Reposted by Aria 哲媛 HuangDevelopmental Biology @devbiol.bsky.social · 05/05/2026#DBfeature Elongation of the nascent avian foregut requires coordination of intrinsic and extrinsic cell behaviors By Olivia Powell, Emily Garcia, Vanshika Sriram, Yi Qu, Nandan L. Nerurkar tinyurl.com/52pecyc5 0127
Aria 哲媛 Huang @azyhuang.bsky.social · 15/04/2026super exciting new system for studying and manipulating branching! 🌳🌳🙆♀️ 010
Aria 哲媛 Huang @azyhuang.bsky.social · 02/04/2026so fortunate to work with everyone on this mission, especially paul who made the magic happen✨ 000
Reposted by Aria 哲媛 Huangaustin (he/him) @austinjgraham.bsky.social · 10/03/2026organs develop in a dynamic environment where their boundaries are constantly changing shape, relaxing, compressing, etc. in synchrony with the embryo. see how this inspired us to create a material for optimal organoid bioprinting & self-organization! www.nature.com/articles/s41...nature.comStress-relaxing granular bioprinting materials enable complex and uniform organoid self-organization - Nature MaterialsA tunable granular biomaterial matrix is developed to support long-term bioprinting. Stress relaxation at high strains and long timescales is shown to be important for tissue self-organization in inte... 295
Reposted by Aria 哲媛 HuangLukasz Bugaj @bugajlab.bsky.social · 30/04/2025Proteins often bind targets using avidity, the combined interaction strength of multiple weak binders. Now we’ve harnessed this principle for compact, *single*-component optogenetic tools for translocation. Lead by phenom PhD student @dennishuang.bsky.social #synbiosky🧵 📝 tinyurl.com/aviatar 1197
Aria 哲媛 Huang @azyhuang.bsky.social · 11/02/2026so excited to have this finally out!!! many cool tools to consider for the organoid enthusiasts and beyond🤩 010
Reposted by Aria 哲媛 HuangLukasz Bugaj @bugajlab.bsky.social · 16/12/2025🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle. Led by superb PhD student Carol Gao. www.biorxiv.org/content/10.1... Implications for drug tolerance/resistance, and includes one big surprise🫧.👇 21918
Reposted by Aria 哲媛 HuangAlex Hughes Lab @hugheslabpenn.bsky.social · 13/12/2025*New preprint alert* uncovering a mechanical pacemaker that synchronizes nephron formation with branching of the kidney's epithelial tubule tree. Read below to learn about this twisty journey lead by Sam Grindel and Sachin Davis in the lab. [Movie by Nils Lindstrom] www.biorxiv.org/content/10.1... 24010
Reposted by Aria 哲媛 HuangLukasz Bugaj @bugajlab.bsky.social · 08/12/2025#Cellbio2025 come see the latest from the lab, including on opto/thermogenetics, condensates, RTK fusions, stress granules, biosensors of clustering. Talks and posters today and tomorrow! 186
Reposted by Aria 哲媛 HuangLukasz Bugaj @bugajlab.bsky.social · 07/12/2025#CellBio2025 come check out the workshop on applying optogenetic tools in cell biology! Today (Sunday) at 5:30p in Rm 121. Note that this session does *not* appear in the app for some reason 0104
Reposted by Aria 哲媛 HuangZikang (Dennis) Huang @dennishuang.bsky.social · 07/12/2025#cellbio2025 please stop by my talk (Mon 4:35 evolution) and poster (Mon 12:45 #B479 optogenetics) tmr! Title: Intraprotein domain competition dictates pulsatile response of photoreceptors shaped by temperature and evolution. BcLOV4 as a model. I’m also looking for postdoc opportunities! 0166
Aria 哲媛 Huang @azyhuang.bsky.social · 07/12/2025if you are attending #CellBio2025 please check out the posters from our lab @hugheslabpenn.bsky.social. The lab will have a great showing this year featuring my talented colleagues @lsprahl.bsky.social @danielalber.bsky.social and many others! 095
Reposted by Aria 哲媛 HuangBabli Adhikary @babliadhikary.bsky.social · 06/10/2025PAK4 dynamics at actively remodeling vertices 🌟 ⚡👀 Check out our recent preprint www.biorxiv.org/content/10.1...biorxiv.orgPAK4 promotes vertex remodeling to maintain epithelial integrity and barrier functionCell-cell junctions are essential for epithelial integrity and barrier function, but the mechanisms regulating their remodeling remain unclear. Here, we investigated the role of the junctional kinase ... 142
Reposted by Aria 哲媛 HuangDevelopment @dev-journal.bsky.social · 01/09/2025📢Call for papers. Submit your latest research to our upcoming special issue – The Extracellular Environment in Development, Regeneration and Stem Cells Guest Editors: Alex Hughes and Rashmi Priya 📅 Deadline: 1 March 2026 journals.biologists.com/dev/pages/ex... #DevBio 01711
