Using engineered scaffolds mimicking intestinal crypts, Maimets et al. show that tissue geometry drives epithelial maturation by regulating YAP activity. Crypt-like structures promote differentiation of fetal cells, providing insight into how form guides function and offering a platform for modeling intestinal development and repair.

Nature Biotechnology - Hughes and colleagues present a developmentally inspired tissue engineering strategy to overcome barriers in kidney tissue generation, enhancing prospects for renal...

The influence of the nervous system on the intestine is carried out by a combination of enteric, sensory, and autonomic innervation. However, disambig…

A 50-year multi-tissue proteomic atlas reveals transcriptome-proteome decoupling, proteostasis decline with amyloid accumulation, and asynchronous aging clocks, identifying circulating senoproteins co...

Diet, microbiota, and other exposures place the intestinal epithelium as a nexus for evolutionary change; however, little is known about genomic changes associated with adaptation to a uniquely human ...

Genome-wide CRISPR screens map how genes support survival and contribute to diverse biological functions. Here, the authors use antiCRISPR to enhance genome-wide CRISPR screening in Drosophila and gen...

Nature Biotechnology - Defining and benchmarking open problems in single-cell analysis

AUDIO • Comment se passer de l'expérimentation animale ?, épisode 2/5 : Comment la souris est devenue le modèle par excellence ?. Une série inédite proposée par France Culture. Écoutez Avec sciences, ...

Human cells injected into amniotic fluid find their way into fetal mouse organs.

During development, cells must interpret extracellular signals with speed and accuracy. While morphogen gradients pattern tissues, how cells respond to dynamic morphogens remains unclear. Here, we inv...

Yu and his colleagues present a 3D spatial transcriptomic map of a CS9 human embryo, investigating several key developmental events during this critical stage of body patterning.

The human endoderm-derived organoid cell atlas (HEOCA) presents an integrative analysis of single-cell transcriptomes across different conditions, sources and protocols. It compares cell types and sta...

O’Connor, Zhang, Stevens, and colleagues present PHAST, a powerful high-throughput platform that enables in vivo screening of 43 engineered tissues within a single animal. PHAST enables rapid identification of cellular and material formulations that support tissue vascularization and engraftment in vivo, paving the way for next-generation therapeutic tissues for regenerative medicine.

This article complements the 2021 International Society for Stem Cell Research (ISSCR) Guidelines for Stem Cell Research and Clinical Translation by explaining what “adequate and appropriate scientifi...

This Review discusses current 2D and 3D microscopy methods for imaging three-dimensional cell cultures and emerging strategies to address key challenges.

High-content phenotypic screens provide a powerful strategy for studying biological systems, but the scale of possible perturbations and cell states makes exhaustive experiments unfeasible. Computatio...