Participants in the study will be randomized to receive two C. difficile vaccine doses six months apart, or a placebo, to learn if an investigational vaccine is safe and can help prevent C. difficile ...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Here the authors define the conformational landscape of human IP3R-2 and identify a ligand-dependent inter-channel interface that mediates receptor clustering during calcium signalling.

The bacterial flagellar motor is finally understood after 50 years. In its workings, columnist Natalie Wolchover finds the essence of life.

The biochemistry lab of Doug Mitchell discovered the enzyme responsible for a rare chemical modification that doesn't exist in human cells, which can potentially become a new target for developing ant...

The Trump administration has slashed the number of grants from the National Institutes of Health, with far fewer focused on women, cancer and mental health.

AI and “protein language” models can speed the design of monoclonal antibodies that prevent or reduce the severity of potentially life-threatening viral infections.

Apply for 2026 Summer Intern - Agents for Structural Biology job with Genentech in South San Francisco, California, United States of America. Students & Graduates at Genentech

Applying for an NIH fellowship can feel overwhelming, but the right guidance makes all the difference. This collection of resources walks you through every stage of the process – from identifying t…

The SBGrid Consortium is an innovative global research computing group operated out of Harvard Medical School. SBGrid provides the global structural biology community with support for research…

Ordered membrane nanodomains colloquially known as “lipid rafts” have many proposed cellular functions. However, pharmacological tools to modulate protein affinity for rafts and to manipulate raft for...

Structure-based drug design has traditionally focused on optimizing static, enthalpic interactions between ligands and proteins or on displacing binding site solvent molecules to entropically favor bi...

Since the inception of the Ancora Innovations partnership in 2018, Vanderbilt and Deerfield Management have enjoyed a robust collaboration. Deerfield’s commitment includes significant support for adva...

By Cameron I. Cohen Cellulases are enzymes responsible for the hydrolysis of glycosidic bonds in cellulose, a polysaccharide which serves as the main structural material in plant cell walls. The effic...

VUSM played a major role in a national conference that showcased the critical need to train biomedical researchers to advance medical care.

In a heartwarming tribute to a remarkable career, more than 70 of his former graduate students and postdoctoral scholars recently traveled from across the globe for a three-day festivity on Oct. 3–5 t...

Vanderbilt’s Dr. Benjamin P. Brown is improving the way the field of drug discovery creates machine learning algorithms to predict a protein’s interactions with a small molecule. These improvements br...

SBGrid member Jens Meiler uses Rosetta to design antibiotic peptides called lanthipeptides with antibiotic properties.

A logbook for the Diffuse Project

The SBGrid Consortium is an innovative global research computing group operated out of Harvard Medical School. SBGrid provides the global structural biology community with support for research…

Interested in the Diffuse Project? Please provide your information to help us shape community engagement and potentially direct you to the right project member.

Cold-adapted cellulases have the potential to reduce energy demands in industrial processes by enabling efficient cellulose saccharification at lower temperatures. However, the structural basis of co...