Aria 哲媛 Huang @azyhuang.bsky.social · 22/08/2025Excited to have it online @natcomms.nature.com many many thanks to @lsprahl.bsky.social, Karen Xu, Jason Burdick, Rob Mauck and other talented people involved! 161
Reposted by Aria 哲媛 HuangElena Scarpa & The Squeezable Cells Lab @squeezycellslab.bsky.social · 06/06/2025Very excited to share the first preprint from the lab: www.biorxiv.org/cgi/content/... We investigated neural crest migration all the way from head to tail of the Zebrafish embryo and we found their nuclei suffer dramatic deformations. Want to know of they cope with feeling squeezed? 🐟🐠🐟 37017
Reposted by Aria 哲媛 HuangAlex Hughes Lab @hugheslabpenn.bsky.social · 03/06/2025Our own @azyhuang.bsky.social is a student this year representing the kidney fanaticsmedia.tenor.comtwo men are standing next to each other with the words `` day 1 you got this '' written on them .ALT: two men are standing next to each other with the words `` day 1 you got this '' written on them . 001
Reposted by Aria 哲媛 HuangLukasz Bugaj @bugajlab.bsky.social · 09/05/2025Are you interested in synthetic and systems biology approaches to study #spatiotemporal processes in cancer? Join NCI for virtual workshops on May 13, 15, & 20 (next week!) from 12:00–4:30 PM ET: registration: events.cancer.gov/nci/syntheti... #SynSysBio4SpatialCancerResearch 1117
Reposted by Aria 哲媛 HuangZikang (Dennis) Huang @dennishuang.bsky.social · 15/04/2025How can an individual protein show adaptation? The light- and temp-sensitive BcLOV4 gives a pulse of translocation during a step input of light. Answer in our preprint: *intra-molecular* feed-forward regulation. bit.ly/3Rg9veD A @bugajlab.bsky.social collab with @nmrkaygee.bsky.social 🧵 12110
Reposted by Aria 哲媛 HuangShashank Shekhar lab @sshekhr.bsky.social · 02/04/2025📢Excited to share our new paper in Nature Physics @naturephysics.bsky.social: Cooperative hydrodynamics accompany multicellular-like colonial organization in the unicellular Stentor! How do single-celled organisms benefit from teamwork? Let’s dive in! #Multicellularity nature.com/articles/s41...? 914238
Reposted by Aria 哲媛 HuangCell Press @cellpress.bsky.social · 02/04/2025Miso made in space tastes nuttier! Researchers successfully make miso at the #InternationalSpaceStation, confirming that making fermented foods in space is possible. www.cell.com/iscience/ful... @medialab.bsky.social Maggie Coblentz @novo-nordisk.bsky.social Joshua D. Evans @cp-cell.bsky.social 053
Reposted by Aria 哲媛 HuangZev Gartner @zevgartner.bsky.social · 20/03/20251. Struggling to integrate single-cell datasets? Finding it hard to resolve clear differentiation trajectories? Reveal the underlying structure in your data with CONCORD. 1226
Reposted by Aria 哲媛 HuangKatalin Susztak @ksusztak.bsky.social · 07/02/2025🎇Our new paper in @ScienceMagazine : Kidney Multiome-Based Genetic Scorecard Reveals Convergent Coding and Regulatory Variants. @Hongbo919Liu science.org/doi/10.1126/...science.orgKidney multiome-based genetic scorecard reveals convergent coding and regulatory variantsKidney dysfunction is a major cause of mortality, but its genetic architecture remains elusive. In this study, we conducted a multiancestry genome-wide association study in 2.2 million individuals and... 106623
Reposted by Aria 哲媛 HuangJoel Boerckel @jboerckel.bsky.social · 24/12/2024Woohoo! Our latest preprint, from @madhura0327.bsky.social, is out today on bioRxiv! YAP regulates periosteal expansion in fracture repair. www.biorxiv.org/content/10.1... 2305
Reposted by Aria 哲媛 HuangAlex Hughes Lab @hugheslabpenn.bsky.social · 20/12/2024Happy holidays from the Hughes lab ✨ #fluorescencefriday 0434
Aria 哲媛 Huang @azyhuang.bsky.social · 17/12/2024Of course it is out the day after my conference talk 🤣😅 at least it’s available for anyone who wants to see pretty figures 020
Reposted by Aria 哲媛 HuangLouis Prahl @lsprahl.bsky.social · 14/12/2024These dancing cells and I are in San Diego for #CellBio2024 this week! Come check out my talk during the "Building Biological Tubes" subgroup on Sunday, December 15 at 9am to hear me present some progress towards controlling epithelial organization in kidney tissues and organoids. 2777
Reposted by Aria 哲媛 HuangAlex Hughes Lab @hugheslabpenn.bsky.social · 14/12/2024Those at @ascbiology.bsky.social #CellBio2024 conference tomorrow, check out @azyhuang.bsky.social Aria Huang's work on 'truly' 3D, live explant cultures of mouse embryonic kidneys for studying cell dynamics and congenital disease! 063
Aria 哲媛 Huang @azyhuang.bsky.social · 10/12/2024inaugural bluesky introduction: science(maybe) meetings happened in 2024 010
