Nature Reviews Molecular Cell Biology, Published online: 14 August 2026; doi:10.1038/s41580-026-01012-9Mitophagy contributes to cellular homeostasis through the recycling of damaged mitochondria and precise control of mitochondrial numbers. In this Review, Martens and Ganley summarize the molecular mechanisms involved in mitophagy pathways, mitophagy regulation and roles in disease.

Effective lysosome function is essential for health, and declines with ageing and disease. Upon lysosome damage, cells mount a complex stress response to restore homeostasis. Membrane ATG8ylation play...

Impairments in intracellular quality-control mechanisms, including autophagy, affect neuronal integrity and function. Despite numerous studies aimed at slowing neuronal deterioration, it remains uncle...

We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog

Two protein complexes that regulate intracellular transport and lysosome positioning were long thought to exist as single, well-defined entities. New structural insights now come from the groups of Da...

After damage from pathogenic, chemical or physical stress, endolysosomal membranes are repaired and resealed by the endosomal sorting complex required for transport (ESCRT) machinery, but how this mem...

Mitochondrial ATP production is essential for life. Mitochondrial function depends on the spatio-temporal coordination of nuclear and mitochondrial genome expression, yet how this coordination occurs ...

The ULK1 complex (ULK1C) and the class III phosphatidylinositol 3-kinase complex I (PI3KC3-C1) act together to initiate autophagy. Human ULK1C consists of ULK1 itself, FIP200, and the HORMA domain het...

CIBSS speaker Prof. Dr. Claudine Kraft is part of a team receiving an ERC Synergy Grant of ten million euros for her research on how autophagy degrades large protein aggregates in health and disease.

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Cryo-electron microscopy was used to study human mechanistic target of rapamycin complex 1 (mTORC1) activation on lysosomal membranes, showing progressive recruitment by RAG–Ragulator, RHEB and R...

Our Group The Loose lab at the Institute of Science and Technology Austria (ISTA) is looking for a highly motivated Master student to join our research on the in vitro reconstitution of signaling n...

Grabarczyk et al. show the structure and mechanism of a non-canonical ubiquitin ligase, which is activated through nucleic-acid-induced oligomerization and is critical for cell survival during immune ...