Skin exhibits a remarkable capacity for regeneration, which requires the coordinated reconstitution of diverse cell types and structures. Merkel cells are mechanosensory cells that detect gentle touch...

This study shows that goblet cells physically compress neighboring intestinal cells, creating fractures in cell–cell junctions that weaken epithelial cohesion, increase gut permeability and reveal how...

This EMBO Workshop on Forces Across Scales will provide an integrative perspective on mechanobiology, a rapidly advancing field that examines how mechanical forces shape biological systems across mol…

Cavanaugh et al. show that embryos from aged mice have increased contractility and tissue viscosity on embryonic day 4.5, which leads to poor spreading and attachment. Similar age-associated mechanica...

The organisation of myelinated axons into specialised domains is essential for saltatory conduction and depends on the polarised distribution of neuronal and glial cell-adhesion molecules, including n...

Tissue regeneration is rare in mammals, but the digit tip can regrow after amputation, whereas injuries beyond the nail do not. How the microenvironment drives divergent outcomes remains unclear. In this study, we found that the extracellular matrix (ECM)...

Highlighted Article: A combination of mathematical modelling, in vivo quantitative microscopy, and pharmacological and biophysical manipulations reveals that cell divisions not only challenge, but als...

Summary: This Review presents mechanical fracture as a unifying morphogenetic strategy and describes how developmental systems actively exploit mechanical fracture to drive morphogenesis, reproduction...

Summary: This Review presents mechanical fracture as a unifying morphogenetic strategy and describes how developmental systems actively exploit mechanical fracture to drive morphogenesis, reproduction...

The combined role of cellular junctions and actomyosin networks in tissues remains unclear. Here, the authors identify a tissue-scale star-shaped network of actomyosin that preserves cell shape, limit...

Employing pharmacology, genetics and all-optical approaches in zebrafish, Braaker et al. find that neuronal activity influences the growth of myelin sheaths along axons by signaling through metabotrop...

A microfluidic measurement method translates oocyte mechanical characterization into oocyte quality assessment.