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SFB Targeted Protein Degradation

@sfb-tpd-vienna.bsky.social
829 followers 289 following 79 posts

FWF-funded Austrian Research Consortium of the labs of Sascha Martens, Alwin Köhler, Andreas Bachmair, Gijs Versteeg, Tim Clausen, David Haselbach, Yasin Dagdas, Silvia Ramundo, Georg Winter, Christian Becker & Ilaria Piazza. www.protein-degradation.org

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Milena Schuhmacher @mschuhmacher.bsky.social · 01/10/2026
So excited to join the Perutz! #lipidtime I will also be looking for new PhD students and postdocs soon ☺️
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Silvia Ramundo @sramundo.bsky.social · 19/08/2026
A stress response can be a great starting point for discovering new biology! By following genes regulated during the chloroplast unfolded protein response, we’re discovering novel factors involved in chloroplast homeostasis. Here’s the first one we characterized: www.pnas.org/doi/10.1073/...
pnas.org
VIA1 is a conserved regulator of thylakoid membrane integrity that acts through VIPP1 | PNAS
Thylakoid membranes are indispensable for oxygenic photosynthesis, yet the mechanisms that protect these membranes from photooxidative damage remai...
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Noelia Urbán Avellaneda @antsinthecarpet.bsky.social · 17/09/2026
🎉Preprint out! In our new manuscript, we reveal that, much like us, wake up (proliferation) and sleeping (quiescence) patterns of adult neural stem cells are controlled by the circadian clock machinery. www.biorxiv.org/content/10.6...
biorxiv.org
PER2- and state-dependent transcriptional programs gate neural stem cell proliferation with niche-specific circadian autonomy
Adult neural stem cells (NSCs) in the mouse brain are predominantly quiescent, with activation tightly regulated to balance neurogenesis and stem cell maintenance. Circadian clocks temporally organize...
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Gregor Mendel Institute of Molecular Plant Biology @gmivienna.bsky.social · 28/05/2026
New study published in Science! Led by @thevirusmc.bsky.social and @plantophagy.bsky.social, former group leader at the GMI of the @oeaw.bsky.social, the researchers set out to understand how autophagy – the cell’s clean-up and recycling system – mediates plant immune response to viral infection.
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COS Heidelberg @cosheidelberg.bsky.social · 29/05/2026
New paper from the Yasin Dagdas (@plantophagy.bsky.social) group, this time in @science.org, on how plant cells cope with viral infection and how selective autophagy delays cell death to give plants a chance to survive. Chapeau and congratulations to all the authors! www.science.org/doi/10.1126/...
science.org
Selective autophagy fine-tunes plant immunity to promote cell survival during viral infection
RNA viruses co-opt host endomembranes to form replication complexes, often triggering cellular stress and immune responses. Here, we show that Arabidopsis thaliana activates selective autophagy to res...
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Clausen Lab @clausenlab.bsky.social · 21/05/2026
Open Postdoc Position - Giant E3 ligases: mysterious mechanisms & non‑protein substrates. Interested? Join us to uncover how these molecular giants tag lipids, RNAs, sugars beyond proteins, on organelles and pathogens, to defend the cell. Details & Application here www.imp.ac.at/career/open-...
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Center of Medical Biotechnology @unidue-zmb.bsky.social · 29/04/2026
Find members of the #ZMB community at #ubfriends2026! @hemmo-lab.bsky.social will be speaking, and @hellerschmiedlab.bsky.social and @leokiss.bsky.social will be there in person. A great chance to connect with the #ubiquitin and #proteindegradation field! Have a great #ubfriends2026!
