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GutTalkMd

@karapedsgastrodoc.bsky.social
597 followers 375 following 22 posts

Pediatric gastroenterologist and physician scientist; Director of the NYU Pain Research Center; gut-brain enthusiast, especially when it comes to mood and neurobehavior.

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MargolisLab @margolislabnyu.bsky.social · 05/03/2026
Food is more than fuel for growing bodies, it may shape developing minds. Higher ultraprocessed food intake in preschool years was associated with more behavioral and emotional symptoms in early childhood. @karapedsgastrodoc.bsky.social jamanetwork.com/journals/jam...
jamanetwork.com
Ultraprocessed Food Consumption and Behavioral Outcomes in Canadian Children
This cohort study examines the associations between intake of ultraprocessed foods at age 3 years and behavioral outcomes at age 5 years among children in Canada.
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MargolisLab @margolislabnyu.bsky.social · 05/03/2026
A gut-acting 5-HT4 drug, prucalopride, shows faster antidepressant/anxiolytic effects than fluoxetine in mice, with parallel shifts in the microbiome. @karapedsgastrodoc.bsky.social www.nature.com/articles/s41...
nature.com
Prucalopride, a serotonin type 4 receptor agonist, induces fast anxiolytic/antidepressant effects and concomitant changes in the gut microbiota - npj Biofilms and Microbiomes
npj Biofilms and Microbiomes - Prucalopride, a serotonin type 4 receptor agonist, induces fast anxiolytic/antidepressant effects and concomitant changes in the gut microbiota
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MargolisLab @margolislabnyu.bsky.social · 09/03/2026
A large cohort study of 126,735 adults followed over 14.5 years show the high prevalence of IBS cases in instances of severe emotional and physical neglect, as well as abuse. @karapedsgastrodoc.bsky.social www.nature.com/articles/s41...
nature.com
Long-term risk of irritable bowel syndrome associated with adverse childhood and adulthood experiences: a large-scale prospective cohort study - Translational Psychiatry
Translational Psychiatry - Long-term risk of irritable bowel syndrome associated with adverse childhood and adulthood experiences: a large-scale prospective cohort study
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MargolisLab @margolislabnyu.bsky.social · 09/03/2026
Another promising finding for 5HT4R agonism! This study found that in participants with previous episodes of depression, 5-HT4R agonist, prucalopride, had pro-cognitive effects (learning, memory & attention). @karapedsgastrodoc.bsky.social doi.org/10.1016/j.ns...
doi.org
Redirecting
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NYU Pain Research Center @nyupainresearch.bsky.social · 11/03/2026
Huge congratulations to PRC Associate Director Steve Davidson on securing an NIH R01 to investigate new targets for diabetic neuropathic pain! #painresearch @sdavidson.bsky.social @yysquare.bsky.social @karapedsgastrodoc.bsky.social
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NYU Pain Research Center @nyupainresearch.bsky.social · 16/03/2026
NEW PRC PAPER 🚨 This study led by @mariafialho.bsky.social from the Bunnett Lab reveals that tryptase from mast cells activates PAR2 on sensory neurons, sustaining painful symptoms induced by an aromatase inhibitor. buff.ly/lVAgUgO @tonelloraquel.bsky.social @karapedsgastrodoc.bsky.social
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MargolisLab @margolislabnyu.bsky.social · 17/03/2026
New from our lab: Untreated maternal depression & early-life stress can rewire gut–brain circuits via enteric + sympathetic pathways, leading to long-term changes in gut motility & pain. www.sciencedirect.com/science/arti... @karapedsgastrodoc.bsky.social @sarahanajjar.bsky.social
