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Martin Loose

@nartimsoole.bsky.social
807 followers 359 following 37 posts

Interested in protein self-organization. We rebuild the bacterial cell division machinery and small GTPase networks in vitro. looselab.ist.ac.at

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Martin Loose @nartimsoole.bsky.social · 01/10/2026
Congratulations to all authors on this epic work! Especially to first author and my former student Philipp! 😀 @radler92.bsky.social
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Paula Navarro @navarropaula.bsky.social · 03/07/2026
🚨 New in @natmicrobiol.nature.com! We reveal how the antibiotic target PBP1b fortifies the E.coli division site against osmotic rupture. Proud this was completed in our independent labs @dmf-unil.bsky.social, with @avettiger.bsky.social. Congratulations to all authors! 🦠❄️🔬 #teamtomo bit.ly/3SCbOg1 👇
doi.org
The penicillin-binding protein PBP1b fortifies the Escherichia coli division site against osmotic rupture - Nature Microbiology
A specific isoform of PBP1b functions independently of the activator protein, LpoB, to drive generation of a wedge-like peptidoglycan structure that strengthens the division site in Escherichia coli.
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Stella Hurtley @smhsci.bsky.social · 17/04/2026
Out now in @science.org Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape | Science www.science.org/doi/10.1126/...
science.org
Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape
Bacteria, like eukaryotes, use conserved cytoskeletal systems for intracellular organization. The plasmid-encoded ParMRC system forms actin-like filaments that segregate low–copy number plasmids. In m...
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Institute of Science and Technology Austria (ISTA) @istaresearch.bsky.social · 16/04/2026
Photosynthetic bacteria helped shape Planet Earth. Among them cyanobacteria—microbes that produced the oxygen in Earth’s atmosphere & made complex life possible. They have captivated scientists for decades by offering insights into how life evolved from single cells into multicellular organisms.
Fluorescent Anabaena. Fluorescently labelled CorM filaments inside Anabaena. These represent a newly discovered cytoskeleton in multicellular cyanobacteria. © Loose group
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Martin Loose @nartimsoole.bsky.social · 16/04/2026
Now out in its final form! www.science.org/doi/10.1126/...
science.org
Science | AAAS
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Brugues Lab @brugueslab.bsky.social · 07/01/2026
Excited to share Alison's @alisonkickuth.bsky.social paper from the lab out in @nature.com this week! We uncovered how a mechanical ratchet mechanism drives cytokinesis in early #zebrafish embryos. Read more in this thread 🧵 and at www.nature.com/articles/s41... 🤩 @poldresden.bsky.social @mpi-cbg.de
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Martin Loose @nartimsoole.bsky.social · 18/12/2025
Time to say goodbye 👋 After finishing his paper and defending his thesis, Marko is starting a new chapter as a postdoc at @cemess.bsky.social (Uni Wien). We’ll miss having you around! Congrats and all the best!
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Martin Loose @nartimsoole.bsky.social · 26/11/2025
Happy to share a new preprint from the lab: Marko became interested in whether the disordered linker of FtsZ might influence how the protein organizes into the Z-ring. And this led to some surprising findings! Preprint: www.biorxiv.org/content/10.1...
biorxiv.org
Charge segregation in the C-terminal linker of FtsZ enables Z-ring scaling with prokaryotic cell width
Bacterial cytokinesis is orchestrated by the Z-ring, a cytoskeletal structure formed by treadmilling filaments of the tubulin-like GTPase FtsZ. During assembly, filament curvature must match the cell ...
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Institute of Science and Technology Austria (ISTA) @istaresearch.bsky.social · 27/10/2025
Our fully-funded PhD program is open for applications! Join us to conduct cutting-edge research at top facilities with guidance from world-class faculty. Through our interdisciplinary training, you can tailor your PhD experience to match your interests and curiosity. Apply now: phd.ista.ac.at
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Martin Loose @nartimsoole.bsky.social · 15/10/2025
The Institute of Science and Technology Austria (ISTA) @istaresearch.bsky.social is hiring a tenure-track staff scientist in Computational Structural Biology (cryo-EM, cryo-ET, structural prediction methods, image analysis)! More info here: apply.ista.ac.at/comp_structu...
