Kücükköse, Luzarowski and colleagues show that removing a single N-terminal amino acid during the maturation of newly imported mitochondrial proteins globally stabilizes mitochondrial protein complexe...

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Plants strategically respond to gravity and actively set defined growth angles. These gravitropic set-point angles (GSAs) shape the width and depth...

Summary: MTFR1L acts at mitochondrial mitophagy initiation sites, linking mitochondrial fission with autophagy by interacting with ULK1, regulating ATG13 stability, and forming a feedback loop that su...

Heinen et al. show that the mitochondrial import complex recruits lipid droplets to the mitochondrial outer membrane. The mitochondrial import complex binds to the lipid metabolism enzyme Ayr1 and con...

Autophagy enables cells to selectively degrade a wide range of macromolecules, and how this process achieves spatial precision within the densely packed cytosol is an active area of investigation. Rec...

CIBSS speaker Prof. Dr. Claudine Kraft is part of a team receiving an ERC Synergy Grant of ten million euros for her research on how autophagy degrades large protein aggregates in health and disease.

Research into how cells initiate and regulate autophagy opens the door to new ways of preventing a range of diseases.,,,European Commission

imageimageLRBA regulates autophagy and antigen presentation, shedding light on the mechanism of immune dysregulation in LRBA deficiency. LRBA directly interacts with PIK3R4 and FYCO1, promoting autop...

Lysosome damage activates multiple pathways to prevent lysosome-dependent cell death, including a repair mechanism involving endoplasmic reticulum (ER…