sciencedirect.com
Enteric and Sympathetic Nervous System Pathways Mediate Early Life Stress Effects on Gut Motility and Pain: Mechanistic Findings with Human Correlation
Adverse experiences during early life can disrupt gut-brain axis development, but the mechanisms linking early life stress (ELS) to long-term gastroin…
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NYU Pain Research Center @nyupainresearch.bsky.social · 17/03/2026
Congratulations to the Margolis Lab on their standout translational study published in Gastroenterology! @karapedsgastrodoc.bsky.social @sarahanajjar.bsky.social @linyhung.bsky.social
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NYU Pain Research Center @nyupainresearch.bsky.social · 24/03/2026
We are thrilled to be at USASP in Philadelphia! Looking forward to a week of great science. @karapedsgastrodoc.bsky.social @sarahanajjar.bsky.social @sdavidson.bsky.social @elisadamo.bsky.social @tonelloraquel.bsky.social @mariafialho.bsky.social @pazduran.bsky.social @badrsokrat.bsky.social
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NYU Pain Research Center @nyupainresearch.bsky.social · 24/03/2026
Please visit our posters today at #USASP! @karapedsgastrodoc.bsky.social @elisadamo.bsky.social @tonelloraquel.bsky.social @pazduran.bsky.social
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NYU Pain Research Center @nyupainresearch.bsky.social · 25/03/2026
Come see us at our presentations today at #USASP2026! @karapedsgastrodoc.bsky.social @jimr-1.bsky.social @afshin419.bsky.social @mariafialho.bsky.social @sarahanajjar.bsky.social @goinsyeah.bsky.social
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NYU Pain Research Center @nyupainresearch.bsky.social · 25/03/2026
Don’t miss Dr. Kara Margolis’ talk this afternoon at #USASP2026 on serotonin signaling in the gut-brain axis! @karapedsgastrodoc.bsky.social
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NYU Pain Research Center @nyupainresearch.bsky.social · 27/03/2026
Very proud of our group’s showing at #USASP2026! Thank you to the organizers of this fantastic meeting! @usasp.bsky.social @karapedsgastrodoc.bsky.social @sdavidson.bsky.social @sarahanajjar.bsky.social @yylab.bsky.social @goinsyeah.bsky.social @pazduran.bsky.social @keylinesc.bsky.social
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NYU Pain Research Center @nyupainresearch.bsky.social · 15/04/2026
@karapedsgastrodoc.bsky.social
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NYU Pain Research Center @nyupainresearch.bsky.social · 27/04/2026
NEW PRC PREPRINT 🚨 The Thomsen Lab identifies a shared hydrophobic “hotspot” within GPCRs that mediates direct competition among their transducers, pointing to a universal mechanism that regulates receptor access & desensitization. buff.ly/OAtZd9X @karapedsgastrodoc.bsky.social
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NYU Pain Research Center @nyupainresearch.bsky.social · 07/05/2026
NEW PRC PAPER 🚨: Research from the @adesgeorges.bsky.social Lab with @harsh3b.bsky.social reveals that beta-arrestin 1 actively drives cell signaling, not just as a scaffold, but as a direct activator. #StructuralBiology #GPCRs buff.ly/4BfXcYz @karapedsgastrodoc.bsky.social
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NYU Pain Research Center @nyupainresearch.bsky.social · 08/05/2026
Very proud to share this @usasp.bsky.social podcast episode featuring PRC postdoc Elisa Damo @elisadamo.bsky.social, one of the Top 5 Travel Awardees from the USASP Annual Scientific Meeting! @karapedsgastrodoc.bsky.social soundcloud.com/usasp/episod...
