Tianqiao and Chrissy Chen Young Investigator Award from @sfn.org Grateful to all lab members and my mentors.
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Ann Kennedy @antihebbiann.bsky.social · 14/10/2025
Come be my newest colleague! Scripps neuro is an energetic and supportive department, and uniquely benefits from proximity to our intimidatingly awesome chem and drug discovery programs. Happy to chat about my experiences here so far!
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Scripps Research @scripps.edu · 10/10/2025
The NIH has awarded a $14.2M Director’s Transformative Research Award to a team led by Nobel Prize-winning neuroscientist @ardemp.bskyverified.social, Prof. @liye-tsri.bsky.social and Assoc. Prof. @xinjin.bsky.social to map interoception and build the first atlas of this hidden sixth sense.
scripps.edu
Scripps Research-led team receives $14.2M NIH award to map the body’s “hidden sixth sense”
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Ann Kennedy @antihebbiann.bsky.social · 09/10/2025
Finally out: our recent work with Nick Betley is a view into how the brain reshapes its behavior in the face of competing survival needs- and also a potential angle on treatment targets for enduring pain. A brief rundown... www.nature.com/articles/s41...
nature.com
A parabrachial hub for need-state control of enduring pain - Nature
Activity in a set of parabranchial neurons in the mouse brain is increased during chronic pain, predicts coping behaviour, and can be modulated by circuits activated by survival threats.
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Xin Jin @xinjin.bsky.social · 08/10/2025
Coming to #SfN2025 in San Diego? Come join our Neuroscience Symposium a day before on Nov 13! Hear from a fantastic speaker lineup and interact with vibrant audience in our community and beyond. Free registration link: www.eventbrite.com/e/dorris-neu...
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Ye Lab @liye-tsri.bsky.social · 20/06/2025
Congrats to @xinjin.bsky.social @tinakim-neuro.bsky.social and many others!
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Ardem Patapoutian @ardemp.bskyverified.social · 03/06/2025
Talked to @KateZernike at @nytimes about my journey and the current moment for scientists in the U.S. “Ardem Patapoutian’s story is not just the American dream, it is the dream of American science.” Read the article here. No subscription required: www.nytimes.com/2025/06/03/u...
nytimes.com
The U.S. Lit a Beacon for Science. Under Trump, Scientists Fear It’s Dimming
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Scripps Research @scripps.edu · 07/05/2025
Congrats to Assist. Prof. Chen Ran (@chenran.bsky.social), one of just 15 selected as a 2025 Searle Scholar! 🌟 His work on how visceral signals are encoded in the brain was recognized for its potential to elucidate disease mechanisms & inform new therapeutics. More: ow.ly/HtLM50VN8sN
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Ann Kennedy @antihebbiann.bsky.social · 20/04/2025
Congratulations to @chenran.bsky.social on being named a Searle Scholar! searlescholars.org/2025/04/14/s...
searlescholars.org
SEARLE SCHOLARS PROGRAM NAMES 15 SCIENTISTS AS SEARLE SCHOLARS FOR 2025
Members of the new class of Searle Scholars pursue ground-breaking research in chemistry and the biomedical sciences. Each receives an award of $300,000 in flexible funding to support his, her, or …
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Chen Ran @chenran.bsky.social · 16/04/2025
Lots of recent papers discuss the nucleus of the solitary tract in interoception. In this review, we take a sensory processing perspective on how interoceptive signals are encoded in the NTS: www.sciencedirect.com/science/arti...
sciencedirect.com
Interoceptive processing in the nucleus of the solitary tract
The interoceptive nervous system continuously monitors the status of visceral organs to synthesize internal perceptions and regulate behavioral and ph…
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Ardem Patapoutian @ardemp.bskyverified.social · 06/03/2025
Great collaboration with @liye-tsri.bsky.social @dlipomi.bsky.social, and Jonathan Long labs and led by Yu Wang and Yunxiao Zhang 2/2
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