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Elias Adriaenssens @elias-adriaenssens.bsky.social · 29/04/2026
My favourite meeting of the year has arrived again! 👇🤩
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SFB Targeted Protein Degradation @sfb-tpd-vienna.bsky.social · 29/04/2026
And we’re off🚀 Great to see the hall filled as Tim Clausen @clausenlab.bsky.social & Silvia Ramundo @sramundo.bsky.social open Ub & Friends Symposium 2026! Looking forward to inspiring talks & lively discussions with this amazing community! Let’s talk all things Ubiquitin & Friends 🙌 #ubfriends2026
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SFB Targeted Protein Degradation @sfb-tpd-vienna.bsky.social · 29/04/2026
The day has come! Ubiquitin & Friends Symposium 2026 will kick off today 🎉 2 days of exciting science & discussions ahead — from #ProteinQualityControl and #autophagy to signaling and the more unconventional corners of #ubiquitin biology! #ubfriends2026 www.protein-degradation.org/symposium/pr...
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SFB Targeted Protein Degradation @sfb-tpd-vienna.bsky.social · 09/04/2026
Fantastic teamwork by Milica Mihailovic & Aleksandra Anisimova from the Karagöz lab @gekaragoz.bsky.social @maxperutzlabs.ac.at together with the @plantophagy.bsky.social lab — Another great collaboration 🙌 within our SFB program, published in @embojournal.org 🔗 link.springer.com/article/10.1...
link.springer.com
The coordinated action of UFMylation and the RQC pathways clears arrested polypeptides at the ER - The EMBO Journal
Clearance of arrested nascent polypeptides resulting from ribosomal stalling is essential for proteostasis. Stalled endoplasmic reticulum (ER)-bound ribosomes are marked by ubiquitin-fold modifier 1 (...
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Max Perutz Labs Vienna @maxperutzlabs.ac.at · 02/03/2026
Fantastic news! 🙌 The Perutz is excited to welcome Danny Nedialkova as a new group leader starting this April! 🎉 She will strengthen the institute's research on the fundamental mechanisms that shape cellular physiology and disease ➡️ www.maxperutzlabs.ac.at/research/res...
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SFB Targeted Protein Degradation @sfb-tpd-vienna.bsky.social · 09/04/2026
Huge congrats to our SFB consortium member @gekaragoz.bsky.social & the great team she coordinates in this Emerging Field project 👏👏👏 Read all about it below 👇
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SFB Targeted Protein Degradation @sfb-tpd-vienna.bsky.social · 08/03/2026
Only one week to register and submit your abstract❗ Sign up now to 💾 your spot ➡️ www.protein-degradation.org/symposium/
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SFB Targeted Protein Degradation @sfb-tpd-vienna.bsky.social · 23/02/2026
And we can't wait 🤩 to welcome you soon @kirsteinlab.bsky.social to our symposium #ubfriends2026!
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Haselbach Lab @haselbachlab.bsky.social · 12/02/2026
This is a video summarizing our recent paper (www.nature.com/articles/s41...) youtu.be/eNY2CRlYTRo
nature.com
A multivalent adaptor mechanism drives the nuclear import of proteasomes - Nature Communications
Nuclear protein homeostasis relies on proteasome import into the nucleus. Here the authors identify how assembled human proteasomes are transported across the nuclear pore complex and reveal a mechani...
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Haselbach Lab @haselbachlab.bsky.social · 11/02/2026
And a new paper from the lab. A follow up to a previous study in which we elucidate the mechanism of the nuclear transport. Read the full story: www.nature.com/articles/s41...
nature.com
A multivalent adaptor mechanism drives the nuclear import of proteasomes - Nature Communications
Nuclear protein homeostasis relies on proteasome import into the nucleus. Here the authors identify how assembled human proteasomes are transported across the nuclear pore complex and reveal a mechani...