soundcloud.com
34. 2026 USASP Annual Meeting Top 5 Trainee Travel Awardees
Listen to the top five travel awardees from the 2026 USASP Annual Meeting which took place from March 23-26, 2026 in Philadelphia, Pennsylvania. In this episode, we will learn on the current work fro
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MargolisLab @margolislabnyu.bsky.social · 18/05/2026
Congratulations to Haoming on graduating from New York University with a Master of Science in Biology from the Graduate School of Arts and Sciences! 🎓✨ Wishing you all the best in your next chapter, we’re so proud of you! @karapedsgastrodoc.bsky.social
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NYU Pain Research Center @nyupainresearch.bsky.social · 28/05/2026
Amazing day so far at the PRC symposium! So much exciting science from our research community and awesome keynote speakers. @karapedsgastrodoc.bsky.social @jimr-1.bsky.social @sarahanajjar.bsky.social @tonelloraquel.bsky.social @elisadamo.bsky.social @pazduran.bsky.social @badrsokrat.bsky.social
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NYU Pain Research Center @nyupainresearch.bsky.social · 29/05/2026
More shots from our PRC Symposium yesterday. We were grateful to host wonderful keynote speakers: Dr. Walter Koroshetz, Dr. Lin Chang, Dr. Jeffrey Hubbell, and Dr. Ru-Rong Ji! @karapedsgastrodoc.bsky.social
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MargolisLab @margolislabnyu.bsky.social · 29/05/2026
Highlights from the 2026 Pain Research Center Symposium! Dr. Kara Margolis presented: “Compartmental Serotonergic Signaling in Gut–Brain Health: Clinical Implications for Mood and Abdominal Pain” Thanks to everyone for a great day of science! @karapedsgastrodoc.bsky.social
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MargolisLab @margolislabnyu.bsky.social · 29/05/2026
The Margolis Lab was proud to be represented by six poster presenters at the 2026 Pain Research Center Symposium! Congratulations to: Sarah, Daniel, Chalystha, Lin, Rahi, Taeseon Great job to everyone who presented and contributed to a fantastic day of science! @karapedsgastrodoc.bsky.social
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MargolisLab @margolislabnyu.bsky.social · 29/05/2026
ConGRADulations, Mariam! 🎓 It has been a pleasure having Mariam in the Margolis Lab through NYU Dentistry's TRIP&ICE program. We are so proud of all she has accomplished and wish her the very best in her next chapter! @karapedsgastrodoc.bsky.social @chalysthalee.bsky.social
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Chalystha Lee @chalysthalee.bsky.social · 11/02/2026
Look who stopped by NYC from across the globe! Felt like worlds colliding having my PhD PI @elimelb.bsky.social and postdoc PI @karapedsgastrodoc.bsky.social in the same room. So fitting on Intl Day of Women&Girls in Science to celebrate two brilliant women who paved the way for me!
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Luca Posa @dr-lupo.bsky.social · 08/12/2025
Such a great day at @nyupainresearch.bsky.social gathering with NYC-area Pain Scientists. Excellent science and people. Thank @karapedsgastrodoc.bsky.social @sdavidson.bsky.social for hosting, my buddie organizer @justinburdge.bsky.social and everyone joined and oresebted! See you next year!
idson.bsky.social
Bluesky
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Justin Burdge, PhD @justinburdge.bsky.social · 08/12/2025
The 1st NYC Area Pain Research Meetup was a roaring success! What started as an idea from @dr-lupo.bsky.social and myself turned into an incredible gathering with the help of @karapedsgastrodoc.bsky.social, and her team at @nyupainresearch.bsky.social. #PainResearch #Neuroscience #Neuroskyence
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GutTalkMd @karapedsgastrodoc.bsky.social · 16/12/2025
Happy holidays from the Margolis lab! Pic after a hard core karaoke party😂
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Justin Burdge, PhD @justinburdge.bsky.social · 05/11/2025
Shoutouts to @nyupainresearch.bsky.social @vabraira.bsky.social @dr-lupo.bsky.social @sdavidson.bsky.social @karapedsgastrodoc.bsky.social for helping organize!
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MargolisLab @margolislabnyu.bsky.social · 24/07/2025
New research reveals that the gut can sense microbial flagellin via TLR5-expressing neuropod cells, triggering PYY release & reducing feeding through a gut–brain neural circuit—independent of microbiota or immune cues. @karapedsgastrodoc.bsky.social 🔗 www.nature.com/articles/s41...
nature.com
A gut sense for a microbial pattern regulates feeding - Nature
A study reveals a gut–brain sensory pathway through which the microbial component flagellin activates neuropod cells in the colon to signal the brain and reduce feeding in mice.
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GutTalkMd @karapedsgastrodoc.bsky.social · 22/07/2025
@chalysthalee.bsky.social did an amazing job presenting at the ISSR! Such a well-deserved travel award and so proud to have her representing the lab!!
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MargolisLab @margolislabnyu.bsky.social · 24/06/2025
A new study shows that food structure plays a key role in determining which gut hormones are released. @karapedsgastrodoc.bsky.social #GLP1 #GutBrainAxis #FoodStructure #Type2Diabetes #ImperialCollege 📖 Nature Metabolism www.nature.com/articles/s42...
nature.com
Upper-gastrointestinal tract metabolite profile regulates glycaemic and satiety responses to meals with contrasting structure: a pilot study - Nature Metabolism
In this randomized crossover pilot study, the authors collected human gastrointestinal digesta using a unique intubation technique to compare how meals with contrasting cellular structures affect post...