apply.ista.ac.at
GenApp
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Stephan Wilmes @stephanwilmes.bsky.social · 02/09/2025
Thrilled to share our newest publication in Science Advances! We uncovered how two RabGEF complexes — Mon1-Ccz1 and Fuzzy-Inturned — adapt to regulate distinct Rab GTPases despite their structurally conserved catalytic core. www.science.org/doi/full/10....
science.org
Mechanistic adaptation of the metazoan RabGEFs Mon1-Ccz1 and Fuzzy-Inturned
The molecular comparison of related RabGEFs reveals adaptation mechanisms of a functional module for specific cellular tasks.
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Martin Loose @nartimsoole.bsky.social · 01/09/2025
We are looking for a Master’s student to join a project on in vitro reconstitution of signaling networks in pathogen–host interactions: combine protein biochemistry, fluorescence microscopy & image analysis. Deadline: September 15. Find out more and apply here: ist.ac.at/en/job/maste...
ist.ac.at
Master Thesis Position – Loose Research Group
Our Group The Loose lab at the Institute of Science and Technology Austria (ISTA) is looking for a highly motivated Master student to join our research on the in vitro reconstitution of signaling n...
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Florian Schur @schurlab.bsky.social · 07/07/2025
We're hiring a postdoc! Join our ActinID project to explore an uncharacterized actin-binding protein. - Background in cell and/or structural biology? - Eager to bridge both fields? Get in touch if you're curious or have questions! #cellbiology #cryoEM #cryoET #actin ista.ac.at/en/job/postd...
ista.ac.at
Postdoc Research Group Schur
The Schur lab at the Institute of Science and Technology Austria (ISTA) has an open postdoc position for a highly motivated candidate to be part of our ERC-funded project ActinID. Our Group ...
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Martin Loose @nartimsoole.bsky.social · 02/07/2025
One of the most exciting discoveries from our lab so far is now online as a preprint! Read a story on how the ParMR and Min systems started to collaborate to create the CorMR cytoskeleton, which now controls cell shape in multicellular cyanobacteria: www.biorxiv.org/content/10.1...
biorxiv.org
Evolutionary repurposing of a DNA segregation machinery into a cytoskeletal system controlling cyanobacterial cell shape
Bacteria, despite their diversity, use conserved cytoskeletal systems for their intracellular organization. In unicellular bacteria, the ParMRC DNA partitioning apparatus is well known for forming act...
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Martin Loose @nartimsoole.bsky.social · 10/04/2025
Looking for a student or postdoc! Want to combine evolutionary analysis + structural modeling with in vitro biochemistry & fluorescence microscopy? Help us uncover new protein-protein interactions — from in silico to in vitro. Join us at @istaresearch.bsky.social 👉 looselab.org 🧬💡🔬🎡
looselab.org
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Martin Loose @nartimsoole.bsky.social · 04/04/2025
Very cool findings from Paula, Andrea et al.! Excited that my student Roman could contribute! See Andrea’s thread below for more details:
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Paula Navarro @navarropaula.bsky.social · 03/04/2025
🚨👉 Please check our recent work on bacterial cell division. In situ Cryo-ET reveals the cellular function of the penicillin binding protein 1b supported by AFM, live-cell imaging, in silico AlphaFold proteome screen and TIRFM. Hope you enjoy the read! #teamtomo #cryo-ET ❄️🔬🐎 big thanks to the team!
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STCmicrobeblog @stcmicrobeblog.bsky.social · 23/03/2025
who doesn't enjoy some beautiful FtsZ rings on a sunday evening? these from 𝘚𝘵𝘢𝘱𝘩𝘺𝘭𝘰𝘤𝘰𝘤𝘤𝘶𝘴 𝘢𝘶𝘳𝘦𝘶𝘴, from all angles, by the @jwveening.bsky.social, posted earlier on 𝕏, on may 6, 2021 Movie S2 from journals.plos.org/plospathogen... #MicroSky
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Martin Loose @nartimsoole.bsky.social · 20/12/2024
Excited about protein biochemistry, fluorescence microscopy, and image analysis? Curious how proteins drive bacterial division or define organelle identity? Join us at ISTA! Apply to the PhD program by Jan 8th: gradschool.ist.ac.at
gradschool.ist.ac.at
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Martin Loose @nartimsoole.bsky.social · 18/12/2024
Input needed: What is your favourite amphipathic helix? I am looking for looots of sequences to train a ML model to find even more. Please tell me! Thanks! :)
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