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Vienna BioCenter @viennabiocenter.bsky.social · 19/02/2026
SAVE THE DATE: Ubiquitin & Friends Symposium 2026 on April 29-30 or even better, sign up now: lnkd.in/eEQmaCYT It takes place at Van Swieten Hall, 1090 Vienna & is organized by the SFB Targeted Protein Degradation (incl. numerous research groups at Vienna BioCenter) @sfb-tpd-vienna.bsky.social
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SFB Targeted Protein Degradation @sfb-tpd-vienna.bsky.social · 22/02/2026
Fantastic teamwork by Irene Schwartz & Valentina Budroni from the lab of @versteegga.bsky.social @maxperutzlabs.ac.at together with colleagues in our SFB consortium & beyond 👏Great to see the story out @natcomms.nature.com 🔗 www.nature.com/articles/s41...
nature.com
Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity - Nature Communications
APOBEC deaminases restrict retroviruses but can also mutate human DNA. Here, the authors show that cancerassociated APOBEC3s with low RNA binding, known to enter the nucleus, are selectively recognize...
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Max Perutz Labs Vienna @maxperutzlabs.ac.at · 30/01/2026
Paper alert! 📢 How do cells fight viruses without harming themselves? 🧬 In @natcomms.nature.com, the @versteegga.bsky.social lab uncover a previously unknown safeguard that keeps DNA-mutating antiviral enzymes in check, protecting the genome while preserving antiviral defense ➡️ tinyurl.com/4xbxz9e8
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Bernd Bauer @berndbauer.bsky.social · 14/02/2026
Why do pathological protein aggregates persist in cells and how can we overcome this? In our new preprint, we show that Tau aggregates fail to initiate selective autophagy and that their autophagic degradation can be restored. #Autophagy #Tau #Proteostasis Out now 👇 www.biorxiv.org/content/10.6...
biorxiv.org
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Haselbach Lab @haselbachlab.bsky.social · 19/01/2026
Have a look at our new structure of co translational folding in yeast. This is collaborative work initialized by the Rospert lab from the @uni-freiburg.de. Structural work has been done by the amazing @lgrundmann.bsky.social Stay tuned for the next ribosome paper from him, following very soon.
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Yasin Dagdas @plantophagy.bsky.social · 10/01/2026
If you are interested in #ubiquitin related topics (Who isn’t???) & looking for a friendly and collegial meeting where you can talk to anyone & everyone, this is your meeting!
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SFB Targeted Protein Degradation @sfb-tpd-vienna.bsky.social · 10/01/2026
Join us for the #Ubiquitin & Friends Symposium 2026, April 29-30, in Vienna! Fantastic guest speakers👇 & many slots for talks from abstracts, flash-talks & posters. Lots of opportunities to network. Register now to save your spot! ➡️ www.protein-degradation.org/symposium/ #ubfriends2026
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SFB Targeted Protein Degradation @sfb-tpd-vienna.bsky.social · 22/12/2025
📢 Extended Application Deadline: 🗓️27 January 2026❗ www.nature.com/naturecareer...
nature.com
Full Professor of Integrative Structure Biology - Vienna BioCenter, Austria job with Max Perutz Labs, University of Vienna | 12848353
Join the Max Perutz Labs as Full Professor to advance cryo-electron tomography & integrative approaches for understanding molecular complexity in situ
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Max Perutz Labs Vienna @maxperutzlabs.ac.at · 31/10/2025
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
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SFB Targeted Protein Degradation @sfb-tpd-vienna.bsky.social · 06/11/2025
Indeed big news 📣! Congratulations to @martenslab.bsky.social for receiving an ERC Synergy Grant — his third ERC-funded project 👏👏👏 See all about it below👇
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Elias Adriaenssens @elias-adriaenssens.bsky.social · 13/08/2025
Absolutely honoured to see our work featured on this month’s cover! 🎉🧬 Artwork by the incredibly talented @doroteaartscience.bsky.social 👇
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Max Perutz Labs Vienna @maxperutzlabs.ac.at · 11/09/2025
Opportunity for skilled hands and sharp minds - at any career stage! 💪 The Köhler Lab is seeking a full-time lab technician to support their research on nuclear envelope biology, chromatin regulation, and cellular stress resilience - apply here ➡️ tinyurl.com/bdfy3w2h
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Max Perutz Labs Vienna @maxperutzlabs.ac.at · 28/08/2025
Congrats to all scientists! 👏 The @versteegga.bsky.social lab has long collaborated with the Clausen lab, and this new study once again highlights the collaborative spirit of the @vbcscitraining.bsky.social ⤵️
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Anna Obenauf @obenaufa.bsky.social · 04/09/2025
Exciting FULL PROFESSORSHIP at the Vienna BioCenter - Molecular Mechanisms of Disease Mechanisms: www.maxperutzlabs.ac.at/news/open-po... Come be our colleague!
