iiinova — where your digital self keeps evolving

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Hans Clevers @hansclevers.bsky.social · 10/05/2026

Short write-up of our journey. Searching for T cell transcription factors, Marc v/d Wetering stumbled across Wnt signaling. Vladja Korinek linked Wnt to colon cancer and crypt biology. Nick Barker discovered the gut stem cell. Toshi Sato invented organoids authors.elsevier.com/a/1n3No6tu0C...

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Joris Hageman @jorihag.bsky.social · 15/04/2026

Very proud to share our new paper on early cancer progression, published in Nature! Beyond the science itself, this project really shows what strong interdisciplinary collaboration can achieve. I feel grateful to have been part of this amazing team. Check out our discoveries below!

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Snippert lab @hugosnippert.bsky.social · 15/04/2026

Huge news! Our research is out in Nature✨ www.nature.com/articles/s41... We’ve uncovered that oncofetal plasticity in colorectal cancer arises far earlier than anyone expected. Providing a new lens on how cancers transition to metastatic disease. Big thanks to my team and collaborators!

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Joris Hageman @jorihag.bsky.social · 29/07/2025

I’m happy to share our new preprint on stem cell regeneration in the human colon! Using new CRISPR knockins in organoids, we show that after stem cell loss, non-stem cells rapidly regenerate them. This process is normally inhibited by the stem cells themselves. Manuscript link: tinyurl.com/3ky4ccxf

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Snippert lab @hugosnippert.bsky.social · 23/07/2025

🔊 Paper alert 1/ Tuft cells are perhaps the coolest cells in our gut orchestrating host defense, but how do they manage? @julian-buissant.bsky.social provides new insights into tuft cell differentiation, and the development of accurate in vitro models for experimental cell biology 🧫🔬🧬 rdcu.be/exou9

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Snippert lab @hugosnippert.bsky.social · 16/07/2025

Big thanks to all our co-authors and in particular @jorihag.bsky.social for conceiving and spearheading this cool project 👏👏 🙌 💪

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Snippert lab @hugosnippert.bsky.social · 16/07/2025

📢 New preprint 🔥 1/ Stem cell regeneration is often viewed as an actively induced process, triggered by damage. But what if plasticity is actively suppressed by the stem cells themselves? We explored plasticity with 'new' cell type ablation tech in normal human colon organoids tinyurl.com/3ky4ccxf

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Trevor Graham @trevorgraham.bsky.social · 07/03/2025

Our #Cancer #Evolution summer school runs again 30 June-3 July at the beautiful Genome Campus in Hinxton, UK sponsored by @wellcometrust.bsky.social Ideal for starters in the field; this year's focus is on using genomic data for cancer evo research. Brilliant & inspiring faculty! bit.ly/40nLdDD

bit.ly

Evolutionary Biology and Ecology of Cancer — 20250630

Evolutionary Biology and Ecology of Cancer

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Snippert lab @hugosnippert.bsky.social · 14/02/2025

📢 Organoid enthusiast: We are preparing for the 3rd edition of OrganoidNL - April 11th! 🔥 Check amazing line up of speakers 🔥 Calvin Kuo @priscaliberali.bsky.social Nicolas Rivron, Ina Sonnen @kaikretzschmar.bsky.social Mina Gouti, and others. Be fast to register in time amolf.nl/organoidnl-s...

amolf.nl

OrganoidNL Symposium - AMOLF

OrganoidNL Symposium 2025 Friday, April 11

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Philip Dunne @profpipdunne.bsky.social · 06/12/2024

Massive congrats to Shania, Svetlana & Noha (not on Bsky) identifying the mechanistic and phenotype cascades underpinning the anti-metastatic response triggered by viral mimicry TLDR; aggressive CMS4 tumours can be reprogrammed towards less aggressive CMS1 biorxiv.org/content/10.1... thread 👇

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Julian Buissant des Amorie @julian-buissant.bsky.social · 03/12/2024

Very happy that our tuft cell story is now on BioRxiv! If you want to know how to induce mature tuft cell phenotypes in organoids check out the preprint

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The Batlle Lab @batllelab.bsky.social · 02/12/2024

📢📢📢

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Snippert lab @hugosnippert.bsky.social · 01/12/2024

New work on #tuft cells, rare guardians of our #gut against invaders. How they work is not known. We show that intestinal tuft types 1&2 are sequentially expressed phenotypes during differentiation. And…we can now generate mature immune-related tuft-2’s in #organoids for more 🔬🧫🧬🔥 shorturl.at/EImjA

shorturl.at

Mature tuft cell phenotypes are sequentially expressed along the intestinal crypt-villus axis following cytokine-induced tuft cell hyperplasia

Intestinal tuft cells are epithelial sentinels that trigger host defense upon detection of parasite-derived compounds. While representing interesting targets for immunomodulatory therapies in inflamma...

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Snippert lab @hugosnippert.bsky.social · 01/12/2024

shorturl.at

Mature tuft cell phenotypes are sequentially expressed along the intestinal crypt-villus axis following cytokine-induced tuft cell hyperplasia

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Snippert lab @hugosnippert.bsky.social · 24/11/2024

Hey all, we are pretty new here Our team likes to be creative with #organoids to solve science questions that excite us. We mostly focus on early-stage colorectal #cancer using #patient #samples. We'll post new work soon 🔥. First an adventurous detour 😊 on #tuft cell differentiation, stay tuned…

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