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MargolisLab @margolislabnyu.bsky.social · 20/06/2025
🩸 A new blood test (WBAIL-2) detects gluten-triggered IL-2 release, offering a non-invasive, accurate way to diagnose celiac disease, even in patients on a gluten-free diet! 🌾❌ Game-changer for gut health. sciencedirect.com/science/arti... #guthealthmatters #WBAIL2 @karapedsgastrodoc.bsky.social
sciencedirect.com
Blood-based T Cell Diagnosis of Celiac Disease
Current diagnosis of celiac disease (CeD) is inaccurate in patients following a gluten-free diet (GFD). Blood-based diagnostics targeting gluten-speci…
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Raquel Tonello @tonelloraquel.bsky.social · 11/06/2025
Excited to share my first senior author paper in Pain! 🎉 We identify Synaptojanin 1 & Endophilin A1 as key endocytic mediators of nociception. Silencing them blocks spinal synaptic transmission and relieves pain in cancer & postoperative models, without affecting normal behavior. buff.ly/caKMGY3
buff.ly
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Joshua Weitz @joshuasweitz.bsky.social · 31/05/2025
How bad will it be? Catastrophic. Proposed cuts to #NSF, #NIH, and #NASA will set the US R&D landscape back 25 yrs+, cause economic and job loss now, and undermine innovations to come. But, this is the WH's *proposed* budget. Speak up now before it is too late. (inflation adjusted $-s below)
NSF, NASA and NIH budgets per year, inflation adjusted from 2000-2025 along with the proposed cuts. NSF includes research component only. Massive cuts across all sectors, well below support spanning 25 years.
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NYU Pain Research Center @nyupainresearch.bsky.social · 30/05/2025
🎤 BLINK AND YOU'LL MISS IT: FLASH TALKS AT THE 5TH ANNUAL AMPIRS! ⚡ This year’s Flash Talks were a whirlwind of brilliance 🎤one mic, infinite insight. And WOW, did our presenters deliver! 👏PRC representing! #PRCpride #violetpride #NYUDental #nyuniversity
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NYU Pain Research Center @nyupainresearch.bsky.social · 31/05/2025
Round two- ding ding! 🥊 Time for an AMPIRS photo dump that’ll knock your lanyard off 😎🚨poster session 2 coming in 🤳📸 picture perfect!👌
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NYU Pain Research Center @nyupainresearch.bsky.social · 31/05/2025
And just like that, AMPIRS takes its final bow! 🎬Huge cheers to our grand finale presenters and a confetti cannon 🎉 of congrats to all the Flash Talk, Poster and Oral Presentation champs! 🏆 You dazzled, you delivered, you definitely deserve it! #PRCpride #MPBpride
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NYU Pain Research Center @nyupainresearch.bsky.social · 31/05/2025
Curtains down on AMPIRS! Dr. Nigel Bunnett, our MPB Chair, brought it home with closing remarks. Huge thanks to our amazing sponsors and a special shoutout to MPB for hosting AMPIRS & Welcoming the Pain Research Center into the fun! And now… cue the real research question: Wheres happy hour? 🍹😄
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MargolisLab @margolislabnyu.bsky.social · 29/05/2025
New study! Aging and nerve injury cause senescent neurons in the peripheral nervous system, driving increased pain; targeting these cells could offer a new pain treatment especially in older adults. @vivtawfik-mdphd.bsky.social @karapedsgastrodoc.bsky.social www.nature.com/articles/s41...
nature.com
Aging and injury drive neuronal senescence in the dorsal root ganglia - Nature Neuroscience
The authors describe a susceptibility of the peripheral nervous system to neuronal senescence with age or injury relevant for sensory dysfunction, such as chronic pain.
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MargolisLab @margolislabnyu.bsky.social · 29/05/2025
IL-18 signaling in epithelial-derived enterochromaffin cells plays a pivotal role in injury response and stem cell activation in the mouse intestine #gutresearch #epithelialcells #IL18 #stemcells @karapedsgastrodoc.bsky.social www.pnas.org/doi/10.1073/...
pnas.org
The IL-18 receptor is expressed on murine small-intestinal enterochromaffin cells and executes a recovery program upon injury | PNAS
Upon injury, epithelial-derived IL-18 is released and induces an inflammatory response in underlying IL18R1+ lamina propria cells. Notably, Il18r1 ...