maxperutzlabs.ac.at
Full Professorship in Molecular Mechanisms of Disease
The Max Perutz Labs - one of Europe’s leading institutes for basic research in the life sciences - invite applications for a Full Professorship in Molecular Mechanisms of Disease. We are seeking outst...
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Nature Cell Biology @natcellbio.nature.com · 14/08/2025
🍹@martenslab.bsky.social @elias-adriaenssens.bsky.social & co show that, unlike soluble, transmembrane cargo receptors initiate autophagosome biogenesis by recruiting the FIP200/ULK1 or WIPI–ATG13 complex, revealing unexpected flexibility in the selective #autophagy machinery. bit.ly/4lpGh9P
bit.ly
Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery - Nature Cell Biology
Adriaenssens et al. show that unlike soluble cargo receptors, transmembrane cargo receptors initiate autophagosome biogenesis by recruiting the FIP200/ULK1 or WIPI–ATG13 complex, revealing unexpected ...
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SFB Targeted Protein Degradation @sfb-tpd-vienna.bsky.social · 29/07/2025
Ready to launch🚀 your own lab? @maxperutzlabs.bsky.social are looking for a #tenure-track Assistant Professor👇👇 Supportive, collaborative institute embedded @viennabiocenter.bsky.social with strong infrastructure and excellent training programs. 🔗 www.maxperutzlabs.ac.at/news/open-po...
maxperutzlabs.ac.at
Tenure-Track Professorship in Mechanistic Cell and Developmental Biology
The Max Perutz Labs, one of Europe’s leading institutes for basic research in the life sciences, invites applications for a tenure-track group leader position. We are seeking exceptional can...
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SFB Targeted Protein Degradation @sfb-tpd-vienna.bsky.social · 25/07/2025
🚀Great work led by @elias-adriaenssens.bsky.social in the Martens lab @maxperutzlabs.bsky.social shows a new mechanism for #mitophagy initiation, revealing unexpected flexibility in the assembly& activation of the #autophagy machinery👇 Check it out 🔗 www.nature.com/articles/s41...
nature.com
Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery - Nature Cell Biology
Adriaenssens et al. show that unlike soluble cargo receptors, transmembrane cargo receptors initiate autophagosome biogenesis by recruiting the FIP200/ULK1 or WIPI–ATG13 complex, revealing unexpected ...
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SFB Targeted Protein Degradation @sfb-tpd-vienna.bsky.social · 25/07/2025
Exciting findings, out now @natcellbio.nature.com 👇👇 Congratulations Elias & all co-authors!
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SFB Targeted Protein Degradation @sfb-tpd-vienna.bsky.social · 22/07/2025
❗Exciting #PhD opportunity in the Piazza Lab 👇 @iplab.bsky.social @scilifelab.se #PhDPosition 🧪🧑‍🔬
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SFB Targeted Protein Degradation @sfb-tpd-vienna.bsky.social · 08/07/2025
📣Exciting opportunity at @maxperutzlabs.bsky.social 👇 A great chance to join an outstanding research environment, based at campus @viennabiocenter.bsky.social Spread the word or apply! 🆕 #professorship #Professur 🔗 www.maxperutzlabs.ac.at/fileadmin/us...
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Christa Buecker @chribue.bsky.social · 02/07/2025
Exciting and rare opportunity to join the @maxperutzlabs.bsky.social and the @viennabiocenter.bsky.social as a Full Professor! www.nature.com/naturecareer...
nature.com
Full Professorship in Molecular Mechanisms of Disease - Vienna BioCenter, Austria job with Max Perutz Labs, University of Vienna | 12841053
Join theMax Perutz Labs as Full Professor to unravel disease mechanisms—from metabolism and stress to RNA regulation, epigenetics, and immunity.
