Human brain organoids were developed for over five years in culture to demonstrate that brain cells can continue to mature and record the passage of time, following human-specific endogenous programs,...

Axon diameter is important for action potential conduction speed, but what molecular pathways influence this neuronal property? This study reports a high-resolution imaging-based chemical screening pi...

The organisation of myelinated axons into specialised domains is essential for saltatory conduction and depends on the polarised distribution of neuronal and glial cell-adhesion molecules, including n...

1610 outstanding postdoctoral researchers were selected for funding among 17,066 applicants.

Organ repair and growth rely on coupling tissue-wide membrane depolarization with intracellular proliferative signaling.

CDC42-effector proteins 1/2 are present in CNS myelin. They facilitate the higher order structure of myelin septin filaments. Their loss impairs septin-dependent scaffolding of myelin. Myelin o...

imageimageProtein and peptide tags can profoundly alter condensation in a tag- and protein-specific manner, both in cells and in vitro, highlighting the need for careful validation in condensate studi...

Myelination of CNS axons requires oligodendrocytes to undergo extensive morphological changes by producing large amounts of myelin membrane with defined protein composition and structure. The formatio...