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NYU Pain Research Center @nyupainresearch.bsky.social · 21/05/2025
@karapedsgastrodoc.bsky.social @margolislabnyu.bsky.social @amergastroassn.bsky.social PRC Website: dental.nyu.edu/research/pai... Margolis Lab: dental.nyu.edu/faculty/mole...
dental.nyu.edu
NYU Pain Research Center
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NYU Pain Research Center @nyupainresearch.bsky.social · 22/05/2025
Yes! Your taste buds do talk to your brain🧠! Thank you Dr. Nirupa Chaudhari for a fantastic talk! #brain #NYUdentistry #PRC
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NYU Pain Research Center @nyupainresearch.bsky.social · 22/05/2025
Tea 🫖 Time ⏰! Happy monthly birthday shoutout! #PRC #NYUdentistry #NYU #MPB 🎂🥳🎈#happybirthday
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NYU Pain Research Center @nyupainresearch.bsky.social · 27/05/2025
A new study with Dr. Yi Ye as a co-author "Associations of Pain, Anxiety, and Depressive Symptoms With Sleep Outcomes in Patients with Head and Neck Squamous Cell Carcinoma: A Cross-Sectional Observational Study" #Pain #Anxiety #Depression #HNSCC onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com
Associations of Pain, Anxiety, and Depressive Symptoms With Sleep Outcomes in Patients With Head and Neck Squamous Cell Carcinoma: A Cross‐Sectional Observational Study
Background This exploratory cross-sectional observational study sought to characterize sleep quality and evaluate its association with sociodemographic, clinicopathological, behavioral, and psycholo...
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NYU Pain Research Center @nyupainresearch.bsky.social · 27/05/2025
Green light for pain relief! 🟢 Researchers found green light therapy reduced osteoarthritis pain in rats, via analgesic endolipids engaging the endocannabinoid system. #PainResearch #GreenLight #Osteoarthritis journals.lww.com/pain/fulltex...
journals.lww.com
Visual exposure to green light therapy reduces knee joint... : PAIN
cytokines in the cerebrospinal fluid. The present study assessed the effect of green light therapy (GLT) on joint pain in a rat model of osteoarthritis (OA) and investigated the role of endolipids. Ma...
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NYU Pain Research Center @nyupainresearch.bsky.social · 29/05/2025
@badrsokrat.bsky.social
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NYU Pain Research Center @nyupainresearch.bsky.social · 30/05/2025
🚨Sound the alarm- it’s an AMPIRS photo dump! 🚨Poster Session 1 brought the heat 🔥 Big shoutout to our amazing PRC members who rocked their posters! #NYUDental #nyuniversity #AMPIRS #Painresearchcenter
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NYU Pain Research Center @nyupainresearch.bsky.social · 17/05/2025
#PRC Highlight: Happy Flash back Friday! Flashing Back to Cinco De Mayo! 💃🕺🏼🪇 MPB Tea Time always celebrating in style! #PRCpride #teatime #🫖 #cincodemayo #flashbackfridays #thankyou #PRC
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NYU Pain Research Center @nyupainresearch.bsky.social · 20/05/2025
New research reveals prolactin as a driver of stress-induced post-surgery pain in women. Blocking prolactin shows promise for better pain management & reduced opioid use! #PostoperativePain #Prolactin #PainResearch www.pnas.org/doi/10.1073/...
pnas.org
A prolactin-targeting antibody to prevent stress-induced peripheral nociceptor sensitization and female postoperative pain | PNAS
Scheduled surgeries elicit stress in many patients. Levels of preoperative stress, anxiety, and female gender are known risk factors for increased ...
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NYU Pain Research Center @nyupainresearch.bsky.social · 20/05/2025
Great talk given to the PRC PRIMED Club by guest speaker Manon Bohic on Spinal Oxytocin Modulates Touch Reward and Pain Relief Through Shared Dorsal Horn Circuits. Manon Bohic is a research associate at Rutgers University.👏 #Thankyou for the visit! #SpinalDorsal #PRC #womeninscience
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