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Vienna BioCenter Scientific Training @vbcscitraining.bsky.social · 02/06/2025
The @viennabiocenter.bsky.social PostDoc Program call is now open! We have 16 fully-funded positions for scientists with a PhD in biology, chemistry, physics, bioinformatics etc. Apply here: training.vbc.ac.at/post-docs/vi... #VBCPostDoc
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Clausen Lab @clausenlab.bsky.social · 24/06/2025
postdoc opening in vienna: study lipid droplets (LDs) with integrative structural biology, uncover how LD proteins shuttle between cytosol & nucleus to regulate lipid metabolism, organelle architecture and immune response. #VIP3 #lipidtime #cryoEM #coffee training.vbc.ac.at/post-docs/vi...
training.vbc.ac.at
VIP³ Post Doc Program (2025 - 2030)
VIP3 is a postdoctoral fellowship program at the Vienna BioCenter offering three – year fellowships that are open to candidates with backgrounds in life sciences, chemistry, physics, medicine, enginee...
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Vienna BioCenter Scientific Training @vbcscitraining.bsky.social · 23/06/2025
👀 Did you know? The Vienna BioCenter offers an English speaking life science community in the most livable city in the world! Want to be part of it? The VIP³ PostDoc Program call is open – apply now for this unique opportunity! training.vbc.ac.at/post-docs/vi... #VBCPostDoc
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SFB Targeted Protein Degradation @sfb-tpd-vienna.bsky.social · 02/07/2025
👏 Big CONGRATS to @sramundo.bsky.social for receiving an FWF @fwf-at.bsky.social ASTRA Award 🌠✨ See all about it 👇
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SFB Targeted Protein Degradation @sfb-tpd-vienna.bsky.social · 23/06/2025
Excellent news ✨Congratulations to Alwin Köhler 👏👏👏@maxperutzlabs.bsky.social See ➡️ www.maxperutzlabs.ac.at/news/latest-...
maxperutzlabs.ac.at
Alwin Köhler awarded ERC Advanced Grant
Alwin Köhler, group leader and scientific director at the Max Perutz Labs, has been awarded a European Research Council (ERC) Advanced Grant to investigate how nuclear pore complexes (NPCs) remodel nu...
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SFB Targeted Protein Degradation @sfb-tpd-vienna.bsky.social · 29/05/2025
🙏Thank you for joining!
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SFB Targeted Protein Degradation @sfb-tpd-vienna.bsky.social · 13/05/2025
Thank you for coming! And CONGRATS for presenting one of the BEST POSTERS 🏅👏
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SFB Targeted Protein Degradation @sfb-tpd-vienna.bsky.social · 13/05/2025
Thank you for coming! It was great having you here ☺️ And congrats again for the Best Short Talk 🏆
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SFB Targeted Protein Degradation @sfb-tpd-vienna.bsky.social · 13/05/2025
After all the (re-)connections on day 1, day 2 of #ubfriends2025 even more fabulous for us 🤩 BIG THANKS to all the speakers & poster presenters for sharing their exciting research, and to EVERYONE who joined us! It was a true pleasure to host this amazing community👇
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SFB Targeted Protein Degradation @sfb-tpd-vienna.bsky.social · 09/05/2025
Day 1 one #ubfriends2025 was full of great 🎤talks, creative elevator pitches, lively poster sessions and stimulating discussions...
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Yasin Dagdas @plantophagy.bsky.social · 08/05/2025
@martenslab.bsky.social kicking off the #ubiquitin&friends symposium @sfb-tpd-vienna.bsky.social
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SFB Targeted Protein Degradation @sfb-tpd-vienna.bsky.social · 08/05/2025
Ready & EXCITED to kick off two exciting days of #Ubiquitin & Friends! #ubfriends2025
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